Cited by 408Wound Healing and TreatmentsMesenchymal stem cell researchPeriodontal Regeneration and Treatments

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Mesenchymal stem cells: Paracrine signaling and differentiation during cutaneous wound repair

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Hocking, Anne M., Gibran, Nicole S.·2010·Experimental Cell Research

DOI 10.1016/j.yexcr.2010.05.009PMC PMC2902653

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Abstract

Cutaneous wounds persist as a health care crisis in spite of increased understanding of the cellular and molecular responses to injury. Contributing significantly to this crisis is the lack of reliable therapies for treatment of wounds that are slow to heal including chronic wounds and deep dermal wounds that develop hypertrophic scars. This article will review the growing evidence demonstrating the promise of multipotent mesenchymal stem/stromal (MSCs) for the treatment of impaired wound healing. MSCs are often referred to as mesenchymal stem cells despite concerns that these cells are not truly stem cells given the lack of evidence demonstrating self-renewal in vivo. Regardless, abundant evidence demonstrates the therapeutic potential of MSCs for repair and regeneration of damaged tissue due to injury or disease. To date, MSC treatment of acute and chronic wounds results in accelerated wound closure with increased epithelialization, granulation tissue formation and angiogenesis. Although there is evidence for MSC differentiation in the wound, most of the therapeutic effects are likely due to MSCs releasing soluble factors that regulate local cellular responses to cutaneous injury. Important challenges need to be overcome before MSCs can be used effectively to treat wounds that are slow to heal.

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Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Wound repair and regeneration
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Mesenchymal stem cells reside in virtually all post-natal organs and tissues
Meirelles, L. D. S., Chagastelles, P. C., & Nardi, N. B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02932 · Cited by 2,472
Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
Horwitz, E. M., Blanc, K. L., Dominici, M., Mueller, I., Slaper‐Cortenbach, I., Marini, F. C., Deans, R. J., Krause, D. S., & Keating, A. (2005) · Cytotherapy · doi:10.1080/14653240500319234 · Cited by 2,071
Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy
Gnecchi, M., Zhang, Z., Ni, A., & Dzau, V. J. (2008) · Circulation Research · doi:10.1161/circresaha.108.176826 · Cited by 2,069
Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis
Wu, Y., Chen, L., Scott, P. G., & Tredget, E. E. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0226 · Cited by 1,700
Fibroblast precursors in normal and irradiated mouse hematopoietic organs.
Aj, F., Jf, G., & Nn, K. (1976) · PubMed · Cited by 1,645
Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays
Bianco, P., Robey, P. G., & Simmons, P. J. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.002 · Cited by 1,618
Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
Chen, L., Tredget, E. E., Wu, P. Y. G., & Wu, Y. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001886 · Cited by 1,610

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Authors: Hocking, A. M., & Gibran, N. S.
Affiliations: University of Washington (US)
Corresponding author: Hocking, Anne M.
ORCID: Hocking, Anne M.
Gibran, Nicole S.
Venue: Experimental Cell Research
Publisher: Elsevier BV
Published: 2010-08
Volume: 316
Issue: 14
Pages: 2213-2219
ISSN: 0014-4827 (ISSN-L)
DOI: 10.1016/j.yexcr.2010.05.009
PMC: PMC2902653
OpenAlex: W2084565323
Cited by: 408
References: 46
Citations by year: 2026: 14 · 2025: 7 · 2024: 21 · 2023: 22 · 2022: 16 · 2021: 30 · 2020: 34 · 2019: 31 · 2018: 40 · 2017: 36 · 2016: 39 · 2015: 27 · 2014: 28 · 2013: 29 · 2012: 17
FWCI: 3.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Cell Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM073624)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK017047)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords: mesenchymal stem cells, skin wound healing, chronic wounds, paracrine signaling, cell differentiation, hypertrophic scars, angiogenesis, granulation tissue, re-epithelialization, delayed wound healing, tissue regeneration
MeSH terms: Humans, Wound Healing, Signal Transduction, Paracrine Communication, Cell Proliferation, Mesenchymal Stem Cells

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Mesenchymal stem cells: Paracrine signaling and differentiation during cutaneous wound repair

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