Thalamic integration of social stimuli regulating parental behavior and the oxytocin system
Open accessAbstract
Critically important components of the maternal neural circuit in the preoptic area robustly activated by suckling were recently identified. In turn, suckling also contributes to hormonal adaptations to motherhood, which includes oxytocin release and consequent milk ejection. Other reproductive or social stimuli can also trigger the release of oxytocin centrally, influencing parental or social behaviors. However, the neuronal pathways that transfer suckling and other somatosensory stimuli to the preoptic area and oxytocin neurons have been poorly characterized. Recently, a relay center of suckling was determined and characterized in the posterior intralaminar complex of the thalamus (PIL). Its neurons containing tuberoinfundibular peptide 39 project to both the preoptic area and oxytocin neurons in the hypothalamus. The present review argues that the PIL is a major relay nucleus conveying somatosensory information supporting maternal behavior and oxytocin release in mothers, and may be involved more generally in social cue evoked oxytocin release, too.
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In rats and mice, several regions provide input to paraventricular oxytocin-expressing cells, including brainstem, thalamic, hypothalamic, and cortical cell populations.
“In rats and mice, several regions provide input to PVN OXT-expressing cells, including the brainstem, thalamic, hypothalamic, and cortical cell populations (56-58)”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [56]
This increase in oxytocin release by the paraventricular nucleus may be driven by posterior intralaminar complex of the thalamus inputs to the paraventricular nucleus.
“This increase in OXT release by the PVN may be driven by the posterior intralaminar complex of the thalamus inputs to the PVN (56).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [56]
The PIL is part of the nonlemniscal auditory pathway that projects to the PVN.
“The PIL is part of the nonlemniscal auditory pathway that projects to the PVN13,21,22”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [22]
The PIL has been implicated in maternal and social behaviours.
“and has also been implicated in maternal and social behaviours22–24.”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [22]
PIL glutamatergic neuron activity may play a role in conveying sensory information about the identity and/or salience of the social stimulus, thus facilitating social recognition memory.
“but may rather play a role in conveying sensory information about the identity and/or the salience of the social stimulus, thus facilitating social recognition memory (1)”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [1]
The PIL is considered a relay center by which sensory information is conveyed to other brain regions for the generation of relevant social behaviors.
“The posterior intralaminar complex of the thalamus (PIL) is considered a relay center by which sensory information is conveyed to other brain regions for the generation of relevant social behaviors (1-6).”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [1]
The PIL is well-positioned to convey sensory cues to the brain social network to modulate social behavior.
“The PIL, located at the posterior thalamus, is wellpositioned to convey sensory cues to the brain social network to modulate social behavior (1).”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [1]
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References 195 · Cited by 64
Research works printed but not linked: 2
- Knobil E Neill JD 2006 Knobil and Neill's Physiology of Reproduction Academic Press San Diego
- Usdin TB Dobolyi A 2009 TIP39 (Tuberoinfundibular peptide 39) Encyclopedia of Neuroscience Squire LR 9 Academic Press Oxford 1009 1017
- Authors
- Dobolyi, A., Cservenák, M., & Young, L. J.
- Affiliations
- Semmelweis University (HU)
- Emory University (US)
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 51
- Pages
- 102-115
- ISSN
- 0091-3022 (ISSN-L)
- PMC
- PMC6175608
- OpenAlex
- W2804926829
- Cited by
- 64
- References
- 195
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 21 · 2019: 2 · 2018: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (ORIP/OD P51OD011132, P50MH100023, R01MH096983)
- Hungarian Scientific Research Fund (K116538)
- Magyar Tudományos Akadémia
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (NKFIH-2920-1/2016-VEKOP-2.3, NKFIH-4300-1/2017-NKP_17, NKFIH-6785-1/2016-VEKOP-2.3.3-15)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- thalamus, maternal behavior, oxytocin release, preoptic area, suckling, somatosensory information, social cues, milk ejection, hypothalamus, oxytocin neurons
- MeSH terms
- Animals, Female, Maternal Behavior, Neuropeptides, Oxytocin, Paraventricular Hypothalamic Nucleus, Preoptic Area, Social Perception, Galanin, Posterior Thalamic Nuclei
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