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A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models

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Lessons from the mouse: potential contribution of bystander lymphocyte activation by viruses to human type 1 diabetes

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Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon-Treated Primary Human Pancreatic Islets

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Immunology of β-Cell Destruction

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Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes

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Type I interferons as key players in pancreatic β-cell dysfunction in type 1 diabetes

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Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas

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TLR7/9 versus TLR3/MDA5 signaling during virus infections and diabetes

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Previous maternal infection protects offspring from enterovirus infection and prevents experimental diabetes development in mice

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Enteroviruses and T1D: Is It the Virus, the Genes or Both which Cause T1D

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Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes

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Modulation of innate immunity in human pancreatic islets infected with enterovirus in vitro

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Toll-like receptor 3 (TLR3) and the development of type 1 diabetes mellitus

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IFN-γ production dominates the early human natural killer cell response to Coxsackievirus infection

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Protection Against Type 1 Diabetes Upon Coxsackievirus B4 Infection and iNKT-Cell Stimulation

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Group B coxsackieviruses and autoimmunity: focus on Type 1 diabetes

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Role of IL-15 and IL-21 in viral immunity: applications for vaccines and therapies

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Interferon signalling in pancreatic beta cells

Helen, E. T. (2009) · Frontiers in bioscience · doi:10.2741/3270 · Cited by 22 · see citing works

Fulminant type 1 diabetes: A comprehensive review of an autoimmune condition

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Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells

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Activation of the 2-5OAS/RNase L pathway in CVB1 or HAV/18f infected FRhK-4 cells does not require induction of OAS1 or OAS2 expression

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Targeting Innate Immunity for Type 1 Diabetes Prevention

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Enteroviral Pathogenesis of Type 1 Diabetes: The Role of Natural Killer Cells

Nekoua, M. P., Dechaumes, A., Sané, F., Alidjinou, E. K., Moutairou, K. A., Yessoufou, A., & Hober, D. (2020) · Microorganisms · doi:10.3390/microorganisms8070989 · Cited by 18 · see citing works

Type III interferons are expressed by Coxsackievirus-infected human primary hepatocytes and regulate hepatocyte permissiveness to infection

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Experimental Neuromyelitis Optica Induces a Type I Interferon Signature in the Spinal Cord

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Tropism Analysis of Two Coxsackie B5 Strains Reveals Virus Growth in Human Primary Pancreatic Islets but not in Exocrine Cell Clusters In Vitro

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RNA-seq methods for identifying differentially expressed gene in human pancreatic islet cells treated with pro-inflammatory cytokines

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The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus

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Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice

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Single-cell transcriptomics reveals a role for pancreatic duct cells as potential mediators of inflammation in diabetes mellitus

Munoz-Garcia, A., Juksar, J., Gröen, N., Zaldumbide, A., de Koning, E. J. P., & Carlotti, F. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1381319 · Cited by 13 · see citing works

Fatty acid synthase (Fasn) inhibits the expression levels of immune response genes via alteration of alternative splicing in islet cells

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Viruses and Type 1 Diabetes: Focus on the Enteroviruses

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Inhibition of Type III Interferon Expression in Intestinal Epithelial Cells—A Strategy Used by Coxsackie B Virus to Evade the Host’s Innate Immune Response at the Primary Site of Infection?

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The target cell response to cytokines governs the autoreactive T cell repertoire in the pancreas of NOD mice

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Brain region-specific expression of genes mapped within quantitative trait loci for behavioral responsiveness to acute stress in Fisher 344 and Wistar Kyoto male rats

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Type I and type II interferon responses in two human liver cell lines (Huh-7 and HuH6)

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Immunobiology of β-Cell Destruction

Torre, D. L. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5441-0_16 · Cited by 10 · see citing works

Fighting Enteroviral Infections to Prevent Type 1 Diabetes

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MafA Expression Preserves Immune Homeostasis in Human and Mouse Islets

Singh, T., Sarmiento, L., Luan, C., Prasad, R. B., Johansson, J. K., Cataldo, L. R., Renström, E., Soneji, S., Cilio, C., & Artner, I. (2018) · Genes · doi:10.3390/genes9120644 · Cited by 10 · see citing works

Dual Role of TLR3 in Inflammation and Cancer Cell Apoptosis

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The interaction between human enteroviruses and type I IFN signaling pathway

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The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes

Geravandi, S., Liu, H., Pahwa, H., Madduri, M. K., Atawneh, F. H., Feriz, A. M., Rafizadeh, S., Kruf, A. E., Khazaei, M., BAHRAMI, P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64508-6 · Cited by 9 · see citing works

