Cited by 114Developmental Biology and Gene RegulationCraniofacial Disorders and TreatmentsNeurogenesis and neuroplasticity mechanisms

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Neural crest cell signaling pathways critical to cranial bone development and pathology

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Mishina, Yuji, Snider, Taylor Nicholas·2014·Experimental Cell Research

DOI 10.1016/j.yexcr.2014.01.019PMC PMC4072849

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Abstract

Neural crest cells appear early during embryogenesis and give rise to many structures in the mature adult. In particular, a specific population of neural crest cells migrates to and populates developing cranial tissues. The ensuing differentiation of these cells via individual complex and often intersecting signaling pathways is indispensible to growth and development of the craniofacial complex. Much research has been devoted to this area of development with particular emphasis on cell signaling events required for physiologic development. Understanding such mechanisms will allow researchers to investigate ways in which they can be exploited in order to treat a multitude of diseases affecting the craniofacial complex. Knowing how these multipotent cells are driven towards distinct fates could, in due course, allow patients to receive regenerative therapies for tissues lost to a variety of pathologies. In order to realize this goal, nucleotide sequencing advances allowing snapshots of entire genomes and exomes are being utilized to identify molecular entities associated with disease states. Once identified, these entities can be validated for biological significance with other methods. A crucial next step is the integration of knowledge gleaned from observations in disease states with normal physiology to generate an explanatory model for craniofacial development. This review seeks to provide a current view of the landscape on cell signaling and fate determination of the neural crest and to provide possible avenues of approach for future research.

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Bone: Formation by Autoinduction
Urist, M. R. (1965) · Science · doi:10.1126/science.150.3698.893 · Cited by 5,529
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Chiang, C. C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062
The primary cilium: a signalling centre during vertebrate development
Goetz, S. C., & Anderson, K. V. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2774 · Cited by 1,824
Vertebrate Smoothened functions at the primary cilium
Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. R., & Reiter, J. F. (2005) · Nature · doi:10.1038/nature04117 · Cited by 1,481
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis
Chai, Y., Jiang, X., Ito, Y., Bringas, P., Han, J., Rowitch, D. H., Soriano, P. M., McMahon, A. P., & Sucov, H. M. (2000) · Development · doi:10.1242/dev.127.8.1671 · Cited by 1,464
Hedgehog signalling in the mouse requires intraflagellar transport proteins
Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., Niswander, L., & Anderson, K. V. (2003) · Nature · doi:10.1038/nature02061 · Cited by 1,425
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
Danielian, P. S., Muccino, D. R., Rowitch, D. H., Michael, S. K., & McMahon, A. P. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00562-3 · Cited by 1,295
Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development
Satokata, I., & Maas, R. L. (1994) · Nature Genetics · doi:10.1038/ng0494-348 · Cited by 1,274
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
Roessler, E., Belloni, E., Gaudenz, K., Jay, P., Berta, P., Scherer, S. W., Tsui, L.-C., & Muenke, M. (1996) · Nature Genetics · doi:10.1038/ng1196-357 · Cited by 1,152
Inactivation of the β-catenin gene by Wnt1-Cre -mediated deletion results in dramatic brain malformation and failure of craniofacial development
Brault, V., Moore, R., Kutsch, S., Ishibashi, M., Rowitch, D. H., McMahon, A. P., Sommer, L., Boussadia, O., & Kemler, R. (2001) · Development · doi:10.1242/dev.128.8.1253 · Cited by 1,076
The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues
Noden, D. M. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90318-4 · Cited by 878
Tissue origins and interactions in the mammalian skull vault.
