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Comparative study on degradation of propranolol and formation of oxidation products by UV/H2O2 and UV/persulfate (PDS)
Abstract
The frequent detection of propranolol, a widely used β-blocker, in wastewater effluents and surface waters has raised serious concern, due to its adverse effects on organisms. UV/hydrogen peroxide (UV/H 2 O 2) and UV/persulfate (UV/PDS) processes are efficient in eliminating propranolol in various waters, but the formation of oxidation products in these processes, as well as the assessment of their toxicity, has not been systematically addressed. In this study, we identified and compared transformation products of propranolol produced by hydroxyl radical (•OH) and sulfate radical (SO 4•-). The electrostatic attraction enhances the reaction between SO 4•- and the protonated form of propranolol, while •OH shows non-selectivity toward both protonated and neutral propranolol species. The hydroxylation of propranolol by •OH occurs at either amine moiety or naphthalene group while SO 4•- favors the oxidation of the electron-rich naphthalene group. Further oxidation by •OH and SO 4•- results in ring-opening products. Bicarbonate and chloride exert no effect on propranolol degradation. The generation of CO 3•- and Cl-containing radicals is favorable to oxidizing naphthalene group. The acute toxicity assay of Vibrio fischeri suggests that SO 4•- generates more toxic products than •OH, while CO 3•- and Cl-containing radicals produce similar toxicity as SO 4•-. High concentrations of bicarbonate in UV/H 2 O 2 increase the toxicity of treated solution.
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“A similar effect is reported for parathion, florfenicol, thiamphenicol, losartan potassium, furosemide, caffeine, carbendazim, anatoxin, propranolol, acetaminophen in UV-based oxidation treatments [129-131].”
From Advanced Oxidation Processes for Degradation of Water Pollutants—Ambivalent Impact of Carbonate Species: A Review (2023) · cites this paper as [130]
Citations
Cites
Buxton, G. V., Greenstock, C. L., Helman, W. P., & Ross, A. B. (1988) · Journal of Physical and Chemical Reference Data · doi:10.1063/1.555805 · Cited by 12,332
Rate Constants for Reactions of Inorganic Radicals in Aqueous Solution
Neta, P., Huie, R. E., & Ross, A. B. (1988) · Journal of Physical and Chemical Reference Data · doi:10.1063/1.555808 · Cited by 3,651
Human Pharmaceuticals in the Aquatic Environment: A Challenge to Green Chemistry
Khetan, S. K., & Collins, T. J. (2007) · Chemical Reviews · doi:10.1021/cr020441w · Cited by 1,172
Yang, Y., Pignatello, J. J., Ma, J., & Mitch, W. A. (2014) · Environmental Science & Technology · doi:10.1021/es404118q · Cited by 1,049
Self-citationGrebel, J. E., Pignatello, J. J., & Mitch, W. A. (2010) · Environmental Science & Technology · doi:10.1021/es1010225 · Cited by 975
Anipsitakis, G. P., Dionysiou, D. D., & Gonzalez, M. A. (2005) · Environmental Science & Technology · doi:10.1021/es050634b · Cited by 911
Rate constants and mechanism of reaction of sulfate radical anion with aromatic compounds
Neta, P., Madhavan, V., Zemel, H., & Fessenden, R. W. (1977) · Journal of the American Chemical Society · doi:10.1021/ja00443a030 · Cited by 899
Yang, Y., Jiang, J., Lu, X., Ma, J., & Liu, Y. (2015) · Environmental Science & Technology · doi:10.1021/es506362e · Cited by 653
Self-citationYang, Y., Lu, X., Jiang, J., Ma, J., Liu, G., Cao, Y., Liu, W., Li, J., Pang, S., Kong, X., et al. (2017) · Water Research · doi:10.1016/j.watres.2017.03.054 · Cited by 637
