Cross-protection by MF59™-adjuvanted influenza vaccine: Neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses
Abstract
Adjuvants enhance antibody response against vaccination. We compared the ability of MF59-adjuvanted and non-adjuvanted subunit influenza vaccines, containing A/Wyoming/3/03(H3N2), to confer cross-protection against four consecutive drifted strains in the elderly. Neutralizing and haemagglutination-inhibiting antibody were measured. MF59-adjuvanted vaccine induced a stronger booster response against A/Panama/2007/99(H3N2) than non-adjuvanted vaccine. A/Panama/2007/99(H3N2) circulated widely during the previous 5 years and was included in vaccines over four consecutive seasons. Broader serological protection against drifted strains that circulated 1 and 2 years after vaccination with A/Wyoming/3/03(H3N2) was observed with MF59-adjuvanted vaccine. Thus, MF59-adjuvanted vaccine confers greater immunogenicity than non-adjuvanted vaccines in vulnerable populations.
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MF59-adjuvanted influenza vaccines induce broad serological protection against strains with antigenic drift.
“In the elderly population, MF59-adjuvanted influenza vaccines enhance seroconversion and seroprotection rates compared with non-adjuvanted vaccines240 and induce broad serological protection against strains with antigenic drift241.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [241]
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Self-citation
- Authors
- Ansaldi, F., Bacilieri, S., Durando, P., Sticchi, L., Valle, L., Montomoli, E., Icardi, G., Gasparini, R., & Crovari, P.
- Affiliations
- Centro interuniversitario per la ricerca sull'influenza e le altre infezioni trasmissibili (IT)
- University of Siena (IT)
- Corresponding author
- Ansaldi, Filippo
- ORCID
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 26
- Issue
- 12
- Pages
- 1525-1529
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2163192885
- Cited by
- 134
- References
- 17
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 14 · 2020: 3 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 3 · 2013: 9 · 2012: 9
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- MF59 adjuvant, influenza vaccination, cross-protection, H3N2, antigenic drift, neutralizing antibodies, hemagglutination inhibition antibodies, secondary immune response, older adults, subunit vaccine, immunogenicity
- MeSH terms
- Adjuvants, Immunologic, Aged, Antibodies, Viral, Cross Reactions, Hemagglutination Inhibition Tests, Humans, Influenza Vaccines, Middle Aged, Neutralization Tests, Polysorbates, Squalene, Influenza A Virus, H3N2 Subtype
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