The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
The cardiac pacemaker current
Abstract
In mammals cardiac rate is determined by the duration of the diastolic depolarization of sinoatrial node (SAN) cells which is mainly determined by the pacemaker I(f) current. f-channels are encoded by four members of the hyperpolarization-activated cyclic nucleotide-gated gene (HCN1-4) family. HCN4 is the most abundant isoform in the SAN, and its relevance to pacemaking has been further supported by the discovery of four loss-of-function mutations in patients with mild or severe forms of cardiac rate disturbances. Due to its selective contribution to pacemaking, the I(f) current is also the pharmacological target of a selective heart rate-reducing agent (ivabradine) currently used in the clinical practice. Albeit to a minor extent, the I(f) current is also present in other spontaneously active myocytes of the cardiac conduction system (atrioventricular node and Purkinje fibres). In working atrial and ventricular myocytes f-channels are expressed at a very low level and do not play any physiological role; however in certain pathological conditions over-expression of HCN proteins may represent an arrhythmogenic mechanism. In this review some of the most recent findings on f/HCN channels contribution to pacemaking are described.
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2 retracted
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Research works printed but not linked: 1
- Shi, 2000, The distribution and prevalence of HCN isoforms in the canine heart and their relation to the voltage dependence of If, Biophys. J., 78, 353A
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Sorted by citations
Lakatta, E. G., Maltsev, V. A., & Vinogradova, T. M. (2010) · Circulation Research · doi:10.1161/circresaha.109.206078 · Cited by 631
Quigley, K. S., Gianaros, P. J., Norman, G. J., Jennings, J. R., Berntson, G. G., & de Geus, E. J. C. (2024) · Psychophysiology · doi:10.1111/psyp.14604 · Cited by 281
Borovac, J. A., D'Amario, D., Bozic, J., & Glavas, D. (2020) · World Journal of Cardiology · doi:10.4330/wjc.v12.i8.373 · Cited by 195
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HCN2 ion channels: an emerging role as the pacemakers of pain
Emery, E. C., Young, G. T., & McNaughton, P. A. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.04.004 · Cited by 118
Metadata
- Authors
- Baruscotti, M., Barbuti, A., & Bucchi, A.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Baruscotti, Mirko
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 48
- Issue
- 1
- Pages
- 55-64
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W2040918451
- Cited by
- 149
- References
- 153
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 1 · 2021: 12 · 2020: 8 · 2019: 4 · 2018: 9 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 20 · 2013: 14 · 2012: 11
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular and Cellular Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Ministero dell'Università e della Ricerca
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- HCN channels, HCN4, sinoatrial node, cardiac pacemaking, ivabradine, heart rate regulation, cardiac arrhythmias, atrioventricular node, Purkinje fibers
- MeSH terms
- Animals, Heart Rate, Humans, Models, Biological, Myocardium, Sinoatrial Node, Cyclic Nucleotide-Gated Cation Channels
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