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Mesenchymal stem cells: Paracrine signaling and differentiation during cutaneous wound repair
Open accessAbstract
Cutaneous wounds persist as a health care crisis in spite of increased understanding of the cellular and molecular responses to injury. Contributing significantly to this crisis is the lack of reliable therapies for treatment of wounds that are slow to heal including chronic wounds and deep dermal wounds that develop hypertrophic scars. This article will review the growing evidence demonstrating the promise of multipotent mesenchymal stem/stromal (MSCs) for the treatment of impaired wound healing. MSCs are often referred to as mesenchymal stem cells despite concerns that these cells are not truly stem cells given the lack of evidence demonstrating self-renewal in vivo. Regardless, abundant evidence demonstrates the therapeutic potential of MSCs for repair and regeneration of damaged tissue due to injury or disease. To date, MSC treatment of acute and chronic wounds results in accelerated wound closure with increased epithelialization, granulation tissue formation and angiogenesis. Although there is evidence for MSC differentiation in the wound, most of the therapeutic effects are likely due to MSCs releasing soluble factors that regulate local cellular responses to cutaneous injury. Important challenges need to be overcome before MSCs can be used effectively to treat wounds that are slow to heal.
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“the BM-MSCs appear to exert their principal therapeutic actions through the secretion of paracrine trophic signals [7].”
From Conditioned Medium from Hypoxic Bone Marrow-Derived Mesenchymal Stem Cells Enhances Wound Healing in Mice (2014) · cites this paper as [7]
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Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Mesenchymal stem cells reside in virtually all post-natal organs and tissues
Meirelles, L. D. S., Chagastelles, P. C., & Nardi, N. B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02932 · Cited by 2,472
Horwitz, E. M., Blanc, K. L., Dominici, M., Mueller, I., Slaper‐Cortenbach, I., Marini, F. C., Deans, R. J., Krause, D. S., & Keating, A. (2005) · Cytotherapy · doi:10.1080/14653240500319234 · Cited by 2,071
Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy
Gnecchi, M., Zhang, Z., Ni, A., & Dzau, V. J. (2008) · Circulation Research · doi:10.1161/circresaha.108.176826 · Cited by 2,069
Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis
Wu, Y., Chen, L., Scott, P. G., & Tredget, E. E. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0226 · Cited by 1,700
Fibroblast precursors in normal and irradiated mouse hematopoietic organs.
Aj, F., Jf, G., & Nn, K. (1976) · PubMed · Cited by 1,645
Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays
Bianco, P., Robey, P. G., & Simmons, P. J. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.002 · Cited by 1,618
Chen, L., Tredget, E. E., Wu, P. Y. G., & Wu, Y. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001886 · Cited by 1,610
Mesenchymal Stem Cell Homing: The Devil Is in the Details
Karp, J. M., & Leng Teo, G. S. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.02.001 · Cited by 1,445
Sasaki, M., Abe, R., Fujita, Y., Ando, S., Inokuma, D., & Shimizu, H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2581 · Cited by 1,004
Peister, A., Mellad, J. A., Larson, B. L., Hall, B. M., Gibson, L. F., & Prockop, D. J. (2003) · Blood · doi:10.1182/blood-2003-09-3070 · Cited by 995
Kim, W.-S., Park, B.-S., Sung, J.-H., Yang, J.-M., Park, S.-B., Kwak, S.-J., & Park, J. (2007) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2007.05.018 · Cited by 860
Falanga, V., Iwamoto, S., Chartier, M., Yufit, T., Butmarc, J., Kouttab, N., Shrayer, D., & Carson, P. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0278 · Cited by 783