Self-citationWols, B. A., & Hofman-Caris, C. H. M. (2012) · Water Research · doi:10.1016/j.watres.2012.03.036 · Cited by 622
The photolysis of hydrogen peroxide at high light intensities
Baxendale, J. H., & Wilson, J. A. (1957) · Transactions of the Faraday Society · doi:10.1039/tf9575300344 · Cited by 571
Degradation of Pharmaceuticals and Metabolite in Synthetic Human Urine by UV, UV/H2O2, and UV/PDS
Zhang, R., Sun, P., Boyer, T. H., Zhao, L., & Huang, C. (2015) · Environmental Science & Technology · doi:10.1021/es504799n · Cited by 514
Canonica, S., Kohn, T., Mac, M., Real, F. J., Wirz, J., & von Gunten, U. (2005) · Environmental Science & Technology · doi:10.1021/es051236b · Cited by 491
Lian, L., Yao, B., Hou, S., Fang, J., Yan, S., & Song, W. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b05536 · Cited by 480
Kostich, M. S., Batt, A. L., & Lazorchak, J. M. (2013) · Environmental Pollution · doi:10.1016/j.envpol.2013.09.013 · Cited by 468
Huggett, D. B., Brooks, B. W., Peterson, B., Foran, C. M., & Schlenk, D. (2002) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-002-1182-7 · Cited by 407
Sulfate radical anion oxidation of diclofenac and sulfamethoxazole for water decontamination
Ahmed, M. M., Barbati, S., Doumenq, P., & Chirón, S. (2012) · Chemical Engineering Journal · doi:10.1016/j.cej.2012.05.040 · Cited by 401
Wu, Z., Fang, J., Xiang, Y., Shang, C., Li, X., Meng, F., & Yang, X. (2016) · Water Research · doi:10.1016/j.watres.2016.08.011 · Cited by 353
Yu, H., Nie, E., Xu, J., Yan, S., Cooper, W. J., & Song, W. (2013) · Water Research · doi:10.1016/j.watres.2013.01.016 · Cited by 350
Rate constants and mechanisms of reaction of chloride (Cl2-) radicals
Hasegawa, K., & Neta, P. (1978) · The Journal of Physical Chemistry · doi:10.1021/j100497a003 · Cited by 349
Yang, Y., Pignatello, J. J., Ma, J., & Mitch, W. A. (2015) · Water Research · doi:10.1016/j.watres.2015.11.049 · Cited by 308
Self-citationInitial risk assessment for three β-blockers found in the aquatic environment
Cleuvers, M. (2005) · Chemosphere · doi:10.1016/j.chemosphere.2004.11.090 · Cited by 271
Quantum Yield of the Iodide-Iodate Chemical Actinometer: Dependence on Wavelength and Concentration¶
Rahn, R. O., Stefan, M. I., Bolton, J. R., Goren, E., Shaw, P.-S., & Lykke, K. R. (2003) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2003)0780146qyotic2.0.co2 · Cited by 244
Free Radical Destruction of β-Blockers in Aqueous Solution
Song, W., Cooper, W. J., Mezyk, S. P., Greaves, J., & Peake, B. M. (2008) · Environmental Science & Technology · doi:10.1021/es702245n · Cited by 191
Escher, B. I., Bramaz, N., Richter, M., & Lienert, J. (2006) · Environmental Science & Technology · doi:10.1021/es052572v · Cited by 183
Mark, G., Schuchmann, M. N., Schuchmann, H., & von Sonntag, C. (1990) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/1010-6030(90)80028-v · Cited by 171
Kinetics and Degradation Products for Direct Photolysis of β-Blockers in Water
Liu, Q.-T., & Williams, H. E. (2006) · Environmental Science & Technology · doi:10.1021/es0616130 · Cited by 168
Keen, O. S., & Linden, K. G. (2013) · Environmental Science & Technology · doi:10.1021/es402472x · Cited by 159
Mártire, D. O., Rosso, J. A., Bertolotti, S. G., Roux, G. A. C. L., Braun, A. M., & Gonzalez, M. C. (2001) · The Journal of Physical Chemistry A · doi:10.1021/jp004630z · Cited by 157
Toxicity assays: a way for evaluating AOPs efficiency
Fernández‐Alba, A. R., Hernando, M. D., Agüera, A., Cáceres, J., & Malato, S. (2002) · Water Research · doi:10.1016/s0043-1354(02)00165-3 · Cited by 156
Reduction Potentials of SO3•-, SO5•-, and S4O6•3-Radicals in Aqueous Solution
