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Comparative study on degradation of propranolol and formation of oxidation products by UV/H2O2 and UV/persulfate (PDS)
Abstract
The frequent detection of propranolol, a widely used β-blocker, in wastewater effluents and surface waters has raised serious concern, due to its adverse effects on organisms. UV/hydrogen peroxide (UV/H 2 O 2) and UV/persulfate (UV/PDS) processes are efficient in eliminating propranolol in various waters, but the formation of oxidation products in these processes, as well as the assessment of their toxicity, has not been systematically addressed. In this study, we identified and compared transformation products of propranolol produced by hydroxyl radical (•OH) and sulfate radical (SO 4•-). The electrostatic attraction enhances the reaction between SO 4•- and the protonated form of propranolol, while •OH shows non-selectivity toward both protonated and neutral propranolol species. The hydroxylation of propranolol by •OH occurs at either amine moiety or naphthalene group while SO 4•- favors the oxidation of the electron-rich naphthalene group. Further oxidation by •OH and SO 4•- results in ring-opening products. Bicarbonate and chloride exert no effect on propranolol degradation. The generation of CO 3•- and Cl-containing radicals is favorable to oxidizing naphthalene group. The acute toxicity assay of Vibrio fischeri suggests that SO 4•- generates more toxic products than •OH, while CO 3•- and Cl-containing radicals produce similar toxicity as SO 4•-. High concentrations of bicarbonate in UV/H 2 O 2 increase the toxicity of treated solution.
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“A similar effect is reported for parathion, florfenicol, thiamphenicol, losartan potassium, furosemide, caffeine, carbendazim, anatoxin, propranolol, acetaminophen in UV-based oxidation treatments [129-131].”
From Advanced Oxidation Processes for Degradation of Water Pollutants—Ambivalent Impact of Carbonate Species: A Review (2023) · cites this paper as [130]
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Scaria, J., & Nidheesh, P. V. (2022) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2022.100830 · Cited by 219
Comparison of UVC and UVC/persulfate processes for tetracycline removal in water
Xu, M., Deng, J., Cai, A., Ma, X., Li, J., Li, Q., & Li, X. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.123320 · Cited by 206
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Metadata
- Authors
- Yang, Y., Cao, Y., Jiang, J., Lu, X., Ma, J., Pang, S., Li, J., Liu, Y., Zhou, Y., & Guan, C.
- Affiliations
- Harbin Institute of Technology (CN)
- Beijing Forestry University (CN)
- Corresponding author
- Jiang, Jin
- Lu, Xinglin
- Venue
- Water Research
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 149
- Pages
- 543-552
- ISSN
- 0043-1354 (ISSN-L)
- OpenAlex
- W2898084354
- Cited by
- 120
- References
- 40
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 17 · 2023: 20 · 2022: 21 · 2021: 14 · 2020: 24 · 2019: 13
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Water Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Post-doctoral International Exchange Program (20160074)
- Topics
- Physical Sciences › Environmental Science › Water Science and Technology › Advanced oxidation water treatment
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
- Keywords
- propranolol, UV/H2O2, UV/persulfate, sulfate radicals, hydroxyl radicals, degradation intermediates, oxidation products, toxicity, hydroxylation, bicarbonate effect, chloride effect, pharmaceuticals in wastewater
- MeSH terms
- Hydrogen Peroxide, Kinetics, Oxidation-Reduction, Propranolol, Sulfates, Ultraviolet Rays, Water Pollutants, Chemical
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