Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes
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Cardiomyocytes and pericytes express ACE2 and TMPRSS2, as well as other accessory proteins needed for viral infection by SARS-CoV-2.
“Thus, cardiomyocytes and pericytes express ACE2 and TMPRSS2, as well as other accessory proteins (ie, NRP1 [neuropilin-1 receptor], CD147 , integrin α 5 β 1, and cathepsin B/L) needed for viral infection by SARS-CoV-2”
From COVID-19, Myocarditis and Pericarditis (2023) · cites this paper as [24]
The “Viral entry, membrane fusion and endocytosis” section reports expression of ACE2, TMPRSS2, furin, and cathepsins B and L in cardiomyocytes. Our copy does not establish the same expression in pericytes or address the sentence’s named accessory proteins NRP1, CD147, and integrin α5β1. It also describes the entry roles of several proteins as hypothesised or proposed, rather than established as necessary. (LLM, conf=0.88)
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- Authors
- Robinson, E. L., Alkass, K., Bergmann, O., Maguire, J. J., Roderick, H. L., & Davenport, A. P.
- Affiliations
- Maastricht University (NL)
- Swedish National Board of Forensic Medicine (SE)
- Karolinska Institutet (SE)
- University of Cambridge (GB)
- University of Oslo (NO)
- Corresponding author
- Davenport, Anthony P.
- ORCID
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 147
- Pages
- 88-91
- ISSN
- 0022-2828 (ISSN-L)
- PMC
- PMC7431326
- OpenAlex
- W3049080691
- Cited by
- 25
- References
- 11
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 12 · 2020: 3
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Molecular and Cellular Cardiology (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Lirias (submittedVersion, other-oa)
- Apollo (University of Cambridge) (submittedVersion, cc-by-nc-nd)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Apollo
- Funders
- Åke Wiberg Stiftelse
- Fonds Wetenschappelijk Onderzoek (90663)
- Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0400-403)
- Zentrum für Regenerative Therapien Dresden
- Wellcome Trust (107715/Z/15/Z)
- EMBO
- Karolinska Institutet
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- SARS-CoV-2, ACE2, TMPRSS2, viral entry, cardiomyocytes, aging, COVID-19 pandemic, cardiovascular disease, hypertension, gene expression, spike protein S1, S2 domain, host cell receptors
- MeSH terms
- Betacoronavirus, Apelin, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Aging, Angiotensins, Bradykinin, Cathepsin B, Humans, Peptidyl-Dipeptidase A, Myocardium, Pneumonia, Viral, Serine Endopeptidases, Coronavirus Infections, Myocytes, Cardiac, Virus Attachment, Virus Internalization, Cathepsin L, Pandemics
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