Jiang, X., Iseki, S., Maxson, R. E., Sucov, H. M., & Morriss-Kay, G. M. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0487 · Cited by 782
Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
Satokata, I., Ma, L., Ohshima, H., Bei, M., Woo, I., Nishizawa, K., Maeda, T., Takano, Y., Uchiyama, M., Heaney, S., et al. (2000) · Nature Genetics · doi:10.1038/74231 · Cited by 737
A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis
Jabs, E. W., Müller, U., Li, X., Ma, L., Luo, W., Haworth, I. S., Klisak, I. J., Sparkes, R. S., Warman, M. L., Mulliken, J. B., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90379-5 · Cited by 673
Mutations in TWIST, a basic helix–loop–helix transcription factor, in Saethre-Chotzen syndrome
Howard, T. D., Paznekas, W. A., Green, E. D., Chiang, L. C., Ma, N. S. F., Luna, R. I. O. D., Delgado, C. G., Gonzalez-Ramos, M., Kline, A. D., & Jabs, E. W. (1997) · Nature Genetics · doi:10.1038/ng0197-36 · Cited by 645
Mutations of the TWIST gene in the Saethre-Chotzene syndrome
Ghouzzi, V. E., Merrer, M. F. L., Perrin‐Schmitt, F., Lajeunie, E., Bénit, P., Rénier, D., Bourgeois, P., Bolcato‐Bellemin, A., Münnich, A., & Bonaventure, J. (1997) · Nature Genetics · doi:10.1038/ng0197-42 · Cited by 644
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
Belloni, E., Muenke, M., Roessler, E., Traverse, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H. F., Donis-Keller, H., Helms, C. A., Hing, A. V., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-353 · Cited by 643
twist is required in head mesenchyme for cranial neural tube morphogenesis.Preprint
Chen, Z., & Behringer, R. R. (1995) · Genes & Development · doi:10.1101/gad.9.6.686 · Cited by 626
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordiaPreprint
Jeong, J., Mao, J., Tenzen, T., Kottmann, A. H., & McMahon, A. P. (2004) · Genes & Development · doi:10.1101/gad.1190304 · Cited by 615
Recent advances in craniofacial morphogenesis
Chai, Y., & Maxson, R. E. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20833 · Cited by 610
Skeletal Cell Fate Decisions Within Periosteum and Bone Marrow During Bone Regeneration
Colnot, C. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081003 · Cited by 590
Cilia and Developmental Signaling
Eggenschwiler, J. T., & Anderson, K. V. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123249 · Cited by 540
Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial archPreprint
Trumpp, A., Depew, M. J., Rubenstein, J. L. R., Bishop, J. M., & Martin, G. R. (1999) · Genes & Development · doi:10.1101/gad.13.23.3136 · Cited by 515
Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development
Bush, J. O., & Jiang, R. (2011) · Development · doi:10.1242/dev.067082 · Cited by 508
Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies
Morriss‐Kay, G. M., & Wilkie, A. O. M. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00475.x · Cited by 483
Relations and interactions between cranial mesoderm and neural crest populations
Noden, D. M., & Trainor, P. A. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00473.x · Cited by 452
Gene-Regulatory Interactions in Neural Crest Evolution and Development
Meulemans, D., & Bronner-Fraser, M. E. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.007 · Cited by 449
Genetics of craniofacial development and malformation
Wilkie, A. O. M., & Morriss‐Kay, G. M. (2001) · Nature Reviews Genetics · doi:10.1038/35076601 · Cited by 442
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
May, S., Ashique, A. M., Karlén, M., Wang, B., Shen, Y., Zarbalis, K., Reiter, J. F., Ericson, J., & Peterson, A. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.08.050 · Cited by 437
Bone morphogenetic protein-3 is a negative regulator of bone density
Daluiski, A., Engstrand, T., Bahamonde, M. E., Gamer, L. W., Agius, E., Stevenson, S., Cox, K. A., Rosen, V., & Lyons, K. M. (2001) · Nature Genetics · doi:10.1038/83810 · Cited by 427
