The cardiac pacemaker current

The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity

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Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes

Kehat, I., Kenyagin‐Karsenti, D., Snir, M., Segev, H., Amit, M., Gepstein, A., Livne, E., Binah, O., Itskovitz‐Eldor, J., & Gepstein, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12131 · Cited by 1,814

Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes

Kehat, I., Kenyagin‐Karsenti, D., Snir, M., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112131 · Cited by 1,536

Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial

Fox, K., Ford, I., Steg, P. G., Tendera, M., & Ferrari, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61170-8 · Cited by 1,099

Differentiation of Human Embryonic Stem Cells to Cardiomyocytes: Role of Coculture With Visceral Endoderm-Like Cells

Mummery, C., Ward-van Oostwaard, D., Doevendans, P., Spijker, R., van den Brink, S., Hassink, R., van der Heyden, M., Opthof, T., Pera, M., de la Riviere, A. B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000068356.38592.68 · Cited by 1,001

Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling

Long, S. B., Campbell, E. B., & MacKinnon, R. (2005) · Science · doi:10.1126/science.1116270 · Cited by 982

Electromechanical integration of cardiomyocytes derived from human embryonic stem cells

Kehat, I., Khimovich, L., Caspi, O., Gepstein, A., Shofti, R., Arbel, G., Huber, I., Satin, J., Itskovitz‐Eldor, J., & Gepstein, L. (2004) · Nature Biotechnology · doi:10.1038/nbt1014 · Cited by 885

Pacemaker Mechanisms in Cardiac Tissue

DiFrancesco, D. (1993) · Annual Review of Physiology · doi:10.1146/annurev.ph.55.030193.002323 · Cited by 867

A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker

Lakatta, E. G., Maltsev, V. A., & Vinogradova, T. M. (2010) · Circulation Research · doi:10.1161/circresaha.109.206078 · Cited by 631

Publication guidelines for human heart rate and heart rate variability studies in psychophysiology—Part 1: Physiological underpinnings and foundations of measurement

Quigley, K. S., Gianaros, P. J., Norman, G. J., Jennings, J. R., Berntson, G. G., & de Geus, E. J. C. (2024) · Psychophysiology · doi:10.1111/psyp.14604 · Cited by 281

Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers

Borovac, J. A., D'Amario, D., Bozic, J., & Glavas, D. (2020) · World Journal of Cardiology · doi:10.4330/wjc.v12.i8.373 · Cited by 195

Deletion of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Auxiliary Subunit TRIP8b Impairs HippocampalIhLocalization and Function and Promotes Antidepressant Behavior in Mice

Lewis, A. S., Vaidya, S. P., Blaiss, C. A., Liu, Z., Stoub, T. R., Brager, D. H., Chen, X., Bender, R. A., Estep, C. M., Popov, A. B., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0936-11.2011 · Cited by 129

HCN2 ion channels: an emerging role as the pacemakers of pain

Emery, E. C., Young, G. T., & McNaughton, P. A. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.04.004 · Cited by 118

Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes

Gouveia, P., Rosa, S. C., Ricotti, L., Abecasis, B., de Almeida, H. V., Monteiro, L. M., Nunes, J., Carvalho, F. S., Serra, M., Luchkin, S. Y., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.048 · Cited by 105

HCN-related channelopathies

Baruscotti, M., Bottelli, G., Milanesi, R., DiFrancesco, J. C., & DiFrancesco, D. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0810-8 · Cited by 100

A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial inappropriate sinus tachycardia

Baruscotti, M., Bucchi, A., Milanesi, R., Paina, M., Barbuti, A., Gnecchi-Ruscone, T., Bianco, E., Vitali-Serdoz, L., Cappato, R., & DiFrancesco, D. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehv582 · Cited by 93

Implantable Triboelectric Nanogenerators for Self‐Powered Cardiovascular Healthcare

Che, Z., O'Donovan, S., Xiao, X., Wan, X., Chen, G., Zhao, X., Zhou, Y., Yin, J., & Chen, J. (2023) · Small · doi:10.1002/smll.202207600 · Cited by 95

Direct Nkx2-5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity

Dorn, T., Goedel, A., Lam, J. T., Haas, J., Tian, X. Y., Herrmann, F. E., Bundschu, K., Dobreva, G. D., Schiemann, M., Dirschinger, R. J., et al. (2014) · Stem Cells · doi:10.1002/stem.1923 · Cited by 92

