Cited by 177Estrogen and related hormone effectsNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.

Membrane estradiol signaling in the brain

Open access

Micevych, Paul, Dominguez, Reymundo·2009·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2009.04.011PMC PMC2720427

Open this paper in CoChat — free account

Abstract

While the physiology of membrane-initiated estradiol signaling in the nervous system has remained elusive, a great deal of progress has been made toward understanding the activation of cell signaling. Membrane-initiated estradiol signaling activates G proteins and their downstream cascades, but the identity of membrane receptors and the proximal signaling mechanism(s) have been more difficult to elucidate. Mounting evidence suggests that classical intracellular estrogen receptor-alpha (ERalpha) and ERbeta are trafficked to the membrane to mediate estradiol cell signaling. Moreover, an interaction of membrane ERalpha and ERbeta with metabotropic glutamate receptors has been identified that explains the pleomorphic actions of membrane-initiated estradiol signaling. This review focuses on the mechanism of actions initiated by membrane estradiol receptors and discusses the role of scaffold proteins and signaling cascades involved in the regulation of nociception, sexual receptivity and the synthesis of neuroprogesterone, an important component in the central nervous system signaling.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.yfrne.2009.04.011

Cites

230 of 230 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cloning of a novel receptor expressed in rat prostate and ovary.
Kuiper, G. G. J. M., Enmark, E., Pelto‐Huikko, M., Nilsson, S., & Gustafsson, J.-Α. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5925 · Cited by 4,802
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A
Green, S., Walter, P., Kumar, V., Krust, A., Bornert, J., Argos, P., & Chambon, P. (1986) · Nature · doi:10.1038/320134a0 · Cited by 2,320
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2005) · Science · doi:10.1126/science.1106943 · Cited by 2,302
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L., & Paul, S. M. (1986) · Science · doi:10.1126/science.2422758 · Cited by 2,225
Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study
Simerly, R. B., Swanson, L. W., Chang, C., & Muramatsu, M. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902940107 · Cited by 2,118
Hormones, Brain and Behavior
(2009) · Elsevier eBooks · doi:10.1016/c2009-1-03789-7 · Cited by 1,543
Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells
Thomas, P., Pang, Y., Filardo, E. J., & Dong, J. (2004) · Endocrinology · doi:10.1210/en.2004-1064 · Cited by 1,410
Estrogen-Induced Activation of Erk-1 and Erk-2 Requires the G Protein-Coupled Receptor Homolog, GPR30, and Occurs via Trans-Activation of the Epidermal Growth Factor Receptor through Release of HB-EGF
Filardo, E. J., Quinn, J. A., Bland, K. I., & Frackelton, A. R. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.10.0532 · Cited by 1,387
Sex differences in pain
Berkley, K. J. (1997) · Behavioral and Brain Sciences · doi:10.1017/s0140525x97221485 · Cited by 1,125
THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION
Krupnick, J. G., & Benovic, J. (1998) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.289 · Cited by 1,121
Sex differences in the perception of noxious experimental stimuli: a meta-analysis
Riley, J. L., Robinson, M. E., Wise, E. A., Myers, C. D., & Fillingim, R. B. (1998) · Pain · doi:10.1016/s0304-3959(97)00199-1 · Cited by 1,085
Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ER and ER Expressed in Chinese Hamster Ovary Cells
Razandi, M., Pedram, A., Greene, G. L., & Levin, E. R. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.2.0239 · Cited by 1,075
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice
Cockayne, D. A., Hamilton, S. G., Zhu, Q., Dunn, P. M., Zhong, Y., Novaković, S. D., Malmberg, A. B., Cain, G. R., Berson, A. E., Kassotakis, L., et al. (2000) · Nature · doi:10.1038/35039519 · Cited by 1,031
A P2X purinoceptor expressed by a subset of sensory neurons
Chen, C., Akopian, A. N., Sivilotti, L. G., Colquhoun, D., Burnstock, G., & Wood, J. N. (1995) · Nature · doi:10.1038/377428a0 · Cited by 1,016
Estrogen receptor pathways to AP-1.
Kushner, P., Agard, D., Greene, G., Scanlan, T., Shiau, A., Uht, R., & Webb, P. (2000) · Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00108-4 · Cited by 953
Tyrosine kinase/p21ras/MAP‐kinase pathway activation by estradiol‐receptor complex in MCF‐7 cells.
Migliaccio, A., Domenico, M. D., Castoria, G., de Falco, A., Bontempo, P., Nola, E., & Auricchio, F. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00471.x · Cited by 950
DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS
Gainetdinov, R. R., Premont, R. T., Bohn, L., Lefkowitz, R. J., & Caron, M. G. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144206 · Cited by 896
GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases
Štefanová, I., Hořejšı́, V., Ansotegui, I. J., Knapp, W., & Stockinger, H. S. J. (1991) · Science · doi:10.1126/science.1719635 · Cited by 826
Hormones, brain and behavior
(2003) · Choice Reviews Online · doi:10.5860/choice.40-2774 · Cited by 705
Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.
