The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.
Membrane estradiol signaling in the brain
Open accessAbstract
While the physiology of membrane-initiated estradiol signaling in the nervous system has remained elusive, a great deal of progress has been made toward understanding the activation of cell signaling. Membrane-initiated estradiol signaling activates G proteins and their downstream cascades, but the identity of membrane receptors and the proximal signaling mechanism(s) have been more difficult to elucidate. Mounting evidence suggests that classical intracellular estrogen receptor-alpha (ERalpha) and ERbeta are trafficked to the membrane to mediate estradiol cell signaling. Moreover, an interaction of membrane ERalpha and ERbeta with metabotropic glutamate receptors has been identified that explains the pleomorphic actions of membrane-initiated estradiol signaling. This review focuses on the mechanism of actions initiated by membrane estradiol receptors and discusses the role of scaffold proteins and signaling cascades involved in the regulation of nociception, sexual receptivity and the synthesis of neuroprogesterone, an important component in the central nervous system signaling.
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“These hypothalamic circuits collectively express the range of ER and employ both nuclear-initiated estrogen signaling (through estrogen response element (ERE)-dependent and ERE-independent pathways) and membrane-initiated estrogen signaling (through palmitoylated nuclear ER (α/β) and E2-responsive GPCR)34.”
From Emerging insights into hypothalamic‐pituitary‐gonadal axis regulation and interaction with stress signalling (2018) · cites this paper as [34]
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“After ligand-dependent receptor activation, ER disassociates from molecular chaperones, dimerizes, and binds to coactivators or corepressors to initiate or suppress transcription34.”
From Emerging insights into hypothalamic‐pituitary‐gonadal axis regulation and interaction with stress signalling (2018) · cites this paper as [34]
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“Nuclear-initiated ERα and ERβ signaling controls gene expression primarily through direct binding to DNA via an ERE.”
From Emerging insights into hypothalamic‐pituitary‐gonadal axis regulation and interaction with stress signalling (2018) · cites this paper as [34]
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“can affect cell physiology over the long term by acting as transcription factors to regulate gene expression (Heldring et al., 2007) or rapidly through non-genomic second messenger cascades (Micevych and Dominguez, 2009)”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Micevych and Dominguez, 2009
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Cites
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Cited by
Sorted by citations
Gillies, G. E., & McArthur, S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002071 · Cited by 733
Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018) · Journal of neuroendocrinology · doi:10.1111/jne.12590 · Cited by 298
Groeneweg, F. L., Karst, H., de Kloet, E. R., & Joëls, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.020 · Cited by 289
Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Piekarski, D. J., Johnson, C. M., Boivin, J. R., Thomas, A. W., Lin, W. C., Delevich, K., M. Galarce, E., & Wilbrecht, L. (2017) · Brain Research · doi:10.1016/j.brainres.2016.08.042 · Cited by 175
The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge
Micevych, P., & Sinchak, K. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00090 · Cited by 64
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Metadata
- Authors
- Micevych, P., & Dominguez, R.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Micevych, Paul
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 30
- Issue
- 3
- Pages
- 315-327
- ISSN
- 0091-3022 (ISSN-L)
- PMC
- PMC2720427
- OpenAlex
- W1980509664
- Cited by
- 177
- References
- 230
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 6 · 2023: 9 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 21 · 2014: 11 · 2013: 20 · 2012: 16
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institute on Aging (AG 14751, P01AG014751)
- National Institute on Drug Abuse (DA013185, R01DA013185)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 042635, R01HD042635, T32HD007228)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- membrane estrogen receptor, estrogen receptor alpha, estrogen receptor beta, metabotropic glutamate receptors, G protein signaling, scaffold proteins, nociception, sexual receptivity, brain
- MeSH terms
- Animals, Brain, Cell Membrane, Estradiol, Humans, Models, Biological, Receptors, Estrogen, Signal Transduction
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