Deep brain stimulation for treatment-resistant depression.
Abstract
Background Major depressive disorder is a common and disabling illness and is the leading cause of disability worldwide. Despite aggressive medical, behavioral, and electroconvulsive therapies, a significant number of patients remain refractory to treatment. Deep brain stimulation (DBS) has proven efficacy in neurobehavioral disorders and, in a general sense, works by modulation of corticostriatopallidothalamocortical circuits implicated in these disorders. Methods Current data, treatment rationales, and future directions are presented. Results The two targets most commonly used for DBS in treatment-resistant depression are the subgenual cingulate gyrus and the ventral capsule/ventral striatum. Data on DBS of these regions are preliminary, with promise shown in early studies. Conclusions Early work suggests DBS may become a therapeutic option in treatment-resistant depression. Further study is justified given the immense burden of disease.
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Carbon-nanotube-based electrical stimulation utilizes unidirectional electrical stimulation, which is more precise and avoids the surgical risks associated with deep macroelectrode insertion used with current methods of deep brain stimulation.
“This strategy utilizes unidirectional electrical stimulation, which is more precise and avoids the surgical risks associated with deep macroelectrode insertion, used with current methods of deep brain stimulation”
From Human Brain/Cloud Interface (2019) · cites this paper as Taghva et al., 2013
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References 52 · Cited by 56
- Authors
- Taghva, A. S., Malone, D. A., & Rezai, A. R.
- Affiliations
- The Ohio State University (US)
- Cleveland Clinic (US)
- Corresponding author
- Taghva, Alexander S.
- Venue
- World Neurosurgery
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 80
- Issue
- 3-4
- Pages
- S27.e17-S27.e24
- ISSN
- 1878-8750 (ISSN-L)
- OpenAlex
- W2083281978
- Cited by
- 56
- References
- 52
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 8 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 5 · 2013: 3
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- World Neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medtronic Neurological
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- deep brain stimulation, treatment-resistant depression, major depressive disorder, ventral capsule/ventral striatum
- MeSH terms
- Corpus Striatum, Drug Resistance, Gyrus Cinguli, Humans, Neural Pathways, Neurosurgery, Nucleus Accumbens, Stereotaxic Techniques, Internal Capsule, Deep Brain Stimulation, History, 20th Century, Depressive Disorder, Treatment-Resistant
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