Advances in NMR Methods To Map Allosteric Sites: From Models to Translation

Boulton, S., & Melacini, G. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00718 · Cited by 90

Adrenergic receptors and metabolism: role in development of cardiovascular disease

Ciccarelli, M., Santulli, G., Pascale, V., Trimarco, B., & Iaccarino, G. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00265 · Cited by 89

Inappropriate sinus tachycardia

Olshansky, B., & Sullivan, R. M. (2019) · EP Europace · doi:10.1093/europace/euy128 · Cited by 80

cAMP Sensitivity of HCN Pacemaker Channels Determines Basal Heart Rate But Is Not Critical for Autonomic Rate Control

Schweizer, P. A., Duhme, N., Thomas, D., Becker, R., Zehelein, J., Draguhn, A., Bruehl, C., Katus, H. A., & Koenen, M. (2010) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.110.949768 · Cited by 79

Propofol and arrhythmias: two sides of the coin

Liu, Q., Kong, A.-L., Chen, R., Qian, C., Liu, S., Sun, B., Wang, L., Song, L., & Jiang, H. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.42 · Cited by 77

HCN Channels Modulators: The Need for Selectivity

Novella Romanelli, M., Sartiani, L., Masi, A., Mannaioni, G., Manetti, D., Mugelli, A., & Cerbai, E. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616999160315130832 · Cited by 73

Nonlinear Dynamics in Cardiology

Krogh‐Madsen, T., & Christini, D. J. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150106 · Cited by 73

Human iPSC modelling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytes

Benzoni, P., Campostrini, G., Landi, S., Bertini, V., Marchina, E., Iascone, M. R., Ahlberg, G., OLESEN, M. S., Crescini, E., Mora, C., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz217 · Cited by 73

If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation

Verrier, R. L., Bonatti, R., Silva, A. F. G., Batatinha, J. A. P., Nearing, B. D., Liu, G., Rajamani, S., Zeng, D., & Belardinelli, L. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.08.007 · Cited by 72

Electroactive biomaterials synergizing with electrostimulation for cardiac tissue regeneration and function-monitoring

Zhang, Y., Friec, A. L., Zhang, Z., Müller, C., Du, T., Dong, M., Liu, Y., & Chen, M. (2023) · Materials Today · doi:10.1016/j.mattod.2023.09.005 · Cited by 75

Multifaceted aspects of charge transfer

Derr, J. B., Tamayo, J., Clark, J. A., Morales, M., Mayther, M. F., Espinoza, E. M., Rybicka‐Jasińska, K., & Vullev, V. I. (2020) · Physical Chemistry Chemical Physics · doi:10.1039/d0cp01556c · Cited by 69

New Therapeutic Targets in Cardiology

Roubille, F., & Tardif, J. (2013) · Circulation · doi:10.1161/circulationaha.112.000145 · Cited by 67

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models

Bucchi, A., Barbuti, A., DiFrancesco, D., & Baruscotti, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00240 · Cited by 63

Embryonic Stem Cell–Derived CD166 + Precursors Develop Into Fully Functional Sinoatrial-Like Cells

Scavone, A., Capilupo, D., Mazzocchi, N., Crespi, A., Zoia, S., Campostrini, G., Bucchi, A., Milanesi, R., Baruscotti, M., Benedetti, S., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.301283 · Cited by 61

Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents

Xu, Y., Chen, S., Cao, Y., Zhou, P., Chen, Z., & Cheng, K. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.05.033 · Cited by 55

Upregulation of the Hyperpolarization-Activated Current Increases Pacemaker Activity of the Sinoatrial Node and Heart Rate During Pregnancy in Mice

Khoury, N. E., Mathieu, S., Marger, L., Ross, J. L., Gebeily, G. E., Éthier, N., & Fiset, C. (2013) · Circulation · doi:10.1161/circulationaha.113.001689 · Cited by 54

Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current

Verkerk, A. O., & Wilders, R. (2014) · EP Europace · doi:10.1093/europace/eut348 · Cited by 48

Canine and human sinoatrial node: differences and similarities in the structure, function, molecular profiles, and arrhythmia

Kalyanasundaram, A., Li, N., Hansen, B. J., Zhao, J., & Fedorov, V. V. (2018) · Journal of Veterinary Cardiology · doi:10.1016/j.jvc.2018.10.004 · Cited by 48

If and SR Ca2+ release both contribute to pacemaker activity in canine sinoatrial node cells