Aronica, S. M., Kraus, W. L., & Katzenellenbogen, B. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8517 · Cited by 670
The β 2 -adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis
Laporte, S. A., Oakley, R. H., Zhang, J., Holt, J. A., Ferguson, S. S. G., Caron, M. G., & Barak, L. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3712 · Cited by 634
Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor
Mermelstein, P. G., Becker, J., & Surmeier, D. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00595.1996 · Cited by 627
Definition of Estrogen Receptor Pathway Critical for Estrogen Positive Feedback to Gonadotropin-Releasing Hormone Neurons and Fertility
Wintermantel, T. M., Campbell, R. E., Porteous, R. W., Bock, D., Gröne, H., Todman, M. G., Korach, K. S., Greiner, E. F., Pérez, C. A., Schütz, G., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.023 · Cited by 598
Identification of a Gene (GPR30) with Homology to the G-Protein-Coupled Receptor Superfamily Associated with Estrogen Receptor Expression in Breast Cancer
Carmeci, C., Thompson, D. A., Ring, H. Z., Francke, U., & Weigel, R. J. (1997) · Genomics · doi:10.1006/geno.1997.4972 · Cited by 590
Sex-related hormonal influences on pain and analgesic responses
Fillingim, R. B., & Ness, T. J. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00017-8 · Cited by 554
Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury
Dubal, D. B., Zhu, H., Yu, J., Rau, S. W., Shughrue, P. J., Merchenthaler, I. J., Kindy, M. S., & Wise, P. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1952 · Cited by 550
ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain Injury
Toran‐Allerand, C. D., Guan, X., MacLusky, N. J., Horváth, T. L., Diano, S., Singh, M., Connolly, E. S., Nethrapalli, I. S., & Tinnikov, A. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08391.2002 · Cited by 547
Drug Transporters in the Central Nervous System: Brain Barriers and Brain Parenchyma Considerations
Lee, G. S., Dallas, S., Hong, M., & Bendayan, R. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01513-8 · Cited by 547
Membrane estrogen receptors identified by multiple antibody labeling and impeded‐ligand binding
Pappas, T. C., Gametchu, B., & Watson, C. S. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.5.7896011 · Cited by 533
Neurotrophic and Neuroprotective Actions of Estrogens and Their Therapeutic Implications
Lee, S. H., & McEwen, B. S. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.569 · Cited by 533
Nature of Functional Estrogen Receptors at the Plasma Membrane
Pedram, A., Razandi, M., & Levin, E. R. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0525 · Cited by 523
The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling
Dauvois, S., White, R., & Parker, M. G. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.4.1377 · Cited by 522
Purinergic Signalling: ATP Release
Bodin, P., & Burnstock, G. (2001) · Neurochemical Research · doi:10.1023/a:1012388618693 · Cited by 521
Estrogen Receptor α Rapidly Activates the IGF-1 Receptor Pathway
Kahlert, S., Nuedling, S., van Eickels, M., Vetter, H., Meyer, R., & Grohé, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910345199 · Cited by 474
Neurosteroidogenesis in Astrocytes, Oligodendrocytes, and Neurons of Cerebral Cortex of Rat Brain
Zwain, I. H., & Yen, S. S. C. (1999) · Endocrinology · doi:10.1210/endo.140.8.6907 · Cited by 470
Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells
Li, L., Haynes, M. P., & Bender, J. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831079100 · Cited by 466
Estrogen-Induced Activation of Mitogen-Activated Protein Kinase in Cerebral Cortical Explants: Convergence of Estrogen and Neurotrophin Signaling Pathways
Singh, M., Sétáló, G., Guan, X., Warren, M., & Toran‐Allerand, C. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01179.1999 · Cited by 465
Facilitation of the lordosis reflex of female rats from the ventromedial nucleus of the hypothalamus.
Pfaff, D. W., & Sakuma, Y. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012690 · Cited by 461
Rapid Signaling of Estrogen in Hypothalamic Neurons Involves a Novel G-Protein-Coupled Estrogen Receptor that Activates Protein Kinase C
Qiu, J., Bosch, M. A., Tobias, S. C., Grandy, D. K., Scanlan, T. S., Rønnekleiv, O. K., & Kelly, M. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-29-09529.2003 · Cited by 460
A Conserved Mechanism for Steroid Receptor Translocation to the Plasma Membrane
Pedram, A., Razandi, M., Sainson, R. C. A., Kim, J. K., Hughes, C. C. W., & Levin, E. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611877200 · Cited by 449
Palmitoylation-dependent Estrogen Receptor α Membrane Localization: Regulation by 17β-Estradiol
Acconcia, F., Ascenzi, P., Bocedi, A., Spisni, E., Tomasi, V., Trentalance, A., Visca, P., & Marino, M. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0547 · Cited by 440
Purine-mediated signalling in pain and visceral perception
Burnstock, G. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01643-6 · Cited by 430
Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.
Lohse, M. J., Benovic, J. L., Caron, M. G., et al. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39754-6 · Cited by 404
The Interaction of β-Arrestin with the AP-2 Adaptor Is Required for the Clustering of β2-Adrenergic Receptor into Clathrin-coated Pits
Laporte, S. A., Oakley, R. H., Holt, J. A., Barak, L. S., & Caron, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002581200 · Cited by 401
Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.
Fawell, S. E., White, R., Hoare, S., Sydenham, M. A., Pagé, M., & Parker, M. G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6883 · Cited by 395
P2X receptors in sensory neurones
Burnstock, G. (2000) · British Journal of Anaesthesia · doi:10.1093/oxfordjournals.bja.a013473 · Cited by 392
Estradiol Activates Group I and II Metabotropic Glutamate Receptor Signaling, Leading to Opposing Influences on cAMP Response Element-Binding Protein
Boulware, M. I., Weick, J. P., Becklund, B. R., Kuo, S. P., Groth, R. D., & Mermelstein, P. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1427-05.2005 · Cited by 386
Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
Filardo, E. J. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00190-x · Cited by 374
Ultrastructural localization of estrogen receptor β immunoreactivity in the rat hippocampal formation
Milner, T. A., Ayoola, K. A., Drake, C., Herrick, S. P., Tabori, N., Mcewen, B. S., Warrier, S., & Alves, S. E. (2005) · The Journal of comparative neurology · doi:10.1002/cne.20724 · Cited by 370
P2X receptors in peripheral neurons
Dunn, P. M., Zhong, Y., & Burnstock, G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00005-3 · Cited by 365
Non-genomic actions of estrogens and their interaction with genomic actions in the brain.
