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Improved system for helper-dependent adenoviral vector production
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“The latest generation of AdV vectors, helper-dependent, or gutless AdV vectors, are devoid of all viral genes. These vectors only contain ITRs and encapsidation (ψ). This allows up to 35 kb packaging capacity, which makes it ideal for delivery of the entire CRISPR/Cas9 system in one vector [10,11]. In addition, these vectors do not elicit chronic immune responses.”
From Viral Delivery Systems for CRISPR (2019) · cites this paper as [11]
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Research works printed but not linked: 17
- Kochanek, 1999, High-capacity adenoviral vectors for gene transfer and somatic gene therapy, Hum. Gene Ther., 10, 2451, 10.1089/10430349950016807 · DOI
- Parks, 2002, Separating fact from fiction, Curr. Gene Ther., 2, 111, 10.2174/1566523024605618 · DOI
- Parks, 1996, A helper-dependent adenovirus vector system, Proc. Natl. Acad. Sci. USA, 93, 13565, 10.1073/pnas.93.24.13565 · DOI · Paper page
- Sandig, 1999, Optimization of the helper-dependent adenovirus system for production and potency in vivo, Proc. Natl. Acad. Sci. USA, 97, 1002, 10.1073/pnas.97.3.1002 · DOI
- Zhou, 2001, A Cre-expressing cell line and an E1/E2a double-deleted virus for preparation of helper-dependent adenovirus vector, Mol. Ther., 3, 613, 10.1006/mthe.2001.0288 · DOI
- Barjot, 2002, Gutted adenoviral vector growth using E1/E2b/E3-deleted helper viruses, J. Gene Med., 4, 480, 10.1002/jgm.305 · DOI
- Reddy, 2002, Sustained human factor VIII expression in hemophilia A mice following systemic delivery of a gutless adenoviral vector, Mol. Ther., 5, 63, 10.1006/mthe.2001.0510 · DOI
- Sakhuja, 2003, Optimization of the generation and propagation of gutless adenoviral vectors, Hum. Gene Ther., 14, 243, 10.1089/10430340360535797 · DOI
- Ng, 2001, Development of a FLP/frt system for generating helper-dependent adenoviral vectors, Mol. Ther., 3, 809, 10.1006/mthe.2001.0323 · DOI
- Umama, 2001, Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination, Nat. Biotechnol., 19, 582, 10.1038/89349 · DOI
- Ng, 2002, Cre levels limit packaging signal excision efficiency in the Cre/loxP helper-dependent adenoviral vector system, J. Virol., 76, 4181, 10.1128/JVI.76.9.4181-4189.2002 · DOI
- Graham, 1987, Growth of 293 cells in suspension culture, J. Gen. Virol., 68, 937, 10.1099/0022-1317-68-3-937 · DOI
- Toietta, 2002, Generation of helper-dependent adenoviral vectors by homologous recombination, Mol. Ther., 5, 204, 10.1006/mthe.2002.0532 · DOI
- Addison, 1997, Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors, J. Gen. Virol., 78, 1653, 10.1099/0022-1317-78-7-1653 · DOI
- Graham, 1977, Characteristics of a human cell line transformed by DNA from human adenovirus 5, J. Gen. Viol., 36, 59, 10.1099/0022-1317-36-1-59 · DOI · Paper page
- Chen, 1996, Production and characterization of human 293 cell lines expressing the site-specific recombinase Cre, Somatic Cell Mol. Genet., 22, 477, 10.1007/BF02369439 · DOI
- Ng, 2002, Methods for the preparation of helper-dependent adenoviral vectors, Methods Mol. Med., 69, 371
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Self-citationViral Delivery Systems for CRISPR
Xu, C. L., Ruan, M. Z. C., Mahajan, V. B., & Tsang, S. H. (2019) · Viruses · doi:10.3390/v11010028 · Cited by 277
Pastore, N., Blomenkamp, K., Annunziata, F., Piccolo, P., Mithbaokar, P., Maria Sepe, R., Vetrini, F., Palmer, D., Ng, P., Polishchuk, E., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202046 · Cited by 142
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Metadata
- Authors
- Palmer, D., & Ng, P.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 8
- Issue
- 5
- Pages
- 846-852
- ISSN
- 1525-0016
- Cited by
- 290
- References
- 0
- Language
- en
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- Palmer, D., & Ng, P. (2003). Improved system for helper-dependent adenoviral vector production. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2003.08.014