Polymorphisms of the Toll-Like Receptor-3 Gene in Autoimmune Adrenal Failure and Type 1 Diabetes in Polish Patients

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Identifying the ‘Achilles heel’ of type 1 diabetes

Battaglia, M., Buckner, J. H., Levings, M. K., Richardson, S. J., Wong, F. S., & Tree, T. I. M. (2020) · Clinical & Experimental Immunology · doi:10.1111/cei.13570 · Cited by 6 · see citing works

Interferon stimulated gene 15 has an anti-apoptotic effect on MIN6 cells

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Distinct activation of primary human BDCA1+ dendritic cells upon interaction with stressed or infected β cells

Schulte, B. M., Kers‐Rebel, E. D., Bottino, R., Piganelli, J. D., Galama, J. M. D., Engelse, M. A., de Koning, E. J. P., & Adema, G. J. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12779 · Cited by 3 · see citing works

Sensing danger in the islet: the roles of pattern recognition receptors in β cells and type 1 diabetes

Tong, L., Tu, Y., Huang, S., & Zheng, P. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1677177 · Cited by 2 · see citing works

The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways

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Enterovirus Infection of Cultured Human Pancreatic Islets

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Interactions between enteroviruses and the host : implications for type 1 diabetes

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Innate Immunity of Human Pancreatic Islets Infected with Different Enterovirus Types

Frisk, G. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4051-2_29

The Role of Integrins in Enterovirus Infections and in Metastasis of Cancer

Karttunen, Å. (2010) · UTUPub (University of Turku)

Host-microbe interactions in coxsackievirus infection : Focus on innate immunity

Hühn, M. H. (2010) · Figshare

A BATTLE BETWEEN HOST AND PATHOGEN: THE INNATE IMMUNE RESPONSE AND ENTEROVIRUS EVASION STRATEGIES

Lind, K. (2014) · Figshare

Studies of immunological risk factors in type 1 diabetes

Walldén, J. (2008) · DiVA (Linkoping University)

The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus O papel do interferon induzido com o domínio C da helicase 1 (IFIH1) no desenvolvimento do diabetes melito tipo 1

de Oliveira, F. D. S., Canani, L. H. S., & Crispim, D. (2013)

Studies of Enterovirus Infection and Induction of Innate Immunity in Human Pancreatic Cells

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Immunology of b-Cell Destruction 37

Lernmark, Å., & Torre, D. L. (2015)

Role of Type I Interferon Signalling in Regulating Cell Survival, Proliferation, and Cytokine Production in Antigen-Presenting Cells

Rasiuk, A. S. (2015) · The Atrium (University of Guelph)

Toll-like receptor 3 (TLR3) and the development of type 1 diabetes mellitus Receptor do tipo Toll 3 (TLR3) e o desenvolvimento do diabetes melito tipo 1

Assmann, T. S., Brondani, L. D. A., Bouças, A. P., Canani, L. H. S., & Crispim, D. (2015)

Current World Literature

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Immunology of β-Cell Destruction

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Immunology of β-Cell Destruction

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Faculty Opinions recommendation of Quantifying the effect of experimental perturbations at single-cell resolution.

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Faculty Opinions recommendation of Mafa expression preserves immune homeostasis in human and mouse islets.

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Avaliação do estado inflamatório em ilhotas de Langerhans de camundongos portadores do tumor sólido de Ehrlich

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Role of MAIT cells in virally-induced type 1 diabetes by Coxsackievirus B4

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Interleukin-1 mediates innate immune signaling and antiviral defense in islets

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Antivirale Immunantwort und Virus-induzierte Apoptose von Insulin-produzierenden Zellen in der Pathogenese des Typ 1 Diabetes

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Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon-Treated Primary Human Pancreatic Islets

(2016)

Interferons in antiviral defense and autoimmunity : Focus on type 1 diabetes

Hultcrantz, M. (2008) · Figshare

Phagocytosis of Enterovirus-Infected Pancreatic β-Cells Triggers Innate Immune Responses in Human Dendritic Cells

Schulte, B. M., Kramer, M., Ansems, M., Lanke, K. H. W., van Doremalen, N., Piganelli, J. D., Bottino, R., Trucco, M., Galama, J. M. D., Adema, G. J., et al. (2010) · Diabetes · doi:10.2337/db09-1071 · Cited by 46 · see citing works

Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection

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Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection

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