Vasudevan, N., & Pfaff, D. (2008) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2007.08.003 · Cited by 360
17β-Estradiol Potentiates Kainate-Induced Currents via Activation of the cAMP Cascade
Gu, Q., & Moss, R. L. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-11-03620.1996 · Cited by 344
Tissue Distribution of Estrogen Receptors Alpha (ER- ) and Beta (ER- ) mRNA in the Midgestational Human Fetus
Brandenberger, A. W., Tee, M. K., Lee, J. Y., Chao, V. A., & Jaffe, R. B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4400 · Cited by 335
STEROIDAL PURE ANTIOESTROGENS
Wakeling, A. E., & Bowler, J. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.112r007 · Cited by 323
Identification of a Structural Determinant Necessary for the Localization and Function of Estrogen Receptor α at the Plasma Membrane
Razandi, M., Alton, G., Pedram, A., Ghonshani, S., Webb, P., & Levin, E. R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.5.1633-1646.2003 · Cited by 319
Phosphorylation and Agonist‐Specific Intracellular Trafficking of an Epitope‐Tagged μ‐Opioid Receptor Expressed in HEK 293 Cells
Arden, J. R., Segredo, V., Wang, Z. J., et al. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041636.x · Cited by 302
Estrogen Receptor Binding to DNA Is Not Required for Its Activity through the Nonclassical AP1 Pathway*
Jakacka, M., Ito, M., Weiss, J., Chien, P.-Y., Gehm, B. D., & Jameson, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008384200 · Cited by 299
Proteasome-Mediated Proteolysis of Estrogen Receptor: A Novel Component in Autologous Down-Regulation
Alarid, E. T., Bakopoulos, N., & Solodin, N. M. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.9.0337 · Cited by 293
Comparative distribution of estrogen receptor-α (ER-α) and β (ER-β) mRNA in the rat pituitary, gonad, and reproductive tract
Shughrue, P. J., Lane, M. V., Scrimo, P. J., & Merchenthaler, I. (1998) · Steroids · doi:10.1016/s0039-128x(98)00054-3 · Cited by 285
Plasma Membrane Estrogen Receptors Are Coupled to Endothelial Nitric-oxide Synthase through Gαi
Wyckoff, M. H., Chambliss, K. L., Mineo, C., Yuhanna, I. S., Mendelsohn, M. E., Mumby, S. M., & Shaul, P. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100312200 · Cited by 282
Detection of Estrogen Receptor-β Messenger Ribonucleic Acid and 125I-Estrogen Binding Sites in Luteinizing Hormone-Releasing Hormone Neurons of the Rat Brain
Hrabovszky, E., Shughrue, P. J., Merchenthaler, I. J., Hajszán, T., Carpenter, C. D., Liposits, Z., & Petersen, S. L. (2000) · Endocrinology · doi:10.1210/endo.141.9.7788 · Cited by 279
GPR30 Does Not Mediate Estrogenic Responses in Reproductive Organs in Mice
Otto, C., Fuchs, I., Kauselmann, G., Kern, H., Zevnik, B., Andreasen, P., Schwarz, G., Altmann, H., Klewer, M., Schoor, M., et al. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.071175 · Cited by 278
Estrogen and Aging Affect the Subcellular Distribution of Estrogen Receptor-α in the Hippocampus of Female Rats
Adams, M. M., Fink, S. E., Shah, R. A., Janssen, W. G. M., Hayashi, S., Milner, T. A., McEwen, B. S., & Morrison, J. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03608.2002 · Cited by 271
Mechanism of the Rapid Effect of 17β-Estradiol on Medial Amygdala Neurons
Nabekura, J., Oomura, Y., Minami, T., Mizuno, Y., & Fukuda, A. (1986) · Science · doi:10.1126/science.3726531 · Cited by 262
Modulation of the GABAA receptor by progesterone metabolites
Callachan, H., Cottrell, G. A., Hather, N. Y., Lambert, J. J., Nooney, J. M., & Peters, J. A. (1987) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1987.0049 · Cited by 256
G Protein-Coupled Receptor 30 Localizes to the Endoplasmic Reticulum and Is Not Activated by Estradiol
Otto, C., Rohde-Schulz, B., Schwarz, G., Fuchs, I., Klewer, M., Brittain, D. E. A., Langer, G., Bader, B., Prelle, K., Nubbemeyer, R., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0269 · Cited by 254
Estradiol and Selective Estrogen Receptor Modulators Differentially Regulate Target Genes with Estrogen Receptors α and β
Tee, M. K., Rogatsky, I., Tzagarakis-Foster, C., Čvoro, A., An, J., Christy, R. J., Yamamoto, K. R., & Leitman, D. C. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-06-0360 · Cited by 230
Distribution and differences of estrogen receptor beta immunoreactivity in the brain of adult male and female rats
Zhang, J., Cai, W.-Q., Zhou, D.-S., & Su, B.-Y. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02460-5 · Cited by 223
Estrogen-Induced Alteration of μ-Opioid Receptor Immunoreactivity in the Medial Preoptic Nucleus and Medial Amygdala
Eckersell, C. B., Popper, P., & Micevych, P. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03967.1998 · Cited by 221
Self-citation
Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats
McRoberts, J. A., Coutinho, S. V., Marvizón, J. C. G., Grady, E. F., Tognetto, M., Sengupta, J. N., Ennes, H. S., Chaban, V. V., Amadesi, S., Créminon, C., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.24848 · Cited by 220
A G-Protein-Coupled Estrogen Receptor Is Involved in Hypothalamic Control of Energy Homeostasis
Qiu, J., Bosch, M. A., Tobias, S. C., Krust, A., Graham, S. M., Murphy, S. J., Korach, K. S., Chambon, P., Scanlan, T. S., Rønnekleiv, O. K., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0327-06.2006 · Cited by 217
Differential colocalization of estrogen receptor β (ERβ) with oxytocin and vasopressin in the paraventricular and supraoptic nuclei of the female rat brain: An immunocytochemical study
Alves, S. E., López, V., McEwen, B. S., & Weiland, N. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3281 · Cited by 217
Signaling by estrogens
Cheskis, B. J., Greger, J., Nagpal, S., & Freedman, L. P. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21253 · Cited by 212
Estrogen receptor messenger ribonucleic acid in female rat brain during the estrous cycle: a comparison with ovariectomized females and intact males
Shughrue, P. J., Bushnell, C. D., & Dorsa, D. M. (1992) · Endocrinology · doi:10.1210/endo.131.1.1612018 · Cited by 211
Membrane Estrogen Receptor-α Interactions with Metabotropic Glutamate Receptor 1a Modulate Female Sexual Receptivity in Rats
Dewing, P., Boulware, M. I., Sinchak, K., Christensen, A., Mermelstein, P. G., & Micevych, P. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0592-07.2007 · Cited by 210
Self-citation
Regulation of Estrogen Receptor Messenger Ribonucleic Acid in Rat Hypothalamus by Sex Steroid Hormones
Simerly, R. B., & Young, B. J. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-3-424 · Cited by 210
Estrogen Receptor Messenger RNA Expression in Rat Hypothalamus as a Function of Genetic Sex and Estrogen Dose*