Integration of FGF and TWIST in calvarial bone and suture development
Rice, D. P. C., Åberg, T., Chan, Y.-S., Tang, Z., Kettunen, P. J., Pakarinen, L., Maxson, R. E., & Thesleff, I. (2000) · Development · doi:10.1242/dev.127.9.1845 · Cited by 407
The role of Axin2 in calvarial morphogenesis and craniosynostosis
Yu, H. I., Jerchow, B., Sheu, T., Liu, B., Costantini, F. D., Puzas, J. E., Birchmeier, W., & Hsu, W. (2005) · Development · doi:10.1242/dev.01786 · Cited by 355
Periosteal Progenitor Cell Fate in Segmental Cortical Bone Graft Transplantations: Implications for Functional Tissue Engineering
Zhang, X., Xie, C. L., Lin, A., Ito, H., Awad, H. A., Lieberman, J. R., Rubery, P. T., Schwarz, E. M., O’Keefe, R. J., & Guldberg, R. E. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050806 · Cited by 353
The role of Sonic hedgehog in normal and abnormal craniofacial morphogenesis
Hu, D. P., & Helms, J. A. (1999) · Development · doi:10.1242/dev.126.21.4873 · Cited by 339
Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool
Spassky, N., Han, Y.-G., Aguilar, A., Strehl, L., Besse, L., Laclef, C., Romaguera Ros, M., Garcia-Verdugo, J. M., & Alvarez-Buylla, A. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.02.026 · Cited by 314
The BMP antagonist noggin regulates cranial suture fusion
Warren, S. M., Brunet, L. J., Harland, R. M., Economides, A. N., & Longaker, M. T. (2003) · Nature · doi:10.1038/nature01545 · Cited by 303
Neural crest stem cells: discovery, properties and potential for therapy
Achilleos, A., & Trainor, P. A. (2012) · Cell Research · doi:10.1038/cr.2012.11 · Cited by 294
Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death
Ahlgren, S. C., & Bronner-Fraser, M. E. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80052-4 · Cited by 291
The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling
Lewis, A. E., Vasudevan, H. N., O’Neill, A. K., Soriano, P., & Bush, J. O. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.04.026 · Cited by 289
Promotion and Attenuation of FGF Signaling Through the Ras-MAPK Pathway
Tsang, M., & Dawid, I. (2004) · Science's STKE · doi:10.1126/stke.2282004pe17 · Cited by 287
BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway
Kamiya, N., Ye, L., Kobayashi, T., Mochida, Y., Yamauchi, M., Kronenberg, H. M., Feng, J. Q., & Mishina, Y. M. (2008) · Development · doi:10.1242/dev.025825 · Cited by 279
Self-citation
A Novel Transgenic Technique That Allows Specific Marking of the Neural Crest Cell Lineage in Mice
Yamauchi, Y., Abe, K., Mantani, A., Hitoshi, Y., Suzuki, M., Osuzu, F., Kuratani, S., & Yamamura, K. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9323 · Cited by 272
Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome.
Yu, K., Herr, A., Waksman, G., & Ornitz, D. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.26.14536 · Cited by 266
FGF signalling during embryo development regulates cilia length in diverse epithelia
Neugebauer, J. M., Amack, J. D., Peterson, A. G., Bisgrove, B. W., & Yost, H. J. (2009) · Nature · doi:10.1038/nature07753 · Cited by 265
BMP signaling and early embryonic patterning
Kishigami, S., & Mishina, Y. M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.04.002 · Cited by 265
Self-citation
Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand
Anderson, J. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.9.1475 · Cited by 248
Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation.
Howe, L. R., Watanabe, O., Leonard, J. N., & Brown, A. M. C. (2003) · PubMed · Cited by 244
Fine Tuning of Craniofacial Morphology by Distant-Acting Enhancers
Attanasio, C., Nord, A. S., Zhu, Y., Blow, M. J., Li, Z., Liberton, D. K., Morrison, H., Plajzer-Frick, I., Holt, A., Hosseini, R., et al. (2013) · Science · doi:10.1126/science.1241006 · Cited by 244
KIF3A is a new microtubule-based anterograde motor in the nerve axon.
