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Cited by 187

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2

Open access
Pastrana, Diana V., Gambhira, Ratish, Buck, Christopher B., Pang, Yuk-Ying S., Thompson, Cynthia D., Culp, Timothy D., Christensen, Neil D., Lowy, Douglas R., Schiller, John T., Roden, Richard B.S.·2005·Virology

Abstract

Vaccination with papillomavirus L2 has been shown to induce neutralizing antibodies that protect against homologous type infection and cross-neutralize a limited number of genital HPVs. Surprisingly, we found that antibodies to bovine papillomavirus (BPV1) L2 amino acids 1-88 induced similar titers of neutralizing antibodies against Human papillomavirus (HPV)16 and 18 and BPV1 pseudoviruses and also neutralized HPV11 native virions. These antibodies also neutralized each of the other pseudovirus types tested, HPV31, HPV6 and Cottontail rabbit papillomavirus (CRPV) pseudoviruses, albeit with lower titers. HPV16, HPV18, HPV31, HPV6 and CRPV L2 anti-sera also displayed some cross-neutralization, but the titers were lower and did not encompass all pseudoviruses tested. This study demonstrates the presence of broadly cross-neutralizing epitopes at the N-terminus of L2 that are shared by cutaneous and mucosal types and by types that infect divergent species. BPV1 L2 was exceptionally effective at inducing cross-neutralizing antibodies to these shared epitopes.

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Crossref · 10.1016/j.virol.2005.04.011

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Metadata

Authors
Pastrana, D. V., Gambhira, R., Buck, C. B., Pang, Y.-Y. S., Thompson, C. D., Culp, T. D., Christensen, N. D., Lowy, D. R., Schiller, J. T., & Roden, R. B. S.
Venue
Virology
Publisher
Elsevier BV
Published
2005-07
Volume
337
Issue
2
Pages
365-372
ISSN
0042-6822 (ISSN-L)
OpenAlex
W2079442139
Cited by
187
References
1
FWCI
9.38
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2. https://app.cochat.ai/papers/10.1016/j.virol.2005.04.011
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Pastrana, D. V., Gambhira, R., Buck, C. B., Pang, Y.-Y. S., Thompson, C. D., Culp, T. D., Christensen, N. D., Lowy, D. R., Schiller, J. T., & Roden, R. B. S. (2005). Cross-neutralization of cutaneous and mucosal Papillomavirus types with anti-sera to the amino terminus of L2. Virology. https://doi.org/10.1016/j.virol.2005.04.011

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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