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The extracellular matrix in development and morphogenesis: A dynamic view

Open access
Rozario, Tania, DeSimone, Douglas W.·2010·Developmental Biology

Abstract

The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at the earliest stages of development. Our understanding of ECM composition, structure and function has grown considerably in the last several decades and this knowledge has revealed that the extracellular microenvironment is critically important for cell growth, survival, differentiation and morphogenesis. ECM and the cellular receptors that interact with it mediate both physical linkages with the cytoskeleton and the bidirectional flow of information between the extracellular and intracellular compartments. This review considers the range of cell and tissue functions attributed to ECM molecules and summarizes recent findings specific to key developmental processes. The importance of ECM as a dynamic repository for growth factors is highlighted along with more recent studies implicating the 3-dimensional organization and physical properties of the ECM as it relates to cell signaling and the regulation of morphogenetic cell behaviors. Embryonic cell and tissue generated forces and mechanical signals arising from ECM adhesion represent emerging areas of interest in this field.

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Crossref · 10.1016/j.ydbio.2009.10.026

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Metadata

Authors
Rozario, T., & DeSimone, D. W.
Venue
Developmental Biology
Publisher
Elsevier BV
Published
2010-05
Volume
341
Issue
1
Pages
126-140
ISSN
0012-1606 (ISSN-L)
OpenAlex
W2130255071
Cited by
1,451
References
11
FWCI
15.98
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The extracellular matrix in development and morphogenesis: A dynamic view. https://app.cochat.ai/papers/10.1016/j.ydbio.2009.10.026
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Rozario, T., & DeSimone, D. W. (2010). The extracellular matrix in development and morphogenesis: A dynamic view. Developmental Biology. https://doi.org/10.1016/j.ydbio.2009.10.026

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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