Kondo, S., Sato-Yoshitake, R., Noda, Y., Aizawa, H., Nakata, T., Matsuura, Y., & Hirokawa, N. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.5.1095 · Cited by 237
Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development
Macatee, T. L., Hammond, B. P., Arenkiel, B. R., Francis, L., Frank, D. U., & Moon, A. (2003) · Development · doi:10.1242/dev.00850 · Cited by 233
Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis
Sharma, V., Fenwick, A. L., Brockop, M. S., McGowan, S. J., Goos, J. A. C., Hoogeboom, A. J. M., Brady, A. F., Jeelani, O., Lynch, S. A., Mulliken, J. B., et al. (2013) · Nature Genetics · doi:10.1038/ng.2531 · Cited by 226
Current perspectives of the signaling pathways directing neural crest induction
Stuhlmiller, T. J., & García‐Castro, M. I. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0991-8 · Cited by 225
Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells
Dudáš, M., Sridurongrit, S., Nagy, A. R., Okazaki, K., & Kaartinen, V. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2003.12.003 · Cited by 216
Wnt signaling mediates regional specification in the vertebrate face
Brugmann, S. A., Goodnough, L. H., Gregorieff, A., Leucht, P., ten Berge, D., Fuerer, C., Clevers, H., Nusse, R., & Helms, J. A. (2007) · Development · doi:10.1242/dev.005132 · Cited by 213
RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis
Shukla, V., Coumoul, X., Wang, R.-H., Kim, H., & Deng, C. (2007) · Nature Genetics · doi:10.1038/ng2096 · Cited by 203
Msx2Gene Dosage Influences the Number of Proliferative Osteogenic Cells in Growth Centers of the Developing Murine Skull: A Possible Mechanism forMSX2-Mediated Craniosynostosis in Humans
Liu, Y., Tang, Z., Kundu, R. K., Wu, L., Luo, W., Zhu, D., Sangiorgi, F. O., Snead, M. L., & Maxson, R. E. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9114 · Cited by 201
Signals and switches in mammalian neural crest cell differentiation
Bhatt, S., Diaz, R., & Trainor, P. A. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008326 · Cited by 200
Craniofacial birth defects: The role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention
Trainor, P. A. (2010) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33454 · Cited by 188
BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium
Stottmann, R. W., Choi, M., Mishina, Y. M., Meyers, E. N., & Klingensmith, J. (2004) · Development · doi:10.1242/dev.01086 · Cited by 186
Self-citation
Variation of BMP3 Contributes to Dog Breed Skull Diversity
Schoenebeck, J. J., Hutchinson, S. A., Byers, A., Beale, H. C., Carrington, B., Faden, D. L., Rimbault, M., Decker, B. J., Kidd, J. M., Sood, R. B., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002849 · Cited by 185
The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre-Chotzen syndrome
Bourgeois, P. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.6.945 · Cited by 185
Combined deficiencies ofMsx1andMsx2cause impaired patterning and survival of the cranial neural crest
Ishii, M., Han, J., Yen, H.-Y., Sucov, H. M., Chai, Y., & Maxson, R. E. (2005) · Development · doi:10.1242/dev.02072 · Cited by 183
Msx2andTwistcooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault
Ishii, M., Merrill, A. E., Chan, Y.-S., Gitelman, I., Rice, D. P. C., Sucov, H. M., & Maxson, R. E. (2003) · Development · doi:10.1242/dev.00793 · Cited by 183
Spatial relations between avian craniofacial neural crest and paraxial mesoderm cells
Evans, D. J. R., & Noden, D. M. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20663 · Cited by 174
Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis
Twigg, S. R. F., Vorgia, E., McGowan, S. J., Peraki, I., Fenwick, A. L., Sharma, V., Allégra, M., Ζαραγκούλιας, Α., Akha, E. S., Knight, S. J. L., et al. (2013) · Nature Genetics · doi:10.1038/ng.2539 · Cited by 173
Reciprocal relationships between Fgf8 and neural crest cells in facial and forebrain development
Creuzet, S., Schuler, B., Couly, G. F., & Douarin, N. M. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400869101 · Cited by 168
Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network
de Crozé, N., Maczkowiak, F., & Monsoro-Burq, A. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010740107 · Cited by 166
Genetics of Craniosynostosis: Genes, Syndromes, Mutations and Genotype-Phenotype Correlations
Passos‐Bueno, M. R., Sertie, A. L., Jehee, F. S., Fanganiello, R. D., & Yeh, E. (2008) · Frontiers of oral physiology/Frontiers of oral biology · doi:10.1159/000115035 · Cited by 163
Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion
Song, L., Li, Y., Wang, K., Wang, Y., Molotkov, A., Gao, L., Zhao, T., Yamagami, T., Wang, Y., Gan, Q., et al. (2009) · Development · doi:10.1242/dev.037440 · Cited by 161
Origin matters: Differences in embryonic tissue origin and Wnt signaling determine the osteogenic potential and healing capacity of frontal and parietal calvarial bones