LAUBER, A. H., Mobbs, C. V., Muramatsu, M., & Pfaff, D. W. (1991) · Endocrinology · doi:10.1210/endo-129-6-3180 · Cited by 209
β-Arrestin1 Interacts with the Catalytic Domain of the Tyrosine Kinase c-SRC
Miller, W. E., Maudsley, S. R., Ahn, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11312 · Cited by 205
Caveolin Proteins Are Essential for Distinct Effects of Membrane Estrogen Receptors in Neurons
Boulware, M. I., Kordasiewicz, H. B., & Mermelstein, P. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1647-07.2007 · Cited by 204
A Membrane Estrogen Receptor Mediates Intracellular Calcium Release in Astrocytes
Chaban, V. V., Lakhter, A. J., & Micevych, P. E. (2004) · Endocrinology · doi:10.1210/en.2004-0149 · Cited by 203
Self-citation
Rapid Estrogen Signaling in the Brain
Raz, L., Khan, M. M., Mahesh, V. B., Vadlamudi, R. K., & Brann, D. W. (2008) · Neurosignals · doi:10.1159/000111559 · Cited by 201
Distribution of estrogen receptor beta (ERβ) mRNA in hypothalamus, midbrain and temporal lobe of spayed macaque: continued expression with hormone replacement
Gundlah, C., Kohama, S. G., Mirkes, S. J., Garyfallou, V. T., Urbanski, H. F., & Bethea, C. L. (2000) · Molecular Brain Research · doi:10.1016/s0006-8993(99)02475-0 · Cited by 199
Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization
von Zastrow, M., & Kobilka, B. K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32329-3 · Cited by 197
Critical in Vivo Roles for Classical Estrogen Receptors in Rapid Estrogen Actions on Intracellular Signaling in Mouse Brain
Ábrahám, I. M., Todman, M. G., Korach, K. S., & Herbison, A. E. (2004) · Endocrinology · doi:10.1210/en.2003-1676 · Cited by 197
Estrogen Receptor Function as Revealed by Knockout Studies: Neuroendocrine and Behavioral Aspects
Rissman, E. F., Wersinger, S. R., Taylor, J. A., & Lubahn, D. B. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1390 · Cited by 197
Estrogen Receptors Are Essential for Female Sexual Receptivity
Rissman, E. F., Early, A. H., Taylor, J. A., Korach, K. S., & Lubahn, D. B. (1997) · Endocrinology · doi:10.1210/endo.138.1.4985 · Cited by 188
Assessing pain threshold in the rat: Changes with estrus and time of day
Martı́nez–Gómez, M., Cruz, Y., Salas, M., Hudson, R., & Pacheco, P. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90040-x · Cited by 185
Involvement of estrogen receptor α, β and oxytocin in social discrimination: a detailed behavioral analysis with knockout female mice
Choleris, E., Ogawa, S., Kavaliers, M., Gustafsson, J.-Α., Korach, K. S., Muglia, L. J., & Pfaff, D. W. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00203.x · Cited by 182
Cell type‐specific ATP‐activated responses in rat dorsal root ganglion neurons
Ueno, S., Tsuda, M., Iwanaga, T., et al. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702319 · Cited by 182
Estrogen receptor-α and -β immunoreactivity and mRNA in neurons of sensory and autonomic ganglia and spinal cord
Papka, R. E., Storey-Workley, M. E., Shughrue, P. J., Merchenthaler, I. J., Collins, J., Usip, S., Saunders, P. T. K., & Shupnik, M. A. (2001) · Cell and Tissue Research · doi:10.1007/s004410100363 · Cited by 178
Role of interleukin‐6 and soluble IL‐6 receptor in region‐specific induction of astrocytic differentiation and neurotrophin expression
März, P., Heese, K., Dimitriades‐Schmutz, B., Rose‐John, S., & Otten, U. (1999) · Glia · doi:10.1002/(sici)1098-1136(199905)26:3 · Cited by 177
Estrogen rapid action via protein complex formation involving ERα and Src
Song, R. X.-D., Zhang, Z., & Santen, R. J. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.06.010 · Cited by 177
The membrane actions of estrogens can potentiate their lordosis behavior-facilitating genomic actions
Kow, L., & Pfaff, D. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404889101 · Cited by 171
Evidence for novel estrogen binding sites in the rat hippocampus
Shughrue, P. J., & Merchenthaler, I. J. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00242-6 · Cited by 170
Cytoplasmic estrogen receptors in rat brain: immunocytochemical evidence using three antibodies with distinct epitopes.
Blaustein, J. D. (1992) · Endocrinology · doi:10.1210/endo.131.3.1380440 · Cited by 168
Estrogen Decreases Rat Hypothalamic Proopiomelanocortin Messenger Ribonucleic Acid Levels*
Wilcox, J. N., & Roberts, J. L. (1985) · Endocrinology · doi:10.1210/endo-117-6-2392 · Cited by 167
Membrane receptors for estrogen, progesterone, and testosterone in the rat brain: Fantasy or reality
Ramirez, V. D., Zheng, J., & Siddique, K. (1996) · Cellular and Molecular Neurobiology · doi:10.1007/bf02088175 · Cited by 166
Rapid actions of estrogens in GH3/B6 pituitary tumor cells via a plasma membrane version of estrogen receptor-α
Watsona, C. (1999) · Steroids · doi:10.1016/s0039-128x(98)00107-x · Cited by 165
Estrogen and the Brain: Beyond ER‐α, ER‐β, and 17β‐Estradiol
Toran‐Allerand, C. D. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1347.009 · Cited by 162
Resveratrol stimulates nitric oxide production by increasing estrogen receptor αa‐Src‐caveolin‐1 interaction and phosphorylation in human umbilical vein endothelial cells
Klinge, C. M., Wickramasinghe, N. S. M. D., Ivanova, M. M., & Dougherty, S. M. (2008) · The FASEB Journal · doi:10.1096/fj.07-103366 · Cited by 162
Progesterone Blockade of Estrogen Activation of μ-Opioid Receptors Regulates Reproductive Behavior
Sinchak, K., & Micevych, P. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05723.2001 · Cited by 157
Self-citation
Membrane Estrogen Receptors Acting Through Metabotropic Glutamate Receptors: An Emerging Mechanism of Estrogen Action in Brain
Micevych, P. E., & Mermelstein, P. G. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8034-z · Cited by 154
Self-citation
Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways
Rapacciuolo, A., Suvarna, S., Barki‐Harrington, L., Luttrell, L. M., Cong, M., Lefkowitz, R. J., & Rockman, H. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305675200 · Cited by 153
Direct Interactions with Gαi and Gβγ Mediate Nongenomic Signaling by Estrogen Receptor α
Kumar, P., Wu, Q., Chambliss, K. L., Yuhanna, I. S., Mumby, S. M., Mineo, C., Tall, G. G., & Shaul, P. W. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0360 · Cited by 150
Human estrogen receptor-α: regulation by synthesis, modification and degradation
Reid, G., Denger, S., Koš, M., & Gannon, F. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8470-2 · Cited by 150
The ins and outs of GPR30: A transmembrane estrogen receptor
Prossnitz, E. R., Oprea, T. I., Sklar, L. A., & Arterburn, J. B. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.006 · Cited by 149
17α-Estradiol: A Brain-Active Estrogen?
