Cited by 136Influenza Virus Research StudiesBacterial Infections and VaccinesRespiratory viral infections research

Cross-protection by MF59™-adjuvanted influenza vaccine: Neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses

Ansaldi, Filippo, Bacilieri, Sabrina, Durando, Paolo, Sticchi, Laura, Valle, Laura, Montomoli, Emanuele, Icardi, Giancarlo, Gasparini, Roberto +1 more·2008·Vaccine

Abstract

Adjuvants enhance antibody response against vaccination. We compared the ability of MF59-adjuvanted and non-adjuvanted subunit influenza vaccines, containing A/Wyoming/3/03(H3N2), to confer cross-protection against four consecutive drifted strains in the elderly. Neutralizing and haemagglutination-inhibiting antibody were measured. MF59-adjuvanted vaccine induced a stronger booster response against A/Panama/2007/99(H3N2) than non-adjuvanted vaccine. A/Panama/2007/99(H3N2) circulated widely during the previous 5 years and was included in vaccines over four consecutive seasons. Broader serological protection against drifted strains that circulated 1 and 2 years after vaccination with A/Wyoming/3/03(H3N2) was observed with MF59-adjuvanted vaccine. Thus, MF59-adjuvanted vaccine confers greater immunogenicity than non-adjuvanted vaccines in vulnerable populations.

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Crossref · 10.1016/j.vaccine.2008.01.019

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  • MF59-adjuvanted influenza vaccines induce broad serological protection against strains with antigenic drift.

    “In the elderly population, MF59-adjuvanted influenza vaccines enhance seroconversion and seroprotection rates compared with non-adjuvanted vaccines240 and induce broad serological protection against strains with antigenic drift241.”

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Authors
Ansaldi, F., Bacilieri, S., Durando, P., Sticchi, L., Valle, L., Montomoli, E., Icardi, G., Gasparini, R., & Crovari, P.
Affiliations
  • Centro interuniversitario per la ricerca sull'influenza e le altre infezioni trasmissibili (IT)
  • University of Siena (IT)
Corresponding author
Ansaldi, Filippo
Venue
Vaccine
Publisher
Elsevier BV
Published
2008-03
Volume
26
Issue
12
Pages
1525-1529
ISSN
0264-410X (ISSN-L)
OpenAlex
W2163192885
Cited by
134
References
17
Citations by year
2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 14 · 2020: 3 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 3 · 2013: 9 · 2012: 9
FWCI
11.58
Type
journal article
Language
en
Open access
closed
Locations
  • Vaccine (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
  • Use Siena air (University of Siena) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Keywords
MF59 adjuvant, influenza vaccination, cross-protection, H3N2, antigenic drift, neutralizing antibodies, hemagglutination inhibition antibodies, secondary immune response, older adults, subunit vaccine, immunogenicity
MeSH terms
Adjuvants, Immunologic, Aged, Antibodies, Viral, Cross Reactions, Hemagglutination Inhibition Tests, Humans, Influenza Vaccines, Middle Aged, Neutralization Tests, Polysorbates, Squalene, Influenza A Virus, H3N2 Subtype

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