Quarto, N., Wan, D. C., Kwan, M. D., Panetta, N. J., Li, S., & Longaker, M. T. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.091116 · Cited by 157
Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities
Ibrahimi, O. A. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh235 · Cited by 153
Constitutive Activation of Fibroblast Growth Factor Receptor-2 by a Point Mutation Associated with Crouzon Syndrome
Neilson, K. M., & Friesel, R. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26037 · Cited by 150
A primary cilia-dependent etiology for midline facial disorders
Brugmann, S. A., Allen, N. C., James, A. W., Mekonnen, Z. K., Madan, E., & Helms, J. A. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq030 · Cited by 149
Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction
Nozawa, Y. I., Lin, C., & Chuang, P. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.04.008 · Cited by 140
A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9
Justice, C. M., Yagnik, G., Kim, Y., Peter, I., Jabs, E. W., Erazo, M., Ye, X., Ainehsazan, E., Shi, L., Cunningham, M. L., et al. (2012) · Nature Genetics · doi:10.1038/ng.2463 · Cited by 140
Dynamic and Differential Regulation of Stem Cell Factor FoxD3 in the Neural Crest Is Encrypted in the Genome
Simões-Costa, M., McKeown, S. J., Tan-Cabugao, J., Sauka‐Spengler, T., & Bronner-Fraser, M. E. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003142 · Cited by 139
Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure
Connerney, J., Andreeva, V., Leshem, Y., Mercado, M. A., Dowell, K. G., Yang, X., Lindner, V., Friesel, R. E., & Spicer, D. B. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.03.037 · Cited by 131
The Balance of WNT and FGF Signaling Influences Mesenchymal Stem Cell Fate During Skeletal Development
Maruyama, T., Mirando, A. J., Deng, C., & Hsu, W. (2010) · Science Signaling · doi:10.1126/scisignal.2000727 · Cited by 129
A Stable Cranial Neural Crest Cell Line from Mouse
Ishii, M., Arias, A. C., Liu, L., Chen, Y., Bronner-Fraser, M. E., & Maxson, R. E. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0155 · Cited by 125
Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice
Lan, Y., Ryan, R. C., Zhang, Z., Bullard, S. A., Bush, J. O., Maltby, K. M., Lidral, A. C., & Jiang, R. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20723 · Cited by 124
Wnt-regulated temporal control of BMP exposure directs the choice between neural plate border and epidermal fate
Patthey, C., Edlund, H., & Gunhaga, L. (2008) · Development · doi:10.1242/dev.025890 · Cited by 123
Sox9 neural crest determinant gene controls patterning and closure of the posterior frontal cranial suture
Sahar, D. E., Longaker, M. T., & Quarto, N. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.022 · Cited by 119
A phylogenetically conserved cis-regulatory module in theMsx2promoter is sufficient for BMP-dependent transcription in murine andDrosophilaembryos
Brugger, S. M., Merrill, A. E., Torres‐Vázquez, J., Wu, N. L., Ting, M.-C., Cho, J. Y.-M., Dobias, S. L., Yi, S. E., Lyons, K. M., Bell, J. R., et al. (2004) · Development · doi:10.1242/dev.01390 · Cited by 117
FGF signals from the nasal pit are necessary for normal facial morphogenesis
Szabo‐Rogers, H. L., Geetha‐Loganathan, P., Nimmagadda, S., Fu, K., & Richman, J. M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.03.027 · Cited by 112
Augmentation of smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice
Komatsu, Y., Yu, P. B., Kamiya, N., Pan, H., Fukuda, T., Scott, G. J., Ray, M. K., Yamamura, K., & Mishina, Y. M. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1857 · Cited by 106
Self-citation
Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of β-catenin in proliferation and differentiation
Liu, B., Yu, H. I., & Hsu, W. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.10.018 · Cited by 106
BMP signaling in development and diseases: A pharmacological perspective
Bandyopadhyay, A., Yadav, P. S., & Prashar, P. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.01.004 · Cited by 105
BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways
Morikawa, Y., Zehir, A., Maska, E. L., Deng, C., Schneider, M. D., Mishina, Y. M., & Cserjesi, P. (2009) · Development · doi:10.1242/dev.038133 · Cited by 99
Self-citation
Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head
Roybal, P. G., Wu, N. L., Sun, J., Ting, M.-C., Schafer, C. A., & Maxson, R. E. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.04.007 · Cited by 89
Craniosynostosis in Twist heterozygous mice: A model for Saethre‐Chotzen syndrome
Carver, E. A., Oram, K. F., & Gridley, T. (2002) · The Anatomical Record · doi:10.1002/ar.10124 · Cited by 88
Metopic sutural closure in the human skull.