Toran‐Allerand, C. D., Tinnikov, A. A., Singh, R. J., & Nethrapalli, I. S. (2005) · Endocrinology · doi:10.1210/en.2004-1616 · Cited by 149
Estrogen interacts with the IGF‐1 system to protect nigrostriatal dopamine and maintain motoric behavior after 6‐hydroxdopamine lesions
Quesada, A., & Micevych, P. E. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10833 · Cited by 147
Self-citation
The Luteinizing Hormone Surge Is Preceded by an Estrogen-Induced Increase of Hypothalamic Progesterone in Ovariectomized and Adrenalectomized Rats
Micevych, P. E., Sinchak, K., Mills, R. H., Tao, L., LaPolt, P. S., & Lu, J. K. H. (2003) · Neuroendocrinology · doi:10.1159/000071703 · Cited by 141
Self-citation
Estradiol Stimulates Progesterone Synthesis in Hypothalamic Astrocyte Cultures
Micevych, P. E., Chaban, V. V., Ogi, J., Dewing, P., Lu, J. K. H., & Sinchak, K. (2006) · Endocrinology · doi:10.1210/en.2006-0774 · Cited by 138
Self-citation
Estradiol inhibits atp-induced intracellular calcium concentration increase in dorsal root ganglia neurons
Chaban, V. V., Mayer, E. A., Ennes, H. S., & Micevych, P. E. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00915-6 · Cited by 134
Self-citation
Uptake of3H-Estradiol by the Female Rat Brain. An Autoradiographic Study
Pfaff, D. W. (1968) · Endocrinology · doi:10.1210/endo-82-6-1149 · Cited by 131
Estradiol Signaling via Sequestrable Surface Receptors
Benten, W. P. M. (2001) · Endocrinology · doi:10.1210/en.142.4.1669 · Cited by 130
Estradiol-Induced Estrogen Receptor-α Trafficking
Bondar, G., Kuo, J., Hamid, N., & Micevych, P. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2107-09.2009 · Cited by 127
Self-citation
Biological basis of visceral pain: recent developments
Al–Chaer, E. D., & Traub, R. J. (2002) · Pain · doi:10.1016/s0304-3959(02)00046-5 · Cited by 126
Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity
Santen, R. J., Song, R., Zhang, Z., Kumar, R., Jeng, M. H., Masamura, A., Lawrence, J., Berstein, L. M., & Yue, W. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.01018 · Cited by 125
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
Touhara, K., Hawes, B. E., van Biesen, T., & Lefkowitz, R. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9284 · Cited by 124
Hindbrain Administration of Estradiol Inhibits Feeding and Activates Estrogen Receptor-α-Expressing Cells in the Nucleus Tractus Solitarius of Ovariectomized Rats
Thammacharoen, S., Lutz, T. A., Geary, N., & Asarian, L. (2007) · Endocrinology · doi:10.1210/en.2007-0340 · Cited by 121
Distribution and localization patterns of estrogen receptor‐β and insulin‐like growth factor‐1 receptors in neurons and glial cells of the female rat substantia nigra: Localization of ERβ and IGF‐1R in substantia nigra
Quesada, A., Romeo, H. E., & Micevych, P. E. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21358 · Cited by 120
Self-citation
Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation
Matsuda, K.-I., Sakamoto, H., Mori, H., Hosokawa, K., Kawamura, A., Itose, M., Nishi, M., Prossnitz, E. R., & Kawata, M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.108 · Cited by 120
Comparative distribution of mRNA encoding the growth hormone secretagogue‐receptor (GHS‐R) in Microcebus murinus (Primate, Lemurian) and rat forebrain and pituitary
Mitchell, V. A., Bouret, S. G., Beauvillain, J., Schilling, A., Perret, M., Kordon, C., & Epelbaum, J. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010115)429:3 · Cited by 119
Estradiol induction of proenkephalin messenger RNA in hypothalamus: dose-response and relation to reproductive behavior in the female rat
Lauber, A. H., Romano, G. J., Mobbs, C. V., Howells, R., & Pfaff, D. W. (1990) · Molecular Brain Research · doi:10.1016/0169-328x(90)90008-2 · Cited by 118
Cloning, Novel Promoter Sequence, and Estrogen Regulation of a Rat Oxytocin Receptor Gene
Bale, T. L., & Dorsa, D. M. (1997) · Endocrinology · doi:10.1210/endo.138.3.4998 · Cited by 118
Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization.
Zhang, J., Ferguson, S. S. G., Barak, L. S., Aber, M. J., Bruno Giros, A., Lefkowitz, R. J., & Caron, M. G. (1997) · PubMed · Cited by 116
Estrogen-induced alterations of spinal cord enkephalin gene expression
Amandusson, Å., Hallbeck, M., Hallbeck, A., Hermanson, O., & Blomqvist, A. G. (1999) · Pain · doi:10.1016/s0304-3959(99)00109-8 · Cited by 115
Autoradiographic Localization of 3H-Estradiol or Its Metabolites in the Central Nervous System of the Developing Rat1
Sheridan, P. J., Sar, M., & Stumpf, W. E. (1974) · Endocrinology · doi:10.1210/endo-94-5-1386 · Cited by 115
Neuroprogesterone: Key to estrogen positive feedback?
Micevych, P. E., Soma, K. K., & Sinchak, K. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.06.009 · Cited by 111
Self-citation
Mapping of neural and signal transduction pathways for lordosis in the search for estrogen actions on the central nervous system
Kow, L., & Pfaff, D. W. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00189-7 · Cited by 110
Anisomycin inhibits the activation of sexual behavior by estradiol and progesterone
Rainbow, T. C., Davis, P. G., & McEwen, B. S. (1980) · Brain Research · doi:10.1016/0006-8993(80)91240-8 · Cited by 110
Estrogen-Induced μ-Opioid Receptor Internalization in the Medial Preoptic Nucleus Is Mediated via Neuropeptide Y-Y1Receptor Activation in the Arcuate Nucleus of Female Rats
Mills, R. H., Sohn, R. K., & Micevych, P. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1366-03.2004 · Cited by 110
Self-citation
Mechanisms of Ovarian Steroid Regulation of Norepinephrine Receptor-Mediated Signal Transduction in the Hypothalamus: Implications for Female Reproductive Physiology
Etgen, A. M., Ansonoff, M. A., & Quesada, A. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1676 · Cited by 109
Endosomal trafficking of Src tyrosine kinase
Sandilands, E., & Frame, M. C. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.05.004 · Cited by 109
Differential Expression and Regulation of Estrogen Receptors (ERs) in Rat Pituitary and Cell Lines: Estrogen Decreases ERα Protein and Estrogen Responsiveness*
Schreihofer, D. A., Stoler, M. H., & Shupnik, M. A. (2000) · Endocrinology · doi:10.1210/endo.141.6.7505 · Cited by 109
Requirements for estrogen receptor α membrane localization and function
Evinger, A. J., & Levin, E. (2005) · Steroids · doi:10.1016/j.steroids.2005.02.015 · Cited by 108
Brain cell nuclear retention of [3H]estradiol doses able to promote lordosis: temporal and regional aspects
McEwen, B. S., Pfaff, D. W., Chaptal, C., et al. (1975) · Brain Research · doi:10.1016/0006-8993(75)90649-6 · Cited by 107
Estradiol Signaling via Sequestrable Surface Receptors
Benten, W. P. M., Stephan, C., Lieberherr, M., & Wunderlich, F. T. (2001) · Endocrinology · doi:10.1210/endo.142.4.8094 · Cited by 106
Membrane-initiated estrogen signaling in hypothalamic neurons.
