Systems approaches to preventing transplanted cell death in cardiac repair
Open accessAbstract
Stem cell transplantation may repair the injured heart, but tissue regeneration is limited by death of transplanted cells. Most cell death occurs in the first few days post-transplantation, likely from a combination of ischemia, anoikis and inflammation. Interventions known to enhance transplanted cell survival include heat shock, over-expressing anti-apoptotic proteins, free radical scavengers, anti-inflammatory therapy and co-delivery of extracellular matrix molecules. Combinatorial use of such interventions markedly enhances graft cell survival, but death still remains a significant problem. We review these challenges to cardiac cell transplantation and present an approach to systematically address them. Most anti-death studies use histology to assess engraftment, which is time- and labor-intensive. To increase throughput, we developed two biochemical approaches to follow graft viability in the mouse heart. The first relies on LacZ enzymatic activity to track genetically modified cells, and the second quantifies human genomic DNA content using repetitive Alu sequences. Both show linear relationships between input cell number and biochemical signal, but require correction for the time lag between cell death and loss of signal. Once optimized, they permit detection of as few as 1 graft cell in 40,000 host cells. Pro-survival effects measured biochemically at three days predict long-term histological engraftment benefits. These methods permitted identification of carbamylated erythropoietin (CEPO) as a pro-survival factor for human embryonic stem cell-derived cardiomyocyte grafts. CEPO's effects were additive to heat shock, implying independent survival pathways. This system should permit combinatorial approaches to enhance graft viability in a fraction of the time required for conventional histology.
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Scaffolds may promote oriented tissue architectures that facilitate diffusion-based mass transfer to reduce the ischemic injury often encountered in cell aggregates or cell transplantation.
“Scaffolds may promote oriented tissue architectures that facilitate diffusion-based mass transfer to reduce the ischemic injury often encountered in cell aggregates or cell transplantation (9).”
From Proangiogenic scaffolds as functional templates for cardiac tissue engineering (2010) · cites this paper as [9]
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Autologous cell transplantation for the treatment of damaged myocardium
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Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation
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Enhanced cell transplantation: preventing apoptosis increases cell survival and ventricular function
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Absence of regeneration in the MRL/MpJ mouse heart following infarction or cryoinjury
Robey, T. E., & Murry, C. E. (2007) · Cardiovascular Pathology · doi:10.1016/j.carpath.2007.01.005 · Cited by 44 · see citing works
Self-citationHeat Shock Treatment Enhances Graft Cell Survival in Skeletal Myoblast Transplantation to the Heart
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Proangiogenic scaffolds as functional templates for cardiac tissue engineering
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Mesenchymal stromal cells: promising treatment for liver cirrhosis
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- Authors
- Robey, T. E., Saiget, M. K., Reinecke, H., & Murry, C. E.
- Affiliations
- University of Washington (US)
- Corresponding author
- Murry, Charles E.
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 45
- Issue
- 4
- Pages
- 567-581
- ISSN
- 0022-2828 (ISSN-L)
- PMC
- PMC2587485
- OpenAlex
- W2165162226
- Cited by
- 404
- References
- 109
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 9 · 2023: 20 · 2022: 15 · 2021: 19 · 2020: 13 · 2019: 20 · 2018: 20 · 2017: 22 · 2016: 33 · 2015: 33 · 2014: 44 · 2013: 42 · 2012: 29
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Molecular and Cellular Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01hl064387-10)
- National Heart, Lung, and Blood Institute (R01-HL064387, P01-HL03174, R24HL064387, R24 HL-64387, R01HL084642, P01HL003174)
- National Institute of General Medical Sciences (P01GM081619)
- National Institute of Biomedical Imaging and Bioengineering (T32EB001650)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- stem cell transplantation, cardiac repair, graft viability, engraftment, anti-apoptotic proteins, heat shock, carbamylated erythropoietin, embryonic stem cell-derived cardiomyocytes, lacZ reporter, cell tracking, ischemia, anoikis, inflammation, anti-inflammatory therapy, radical scavengers
- MeSH terms
- Animals, Graft Survival, Heart Injuries, Humans, Inflammation, Cell Hypoxia, Anoikis, Myocytes, Cardiac, Mice, Embryonic Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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