Cited by 146Hypothalamic control of reproductive hormonesEpigenetics and DNA MethylationReproductive Biology and Fertility

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Epigenetic regulation of female puberty

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Lomniczi, Alejandro, Wright, Hollis, Ojeda, Sergio R.·2015·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2014.08.003PMC PMC6824271

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Abstract

Substantial progress has been made in recent years toward deciphering the molecular and genetic underpinnings of the pubertal process. The availability of powerful new methods to interrogate the human genome has led to the identification of genes that are essential for puberty to occur. Evidence has also emerged suggesting that the initiation of puberty requires the coordinated activity of gene sets organized into functional networks. At a cellular level, it is currently thought that loss of transsynaptic inhibition, accompanied by an increase in excitatory inputs, results in the pubertal activation of GnRH release. This concept notwithstanding, a mechanism of epigenetic repression targeting genes required for the pubertal activation of GnRH neurons was recently identified as a core component of the molecular machinery underlying the central restraint of puberty. In this chapter we will discuss the potential contribution of various mechanisms of epigenetic regulation to the hypothalamic control of female puberty.

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1 retracted

GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis
Fujiki, R., Chikanishi, T., Hashiba, W., Ito, H., Takada, I., Roeder, R. G., Kitagawa, H., & Kato, S. (2009) · Nature · doi:10.1038/nature07954 · Cited by 171
Retracted
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Untitled work
(2008) · doi:10.1038/nrg2290 · Cited by 5,199
The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function
Warde-Farley, D., Donaldson, S. L., Comes, O., Zuberi, K., Badrawi, R., Chao, P., Franz, M., Grouios, C., Kazi, F., Lopes, C. T., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq537 · Cited by 4,835
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X. H., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,246
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098
Gene Silencing in Cancer in Association with Promoter Hypermethylation
Herman, J. G., & Baylin, S. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023075 · Cited by 3,471

Show all 239 references

Research works printed but not linked: 4

Kordon, 1994, Role of classic and peptide neuromediators in the neuroendocrine regulation of luteinizing hormone and prolactin, second ed., vol. 1, 1621
Nakahata, 2008, The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control, Cell, 134, 329, 10.1016/j.cell.2008.07.002 · DOI · Paper page
Ojeda, 1994, Puberty in the rat, second ed., vol. 2, 363
Parent, 2001, Endocrine disrupter contribution to sexual precocity: suggestive detection of pesticide derivatives in patients immigrant to Belgium and stimulation of GnRH pulsatility in rat hypothalamus, Pediatr. Res., 49, 139A

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Authors: Lomniczi, A., Wright, H., & Ojeda, S. R.
Affiliations: Oregon National Primate Research Center (US)
Corresponding author: Lomniczi, Alejandro
Ojeda, Sergio R.
ORCID: Lomniczi, Alejandro
Ojeda, Sergio R.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2015-01
Volume: 36
Pages: 90-107
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2014.08.003
PMC: PMC6824271
OpenAlex: W2048700120
Cited by: 136
References: 239
Citations by year: 2026: 4 · 2025: 7 · 2024: 9 · 2023: 12 · 2022: 12 · 2021: 16 · 2020: 9 · 2019: 15 · 2018: 17 · 2017: 11 · 2016: 18 · 2015: 3
FWCI: 1.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: epigenetic regulation, female puberty, GnRH neurons, excitatory synaptic input, gene regulatory networks
MeSH terms: Animals, Female, Humans, Hypothalamus, Gonadotropin-Releasing Hormone, Neurons, Puberty, Sexual Maturation, Epigenesis, Genetic

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