Cited by 104Gut microbiota and healthOral microbiology and periodontitis researchReproductive tract infections research

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Gut microbial diversity and genus-level differences identified in cervical cancer patients versus healthy controls

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Sims, Travis T., Colbert, Lauren E., Zheng, Jiali, Delgado Medrano, Andrea Y., Hoffman, Kristi L., Ramondetta, Lois, Jazaeri, Amir, Jhingran, Anuja, Schmeler, Kathleen M., Daniel, Carrie R., Klopp, Ann·2019·Gynecologic Oncology

DOI 10.1016/j.ygyno.2019.09.002PMC PMC6825899

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Abstract

Objectives The aim of this study was to characterize variation in the gut microbiome of women with locally advanced cervical cancer and compare it to healthy controls. Methods We characterized the 16S rDNA fecal microbiome in 42 cervical cancer patients and 46 healthy female controls. Shannon diversity index (SDI) was used to evaluate alpha (within sample) diversity. Beta (between sample) diversity was examined using principle coordinate analysis (PCoA) of unweighted Unifrac distances. Relative abundance of microbial taxa was compared between samples using Linear Discriminant Analysis Effect Size (LEfSe). Results Within cervical cancer patients, bacterial alpha diversity was positively correlated with age (p = 0.22) but exhibited an inverse relationship in control subjects (p < 0.01). Alpha diversity was significantly higher in cervical cancer patients as compared to controls (p < 0.05), though stratification by age suggested this relationship was restricted to older women (>50 years; p < 0.01). Beta diversity (unweighted Unifrac; p < 0.01) also significantly differed between cervical cancer patients and controls. Based on age- and race-adjusted LEfSe analysis, multiple taxa significantly differed between cervical cancer patients and controls. Prevotella, Porphyromonas, and Dialister were significantly enriched in cervical cancer patients, while Bacteroides, Alistipes and members of the Lachnospiracea family were significantly enriched in healthy subjects. Conclusion Our study suggests differences in gut microbiota diversity and composition between cervical cancer patients and controls. Associations within the gut microbiome by age may reflect etiologic/clinical differences. These findings provide rationale for further study of the gut microbiome in cervical cancer.

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Additional file 2 of Metagenomes of rectal swabs in larger, advanced stage cervical cancers have enhanced mucus degrading functionalities and distinct taxonomic structure
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Additional file 2 of The effect of acupuncture on tumor growth and gut microbiota in mice inoculated with osteosarcoma cells
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Additional file 5 of Resveratrol ameliorates liver fibrosis induced by nonpathogenic Staphylococcus in BALB/c mice through inhibiting its growth
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Additional file 1 of Resveratrol ameliorates liver fibrosis induced by nonpathogenic Staphylococcus in BALB/c mice through inhibiting its growth
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Additional file 4 of Resveratrol ameliorates liver fibrosis induced by nonpathogenic Staphylococcus in BALB/c mice through inhibiting its growth
Li, Z., Dong, J., Wang, M., Yan, J., Hu, Y., Liu, Y., Yajie, P., & Li, H. (2022) · Figshare · doi:10.6084/m9.figshare.19711337
Additional file 2 of Resveratrol ameliorates liver fibrosis induced by nonpathogenic Staphylococcus in BALB/c mice through inhibiting its growth
Li, Z., Dong, J., Wang, M., Yan, J., Hu, Y., Liu, Y., Yajie, P., & Li, H. (2022) · Figshare · doi:10.6084/m9.figshare.19711331
Additional file 3 of The effect of acupuncture on tumor growth and gut microbiota in mice inoculated with osteosarcoma cells
Xu, X., Feng, X., He, M., Zhang, Z., Wang, J., Zhu, H., Li, T., Wang, F., Sun, M., & Wang, Z. (2020) · Figshare · doi:10.6084/m9.figshare.12097263
Additional file 1 of Metagenomes of rectal swabs in larger, advanced stage cervical cancers have enhanced mucus degrading functionalities and distinct taxonomic structure
Karpinets, T. V., Wu, X., Solley, T. N., Alam, M. B. E., Sims, T. T., Yoshida-Court, K., Lynn, E. J., Ahmed-Kaddar, M., Biegert, G. W. G., Yue, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20787055
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Additional file 1 of Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis
Zhou, Z., Feng, Y., Xie, L., Ma, S., Cai, Z., & Ma, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25025824
Additional file 3 of Resveratrol ameliorates liver fibrosis induced by nonpathogenic Staphylococcus in BALB/c mice through inhibiting its growth
Li, Z., Dong, J., Wang, M., Yan, J., Hu, Y., Liu, Y., Yajie, P., & Li, H. (2022) · Figshare · doi:10.6084/m9.figshare.19711334
Additional file 4 of The effect of acupuncture on tumor growth and gut microbiota in mice inoculated with osteosarcoma cells
Xu, X., Feng, X., He, M., Zhang, Z., Wang, J., Zhu, H., Li, T., Wang, F., Sun, M., & Wang, Z. (2020) · Figshare · doi:10.6084/m9.figshare.12097269
Impact of gut microbiota on atypical endometrial hyperplasia and endometrial cancer: a comprehensive analysis of microbial composition and metabolomic profiling
Peng, H., Chen, J., Shao, Y., Li, J., Chen, M., He, C., Sun, J., Wang, W., Cao, X., Yang, H., et al. (2026) · BMC Microbiology · doi:10.1186/s12866-025-04568-2 · Cited by 1

Authors: Sims, T. T., Colbert, L. E., Zheng, J., Delgado Medrano, A. Y., Hoffman, K. L., Ramondetta, L., Jazaeri, A., Jhingran, A., Schmeler, K. M., Daniel, C. R., & Klopp, A.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Baylor College of Medicine (US)
Corresponding author: Sims, Travis T.
ORCID: Sims, Travis T.
Colbert, Lauren E.
Hoffman, Kristi L.
Ramondetta, Lois
Jazaeri, Amir
Jhingran, Anuja
Schmeler, Kathleen M.
Daniel, Carrie R.
Klopp, Ann
Venue: Gynecologic Oncology
Publisher: Elsevier BV
Published: 2019-11
Volume: 155
Issue: 2
Pages: 237-244
ISSN: 0090-8258 (ISSN-L)
DOI: 10.1016/j.ygyno.2019.09.002
PMC: PMC6825899
OpenAlex: W2972964609
Cited by: 100
References: 38
Citations by year: 2026: 8 · 2025: 20 · 2024: 18 · 2023: 10 · 2022: 20 · 2021: 17 · 2020: 6
FWCI: 3.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Gynecologic Oncology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: University of Texas MD Anderson Cancer Center
National Institutes of Health (5T32 CA101642-13)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords: gut microbiota, cervical cancer, microbiome diversity, alpha diversity, beta diversity, Prevotella, Porphyromonas, Dialister, Bacteroides, Alistipes, age differences, fecal microbiota, locally advanced cervical cancer
MeSH terms: Gastrointestinal Microbiome, Aged, Uterine Cervical Neoplasms, Feces, Female, Humans, Lymphatic Metastasis, Middle Aged, Neoplasm Staging, Prospective Studies

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Gut microbial diversity and genus-level differences identified in cervical cancer patients versus healthy controls

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