Gao, Z., Chen, B., Joiner, M.-L. A., Wu, Y., Guan, X., Koval, O. M., Chaudhary, A. K., Cunha, S. R., Mohler, P. J., Martins, J. B., et al. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.03.019 · Cited by 47

Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels

Weisbrod, D., Haron‐Khun, S., Bueno, H., Peretz, A. S., & Attali, B. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.135 · Cited by 44

Reduction of thalamic and cortical I h by deletion of TRIP8b produces a mouse model of human absence epilepsy

Heuermann, R. J., Jaramillo, T. C., Ying, S.-W., Suter, B. A., Lyman, K. A., Han, Y. S., Lewis, A. S., Hampton, T., Shepherd, G. M., Goldstein, P. A., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.10.005 · Cited by 44

Human derived cardiomyocytes: A decade of knowledge after the discovery of induced pluripotent stem cells

Barbuti, A., Benzoni, P., Campostrini, G., & Dell’Era, P. (2016) · Developmental Dynamics · doi:10.1002/dvdy.24455 · Cited by 44

Combined Actions of Ivabradine and Ranolazine Reduce Ventricular Rate During Atrial Fibrillation

Verrier, R. L., Silva, A. F. G., Bonatti, R., Batatinha, J. A. P., Nearing, B. D., Liu, G., Rajamani, S., Zeng, D., & Belardinelli, L. (2014) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12569 · Cited by 39

Adrenergic Receptors

Ciccarelli, M., Sorriento, D., Coscioni, E., Iaccarino, G., & Santulli, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803111-7.00011-7 · Cited by 40

A detailed characterization of the hyperpolarization-activated “funny” current (If) in human-induced pluripotent stem cell (iPSC)–derived cardiomyocytes with pacemaker activity

Giannetti, F., Benzoni, P., Campostrini, G., Milanesi, R., Bucchi, A., Baruscotti, M., Dell’Era, P., Rossini, A., & Barbuti, A. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02571-w · Cited by 38

Timing, Sleep, and Respiration in Health and Disease

Buchanan, G. F. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-396971-2.00008-7 · Cited by 40

Stem Cell–Derived Nodal-Like Cardiomyocytes as a Novel Pharmacologic Tool: Insights from Sinoatrial Node Development and Function

Barbuti, A., & Robinson, R. B. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009597 · Cited by 38

Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If “funny” current

Baruscotti, M., Bianco, E., Bucchi, A., & DiFrancesco, D. (2016) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-015-0097-y · Cited by 37

Design, Synthesis, and Preliminary Biological Evaluation of New Isoform-Selective f-Current Blockers

Melchiorre, M., Lungo, M. D., Guandalini, L., Martini, E., Dei, S., Manetti, D., Scapecchi, S., Teodori, E., Sartiani, L., Mugelli, A., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm1006758 · Cited by 37

The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction

Milanesi, R., Bucchi, A., & Baruscotti, M. (2015) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-015-9998-z · Cited by 37

Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients

Shim, S., Eom, K., Jeong, J., & Kim, S. J. (2020) · Micromachines · doi:10.3390/mi11050535 · Cited by 35

Bidirectional flow of the funny current (I f ) during the pacemaking cycle in murine sinoatrial node myocytes

Peters, C. H., Liu, P. W., Morotti, S., Gantz, S. C., Grandi, E., Bean, B. P., & Proenza, C. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104668118 · Cited by 32

Relaxin promotes growth and maturation of mouse neonatal cardiomyocytes in vitro: clues for cardiac regeneration

Nistri, S., Pini, A., Sassoli, C., Squecco, R., Francini, F., Formigli, L., & Bani, D. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01328.x · Cited by 32

Ivabradine for controlling heart rate in permanent atrial fibrillation: A translational clinical trial

Fontenla, A., Tamargo, J. L., Salgado‐Aranda, R., López‐Gil, M., Mejía, E. R., Matía, R., Toquero, J., Padilla, I. M., Al-Mahdi, E. A. R., Fernandez, F., et al. (2023) · Heart Rhythm · doi:10.1016/j.hrthm.2023.02.012 · Cited by 32

Small and Intermediate Calcium Activated Potassium Channels in the Heart: Role and Strategies in the Treatment of Cardiovascular Diseases

Weisbrod, D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.590534 · Cited by 28

Pathophysiological relevance of the cardiac β2-adrenergic receptor and its potential as a therapeutic target to improve cardiac function

Pérez‐Schindler, J., Philp, A., & Hernández-Cascales, J. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.11.001 · Cited by 28

