The DOI matches its Crossref record; 139 of the 141 references it cites were found in a registry or an index.
Neural crest cell signaling pathways critical to cranial bone development and pathology
Open accessAbstract
Neural crest cells appear early during embryogenesis and give rise to many structures in the mature adult. In particular, a specific population of neural crest cells migrates to and populates developing cranial tissues. The ensuing differentiation of these cells via individual complex and often intersecting signaling pathways is indispensible to growth and development of the craniofacial complex. Much research has been devoted to this area of development with particular emphasis on cell signaling events required for physiologic development. Understanding such mechanisms will allow researchers to investigate ways in which they can be exploited in order to treat a multitude of diseases affecting the craniofacial complex. Knowing how these multipotent cells are driven towards distinct fates could, in due course, allow patients to receive regenerative therapies for tissues lost to a variety of pathologies. In order to realize this goal, nucleotide sequencing advances allowing snapshots of entire genomes and exomes are being utilized to identify molecular entities associated with disease states. Once identified, these entities can be validated for biological significance with other methods. A crucial next step is the integration of knowledge gleaned from observations in disease states with normal physiology to generate an explanatory model for craniofacial development. This review seeks to provide a current view of the landscape on cell signaling and fate determination of the neural crest and to provide possible avenues of approach for future research.
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“As shown in fig. S2A, a manually curated signature from an extensive literature review (23–28) validated the cranial identity of our NCSC lines, while clustering by Pearson correlation excluded the presence of any genotype- or hairpin-specific expression change.”
From Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication (2019) · cites this paper as [28]
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Developmental Anatomy and Histology of the Scalp and Calvarium
Kılıç, K. D., Orif, S. E., Turgut, A. Ç., Çelik, S., & Uyanıkgil, Y. (2025) · Springer eBooks · doi:10.1007/978-3-031-88244-9_3 · Cited by 1
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PRDM16 is necessary for sensory neuronal development in the Trigeminal GanglionPreprint
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Shukla, N., Cook, L. E., Vespasiani, D. M., Pask, A. J., & Romero, I. G. (2026) · Genome Research · doi:10.1101/gr.281284.125
PRDM16 is necessary for sensory neuronal development and differentiation in the trigeminal ganglion
Raha, F., Gao, Q., Shull, L. C., & Artinger, K. (2026) · Developmental Dynamics · doi:10.1002/dvdy.70191 · Cited by 1
Metadata
- Authors
- Mishina, Y., & Snider, T. N.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Mishina, Yuji
- ORCID
- Mishina, Yuji
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 325
- Issue
- 2
- Pages
- 138-147
- ISSN
- 0014-4827 (ISSN-L)
- PMC
- PMC4072849
- OpenAlex
- W2037680071
- Cited by
- 114
- References
- 141
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 13 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 3
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (R01DE020843, T32DE007057)
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Surgery › Craniofacial Disorders and Treatments
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- neural crest cells, cranial bone development, craniofacial development, signaling pathways, cell fate determination, regenerative therapy, craniofacial diseases, craniofacial embryology
- MeSH terms
- Animals, Bone Development, Humans, Neural Crest, Skull, Signal Transduction, Embryonic Development
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