Kelly, M. J., & Rønnekleiv, O. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.04.014 · Cited by 104
Detection of Estrogen Receptor- Messenger Ribonucleic Acid and 125I-Estrogen Binding Sites in Luteinizing Hormone-Releasing Hormone Neurons of the Rat Brain
Hrabovszky, E. (2000) · Endocrinology · doi:10.1210/en.141.9.3506 · Cited by 104
Estrogen Mobilizes a Subset of Estrogen Receptor-α-Immunoreactive Vesicles in Inhibitory Presynaptic Boutons in Hippocampal CA1
Hart, S. A., Snyder, M. A., Smejkalová, T., & Woolley, C. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5436-06.2007 · Cited by 100
Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells
Gilad, L. A., Bresler, T., Gnainsky, J., et al. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05770 · Cited by 99
Estrogen receptor‐β, but not estrogen receptor‐α, is expressed in prolactin neurons of the female rat paraventricular and supraoptic nuclei: Comparison with other neuropeptides
Suzuki, S., & Handa, R. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20457 · Cited by 97
Estrogen Induces de novo Progesterone Synthesis in Astrocytes
Sinchak, K., Mills, R. H., Tao, L., LaPolt, P. S., Lu, J. K. H., & Micevych, P. E. (2003) · Developmental Neuroscience · doi:10.1159/000073511 · Cited by 97
Self-citation
Ubiquitination of the Rat Uterine Estrogen Receptor: Dependence on Estradiol
Nirmala, P. B., & Thampan, R. V. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2093 · Cited by 96
Estrogen receptor-immunostaining of neuronal cytoplasmic processes as well as cell nuclei in guinea pig brain
Blaustein, J. D., & Turcotte, J. C. (1989) · Brain Research · doi:10.1016/0006-8993(89)91219-5 · Cited by 95
Chapter 2 Estrogen modulates oxytocin gene expression in regions of the rat supraoptic and paraventricular nuclei that contain estrogen receptor-β
Shughrue, P. J., Dellovade, T., & Merchenthaler, I. J. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39004-6 · Cited by 93
Regulation of Cyclic Adenosine 3′,5′-Monophosphate Signaling and Pulsatile Neurosecretion by Gi-coupled Plasma Membrane Estrogen Receptors in Immortalized Gonadotropin-Releasing Hormone Neurons
Navarro, C. E., Saeed, S. A., Murdock, C. M., Martínez‐Fuentes, A. J., Arora, K. K., Krsmanović, L. Z., & Catt, K. J. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0040 · Cited by 93
Agonist‐induced internalization of the metabotropic glutamate receptor 1a is arrestin‐ and dynamin‐dependent
Mundell, S. J., Matharu, A., Pula, G., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00421.x · Cited by 92
Estrogen receptor‐α is required for estrogen‐induced μ‐opioid receptor internalization
Micevych, P. E., Rissman, E. F., Gustafsson, J.-Α., et al. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10526 · Cited by 91
Self-citation
Estrogen-Binding Sites and Their Functional Capacity in Estrogen Receptor Double Knockout Mouse Brain
Shughrue, P. J., Askew, G. R., Dellovade, T., & Merchenthaler, I. J. (2002) · Endocrinology · doi:10.1210/endo.143.5.8772 · Cited by 90
Increased accumulation of oxytocin messenger ribonucleic acid in the hypothalamus of the female rat: induction by long term estradiol and progesterone administration and subsequent progesterone withdrawal
Crowley, R. S., Insel, T. R., O’Keefe, J. A., Kim, N. B., & Amico, J. A. (1995) · Endocrinology · doi:10.1210/endo.136.1.7828535 · Cited by 89
Estrogen regulates preproenkephalin-A mRNA levels in the rat ventromedial nucleus: temporal and cellular aspects
Priest, C. A., Eckersell, C. B., & Micevych, P. E. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00213-x · Cited by 88
Self-citation
Voltage-dependent anion channel (VDAC) participates in amyloid beta-induced toxicity and interacts with plasma membrane estrogen receptor α in septal and hippocampal neurons
Marín, R., Ramírez, C. M., Marin, R., Ramírez, C. M., González‐Gómez, M., González-Muñoz, E., Antonio Zorzano, A., Camps, M., Alonso, R., & Díaz, M. L. (2007) · Molecular Membrane Biology · doi:10.1080/09687860601055559 · Cited by 86
Characterization of Calcium Signaling by Purinergic Receptor-Channels Expressed in Excitable Cells
Koshimizu, T., Goor, F. V., Tomić, M., et al. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.5.936 · Cited by 85
Differential regulation of proenkephalin gene expression by estrogen in the ventromedial hypothalamus of male and female rats: implications for the molecular basis of a sexually differentiated behavior
Romano, G. J., Mobbs, C. V., Lauber, A. H., et al. (1990) · Brain Research · doi:10.1016/0006-8993(90)90009-z · Cited by 85
Membrane Estrogen Receptor-α Interacts with Metabotropic Glutamate Receptor Type 1a to Mobilize Intracellular Calcium in Hypothalamic Astrocytes
Kuo, J., Hariri, O. R., Bondar, G., Ogi, J., & Micevych, P. E. (2008) · Endocrinology · doi:10.1210/en.2008-0994 · Cited by 84
Self-citation
Non-nuclear estrogen receptor ? and ? in the hippocampus of male and female rats
Kalita, K. B., Szymczak, S., & Kaczmarek, L. (2005) · Hippocampus · doi:10.1002/hipo.20066 · Cited by 83
Colonic inflammation induces fos expression in the thoracolumbar spinal cord increasing activity in the spinoparabrachial pathway
Traub, R. J., & Murphy, A. Z. (2002) · Pain · doi:10.1016/s0304-3959(01)00381-5 · Cited by 83
17β-Estradiol inhibits high-voltage-activated calcium channel currents in rat sensory neurons via a non-genomic mechanism
Lee, D. Y., Chai, Y. G., Lee, E. B., Kim, K. W., Nah, S.-Y., Oh, T. H., & Rhim, H. (2002) · Life Sciences · doi:10.1016/s0024-3205(01)01534-x · Cited by 82
Estrogen receptor-α and -β coexist in a subpopulation of sensory neurons of female rat dorsal root ganglia
