Characteristics of a human cell line transformed by DNA from human adenovirus type 5

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · see citing works

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., & Harlow, E. (1988) · Nature · doi:10.1038/334124a0 · Cited by 1,403 · see citing works

Viral vector platforms within the gene therapy landscape

Bulcha, J. T., Wang, Y., Ma, H., Tai, P. W. L., & Gao, G. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00487-6 · Cited by 1,404 · see citing works

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218599110 · Cited by 1,191 · see citing works

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k

Jefferies, H. B. J., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B., & Thomas, G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.12.3693 · Cited by 934 · see citing works

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

Wong, G. H. W., Elwell, J. H., Oberley, L. W., & Goeddel, D. V. (1989) · Cell · doi:10.1016/0092-8674(89)90944-6 · Cited by 802 · see citing works

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

Ferrari, F. K., Samulski, T., Shenk, T., & Samulski, R. J. (1996) · Journal of Virology · doi:10.1128/jvi.70.5.3227-3234.1996 · Cited by 761 · see citing works

A Helper-Dependent Adenovirus Vector System: Removal of Helper Virus by Cre-Mediated Excision of the Viral Packaging Signal

Parks, R. J., Chen, L., Anton, M., Sankar, U., Rudnicki, M. A., & Graham, F. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13565 · Cited by 725 · see citing works

Telomerase activity in human ovarian carcinoma.

Counter, C. M., Hirte, H. W., Bacchetti, S., & Harley, C. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.2900 · Cited by 677 · see citing works

Adenoviruses as vaccine vectors

Tatsis, N., & Ertl, H. C. J. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.07.013 · Cited by 669 · see citing works

Physiology of the prion protein

Linden, R., Martins, V. R., Prado, M. A. M., Cammarota, M., Izquierdo, I., & Brentani, R. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00007.2007 · Cited by 617 · see citing works

Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors

Bartlett, J. S., Wilcher, R., & Samulski, R. J. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2777-2785.2000 · Cited by 532 · see citing works

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes

Counter, C. M., Botelho, F. M., Wang, P., Harley, C. B., & Bacchetti, S. (1994) · Journal of Virology · doi:10.1128/jvi.68.5.3410-3414.1994 · Cited by 355 · see citing works

Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons

Naruse, S., Thinakaran, G., Luo, J.-J., Kusiak, J. W., Tomita, T., Iwatsubo, T., Qian, X., Ginty, D. D., Price, D. L., Borchelt, D. R., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80637-6 · Cited by 355 · see citing works

Rescue of adeno-associated virus from recombinant plasmids: Gene correction within the terminal repeats of AAV

Samulski, R. J., Srivastava, A., Berns, K. I., & Muzyczka, N. (1983) · Cell · doi:10.1016/0092-8674(83)90342-2 · Cited by 297 · see citing works

Therapeutic glycoprotein production in mammalian cells

Lalonde, M.-E., & Durocher, Y. (2017) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2017.04.028 · Cited by 296 · see citing works

The nature of telomere fusion and a definition of the critical telomere length in human cells

Capper, R., Britt-Compton, B., Tankimanova, M., Rowson, J., Letsolo, B., Man, S., Haughton, M., & Baird, D. M. (2007) · Genes & Development · doi:10.1101/gad.439107 · Cited by 294 · see citing works

Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of <i>Mertk</i>

Vollrath, D., Feng, W., Duncan, J. L., Yasumura, D., D'Cruz, P. M., Chappelow, A., Matthes, M. T., Kay, M. A., & LaVail, M. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221364198 · Cited by 290 · see citing works

Cloning of infectious adeno-associated virus genomes in bacterial plasmids

Laughlin, C. A., Tratschin, J.-D., Coon, H., & Carter, B. J. (1983) · Gene · doi:10.1016/0378-1119(83)90217-2 · Cited by 266 · see citing works

A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene.

Logan, J., Falck-Pedersen, E., Darnell, J. E., & Shenk, T. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8306 · Cited by 261 · see citing works

Gene Therapy with Viral Vectors

Kootstra, N. A., & Verma, I. M. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140257 · Cited by 267 · see citing works

Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes

Halbert, C. L., Rutledge, E. A., Allen, J. M., Russell, D. W., & Miller, A. D. (2000) · Journal of Virology · doi:10.1128/jvi.74.3.1524-1532.2000 · Cited by 259 · see citing works

Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site.

