Cited by 1,726Artificial Intelligence ApplicationsMachine Learning in Materials ScienceImpact of AI and Big Data on Business and Society

Artificial intelligence: A powerful paradigm for scientific research

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Xu, Yongjun, Liu, Xin, Cao, Xin, Huang, Changping, Liu, Enke, Qian, Sen, Liu, Xingchen, Wu, Yanjun +40 more·2021·The Innovation

Abstract

Artificial intelligence (AI) coupled with promising machine learning (ML) techniques well known from computer science is broadly affecting many aspects of various fields including science and technology, industry, and even our day-to-day life. The ML techniques have been developed to analyze high-throughput data with a view to obtaining useful insights, categorizing, predicting, and making evidence-based decisions in novel ways, which will promote the growth of novel applications and fuel the sustainable booming of AI. This paper undertakes a comprehensive survey on the development and application of AI in different aspects of fundamental sciences, including information science, mathematics, medical science, materials science, geoscience, life science, physics, and chemistry. The challenges that each discipline of science meets, and the potentials of AI techniques to handle these challenges, are discussed in detail. Moreover, we shed light on new research trends entailing the integration of AI into each scientific discipline. The aim of this paper is to provide a broad research guideline on fundamental sciences with potential infusion of AI, to help motivate researchers to deeply understand the state-of-the-art applications of AI-based fundamental sciences, and thereby to help promote the continuous development of these fundamental sciences.

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Crossref · 10.1016/j.xinn.2021.100179

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  • The rapid growth of AI has accelerated discoveries across diverse scientific fields and affected every work environment and is reshaping the labor market with unprecedented speed and scale, with 40% of the global workforce expected to require AI.

    “The rapid growth of AI has accelerated discoveries across diverse scientific fields and affected every work environment [62–65] and is reshaping the labor market with unprecedented speed and scale, with 40% of the global workforce expected to require AI, enhancing the need for significant AI upskilling or reskilling [66].”

    From Use of artificial intelligence in critical care: opportunities and obstacles (2024) · cites this paper as [64]

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  • The use of DeepMind to solve the protein folding problem is one of the most impressive examples of AI in research.

    “The use of DeepMind to solve the protein folding problem is perhaps one of the most impressive example of this type of application of AI in research, but there are many others [2, 63, 64].”
  • AlphaFold combines deep learning innovations to predict three-dimensional protein structures at or near experimental scale resolution.

    “AlphaFold has combined numerous deep learning innovations to predict the three-dimensional (3D) structures of proteins at or near experimental scale resolution”

    From AlphaFold, Artificial Intelligence (AI), and Allostery (2022) · cites this paper as [2]

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References 202 · Cited by 1,726

Research works printed but not linked: 2

  1. [15]Real E. Moore S. Selle A. Large-scale evolution of image classifiers International Conference on Machine Learning 2017 PMLR 2902 2911
  2. [38]Shuford E.H. Some Bayesian learning processes. Technical documentary report. United States. Air force. Systems command Electron. Syst. Division 86 1963 1 39 14131123

Authors
Xu, Y., Liu, X., Cao, X., Huang, C., Liu, E., Qian, S., Liu, X., Wu, Y., Dong, F., Qiu, C.-W., Qiu, J., Hua, K., Su, W., Wu, J., Xu, H., Han, Y., Fu, C., Yin, Z., Liu, M., Roepman, R., Dietmann, S., Virta, M., Kengara, F., Zhang, Z., Zhang, L., Zhao, T., Dai, J., Yang, J., Lan, L., Luo, M., Liu, Z., An, T., Zhang, B., He, X., Cong, S., Liu, X., Zhang, W., Lewis, J. P., Tiedje, J. M., Wang, Q., An, Z., Wang, F., Zhang, L., Huang, T., Lu, C., Cai, Z., Wang, F., & Zhang, J.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Shanghai Medical College of Fudan University (CN)
  • National Center for Nanoscience and Technology (CN)
  • National University of Singapore (SG)
  • Dalian Polytechnic University (CN)
  • Second Affiliated Hospital of Zhejiang University (CN)
  • Peking University Third Hospital (CN)
  • Zhejiang Provincial People's Hospital (CN)
  • Zhejiang University (CN)
  • Radboud University Nijmegen (NL)
  • Washington University in St. Louis (US)
  • University of Helsinki (FI)
  • Bomet University (KE)
  • Shihezi University (CN)
  • Hong Kong Baptist University (HK)
  • Michigan State University (US)
  • Georgia State University (US)
Corresponding author
  • Wang, Qi
  • An, Zhulin
  • Wang, Fei
  • Zhang, Libo
  • Huang, Tao
  • Cai, Zhipeng
  • Zhang, Jiabao
Venue
The Innovation
Publisher
Elsevier BV
Published
2021-11
Volume
2
Issue
4
Pages
100179
ISSN
2666-6758 (ISSN-L)
OpenAlex
W3210165781
Cited by
1,726
References
202
Citations by year
2026: 296 · 2025: 574 · 2024: 520 · 2023: 242 · 2022: 89 · 2021: 3 · 2020: 1
FWCI
15.44
Type
journal article
Language
en
Open access
Locations
  • The Innovation (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Työväentutkimus Vuosikirja (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
Funders
  • Science Fund for Distinguished Young Scholars of Fujian Province (2019J06023)
  • Chinese Academy of Sciences (ZDBS-LY-DQC012, ZDBS-LY-7022, YSBR-005, KFJ-STS-QYZX-050)
  • NSFC (61902376, 52173241, 12075253, 11971466)
  • State Key Laboratory of Particle Detection and Electronics (SKLPDE-ZZ-201902)
  • National Key Research and Development Program of China (2018YFA0404603, 2019YFA0704900, 2020YFB1313700, 2020YFC1807000)
  • Youth Innovation Promotion Association of the Chinese Academy of Sciences
Topics
  • Physical Sciences › Computer Science › Artificial Intelligence › Artificial Intelligence Applications
  • Physical Sciences › Materials Science › Materials Chemistry › Machine Learning in Materials Science
  • Social Sciences › Decision Sciences › Management Science and Operations Research › Impact of AI and Big Data on Business and Society
Keywords
artificial intelligence, machine learning, high-throughput data analysis, scientific discovery, medical sciences, earth sciences, information science, mathematics

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