Papka, R. E., & Storey-Workley, M. E. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02562-9 · Cited by 80
Non-classical estrogen modulation of presynaptic GABA terminals modulates calcium dynamics in gonadotropin-releasing hormone (GnRH) neurons
Romanò, N., Lee, K., Ábrahám, I., Jasoni, C., & Herbison, A. (2008) · Endocrinology · doi:10.1210/en.2008-0424 · Cited by 80
Estrogen receptor-α mediates estradiol attenuation of ATP-induced Ca2+ signaling in mouse dorsal root ganglion neurons
Chaban, V. V., & Micevych, P. E. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20524 · Cited by 78
Self-citation
Estrogen induces rapid translocation of estrogen receptor β, but not estrogen receptor α, to the neuronal plasma membrane
Sheldahl, L. C., Shapiro, R. A., Bryant, D. N., Koerner, I. P., & Dorsa, D. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.035 · Cited by 77
Changes in visceral pain reactivity as a function of estrous cycle in female rats with artificial ureteral calculosis
Giamberardino, M. A., Affaitati, G., Valente, R., Iezzi, S., & Vecchiet, L. (1997) · Brain Research · doi:10.1016/s0006-8993(97)81711-8 · Cited by 77
Estrogen modulation of K+ channel activity in hypothalamic neurons involved in the control of the reproductive axis
Kelly, M. J., Rønnekleiv, O. K., Ibrahim, N., Lagrange, A. H., & Wagner, E. J. (2002) · Steroids · doi:10.1016/s0039-128x(01)00181-7 · Cited by 77
Autologous Down-Regulation of Messenger Ribonucleic Acid and Protein Levels for Estrogen Receptors in MCF-7 Cells: An Inverse Correlation to Progesterone Receptor Levels*
Ree, A. H., Landmark, B. F., Eskild, W., LEVY, F. O., Lahooti, H., Jahnsen, T., Aakvaag, A., & Hansson, V. (1989) · Endocrinology · doi:10.1210/endo-124-5-2577 · Cited by 75
Rapid Estrogenic Regulation of Extracellular Signal- Regulated Kinase 1/2 Signaling in Cerebellar Granule Cells Involves a G Protein- and Protein Kinase A-Dependent Mechanism and Intracellular Activation of Protein Phosphatase 2A
Belcher, S. M., Le, H. H., Spurling, L., & Wong, J. K. (2005) · Endocrinology · doi:10.1210/en.2005-0564 · Cited by 75
Ligand-independent activation of oestrogen receptor α by caveolin-1
Schlegel, A., Chenguang, W. A. N. G., Pestell, R. G., & Lisanti, M. P. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590203 · Cited by 74
Cytoplasmic estrogen receptors in rat brain: immunocytochemical evidence using three antibodies with distinct epitopes
Blaustein, J. D. (1992) · Endocrinology · doi:10.1210/en.131.3.1336 · Cited by 74
Proteasome-Mediated Proteolysis of Estrogen Receptor: A Novel Component in Autologous Down-Regulation
Alarid, E. T. (1999) · Molecular Endocrinology · doi:10.1210/me.13.9.1522 · Cited by 74
Estrous cycle phase variations in visceromotor and cardiovascular responses to colonic distension in the anesthetized rat
Sapsed-Byrne, S. M., Ma, D., Ridout, D. A., & Holdcroft, A. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00989-4 · Cited by 71
Changes in P2X receptor responses of sensory neurons from P2X3‐deficient mice
Zhong, Y., Dunn, P. M., Bardini, M., et al. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01805.x · Cited by 71
Estrogen receptor α is expressed on the cell-surface of embryonic hypothalamic neurons
Gorosito, S. V., Lorenzo, A., & Cambiasso, M. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.001 · Cited by 68
Expression of estrogen receptor α and β transcripts in female monkey hippocampus and hypothalamus
Register, T. C., Shively, C. A., & Lewis, C. E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00036-5 · Cited by 68
Role of receptor complexes in the extranuclear actions of estrogen receptor α in breast cancer
Song, R. X.-D., Fan, P., Yue, W., Chen, Y., & Santen, R. J. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01322 · Cited by 67
Orphanin FQ/nociceptin in the ventromedial nucleus facilitates lordosis in female rats
Sinchak, K., Hendricks, D. G., Baroudi, R., et al. (1997) · Neuroreport · doi:10.1097/00001756-199712220-00004 · Cited by 66
Protein Kinase C Signaling in the Hypothalamic Arcuate Nucleus Regulates Sexual Receptivity in Female Rats
Dewing, P., Christensen, A., Bondar, G., & Micevych, P. E. (2008) · Endocrinology · doi:10.1210/en.2008-0847 · Cited by 66
Self-citation
Nongenomic Inhibition of Catecholamine Secretion by 17β‐Estradiol in PC12 Cells
Kim, Y., Hur, E., Park, T., & Kim, K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742490.x · Cited by 63
Temporal variation in estrogen receptor-α protein turnover in the presence of estrogen
Valley, C. C., Solodin, N. M., Powers, G. L., Ellison, S. J., & Alarid, E. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-07-0067 · Cited by 63
Electron microscopic visualization of membrane-mediated uptake and translocation of estrogen-BSA:colloidal gold by hep G2 cells
Moats, R. K., & Ramirez, V. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1660631 · Cited by 60
Progesterone facilitation of lordosis in male and female Sprague-Dawley rats following priming with estradiol pulses
Olster, D. H. (1988) · Hormones and Behavior · doi:10.1016/0018-506x(88)90002-5 · Cited by 59
Effect of β-estradiol on voltage-gated Ca2+ channels in rat hippocampal neurons: a comparison with dehydroepiandrosterone
Kurata, K., Takebayashi, M., Kagaya, A., Morinobu, S., & Yamawaki, S. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00880-9 · Cited by 59
The noradrenergic inhibition of an apamin-sensitive, small-conductance Ca2+-activated K+ channel in hypothalamic gamma-aminobutyric acid neurons: pharmacology, estrogen sensitivity, and relevance to the control of the reproductive axis.