Manzanares‐Céspedes, M. C., Goret-Nicaise, M., & Dhem, A. (1988) · PubMed · Cited by 87
Fuz Mutant Mice Reveal Shared Mechanisms between Ciliopathies and FGF-Related Syndromes
Tabler, J. M., Barrell, W. B., Szabo‐Rogers, H. L., Healy, C., Yeung, Y., Perdiguero, E. G., Schulz, C., Yannakoudakis, B. Z., Mesbahi, A., Wlodarczyk, B. J., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.05.021 · Cited by 87
The emerging face of primary cilia
Zaghloul, N. A., & Brugmann, S. A. (2011) · genesis · doi:10.1002/dvg.20728 · Cited by 86
Molecular mechanisms in calvarial bone and suture development, and their relation to craniosynostosis
Rice, D. P. C. (2003) · European Journal of Orthodontics · doi:10.1093/ejo/25.2.139 · Cited by 85
New insights on the roles of BMP signaling in bone—A review of recent mouse genetic studies
Kamiya, N., & Mishina, Y. M. (2011) · BioFactors · doi:10.1002/biof.139 · Cited by 84
Self-citation
The cephalic neural crest of amniote vertebrates is composed of a large majority of precursors endowed with neural, melanocytic, chondrogenic and osteogenic potentialities
Dupin, É., Calloni, G. W., & Douarin, N. M. L. (2010) · Cell Cycle · doi:10.4161/cc.9.2.10491 · Cited by 82
Expression of WNT signalling pathway genes during chicken craniofacial development
Geetha‐Loganathan, P., Nimmagadda, S., Antoni, L., Fu, K., Whiting, C. J., Francis‐West, P. H., & Richman, J. M. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21934 · Cited by 82
Differential activation of canonical Wnt signaling determines cranial sutures fate: A novel mechanism for sagittal suture craniosynostosis
Behr, B., Longaker, M. T., & Quarto, N. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.06.009 · Cited by 80
Genotypic and phenotypic analysis of 396 individuals with mutations in Sonic Hedgehog
Solomon, B. D., Bear, K. A., Wyllie, A., Keaton, A. A., Dubourg, C., David, V., Mercier, S., Odent, S., Hehr, U., Paulussen, A. D. C., et al. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101008 · Cited by 76
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms
Kolpakova-Hart, E., Jinnin, M., Hou, B., Fukai, N., & Olsen, B. R. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.07.018 · Cited by 75
Neural Crest Inducing Signals
Basch, M. L., & Bronner-Fraser, M. E. (2007) · Springer eBooks · doi:10.1007/978-0-387-46954-6_2 · Cited by 74
Craniofacial ciliopathies: A new classification for craniofacial disorders
Brugmann, S. A., Cordero, D. R., & Helms, J. A. (2010) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33727 · Cited by 66
Activation of FGF Signaling Mediates Proliferative and Osteogenic Differences between Neural Crest Derived Frontal and Mesoderm Parietal Derived Bone
Li, S., Quarto, N., & Longaker, M. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014033 · Cited by 65
A deletion and a duplication in distal 22q11.2 deletion syndrome region. Clinical implications and review
Fernández, L., Nevado, J., Santos, F., Heine‐Suñer, D., Martínez‐Glez, V., García‐Miñáur, S., Palomo, R., Delicado, A., Pajares, I. L., Palomares‐Bralo, M., et al. (2009) · BMC Medical Genetics · doi:10.1186/1471-2350-10-48 · Cited by 65
Inhibition of neutrophil oxidative burst and granule secretion by Wortmannin: Potential role of MAP kinase and renaturable kinases
Sue‐A‐Quan, A. K., Fialkow, L., Vlahos, C. J., Schelm, J. A., Grinstein, S., Butler, J. R., & Downey, G. P. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199707)172:1 · Cited by 63
Different endogenous threshold levels of Fibroblast Growth Factor-ligands determine the healing potential of frontal and parietal bones
Behr, B., Panetta, N. J., Longaker, M. T., & Quarto, N. (2010) · Bone · doi:10.1016/j.bone.2010.05.008 · Cited by 62
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Dwivedi, P. P., Grose, R., Filmus, J., Hii, C. S. T., Xian, C. J., Anderson, P. J., & Powell, B. C. (2013) · Bone · doi:10.1016/j.bone.2013.04.013 · Cited by 59
New Developments in Cranial Suture Research