Gesemann, M., Denzer, A. J., & Ruegg, M. A. (1995) · The Journal of cell biology · doi:10.1083/jcb.128.4.625 · Cited by 236 · see citing works

Large-Scale transfection of mammalian cells for the fast production of recombinant protein

Pham, P. L., Kamen, A., & Durocher, Y. (2006) · Molecular Biotechnology · doi:10.1385/mb:34:2:225 · Cited by 236 · see citing works

Arrest of G ₁ -S Progression by the p53-Inducible Gene <i>PC3</i> Is Rb Dependent and Relies on the Inhibition of Cyclin D1 Transcription

Guardavaccaro, D., Corrente, G., Covone, F., Micheli, L., D'Agnano, I., Starace, G., Caruso, M., & Tirone, F. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1797-1815.2000 · Cited by 230 · see citing works

Lentiviral vectors for enhanced gene expression in human hematopoietic cells

Ramezani, A., Hawley, T. S., & Hawley, R. G. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0190 · Cited by 217 · see citing works

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor1α promoter

Gill, D., Smyth, S., Goddard, C., Pringle, I., Higgins, C., Colledge, W., & Hyde, S. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301561 · Cited by 214 · see citing works

Current Advances and Future Challenges in Adenoviral Vector Biology and Targeting

Campos, S., & Barry, M. (2007) · Current Gene Therapy · doi:10.2174/156652307780859062 · Cited by 210 · see citing works

Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration

Halbert, C. L., Standaert, T. A., Aitken, M. L., Alexander, I. E., Russell, D. W., & Miller, A. D. (1997) · Journal of Virology · doi:10.1128/jvi.71.8.5932-5941.1997 · Cited by 205 · see citing works

Successful Readministration of Adeno-Associated Virus Vectors to the Mouse Lung Requires Transient Immunosuppression during the Initial Exposure

Halbert, C. L., Standaert, T. A., Wilson, C. B., & Miller, A. D. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9795-9805.1998 · Cited by 203 · see citing works

A Human Parvovirus, Adeno-Associated Virus, as a Eucaryotic Vector: Transient Expression and Encapsidation of the Procaryotic Gene for Chloramphenicol Acetyltransferase

Tratschin, J. D., West, M. H., Sandbank, T., & Carter, B. J. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.10.2072 · Cited by 202 · see citing works

Elimination of both E1 and E2 from adenovirus vectors further improves prospects for in vivo human gene therapy

Gorziglia, M. I., Kadan, M. J., Yei, S., Lim, J., Lee, G. M., Luthra, R., & Trapnell, B. C. (1996) · Journal of Virology · doi:10.1128/jvi.70.6.4173-4178.1996 · Cited by 193 · see citing works

Gene Expression from Adeno-associated Virus Vectors in Airway Epithelial Cells

Flotte, T. R., Solow, R., Owens, R. A., Afione, S., Zeitlin, P. L., & Carter, B. J. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/7.3.349 · Cited by 167 · see citing works

Muscle-Specific Promoters May Be Necessary for Adeno-Associated Virus-Mediated Gene Transfer in the Treatment of Muscular Dystrophies

Cordier, L., Gao, G.-P., Hack, A. A., McNally, E. M., Wilson, J. M., Chirmule, N., & Sweeney, H. L. (2001) · Human Gene Therapy · doi:10.1089/104303401750061267 · Cited by 152 · see citing works

Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Tsai, S. J., Atai, N. A., Cacciottolo, M., Nice, J., Salehi, A., Guo, C., Sedgwick, A., Kanagavelu, S., & Gould, S. J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101266 · Cited by 142 · see citing works

Efficient mouse airway transduction following recombination between AAV vectors carrying parts of a larger gene

Halbert, C. L., Allen, J. M., & Miller, A. D. (2002) · Nature Biotechnology · doi:10.1038/nbt0702-697 · Cited by 121 · see citing works

Opportunities and Challenges for Molecular Understanding of Ciliopathies–The 100,000 Genomes Project

Wheway, G., Genomics England Research Consortium, & Mitchison, H. M. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00127 · Cited by 99 · see citing works

Cas9/gRNA targeted excision of cystic fibrosis-causing deep-intronic splicing mutations restores normal splicing of CFTR mRNA

Sanz, D. J., Hollywood, J. A., Scallan, M. F., & Harrison, P. T. (2017) · PLOS ONE · doi:10.1371/journal.pone.0184009 · Cited by 92 · see citing works

Manufacturing of recombinant adeno-associated viruses using mammalian expression platforms

