The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Foxa2 is required for the differentiation of pancreatic α-cells
Open accessAbstract
The differentiation of insulin-producing beta-cells has been investigated in great detail; however, little is known about the factors that delineate the second-most abundant endocrine lineage, the glucagon-producing alpha-cell. Here we utilize a novel YAC-based Foxa3Cre transgene to delete the winged helix transcription factor Foxa2 (formerly HNF-3beta) in the pancreatic primordium during midgestation. The resulting Foxa2(loxP/loxP); Foxa3Cre mice are severely hypoglycemic and die within the first week of life. Mutant mice are hypoglucagonemic secondary to a 90% reduction of glucagon expression. While the number of mature glucagon-positive alpha-cells is dramatically reduced, specification of alpha-cell progenitors is not affected by Foxa2 deficiency. By marker gene analysis, we show that the expression of the alpha-cell transcription factors Arx, Pax6, and Brn4 does not require Foxa2 in the transcriptional hierarchy governing alpha-cell differentiation.
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Cites
Ang, S.-L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J., & Zaret, K. S. (1993) · Development · doi:10.1242/dev.119.4.1301 · Cited by 618 · cited 1×
“In addition to Foxa2, the related winged helix family members Foxa1 and Foxa3 are expressed at the onset of definite endoderm development, with Foxa2 being activated first, followed by Foxa1, and finally Foxa3 (Ang et al., 1993; Monaghan et al., 1993; Sasaki and Hogan, 1993).”
BackgroundThe ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
Wierup, N., Svensson, H., Mulder, H., & Sundler, F. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(02)00067-8 · Cited by 457
Notochord to endoderm signaling is required for pancreas development
Kim, S. K., Hebrok, M., & Melton, D. A. (1997) · Development · doi:10.1242/dev.124.21.4243 · Cited by 405
Cited by
Glucagon-like peptide 1 (GLP-1)
Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868
The initiation of liver development is dependent on Foxa transcription factors
Lee, C. S., Friedman, J. R., Fulmer, J. T., & Kaestner, K. H. (2005) · Nature · doi:10.1038/nature03649 · Cited by 581
Self-citationDeepCpG: accurate prediction of single-cell DNA methylation states using deep learning
Angermueller, C., Lee, H. J., Reik, W., & Stegle, O. (2017) · Genome Biology · doi:10.1186/s13059-017-1189-z · Cited by 536
Developmental biology of the pancreas: A comprehensive review
Gittes, G. K. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 451
Notch signaling controls liver development by regulating biliary differentiation
Zong, Y., Panikkar, A., Xu, J., Antoniou, A., Raynaud, P., Lemaigre, F., & Stanger, B. Z. (2009) · Development · doi:10.1242/dev.029140 · Cited by 444
Metadata
- Authors
- Lee, C. S., Sund, N. J., Behr, R., Herrera, P. L., & Kaestner, K. H.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 278
- Issue
- 2
- Pages
- 484-495
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1991484455
- Cited by
- 199
- References
- 3
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, C. S., Sund, N. J., Behr, R., Herrera, P. L., & Kaestner, K. H. (2005). Foxa2 is required for the differentiation of pancreatic α-cells. Developmental Biology. https://doi.org/10.1016/j.ydbio.2004.10.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
