The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Chlorine disinfection increases both intracellular and extracellular antibiotic resistance genes in a full-scale wastewater treatment plant
Open accessAbstract
The emergence and spread of antibiotic resistance has posed a major threat to both human health and environmental ecosystem. Although the disinfection has been proved to be efficient to control the occurrence of pathogens, little effort is dedicated to revealing potential impacts of disinfection on transmission of antibiotic resistance genes (ARGs), particularly for free-living ARGs in final disinfected effluent of urban wastewater treatment plants (UWWTP). Here, we investigated the effects of chlorine disinfection on the occurrence and concentration of both extracellular ARGs (eARGs) and intracellular ARGs (iARGs) in a full-scale UWWTP over a year. We reported that the concentrations of both eARGs and iARGs would be increased by the disinfection with chlorine dioxide (ClO2). Specifically, chlorination preferentially increased the abundances of eARGs against macrolide (ermB), tetracycline (tetA, tetB and tetC), sulfonamide (sul1, sul2 and sul3), β-lactam (ampC), aminoglycosides (aph(2')-Id), rifampicin (katG) and vancomycin (vanA) up to 3.8 folds. Similarly, the abundances of iARGs were also increased up to 7.8 folds after chlorination. In terms of correlation analyses, the abundance of Escherichia coli before chlorination showed a strong positive correlation with the total eARG concentration, while lower temperature and higher ammonium concentration were assumed to be associated with the concentration of iARGs. This study suggests the chlorine disinfection could increase the abundances of both iARGs and eARGs, thereby posing risk of the dissemination of antibiotic resistance in environments.
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Cited by
Li, S., Zhang, C., Li, F., Hua, T., Zhou, Q., & Ho, S.-H. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.125148 · Cited by 267
Jin, M., Lu, J., Chen, Z., Nguyen, S. H., Mao, L., Li, J., Yuan, Z., & Guo, J. (2018) · Environment International · doi:10.1016/j.envint.2018.07.046 · Cited by 182
Self-citationZammit, I., Marano, R. B. M., Vaiano, V., Cytryn, E., & Rizzo, L. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c01565 · Cited by 71
Zhao, X., Su, H., Xu, W., Hu, X., Xu, Y., Wen, G., & Cao, Y. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146348 · Cited by 36
Burch, T. R., Newton, R. J., Kimbell, L. K., LaMartina, E. L., O'Malley, K., Thomson, S. M., Marshall, C. W., & McNamara, P. J. (2022) · Environmental Science: Water Research & Technology · doi:10.1039/d2ew00087c · Cited by 26
Metadata
- Authors
- Liu, S.-S., Qu, H.-M., Yang, D., Hu, H., Liu, W.-L., Qiu, Z.-G., Hou, A.-M., Guo, J., Li, J.-W., Shen, Z.-Q., & Jin, M.
- Venue
- Water Research
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 136
- Pages
- 131-136
- ISSN
- 0043-1354 (ISSN-L)
- OpenAlex
- W2791764985
- Cited by
- 419
- References
- 35
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liu, S.-S., Qu, H.-M., Yang, D., Hu, H., Liu, W.-L., Qiu, Z.-G., Hou, A.-M., Guo, J., Li, J.-W., Shen, Z.-Q., & Jin, M. (2018). Chlorine disinfection increases both intracellular and extracellular antibiotic resistance genes in a full-scale wastewater treatment plant. Water Research. https://doi.org/10.1016/j.watres.2018.02.036
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