The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity
Open accessAbstract
Isl1 and Nkx2–5 expressing cardiovascular progenitors play pivotal roles in cardiogenesis. Previously reported Cre-based fate mapping studies showed that Isl1 progenitors contribute predominantly to the derivatives of the second heart field, and Nkx2–5 progenitors contributed mainly to the cardiomyocyte lineage. However, partial recombination of Cre reporter genes can complicate interpretation of Cre fate mapping experiments. We found that a Gata4-based Cre-activated reporter was recombined by Isl1Cre and Nkx2–5Cre in a substantially broader domain than previously reported using standard Cre-activated reporters. The expanded Isl1 and Nkx2–5 cardiac fate maps were remarkably similar, and included extensive contributions to cardiomyocyte, endocardial, and smooth muscle lineages in all four cardiac chambers. These data indicate that Isl1 is expressed in progenitors of both primary and secondary heart fields, and that Nkx2–5 is expressed in progenitors of cardiac endothelium and smooth muscle, in addition to cardiomyocytes. These results have important implications for our understanding of cardiac lineage diversification in vivo, and for the interpretation of Cre-based fate maps.
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Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0106 · Cited by 1,241
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.
Lakso, M., Pichel, J. G., Gorman, J. R., Sauer, B., Okamoto, Y., Lee, E., Alt, F. W., & Westphal, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5860 · Cited by 1,125
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
Zhou, B., Ma, Q., Rajagopal, S., Wu, S. M., Domian, I., Rivera-Feliciano, J., Jiang, D., von Gise, A., Ikeda, S., Chien, K. R., et al. (2008) · Nature · doi:10.1038/nature07060 · Cited by 1,019
Self-citationIsl1Cre reveals a common Bmp pathway in heart and limb development
Yang, L., Cai, C.-L., Lin, L., Qyang, Y., Chung, C., Monteiro, R. M., Mummery, C. L., Fishman, G. I., Cogen, A., & Evans, S. (2006) · Development · doi:10.1242/dev.02322 · Cited by 267
Development of heart valves requires Gata4 expression in endothelial-derived cells
Rivera-Feliciano, J., Lee, K.-H., Kong, S. W., Rajagopal, S., Ma, Q., Springer, Z., Izumo, S., Tabin, C. J., & Pu, W. T. (2006) · Development · doi:10.1242/dev.02519 · Cited by 190
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Cited by
Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease
von Gise, A., & Pu, W. T. (2012) · Circulation Research · doi:10.1161/circresaha.111.259960 · Cited by 419
Self-citationAdult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin
Chong, J. J. H., Chandrakanthan, V., Xaymardan, M., Asli, N. S., Li, J., Ahmed, I., Heffernan, C., Menon, M. K., Scarlett, C. J., Rashidianfar, A., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.10.002 · Cited by 389
Self-citationThe role of secondary heart field in cardiac development
Dyer, L. A., & Kirby, M. L. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.009 · Cited by 261
Generation of the epicardial lineage from human pluripotent stem cells
Witty, A. D., Mihic, A., Tam, R. Y., Fisher, S. A., Mikryukov, A., Shoichet, M. S., Li, R.-K., Kattman, S. J., & Keller, G. (2014) · Nature Biotechnology · doi:10.1038/nbt.3002 · Cited by 180
Zhou, B., von Gise, A., Ma, Q., Hu, Y. W., & Pu, W. T. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.12.007 · Cited by 163
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Metadata
- Authors
- Ma, Q., Zhou, B., & Pu, W. T.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 323
- Issue
- 1
- Pages
- 98-104
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1967444593
- Cited by
- 216
- References
- 5
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ma, Q., Zhou, B., & Pu, W. T. (2008). Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Developmental Biology. https://doi.org/10.1016/j.ydbio.2008.08.013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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