Wagner, E. J., Rønnekleiv, O. K., & Kelly, M. J. (2001) · PubMed · Cited by 57
Visualizing Activation of Opioid Circuits by Internalization of G Protein-Coupled Receptors
Sinchak, K., & Micevych, P. E. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:2:197 · Cited by 56
Self-citation
The Amino-terminal Domain of G-protein-coupled Receptor Kinase 2 Is a Regulatory Gβγ Binding Site
Eichmann, T., Lorenz, K., Hoffmann, M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m204795200 · Cited by 55
Development of the Limbic-Hypothalamic Cholecystokinin Circuit: A Model of Sexual Differentiation. pp. 11–22
Micevych, P. E., & Ulibarri, C. (1992) · Developmental Neuroscience · doi:10.1159/000111643 · Cited by 55
Self-citation
Examination of estradiol effects on the rapid estradiol mediated increase in hippocampal synaptic transmission in estrogen receptor α knockout mice
Fugger, H. N., Kumar, A. V., Lubahn, D., Korach, K., & Foster, T. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02083-3 · Cited by 52
Sex-specific densities of estrogen receptors alpha and beta in the subnuclei of the nucleus tractus solitarius, hypoglossal nucleus and dorsal vagal motor nucleus weanling rats
Schlenker, E. H., & Hansen, S. N. (2006) · Brain Research · doi:10.1016/j.brainres.2006.09.035 · Cited by 51
17β-Estradiol-Mediated Neuroprotection and ERK Activation Require a Pertussis Toxin-Sensitive Mechanism Involving GRK2 and β-Arrestin-1
Dominguez, R., Hu, E., Zhou, M., & Baudry, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0550-09.2009 · Cited by 50
Self-citation
Transcription of estrogen receptor α and β in mouse cerebral cortex: Effect of age, sex, 17β-estradiol and testosterone
Thakur, M. K., & Sharma, P. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.08.019 · Cited by 50
Functional alterations of the nigrostriatal dopamine system in estrogen receptor-α knockout (ERKO) mice
Küppers, E., Krust, A., Chambon, P., & Beyer, C. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.007 · Cited by 50
Estrogen-induced synaptic remodelling in adult rat brain is accompanied by the reorganization of neuronal membranes
Olmos, G., Aguilera, P., Tranque, P., Naftolin, F. N., & García‐Segura, L. M. (1987) · Brain Research · doi:10.1016/0006-8993(87)90483-5 · Cited by 50
Temporal regulation by estrogen of β-preprotachykinin mRNA expression in the rat ventromedial nucleus of the hypothalamus
Priest, C. A., Vink, K. L., & Micevych, P. E. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00184-g · Cited by 49
Self-citation
Neurite‐localized estrogen receptor‐α mediates rapid signaling by estrogen
Xu, Y., Traystman, R. J., Hurn, P. D., & Wang, M. M. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10725 · Cited by 48
Estradiol alters transcription factor gene expression in primate prefrontal cortex
Wang, J., Cheng, C. M., Zhou, J., Smith, A., Weickert, C. S., Perlman, W. R., Becker, K. G., Powell, D., & Bondy, C. A. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20076 · Cited by 47
Estrogen mediated inhibition of dopamine transport in the striatum: Regulation by Gαi/o
Thompson, T. L., & Certain, M. E. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.02.005 · Cited by 44
Rapid Uptake and Binding of Estradiol-17β-6-(O-carboxymethyl)oxime:125I-labeled Bsa by Female Rat Liver1
Moats, R. K., & Ramirez, V. D. (1998) · Biology of Reproduction · doi:10.1095/biolreprod58.2.531 · Cited by 44
Steroid hormone rapid signaling: The pivotal role of S-Palmitoylation
Marino, M., & Ascenzi, P. (2006) · IUBMB Life · doi:10.1080/15216540601019485 · Cited by 43
Plasma Membrane Is the Primary Site of Localization of the Nonactivated Estrogen Receptor in the Goat Uterus: Hormone Binding Causes Receptor Internalization
Narayanan, K., & Thampan, R. V. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0006 · Cited by 42
Neuronal membrane remodelling during the oestrus cycle: a freeze-fracture study in the arcuate nucleus of the rat hypothalamus
García‐Segura, L. M., Hernandez, P., Olmos, G., Tranque, P., & Naftolin, F. N. (1988) · Journal of Neurocytology · doi:10.1007/bf01187859 · Cited by 42
Estrogen Receptor (ER) β Modulates ERα Responses to Estrogens in the Developing Rat Ventromedial Nucleus of the Hypothalamus
Gonzales, K. L., Tetel, M. J., & Wagner, C. K. (2008) · Endocrinology · doi:10.1210/en.2008-0511 · Cited by 42

Research works printed but not linked: 3

Dewing, 2007, Membrane estrogen receptor–alpha interactions with metabotropic glutamate receptor 1a modulate female sexual receptivity in rats, J. Neurosci., 27, 9294, 10.1523/JNEUROSCI.0592-07.2007 · DOI
Kuo, 2009, Membrane estradiol receptors interact with metabotropic glutamate receptors to mobilize intracellular calcium in hypothalamic astrocytes, Endocrinology, 150, 1369, 10.1210/en.2008-0994 · DOI
Sawyer, 1963, Induction of estrus in the ovariectomized cat by local hypothalamic treatment with estrogen, Anat. Rec., 145, 280

Sorted by citations

Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines
Gillies, G. E., & McArthur, S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002071 · Cited by 733
Emerging insights into hypothalamic‐pituitary‐gonadal axis regulation and interaction with stress signalling
Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018) · Journal of neuroendocrinology · doi:10.1111/jne.12590 · Cited by 298
Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling
Groeneweg, F. L., Karst, H., de Kloet, E. R., & Joëls, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.020 · Cited by 289
Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Piekarski, D. J., Johnson, C. M., Boivin, J. R., Thomas, A. W., Lin, W. C., Delevich, K., M. Galarce, E., & Wilbrecht, L. (2017) · Brain Research · doi:10.1016/j.brainres.2016.08.042 · Cited by 175
The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge
Micevych, P., & Sinchak, K. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00090 · Cited by 64
Self-citation

See all 177

Authors: Micevych, P., & Dominguez, R.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Micevych, Paul
ORCID: Micevych, Paul
Dominguez, Reymundo
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2009-08
Volume: 30
Issue: 3
Pages: 315-327
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2009.04.011
PMC: PMC2720427
OpenAlex: W1980509664
Cited by: 177
References: 230
Citations by year: 2026: 4 · 2025: 1 · 2024: 6 · 2023: 9 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 21 · 2014: 11 · 2013: 20 · 2012: 16
FWCI: 1.80
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eCite Digital Repository (University of Tasmania) (submittedVersion)
Figshare (submittedVersion, cc-by)
Funders: National Institute on Aging (AG 14751, P01AG014751)
National Institute on Drug Abuse (DA013185, R01DA013185)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 042635, R01HD042635, T32HD007228)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: membrane estrogen receptor, estrogen receptor alpha, estrogen receptor beta, metabotropic glutamate receptors, G protein signaling, scaffold proteins, nociception, sexual receptivity, brain
MeSH terms: Animals, Brain, Cell Membrane, Estradiol, Humans, Models, Biological, Receptors, Estrogen, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Membrane estradiol signaling in the brain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks