The DOI matches its Crossref record; 252 of the 254 references it cites were found in a registry or an index.
Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents
Open accessAbstract
Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such distortion of distribution is a recent phenomenon. This suggests changing environmental influences including the possible role of nutrition, stress and endocrine disruptors. Our ability to assess neuroendocrine effects and mechanisms is very limited in humans. Using the rodent as a model, we examine the impact of environmental factors on the individual variations in pubertal timing and the possible underlying mechanisms. The capacity of environmental factors to shape functioning of the neuroendocrine system is thought to be maximal during fetal and early postnatal life and possibly less important when approaching the time of onset of puberty.
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Metadata
- Authors
- Parent, A.-S., Franssen, D., Fudvoye, J., Gérard, A., & Bourguignon, J.-P.
- Affiliations
- University of Liège (BE)
- Corresponding author
- Bourguignon, Jean-Pierre
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 38
- Pages
- 12-36
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W2089917595
- Cited by
- 175
- References
- 254
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 12 · 2023: 26 · 2022: 18 · 2021: 16 · 2020: 14 · 2019: 19 · 2018: 13 · 2017: 12 · 2016: 20 · 2015: 11
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- green
- orbi.uliege.be
- Licence
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Funders
- Belgian Foundation for Research
- European Commission
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- pubertal timing, endocrine disruptors, neuroendocrine regulation, puberty onset, developmental origins of health and disease, nutrition, stress, rodent models
- MeSH terms
- Animals, Environment, Environmental Exposure, Humans, Neurosecretory Systems, Rodentia, Sexual Maturation, Endocrine Disruptors
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