Kidd, S. M., Spaeth, E. L., Dembinski, J. L., Dietrich, M. F., Watson, K., Klopp, A. H., Battula, V. L., Weil, M., Andreeff, M., & Marini, F. C. (2009) · Stem Cells · doi:10.1002/stem.187 · Cited by 680
Contribution of Bone Marrow–Derived Cells to Skin: Collagen Deposition and Wound Repair
Fathke, C., Wilson, L., Hutter, J., Kapoor, V., Smith, A. N., Hocking, A. M., & Isik, F. F. (2004) · Stem Cells · doi:10.1634/stemcells.22-5-812 · Cited by 495
Self-citationImmunomodulation by Mesenchymal Stem Cells
Abdi, R., Fiorina, P., Adra, C. N., Atkinson, M. A., & Sayegh, M. H. (2008) · Diabetes · doi:10.2337/db08-0180 · Cited by 465
Lee, E. Y., Xia, Y., Kim, W., Kim, M. H., Kim, T. H., Kim, K. J., Park, B., & Sung, J. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00499.x · Cited by 423
Participation of bone marrow derived cells in cutaneous wound healing
Badiavas, E. V., Abedi, M., Butmarc, J. R., Falanga, V., & Quesenberry, P. J. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10260 · Cited by 419
Oh, J. Y., Kim, M. K., Shin, M. S., Lee, H. J., Ko, J. H., Wee, W. R., & Lee, J. H. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0737 · Cited by 396
Hong, H. S., Lee, J., Lee, E., Kwon, Y. S., Lee, E., Ahn, W., Jiang, M. H., Kim, J. C., & Son, Y. (2009) · Nature Medicine · doi:10.1038/nm.1909 · Cited by 349
Concise Review: Mesenchymal Stromal Cells: Potential for Cardiovascular Repair
Psaltis, P. J., Zannettino, A. C. W., Worthley, S. G., & Gronthos, S. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0428 · Cited by 303
Exploring the role of stem cells in cutaneous wound healing
Lau, K., Paus, R., Tiede, S., Day, P., & Bayat, A. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00942.x · Cited by 279
Bone marrow‐derived mesenchymal stromal cells accelerate wound healing in the rat
McFarlin, K., Gao, X., Liu, Y. B., Dulchavsky, D. S., Kwon, D., Arbab, A. S., Bansal, M., Li, Y., Chopp, M., Dulchavsky, S. A., et al. (2006) · Wound Repair and Regeneration · doi:10.1111/j.1743-6109.2006.00153.x · Cited by 249
Potier, E., Ferreira, E., Meunier, A., Sedel, L., Logeart‐Avramoglou, D., & Petite, H. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0325 · Cited by 223
Mesenchymal stem cells induce dermal fibroblast responses to injury
Smith, A. N., Willis, E., Chan, V. T., Muffley, L. A., Isik, F. F., Gibran, N. S., & Hocking, A. M. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.08.001 · Cited by 222
Self-citationAdult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages
Li, H., Fu, X., Ouyang, Y., Cai, C., Wang, J., & Sun, T. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0270-9 · Cited by 201
Analysis of Allogenicity of Mesenchymal Stem Cells in Engraftment and Wound Healing in Mice
Chen, L., Tredget, E. E., Liu, C., & Wu, Y. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007119 · Cited by 193
Wagner, W., Feldmann, R. E., Seckinger, A., Maurer, M. H., Wein, F., Blake, J., Krause, U., Kalenka, A., Bürgers, H. F., Saffrich, R., et al. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.01.002 · Cited by 189
Metabolic Flexibility Permits Mesenchymal Stem Cell Survival in an Ischemic Environment
Mylotte, L. A., Duffy, A. M., Murphy, M. J., O’Brien, T., Afshin Samali, A., Barry, F., & Szegezdi, É. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1072 · Cited by 183
Alfaro, M. P., Pagni, M., Vincent, A., Atkinson, J. B., Hill, M. F., Cates, J., Davidson, J. M., Rottman, J. N., Lee, E. N., & Young, P. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803437105 · Cited by 174
In Vivo Characterization of Bone Marrow–Derived Fibroblasts Recruited into Fibrotic Lesions
Ishii, G., Sangai, T., Sugiyama, K., Ito, T. K., Hasebe, T., Endoh, Y., Magae, J., & Ochiai, A. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0183 · Cited by 156
