Microarray analysis of PDGFRα + populations in ES cell differentiation culture identifies genes involved in differentiation of mesoderm and mesenchyme including ARID3b that is essential for development of embryonic mesenchymal cells
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An inherent difficulty in using DNA microarray technology on the early mouse embryo is its relatively small size. In this study, we investigated whether use of ES cell differentiation culture, which has no theoretical limit in the number of cells that can be generated, can improve this situation. Seven distinct ES-cell-derived populations were analyzed by DNA microarray and examined for genes whose distribution patterns are similar to those of PDGFRalpha, a gene implicated in differentiation of mesoderm/mesenchymal lineages. Using software developed in our laboratory, we formed a group of 30 genes which showed the highest similarity to PDGFRalpha, 18 of these genes were shown to be involved in development of either mesodermal, mesenchymal or neural crest cells. This list also contains several genes whose role in embryogenesis has not yet been fully identified. One such molecule is mARID3b. The mARID3b expression is found in the paraxial mesoderm and cranial mesenchyme. mARID3b-null mouse showed early embryonic lethality, and most phenotypes of this mutant appear to develop from a failure to generate a sufficient number of cranial mesenchymal cells. These results demonstrate the potential use of ES cell differentiation culture in identifying novel genes playing an indispensable role in embryogenesis.
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The first chromosome B3 region contains three genes, including ARID3B.
“The first contains three genes, including ARID3B (AT rich interactive domain 3B), which plays a critical role in neural crest cell survival (48).”
From Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication (2014) · cites this paper as [48]
ARID3B plays a critical role in neural crest cell survival.
“The first contains three genes, including ARID3B (AT rich interactive domain 3B), which plays a critical role in neural crest cell survival (48).”
From Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication (2014) · cites this paper as [48]
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- Authors
- Takebe, A., Era, T., Okada, M., Martin Jakt, L., Kuroda, Y., & Nishikawa, S.-I.
- Affiliations
- RIKEN (JP)
- Kobe University (JP)
- Corresponding author
- Era, Takumi
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 293
- Issue
- 1
- Pages
- 25-37
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2031911590
- Cited by
- 54
- References
- 36
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 7
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2670 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Kobe University Repository Kernel (Kobe University) (submittedVersion, other-oa)
- Funders
- Ministry of Education and Science (16606005, 17045039)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- PDGFRA, embryonic stem cell differentiation, mesoderm differentiation, mesenchymal differentiation, ARID3B, cranial mesenchyme, paraxial mesoderm, neural crest, gene expression profiling, embryonic lethality, embryonic development, early mouse embryo
- MeSH terms
- Animals, Cell Differentiation, Cells, Cultured, DNA-Binding Proteins, Growth Substances, Head, Mesoderm, Mice, Inbred C57BL, Stem Cells, Mice, Knockout, Oligonucleotide Array Sequence Analysis, Receptor, Platelet-Derived Growth Factor alpha, Gene Expression Profiling, Mice
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