Prevalence and distribution of single and multiple HPV infections in cytologically abnormal cervical samples from Italian women
Abstract
The prevalence of single and multiple HPV infections was assessed over a cohort of 213 women with cytological abnormalities and its association with cervical neoplasia established. Roche linear array HPV genotyping test was used to identify HPV genotypes. The most prevalent HPV genotypes in cervical cancer samples were HPV16 (61.2%), HPV52 (16.1%), HPV18 (12.9%) and HPV 31 (9.6%). Multiple HR and LR HPV infections, comprising between two and 5+ HPV types, were identified in 49.7% of samples, with a significantly lower number in severe dysplasia and cervical cancer samples (p<0.05). These results seem to indicate that detection of multiple HPV infection with HR-HPV types is not significantly better as a predictor of cervical cancer than single HR-HPV infection, though further longitudinal studies are needed to better clarify the relevance of these infections to the progression of cervical neoplasia.
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The role of multiple HPV infections in the progression of cervical disease is still controversial.
“The role of multiple HPV infections in the progression of cervical disease is still controversial.”
From Comparative evaluation of Allplex HPV28 and Anyplex II HPV28 assays for high-risk HPV genotyping in cervical samples (2025) · cites this paper as [26]
In some studies, multiple HPV infections were not associated with an increased risk of cervical cancer in women with cytological abnormalities.
“In some studies, multiple HPV infections were not associated with an increased risk of cervical cancer in women with cytological abnormalities [24–26].”
From Comparative evaluation of Allplex HPV28 and Anyplex II HPV28 assays for high-risk HPV genotyping in cervical samples (2025) · cites this paper as [26]
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Mafi, S., Theuillon, F., Meyer, S., Woillard, J.-B., Dupont, M., Rogez, S., Alain, S., & Hantz, S. (2025) · PLOS ONE · doi:10.1371/journal.pone.0320978 · Cited by 9 · see citing works
“In some studies, multiple HPV infections were not associated with an increased risk of cervical cancer in women with cytological abnormalities [24–26].”
- Authors
- Gargiulo, F., De Francesco, M. A., Schreiber, C., Ciravolo, G., Salinaro, F., Valloncini, B., & Manca, N.
- Affiliations
- University of Brescia (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Corresponding author
- Gargiulo, F.
- ORCID
- Gargiulo, F.
- Venue
- Virus Research
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 125
- Issue
- 2
- Pages
- 176-182
- ISSN
- 0168-1702 (ISSN-L)
- OpenAlex
- W2077809048
- Cited by
- 81
- References
- 0
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 6 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Virus Research (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Funders
- Ministero dell'Università e della Ricerca
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- human papillomavirus, multiple HPV infection, high-risk HPV, low-risk HPV, HPV genotyping, cervical cancer, cervical intraepithelial neoplasia, HPV16, HPV52, HPV 18, HPV 31, Italian women
- MeSH terms
- Adult, Aged, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, DNA, Viral, Female, Humans, Italy, Middle Aged, Vaginal Smears, Prevalence, Papillomaviridae, Papillomavirus Infections
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