Warren, S. M., Greenwald, J. A., Spector, J. A., Bouletreau, P. J., Mehrara, B. J., & Longaker, M. T. (2001) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-200102000-00034 · Cited by 58
Periosteal BMP2 activity drives bone graft healing
Chappuis, V., Gamer, L. W., Cox, K. A., Lowery, J. W., Bosshardt, D. D., & Rosen, V. (2012) · Bone · doi:10.1016/j.bone.2012.07.017 · Cited by 57
Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2
Sun, J., Ishii, M., Ting, M.-C., & Maxson, R. (2013) · Development · doi:10.1242/dev.085225 · Cited by 57
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Zhang, Z., Wlodarczyk, B. J., Niederreither, K., Venugopalan, S. R., Florez, S. L., Finnell, R. H., & Amendt, B. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024608 · Cited by 57
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Nomura-Kitabayashi, A., Phoon, C. K. L., Kishigami, S., Rosenthal, J., Yamauchi, Y., Abe, K., Yamamura, K., Samtani, R. R., Lo, C. W., & Mishina, Y. M. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00304.2009 · Cited by 57
Self-citation
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Mirando, A. J., Maruyama, T., Fu, J., Yu, H. I., & Hsu, W. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-116 · Cited by 41
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How studies on the avian embryo have opened new avenues in the understanding of development: A view about the neural and hematopoietic systems
Douarin, N. M. L., & Dieterlen‐Lièvre, F. (2012) · Development Growth & Differentiation · doi:10.1111/dgd.12015 · Cited by 38
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Cooper, G. M., Curry, C., Barbano, T., Burrows, A. M., Vecchione, L., Caccamese, J. F., Norbutt, C., Costello, B. J., Losee, J. E., Moursi, A. M., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070410 · Cited by 37
Roles of organizer factors and BMP antagonism in mammalian forebrain establishment
Yang, Y., & Klingensmith, J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.014 · Cited by 35
Roles of bone morphogenetic protein signaling and its antagonism in holoprosencephaly
Klingensmith, J., Matsui, M., Yang, Y., & Anderson, R. M. (2010) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30256 · Cited by 35
Integration of Multiple Signaling Pathways Determines Differences in the Osteogenic Potential and Tissue Regeneration of Neural Crest-Derived and Mesoderm-Derived Calvarial Bones
Senarath-Yapa, K., Li, S., Meyer, N. P., Longaker, M. T., & Quarto, N. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14035978 · Cited by 34
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Wang, S., Komatsu, Y., & Mishina, Y. M. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.026 · Cited by 32
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Authors: Mishina, Y., & Snider, T. N.
Affiliations: University of Michigan (US)
Corresponding author: Mishina, Yuji
ORCID: Mishina, Yuji
Venue: Experimental Cell Research
Publisher: Elsevier BV
Published: 2014-07
Volume: 325
Issue: 2
Pages: 138-147
ISSN: 0014-4827 (ISSN-L)
DOI: 10.1016/j.yexcr.2014.01.019
PMC: PMC4072849
OpenAlex: W2037680071
Cited by: 114
References: 141
Citations by year: 2026: 12 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 13 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 3
FWCI: 0.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Cell Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Dental and Craniofacial Research (R01DE020843, T32DE007057)
Core Research for Evolutional Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Surgery › Craniofacial Disorders and Treatments
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: neural crest cells, cranial bone development, craniofacial development, signaling pathways, cell fate determination, regenerative therapy, craniofacial diseases, craniofacial embryology
MeSH terms: Animals, Bone Development, Humans, Neural Crest, Skull, Signal Transduction, Embryonic Development

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Neural crest cell signaling pathways critical to cranial bone development and pathology

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