Das, T. N., Huie, R. E., & Neta, P. (1999) · The Journal of Physical Chemistry A · doi:10.1021/jp9900234 · Cited by 148
Santiago‐Morales, J., Agüera, A., Gómez‐Ramos, M. D. M., Fernández‐Alba, A. R., Giménez, J., Esplugás, S., & Rosal, R. (2012) · Applied Catalysis B: Environmental · doi:10.1016/j.apcatb.2012.09.023 · Cited by 103
Liu, Y., Jiang, J., Ma, J., Yang, Y., Luo, C., Huangfu, X., & Guo, Z. (2014) · Water Research · doi:10.1016/j.watres.2014.10.050 · Cited by 103
Self-citationOzonation of Propranolol: Formation of Oxidation Products
Benner, J., & Ternes, T. A. (2009) · Environmental Science & Technology · doi:10.1021/es900282c · Cited by 97
Beitz, T., Bechmann, W., & Mitzner, R. (1998) · The Journal of Physical Chemistry A · doi:10.1021/jp980655a · Cited by 88
Steenken, S., Warren, C. J., & Gilbert, B. C. (1990) · Journal of the Chemical Society Perkin Transactions 2 · doi:10.1039/p29900000335 · Cited by 71
Anastasio, C., & Matthew, B. M. (2006) · Atmospheric chemistry and physics · doi:10.5194/acp-6-2439-2006 · Cited by 54
Wang, B., Dai, G., Deng, S., Huang, J. G., Wang, Y., & Yu, G. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2015.03.030 · Cited by 43
NDRL/NIST Solution Kinetics Database on the WEB
Huie, R. E. (2003) · Journal of Research (NIST JRES) - · Cited by 38
Sortino, S., Petralia, S., Boscá, F., & Miranda, M. A. (2002) · Photochemical & Photobiological Sciences · doi:10.1039/b109232d · Cited by 28
Research works printed but not linked: 1
- Huggett, 2002, Toxicity of select beta adrenergic receptor-blocking pharmaceuticals (B-blockers) on aquatic organisms, Arch. Environ. Contam. Toxicol., 43, 229, 10.1007/s00244-002-1182-7 · DOI · Paper page
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Scaria, J., & Nidheesh, P. V. (2022) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2022.100830 · Cited by 219
Comparison of UVC and UVC/persulfate processes for tetracycline removal in water
Xu, M., Deng, J., Cai, A., Ma, X., Li, J., Li, Q., & Li, X. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.123320 · Cited by 206
Self-citationZhang, B., Wang, X., Fang, Z., Wang, S., Shan, C., Wei, S., & Pan, B. (2021) · Water Research · doi:10.1016/j.watres.2021.117158 · Cited by 193
Chen, C., Wu, Z., Zheng, S., Wang, L., Niu, X.-Z., & Fang, J. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c02377 · Cited by 180
Metadata
- Authors
- Yang, Y., Cao, Y., Jiang, J., Lu, X., Ma, J., Pang, S., Li, J., Liu, Y., Zhou, Y., & Guan, C.
- Affiliations
- Harbin Institute of Technology (CN)
- Beijing Forestry University (CN)
- Corresponding author
- Jiang, Jin
- Lu, Xinglin
- Venue
- Water Research
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 149
- Pages
- 543-552
- ISSN
- 0043-1354 (ISSN-L)
- OpenAlex
- W2898084354
- Cited by
- 120
- References
- 40
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 17 · 2023: 20 · 2022: 21 · 2021: 14 · 2020: 24 · 2019: 13
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Water Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Post-doctoral International Exchange Program (20160074)
- Topics
- Physical Sciences › Environmental Science › Water Science and Technology › Advanced oxidation water treatment
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
- Keywords
- propranolol, UV/H2O2, UV/persulfate, sulfate radicals, hydroxyl radicals, degradation intermediates, oxidation products, toxicity, hydroxylation, bicarbonate effect, chloride effect, pharmaceuticals in wastewater
- MeSH terms
- Hydrogen Peroxide, Kinetics, Oxidation-Reduction, Propranolol, Sulfates, Ultraviolet Rays, Water Pollutants, Chemical
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