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Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

Raper, Steven E, Chirmule, Narendra, Lee, Frank S, Wivel, Nelson A, Bagg, Adam, Gao, Guang-ping, Wilson, James M, Batshaw, Mark L·2003·Molecular Genetics and Metabolism

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Research works printed but not linked: 37

  1. Whittington, 1998, Liver transplantation for the treatment of urea cycle disorders, J. Inher. Metab. Dis., 21, 112, 10.1023/A:1005317909946 · DOI
  2. Morsy, 1993, Efficient adenoviral-mediated ornithine transcarbamylase expression in deficient mouse and human hepatocytes, J. Clin. Invest., 92, 1580, 10.1172/JCI116739 · doi:10.1172/jci116739
  3. Stratford-Perricaudet, 1990, Evaluation of the transfer and expression in mice of an enzyme encoding gene using a human adenovirus vector, Human Gene Ther., 1, 241, 10.1089/hum.1990.1.3-241 · DOI · Paper page
  4. Morsy, 1996, Patient selection may affect gene therapy success: dominant negative effects observed for ornithine transcarbamylase in mouse and human hepatocytes, J. Clin. Invest., 97, 826, 10.1172/JCI118482 · DOI
  5. Ye, 1996, Prolonged metabolic correction in adult ornithine transcarbamylase-deficient mice with adenoviral vectors, J. Biol. Chem., 271, 3639, 10.1074/jbc.271.7.3639 · DOI
  6. Yang, 1994, Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy, Proc. Natl. Acad. Sci. USA, 91, 4407, 10.1073/pnas.91.10.4407 · DOI · Paper page
  7. Ye, 1997, Adenovirus-mediated in vivo gene transfer rapidly protects ornithine transcarbamylase-deficient mice from an ammonium challenge, Pediatr. Res., 41, 527, 10.1203/00006450-199704000-00012 · DOI
  8. Nunes, 1999, Gene transfer into the liver of non-human primates with E1-deleted recombinant adenoviral vectors: safety of readministration, Hum. Gene Ther., 10, 2515, 10.1089/10430349950016852 · DOI
  9. Gao, 1996, Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy, J. Virol., 70, 8934, 10.1128/JVI.70.12.8934-8943.1996 · DOI · Paper page
  10. Christ, 2000, Modulation of the inflammatory properties and hepatoxicity of recombinant adenovirus vectors by the viral E4 gene products, Hum. Gene Ther., 11, 415, 10.1089/10430340050015888 · DOI
  11. Dedieu, 1997, Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenovirus, J. Virol., 71, 4626, 10.1128/JVI.71.6.4626-4637.1997 · DOI · Paper page
  12. Wang, 1997, Persistent transgene expression in mouse liver following in vivo gene transfer with a ΔE1/ΔE4 adenovirus vector, Gene Ther., 4, 393, 10.1038/sj.gt.3300404 · doi:10.1038/sj.gt.3300404
  13. Ye, 1998, Evaluating the potential of germ line transmission after intravenous administration of recombinant adenovirus in the C3H mouse, Hum. Gene Ther., 9, 2135, 10.1089/hum.1998.9.14-2135 · doi:10.1089/hum.1998.9.14-2135
  14. Raper, 1998, Selective gene transfer into the liver of non-human primates with E1-deleted, E2A-defective, or E1–E4 deleted recombinant adenoviruses, Hum. Gene Ther., 9, 671, 10.1089/hum.1998.9.5-671 · DOI
  15. Reid, 2001, Intra-arterial administration of a replication-selective adenovirus (dl 1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial, Gene Ther., 8, 1518, 10.1038/sj.gt.3301512 · DOI · Paper page
  16. Raper, 2002, A pilot study of in vivo liver directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency, Hum. Gene Ther., 13, 163, 10.1089/10430340152712719 · DOI · Paper page
  17. Maddalena, 1988, Mosaicism for an intragenic deletion in a boy with mild ornithine transcarbamylase deficiency, N. Engl. J. Med., 319, 999, 10.1056/NEJM198810133191507 · DOI
  18. Batshaw, 1984, Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis, N. Engl. J. Med., 310, 1630, 10.1056/NEJM198406213102503 · DOI
  19. Sauaia, 1994, Early predictors of postinjury multiple organ failure, Arch. Surg., 129, 39, 10.1001/archsurg.1994.01420250051006 · DOI · Paper page