Javazon, E. H., Keswani, S. G., Badillo, A. T., Crombleholme, T. M., Zoltick, P. W., Radu, A. P., Kozin, E. D., Beggs, K. J., Malik, A. A., & Flake, A. W. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00237.x · Cited by 147
Engrafted Bone Marrow-Derived Flk-1 + Mesenchymal Stem Cells Regenerate Skin Tissue
Deng, W., Han, Q., Liao, L., Li, C., Ge, W., Zhao, Z., You, S., Deng, H., Murad, F., & Zhao, R. C. H. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.110 · Cited by 139
Promotion of incisional wound repair by human mesenchymal stem cell transplantation
Stoff, A., Rivera, Á. A., Banerjee, N. S., Moore, S. T., Numnum, T. M., Espinosa‐de‐los‐Monteros, A., Richter, D. F., Siegal, G. P., Chow, L. T., Feldman, D. S., et al. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00792.x · Cited by 130
Brittan, M., Braun, K. M., Reynolds, L. E., Conti, F. J. A., Reynolds, A. R., Poulsom, R., Alison, M. R., Wright, N. A., & Hodivala‐Dilke, K. (2004) · The Journal of Pathology · doi:10.1002/path.1682 · Cited by 118
Barzilay, R., Melamed, E., & Offen, D. (2009) · Stem Cells · doi:10.1002/stem.172 · Cited by 117
Contribution of Stem Cells to Kidney Repair
Bussolati, B., Tetta, C., & Camussi, G. (2008) · American Journal of Nephrology · doi:10.1159/000137681 · Cited by 86
Cell therapy approaches for lung diseases: current status
Sueblinvong, V., & Weiss, D. J. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.03.002 · Cited by 85
Human Bone Marrow Mesenchymal Stem Cells: A Systematic Reappraisal Via the Genostem Experience
Charbord, P., Livne, E., Groß, G., Häupl, T., Neves, N. M., Marie, P. J., Bianco, P., & Jørgensen, C. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9125-6 · Cited by 78
Regeneration of the ischemic brain by engineered stem cells: Fuelling endogenous repair processes
van Velthoven, C. T. J., Kavelaars, A., van Bel, F., & Heijnen, C. J. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.03.003 · Cited by 75
Dominici, M., Paolucci, P., Conte, P., & Horwitz, E. M. (2009) · Transplantation · doi:10.1097/tp.0b013e3181a283ee · Cited by 73
Kim, S., Song, C. K., Shon, S. K., Lee, K. Y., Kim, C. H., Lee, M. J., & Wang, L. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0766-1 · Cited by 67
Stem/progenitor cells in liver injury repair and regeneration
Zhao, Q., Ren, H., Zhu, D., & Han, Z. (2009) · Biology of the Cell · doi:10.1042/bc20080105 · Cited by 55
Immune response to stem cells and strategies to induce tolerance
Batten, P., Rosenthal, N. A., & Yacoub, M. H. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2120 · Cited by 19
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Fibroblast heterogeneity: implications for human disease
Lynch, M. D., & Watt, F. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93555 · Cited by 507
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Metadata
- Authors
- Hocking, A. M., & Gibran, N. S.
- Affiliations
- University of Washington (US)
- Corresponding author
- Hocking, Anne M.
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 316
- Issue
- 14
- Pages
- 2213-2219
- ISSN
- 0014-4827 (ISSN-L)
- PMC
- PMC2902653
- OpenAlex
- W2084565323
- Cited by
- 408
- References
- 46
- Citations by year
- 2026: 14 · 2025: 7 · 2024: 21 · 2023: 22 · 2022: 16 · 2021: 30 · 2020: 34 · 2019: 31 · 2018: 40 · 2017: 36 · 2016: 39 · 2015: 27 · 2014: 28 · 2013: 29 · 2012: 17
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM073624)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK017047)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Keywords
- mesenchymal stem cells, skin wound healing, chronic wounds, paracrine signaling, cell differentiation, hypertrophic scars, angiogenesis, granulation tissue, re-epithelialization, delayed wound healing, tissue regeneration
- MeSH terms
- Humans, Wound Healing, Signal Transduction, Paracrine Communication, Cell Proliferation, Mesenchymal Stem Cells
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