Robert, M., Chahal, P. S., Audy, A., Kamen, A., Gilbert, R., & Gaillet, B. (2017) · Biotechnology Journal · doi:10.1002/biot.201600193 · Cited by 89 · see citing works

Implications of the Innate Immune Response to Adenovirus and Adenoviral Vectors

Gregory, S. M., Nazir, S. A., & Metcalf, J. P. (2011) · Future Virology · doi:10.2217/fvl.11.6 · Cited by 89 · see citing works

Reprogramming of Telomerase by Expression of Mutant Telomerase RNA Template in Human Cells Leads to Altered Telomeres That Correlate with Reduced Cell Viability

Marušić, L., Anton, M., Tidy, A., Wang, P., Villeponteau, B., & Bacchetti, S. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6394 · Cited by 74 · see citing works

Development of Retinoblastoma in the Absence of Telomerase Activity

Gupta, J., Han, L.-P., Wang, P., Gallie, B. L., & Bacchetti, S. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.16.1152 · Cited by 74 · see citing works

Retrovirus and lentivirus vector design and methods of cell conditioning

Cooray, S., Howe, S. J., & Thrasher, A. J. (2012) · Methods in Enzymology · doi:10.1016/b978-0-12-386509-0.00003-x · Cited by 65 · see citing works

A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation

Liu, Q., Lei, J. X., Sikorska, M., & Liu, R. (2008) · Molecular Neurodegeneration · doi:10.1186/1750-1326-3-4 · Cited by 66 · see citing works

Topology and Membrane Association of Lecithin: Retinol Acyltransferase

Moise, A. R., Golczak, M., Imanishi, Y., & Palczewski, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608315200 · Cited by 59 · see citing works

Myocardial gene transfer and long-term expression following intracoronary delivery of adeno-associated virus

Kaspar, B. K., Roth, D. M., Chin Lai, N., Drumm, J. D., Erickson, D. A., McKirnan, M. D., & Hammond, H. K. (2005) · The Journal of Gene Medicine · doi:10.1002/jgm.665 · Cited by 59 · see citing works

Trans-splicing adeno-associated viral vector-mediated gene therapy is limited by the accumulation of spliced mRNA but not by dual vector coinfection efficiency

Xu, Z., Yue, Y., Lai, Y., Ye, C., Qiu, J., Pintel, D. J., & Duan, D. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.896 · Cited by 55 · see citing works

Optimising non-viral gene delivery in a tumour spheroid model

Mellor, H. R., Davies, L. A., Caspar, H., Pringle, C. R., Hyde, S. C., Gill, D. R., & Callaghan, R. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.947 · Cited by 49 · see citing works

Specificity of Zebrafish Retinol Saturase:  Formation of All-<i>trans</i>-13,14-dihydroretinol and All-<i>trans</i>-7,8- dihydroretinol

Moise, A. R., Isken, A., Domínguez, M., de Lera, A. R., von Lintig, J., & Palczewski, K. (2007) · Biochemistry · doi:10.1021/bi062147u · Cited by 45 · see citing works

Binding of the transcription factor EBP-80 mediates the methylation response of an intracisternal A-particle long terminal repeat promoter.

Falzon, M., & Kuff, E. L. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.1.117 · Cited by 37 · see citing works

Prolonged Prophylactic Protection from Botulism with a Single Adenovirus Treatment Promoting Serum Expression of a VHH-Based Antitoxin Protein

Mukherjee, J., Dmitriev, I., Debatis, M., Tremblay, J. M., Beamer, G., Kashentseva, E. A., Curiel, D. T., & Shoemaker, C. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106422 · Cited by 37 · see citing works

High level of C-type natriuretic peptide induced by hyperandrogen-mediated anovulation in polycystic ovary syndrome mice

Wang, X., Wang, H., Liu, W., Zhang, Z., Zhang, Y., Zhang, W., Chen, Z., Xia, G., & Wang, C. (2018) · Clinical Science · doi:10.1042/cs20171394 · Cited by 30 · see citing works

Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1

Nicoli, A., Haag, F., Marcinek, P., He, R., Kreißl, J., Stein, J., Marchetto, A., Dunkel, A., Hofmann, T., Krautwurst, D., et al. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.2c00752 · Cited by 28 · see citing works

Adenovirus vectors deleted for genes essential for viral DNA replication

Schaack, J. (2005) · Frontiers in Bioscience · doi:10.2741/1607 · Cited by 26 · see citing works