Nitric oxide modulates the expression of endothelial cell adhesion molecules involved in angiogenesis and leukocyte recruitment
Abstract
Tumor angiogenesis and immune response have in common to be cell recognition mechanisms, which are based on specific adhesion molecules and dependent on nitric oxide (NO(•)). The aim of the present study is to deepen the mechanisms of angiogenesis and inflammation regulation by NO(•) to find out the molecular regulation processes that govern endothelial cell permeability and leukocyte transmigration. Effects of NO(•), either exogenous or produced in hypoxic conditions, were studied on microvascular endothelial cells from skin and lymph node because of their strong involvement in melanoma progression. We found that NO(•) down-regulation of pseudo-vessel formation was linked to a decrease in endothelial cell ability to adhere to each other which can be explain, in part, by the inhibition of PECAM-1/CD31 expression. On the other hand, NO(•) was shown to be able to decrease leukocyte adhesion on an endothelial monolayer, performed either in static or in rolling conditions, and to modulate differentially CD34, ICAM-1/CD54, ICAM-2/CD102 and VCAM-1/CD106 expression. In conclusion, during angiogenesis and leukocyte recruitment, NO(•) regulates cell interactions by controlling adhesion molecule expression and subsequently cell adhesion. Moreover, each endothelial cell type presents its own organospecific response to NO(•), reflecting the functions of the tissue they originate from.
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Carreau et al. reported reduced leukocyte adhesion at elevated nitric oxide concentrations, suggesting that nitric oxide could reduce localization of inflammatory cells at the device-tissue interface.
“Carreau et al. reported reduced leukocyte adhesion at elevated NO concentrations, suggesting NO could reduce localization of inflammatory cells at the device-tissue interface.216”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [216]
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References 46 · Cited by 88
- Authors
- Carreau, A., Kieda, C., & Grillon, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Grillon, Catherine
- ORCID
- Grillon, Catherine
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 2011-01-01
- Volume
- 317
- Issue
- 1
- Pages
- 29-41
- ISSN
- 0014-4827 (ISSN-L)
- OpenAlex
- W1969592877
- Cited by
- 88
- References
- 46
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 4 · 2014: 1 · 2013: 9 · 2012: 5
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- nitric oxide, endothelial adhesion molecules, angiogenesis, leukocyte recruitment, leukocyte adhesion, PECAM-1/CD31, CD34, endothelial permeability, leukocyte transmigration, hypoxia, melanoma, microvascular endothelial cells, skin, lymph nodes, inflammation
- MeSH terms
- Cell Communication, Cell Line, Chemotaxis, Leukocyte, Humans, Leukocytes, Nitric Oxide, Down-Regulation, Cell Adhesion Molecules, Neovascularization, Physiologic, Nitric Oxide Donors, Endothelial Cells, Cell Migration Assays, Leukocyte
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