Identification and classification of interstitial cells in the mouse renal pelvis

Grainger, N., Freeman, R. S., Shonnard, C. C., Drumm, B. T., Koh, S. D., Ward, S. M., & Sanders, K. M. (2020) · The Journal of Physiology · doi:10.1113/jp278888 · Cited by 28

If Inhibition in Cardiovascular Diseases

Thollon, C., & Vilaine, J. (2010) · Advances in pharmacology · doi:10.1016/s1054-3589(10)59003-3 · Cited by 28

Ivabradine: An Intelligent Drug for the Treatment of Ischemic Heart Disease

Riccioni, G. (2012) · Molecules · doi:10.3390/molecules171113592 · Cited by 28

If Channel as an Emerging Therapeutic Target for Cardiovascular Diseases: A Review of Current Evidence and Controversies

Mengesha, H. G., Tafesse, T. B., & Bule, M. H. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00874 · Cited by 27

A mutant HCN4 channel in a family with bradycardia, left bundle branch block, and left ventricular noncompaction

Yokoyama, R., Kinoshita, K., Hata, Y., Abe, M., Matsuoka, K., Hirono, K., Kano, M., Nakazawa, M., Ichida, F., Nishida, N., et al. (2018) · Heart and Vessels · doi:10.1007/s00380-018-1116-6 · Cited by 27

Ionic Mechanisms of Pacemaker Activity in Spontaneously Contracting Atrial HL-1 Cells

Yang, Z., & Murray, K. T. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181fda7c4 · Cited by 27

Exploring anodal and cathodal make and break cardiac excitation mechanisms in a 3D anisotropic bidomain model

Colli-Franzone, P., Pavarino, L. F., & Scacchi, S. (2011) · Mathematical Biosciences · doi:10.1016/j.mbs.2011.02.002 · Cited by 26

Ion‐channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells

Mishra, P., & Narayanan, R. (2021) · Physiological Reports · doi:10.14814/phy2.14963 · Cited by 25

Smart Bioelectronics for Real-Time Diagnosis and Therapy of Body Organ Functions

Guo, L., Lee, H. K., Oh, S., Koirala, G. R., & Kim, T. (2025) · ACS Sensors · doi:10.1021/acssensors.5c00024 · Cited by 23

Up-regulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3 (HCN3) by Specific Interaction with K+ Channel Tetramerization Domain-containing Protein 3 (KCTD3)

Cao-Ehlker, X., Zong, X., Hammelmann, V., Grüner, C., Fenske, S., Michalakis, S., Wahl‐Schott, C., & Biel, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.434803 · Cited by 24

Early cardiac electrographic and molecular remodeling in a model of status epilepticus and acquired epilepsy

Brewster, A. L., Marzec, K., Hairston, A., Ho, M., Anderson, A. E., & Lai, Y. (2016) · Epilepsia · doi:10.1111/epi.13516 · Cited by 23

Inhibition of If in the atrioventricular node as a mechanism for dronedarone’s reduction in ventricular rate during atrial fibrillation

Verrier, R. L., Sobrado, M. F., Pagotto, V. P. F., Kanas, A. F., Machado, A. D., Varone, B. B., Sobrado, L. F., Nearing, B. D., Zeng, D., & Belardinelli, L. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.08.007 · Cited by 22

Evaluation of in vitro models of stem cell-derived cardiomyocytes to screen for potential cardiotoxicity of chemicals

Shi, M., Tien, N. T., de Haan, L., Louisse, J., Rietjens, I. M. C. M., & Bouwmeester, H. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104891 · Cited by 22

Mineralocorticoid receptor overexpression in embryonic stem cell-derived cardiomyocytes increases their beating frequency

Menuet, D. L., Munier, M., Méduri, G., Viengchareun, S., & Lombès, M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq087 · Cited by 22

Ivabradine: from molecular basis to clinical effectiveness

Riccioni, G. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0014-9 · Cited by 22

Inhibitory effects of sevoflurane on pacemaking activity of sinoatrial node cells in guinea‐pig heart

Kojima, A., Kitagawa, H., Omatsu‐Kanbe, M., Matsuura, H., & Nosaka, S. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01914.x · Cited by 19

miR-786 Regulation of a Fatty-Acid Elongase Contributes to Rhythmic Calcium-Wave Initiation in C. elegans

Kemp, B. J., Allman, E. L., Immerman, L., Mohnen, M., Peters, M. A., Nehrke, K. W., & Abbott, A. L. (2012) · Current Biology · doi:10.1016/j.cub.2012.09.047 · Cited by 19