  20. Faist, 1996, Update on the mechanisms of immune suppression of injury and immune modulation, World J. Surg., 20, 454, 10.1007/s002689900071 · DOI · Paper page
  21. Biffl, 1996, Interleukin-6 in the injured patient: marker of injury or mediator of inflammation?, Ann. Surg., 224, 647, 10.1097/00000658-199611000-00009 · DOI · Paper page
  22. Headley, 1997, Infections and the inflammatory response in acute respiratory distress syndrome, Chest, 111, 1306, 10.1378/chest.111.5.1306 · DOI · Paper page
  23. van der Poll, 1990, Activation of coagulation after administration of tumor necrosis factor to normal subjects, N. Engl. J. Med., 322, 1622, 10.1056/NEJM199006073222302 · DOI · Paper page
  24. Levi, 1997, The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia, Eur. J. Clin. Invest., 27, 3, 10.1046/j.1365-2362.1997.570614.x · DOI · Paper page
  25. Zhang, 1998, Inhibition of tumor necrosis factor α decreases inflammation and prolongs adenovirus gene expression in lung and liver, Hum. Gene Ther., 9, 1875, 10.1089/hum.1998.9.13-1875 · DOI
  26. Zhang, 2001, Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages, Mol. Ther., 3, 697, 10.1006/mthe.2001.0329 · DOI · Paper page
  27. Schnell, 2001, Activation of innate immunity of nonhuman primates following intraportal administration of adenoviral vectors, Mol. Ther., 3, 708, 10.1006/mthe.2001.0330 · DOI · Paper page
  28. Bone, 1991, The pathogenesis of sepsis, Ann. Intern. Med., 115, 457, 10.7326/0003-4819-115-6-457 · DOI · Paper page
  29. Partrick, 1999, Release of anti-inflammatory mediators after major torso trauma correlates with the development of postinjury multiple organ failure, Am. J. Surg., 178, 564, 10.1016/S0002-9610(99)00240-8 · DOI
  30. Schroder, 1995, Pattern of soluble TNF receptors I and II in sepsis, Infection, 23, 143, 10.1007/BF01793854 · DOI
  31. Yang, 1994, MHC Class I restricted cytotoxic lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses, Immunity, 1, 433, 10.1016/1074-7613(94)90074-4 · DOI · Paper page
  32. Zsengeller, 1995, Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune deficient (nu/nu) mice, Hum. Gene Ther., 6, 457, 10.1089/hum.1995.6.4-457 · DOI
  33. Yang, 1995, Cellular and humoral immune responses to antigens create barriers to lung directed gene therapy with recombinant adenoviruses, J. Virol., 69, 2004, 10.1128/JVI.69.4.2004-2015.1995 · DOI · Paper page
  34. Tripathy, 1996, Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors, Nat. Med., 2, 545, 10.1038/nm0596-545 · DOI · Paper page
  35. Yao, 1996, Adenovirus-mediated transfer of human factor IX gene in immunodeficient and normal mice: evidence for prolonged stability and activity of the transgene in liver, Viral Immunol., 9, 141, 10.1089/vim.1996.9.141 · doi:10.1089/vim.1996.9.141
  36. Morral, 1997, Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors, Hum. Gene Ther., 8, 1275, 10.1089/hum.1997.8.10-1275 · DOI
  37. Tao, 2001, Sequestration of adenorival vector by Kupffer cells leads to a non-linear dose response of transduction in liver, Mol. Ther., 3, 28, 10.1006/mthe.2000.0227 · DOI · Paper page

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Metadata

Authors
Raper, S. E., Chirmule, N., Lee, F. S., Wivel, N. A., Bagg, A., Gao, G.-P., Wilson, J. M., & Batshaw, M. L.
Venue
Molecular Genetics and Metabolism
Publisher
Elsevier BV
Published
2003-09
Volume
80
Issue
1-2
Pages
148-158
ISSN
1096-7192 (ISSN-L)
OpenAlex
W2093424805
Cited by
1,498
References
2
FWCI
33.49
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. https://app.cochat.ai/papers/10.1016/j.ymgme.2003.08.016
The paper
Raper, S. E., Chirmule, N., Lee, F. S., Wivel, N. A., Bagg, A., Gao, G.-P., Wilson, J. M., & Batshaw, M. L. (2003). Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Molecular Genetics and Metabolism. https://doi.org/10.1016/j.ymgme.2003.08.016

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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