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Cited by 97Estrogen and related hormone effectsMemory and Neural MechanismsNeuroendocrine regulation and behavior

Estrogens and cognition: Friends or foes?

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Korol, Donna L., Pisani, Samantha L.·2015·Hormones and Behavior
DOI 10.1016/j.yhbeh.2015.06.017PMC PMC4573330
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Abstract

This article is part of a Special Issue "Estradiol and cognition". Estrogens are becoming well known for their robust enhancement on cognition particularly for learning and memory that relies upon functioning of the hippocampus and related neural systems. What is also emerging is that estrogen modulation of cognition is not uniform, at times enhancing yet at other times impairing learning. This review explores the bidirectional effects of estrogens on learning from a multiple memory systems view, focusing on the hippocampus and striatum, whereby modulation by estrogens sorts according to task attributes and neural systems engaged during cognition. We highlight our findings showing that the ability to solve hippocampus-sensitive tasks typically improves under relatively high estrogen status while the ability to solve striatum-sensitive tasks degrades with estrogen exposures. Though constrained by dose and timing of exposure, these opposing enhancements and impairments of cognition can be observed following treatments with different estrogenic compounds including the hormone estradiol, the isoflavone genistein found in soybeans, and agonists that are selective for specific estrogen receptors, suggesting that activation of a single receptor type is sufficient to produce the observed shifts in learning strategies. Using this multi-dimensional framework will allow us to extend our thinking of the relationship between estrogens and cognition to other brain regions and cognitive functions.

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  137. Zurkovsky L Serio SJ Korol DL 2011 Intra-striatal estradiol in female rats impairs response learning within two hours of treatment Horm Behav 60 470 477 21820439

Cited by

Sorted by citations

Authors
Korol, D. L., & Pisani, S. L.
Affiliations
  • SUNY Upstate Medical University (US)
  • University of Illinois Urbana-Champaign (US)
Corresponding author
Korol, Donna L.
ORCID
Korol, Donna L.
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2015-08
Volume
74
Pages
105-115
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2015.06.017
PMC
PMC4573330
OpenAlex
W801877057
Cited by
97
References
0
Citations by year
2026: 5 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 16 · 2020: 15 · 2019: 6 · 2018: 10 · 2017: 9 · 2016: 10 · 2015: 3
FWCI
1.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Hormones and Behavior (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH (P50 AT006268, P01 AG024387)
  • NSF (IBN 0081061, IOB 0520876)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
estrogen, estradiol, cognition, learning, memory, hippocampus, striatum, multiple memory systems, estrogen receptor agonists, genistein, isoflavones
MeSH terms
Animals, Brain, Cognition, Estradiol, Estrogens, Hippocampus, Humans, Memory

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