Sinus node revisited

Lau, D. H., Roberts‐Thomson, K. C., & Sanders, P. (2010) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32834138f4 · Cited by 19

Cell-specific Dynamic Clamp analysis of the role of funny If current in cardiac pacemaking

Ravagli, E., Bucchi, A., Bartolucci, C., Paina, M., Baruscotti, M., DiFrancesco, D., & Severi, S. (2015) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2015.12.004 · Cited by 19

Investigating LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Shemer, Y., Mekies, L. N., Jehuda, R. B., Baskin, P., Shulman, R., Eisen, B., Regev, D., Arbustini, E., Gerull, B., Gherghiceanu, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157874 · Cited by 18

Ivabradine: recent and potential applications in clinical practice

Riccioni, G. (2011) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2011.548321 · Cited by 18

Stable angina pectoris: antianginal therapies and future directions

CHAITMAN, B. R., & Laddu, A. A. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.129 · Cited by 17

Introducing a novel mechanism to control heart rate in the ancestral pacific hagfish

Wilson, C. M., Roa, J. N., Cox, G., Tresguerres, M., & Farrell, A. P. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.138198 · Cited by 17

Genetically-engineered mesenchymal stem cells transfected with human HCN1 gene to create cardiac pacemaker cells

Zhou, Y., Yang, X., Li, H.-X., Han, L.-H., & Jiang, W. (2013) · Journal of International Medical Research · doi:10.1177/0300060513501123 · Cited by 16

Dronedarone's Inhibition of If Current Is the Primary Mechanism Responsible for Its Bradycardic Effect

Sobrado, L. F., Varone, B. B., Machado, A. D., Nearing, B. D., Zeng, D., Belardinelli, L., & Verrier, R. L. (2013) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12155 · Cited by 15

Peripheral hyperpolarization‐activated cyclic nucleotide‐gated channels contribute to inflammation‐induced hypersensitivity of the rat temporomandibular joint

Hatch, R. J., Jennings, E. A., & Ivanusic, J. J. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00261.x · Cited by 15

Inherited and Acquired Rhythm Disturbances in Sick Sinus Syndrome, Brugada Syndrome, and Atrial Fibrillation: Lessons from Preclinical Modeling

Iop, L., Iliceto, S., Civieri, G., & Tona, F. (2021) · Cells · doi:10.3390/cells10113175 · Cited by 14

Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy

Lai, Y., Li, N., Lawrence, W. S., Wang, S., Levine, A. T., Burchhardt, D. M., Pautler, R. G., Valderrábano, M., Wehrens, X. H. T., & Anderson, A. E. (2018) · Epilepsia Open · doi:10.1002/epi4.12107 · Cited by 14

Reduced models for the pacemaker dynamics of cardiac cells

Herrera-Valdez, M. A., & Lega, J. C. (2010) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2010.09.042 · Cited by 14

Blocking effects of acehytisine on pacemaker currents (If) in sinoatrial node cells and human HCN4 channels expressed in Xenopus laevis oocytes

Fan, X., Chen, Y., Xing, J., Wu, P., Chen, H., Yang, J., Zhang, J., Wang, X., & Huang, C. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.10.039 · Cited by 13

Interplay of sync and swarm: Theory and application of swarmalators

Sar, G. K., O’Keeffe, K. P., Lizárraga, J. U. F., de Aguiar, M. A. M., Bettstetter, C., & Ghosh, D. (2026) · Physics Reports · doi:10.1016/j.physrep.2026.01.002 · Cited by 13

Antagonist molecules in the treatment of angina

Gupta, A. K., Winchester, D. E., & Pepine, C. J. (2013) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2013.834329 · Cited by 12

Enhancing regeneration and functionality of excitable tissues via integrating bioelectronics and bioengineered constructs

Meng, Z., Gu, B., Yao, C., Li, J., Yu, K., Ding, Y. C., He, P., Jiang, N., Li, D., & He, J. (2024) · International Journal of Extreme Manufacturing · doi:10.1088/2631-7990/ad9365 · Cited by 9

Non-canonical Molecular Targets for Novel Analgesics: Intracellular Calcium and HCN Channels

Cook, D. C., & Goldstein, P. A. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210119153047 · Cited by 9

Recovery of Advanced Atrioventricular Block by Cilostazol

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Effect of hyperpolarization-activated current If on robustness of sinoatrial node pacemaking: theoretical study on influence of intracellular Na+ concentration

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