Cited by 146Hypothalamic control of reproductive hormonesEpigenetics and DNA MethylationReproductive Biology and Fertility

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Epigenetic regulation of female puberty

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Lomniczi, Alejandro, Wright, Hollis, Ojeda, Sergio R.·2015·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2014.08.003PMC PMC6824271

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Abstract

Substantial progress has been made in recent years toward deciphering the molecular and genetic underpinnings of the pubertal process. The availability of powerful new methods to interrogate the human genome has led to the identification of genes that are essential for puberty to occur. Evidence has also emerged suggesting that the initiation of puberty requires the coordinated activity of gene sets organized into functional networks. At a cellular level, it is currently thought that loss of transsynaptic inhibition, accompanied by an increase in excitatory inputs, results in the pubertal activation of GnRH release. This concept notwithstanding, a mechanism of epigenetic repression targeting genes required for the pubertal activation of GnRH neurons was recently identified as a core component of the molecular machinery underlying the central restraint of puberty. In this chapter we will discuss the potential contribution of various mechanisms of epigenetic regulation to the hypothalamic control of female puberty.

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Authors: Lomniczi, A., Wright, H., & Ojeda, S. R.
Affiliations: Oregon National Primate Research Center (US)
Corresponding author: Lomniczi, Alejandro
Ojeda, Sergio R.
ORCID: Lomniczi, Alejandro
Ojeda, Sergio R.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2015-01
Volume: 36
Pages: 90-107
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2014.08.003
PMC: PMC6824271
OpenAlex: W2048700120
Cited by: 136
References: 239
Citations by year: 2026: 4 · 2025: 7 · 2024: 9 · 2023: 12 · 2022: 12 · 2021: 16 · 2020: 9 · 2019: 15 · 2018: 17 · 2017: 11 · 2016: 18 · 2015: 3
FWCI: 1.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords: epigenetic regulation, female puberty, GnRH neurons, excitatory synaptic input, gene regulatory networks
MeSH terms: Animals, Female, Humans, Hypothalamus, Gonadotropin-Releasing Hormone, Neurons, Puberty, Sexual Maturation, Epigenesis, Genetic

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Epigenetic regulation of female puberty

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