A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
Sabnis, Staci, Kumarasinghe, E. Sathyajith, Salerno, Timothy, Mihai, Cosmin, Ketova, Tatiana, Senn, Joseph J., Lynn, Andy, Bulychev, Alex, McFadyen, Iain, Chan, Joyce, Almarsson, Örn, Stanton, Matthew G., Benenato, Kerry E.·2018·Molecular Therapy
Cited by (820)
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- Comparison of RT-qPCR With Branched DNA to Quantify a Lipid Nanoparticle–Encapsulated mRNA Therapeutic in Serum and Liver Tissue Samples From Nonclinical PK StudiesJessica Ortiz, Laura Brunner, Lei Ci, Rena C. Baek, Darshana Jani, Jean-Claude A. Marshall, Jason J Pennucci · 2025 · The AAPS Journal
- Transfection via RNA-Based Nanoparticles: Comparing Encapsulation vs Adsorption Approaches of RNA IncorporationAmy E. Laturski, Maria T. Dulay, Jillian L. Perry, Joseph M. DeSimone · 2025 · Bioconjugate Chemistry
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- Systemic Administered mRNA as Therapy for Metabolic DiseasesHervé Puy, Jean‐Charles Deybach, Laurent Gouya · 2018 · Trends in Molecular Medicine
- Controlling Protein Expression by Delivery of RNA Therapeutics Using Lipid NanoparticlesPaulo J.C. Lin, Ying K. Tam · 2019 · Elsevier eBooks
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- Exploring the future of mRNA delivery: Beyond lipid nanoparticlesAljoscha Gabelmann, Achim Biesel, Brigitta Loretz, Claus‐Michael Lehr · 2025 · Biochemical and Biophysical Research Communications
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- Alternative Structural Lipids Impact mRNA-Lipid Nanoparticle Morphology, Stability, and ActivityChelsea R. Thorn, James Collin Hickey, Ying‐Chih Chi, Mingzhang Maple Wang, Karina Ng Huang, Sue‐Jean Hong, Qin Zou, Hong-My Nguyen, Roger H. Pak, Patrick Lim Soo · 2025 · Molecular Pharmaceutics
- RNA therapeutics 2.0: Expanding the landscape from mRNA vaccines to splicing modulators and beyondPawan N. Karwa, Nikhil S. Sakle · 2026 · Biotechnology Advances
- Inhalable lipid nanoparticles for macrophage-specific STING gene editing to ameliorate pulmonary fibrosisYangeng Wang, Xie Liu, Wenzhe Xuan, Wanling Huang, Yueqiang Zhu, Chengqiong Mao, Yang Liu · 2026 · Molecular Therapy
- Nanomaterial-enabled RNA therapeutics: bridging delivery barriers to clinical translationKshipra Pandey, Sneha Jha, Loka Bikash Chaliha, Haren B. Gosai, Ritu Patel · 2026 · Frontiers in Nanotechnology
- A Multidimensional Approach to Modulating Ionizable Lipids for High‐Performing and Organ‐Selective mRNA DeliveryZepeng He, Zhicheng Le, Yi Shi, Lixin Liu, Zhijia Liu, Yongming Chen · 2023 · Angewandte Chemie
- A pan-orthoebolavirus neutralizing antibody encoded by mRNA effectively prevents virus infectionPengfei Fan, Bingjie Sun, Zixuan Liu, Ting Fang, Yi Ren, Xiaofan Zhao, Zhenwei Song, Yilong Yang, Jianmin Li, Changming Yu et al. · 2024 · Emerging Microbes & Infections
- Biofabrication of Autologous Human Hepatocytes for Transplantation: How Do We Get There?Nandini Agarwal, Branimir Popovic, Nicole Jenna Martucci, Nicolas Alejandro Fraunhoffer, Alejandro Soto–Gutiérrez · 2018 · Gene Expression
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- Future prospects in mRNA vaccine developmentLondiwe Simphiwe Mbatha, Jude Akinyelu, Fiona Maiyo, Tukayi Kudanga · 2023 · Biomedical Materials
- Lipid-based nanoparticles and their recent advancesOnteru Sujeevan · 2024 · GSC Advanced Research and Reviews
- Lymphatic Endothelial Cells Produce Chemokines in Response to the Lipid Nanoparticles Used in RNA VaccinesYi Liu, Miho Suzuoki, Hiroki Tanaka, Yu Sakurai, Hiroto Hatakeyama, Hidetaka Akita · 2024 · Biological and Pharmaceutical Bulletin
- Delivery Aspects for Implementing siRNA Therapeutics for Blood DiseasesSaba Abbasi Dezfouli, Marcel E. Michailides, Hasan Uludağ · 2024 · Biochemistry
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- Structural heterogeneity in mRNA-LNP subpopulations revealed by AF4-SAXS: implications for cargo loading and cell transfectionAdrian Sanchez-Fernandez, Keira A. Donnelly, Hans Bolinsson, Anna-Maria Börjesdotter, Thomas Rønnemoes Bobak, Simon Erlendsson, Meysam Mohammadi Zerankeshi, Khaled AboulFotouh, Mohammed R. Kawelah, Fátima Herranz-Trillo et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Structure–Function Correlation of Clinically Inspired Lipid Nanoparticles for Lung and Spleen Targeted mRNA DeliveryNatalia P. Martínez, Haitao Yu, Joshua Iscaro, Hao Wang, Brendan Dyett, Jacinta White, Celesta Fong, Calum John Drummond, Steven Bozinovski, Jiali Zhai · 2025 · Advanced Healthcare Materials
- Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational MethodsRuichu Gu, Duanmiao Si, Dingwei Lei, Xiaoxue Xie, Yongge Li, Han Wen · 2026 · MedComm
- The Versatile Applications of Antisense Oligonucleotides in Modern MedicineXue‐hai Liang, Lingdi Zhang · 2026 · International Journal of Molecular Sciences
- Synthesis of novel cholesterol-based ionizable lipids for mRNA deliveryRui Qian, Aftab Ullah, Junming Cui, Xinxi Cai, Jin Cao, Lin Hai Wu, Song Shen · 2024 · Colloids and Surfaces B Biointerfaces
- A bibliometric insight into nanomaterials in vaccine: trends, collaborations, and future avenuesBeibei Wu, Ye Liu, Xuexue Zhang, Ding Luo, Xuejie Wang, Chen Qiao, Jian Liu · 2024 · Frontiers in Immunology
- Determining the Role of Surfactant on the Cytosolic Delivery of DNA Cross-Linked MicellesIna F. de la Fuente, Shraddha S. Sawant, Kiang Wei Kho, Nirod Kumar Sarangi, Rachelle C. Canete, Suman Pal, Lisa H. Liang, Tia E. Keyes, Jessica L. Rouge · 2024 · ACS Applied Materials & Interfaces
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- Modeling the potential health impacts of delayed strain selection on influenza hospitalization and mortality with mRNA vaccinesFardad Haghpanah, Alisa Hamilton, Eili Y. Klein · 2023 · Vaccine X
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- Characterization of a novel conditional knockout mouse model to assess efficacy of mRNA therapy in the context of severe OTC deficiencyJenny Zhou, Shi Liang, Ling Yin, Andrea Frassetto, Anne-Renee Graham, Rebecca A. White, Maria Principe, Madelyn Severson, Tiffany Palmer, Shan K. Naidu et al. · 2025 · Molecular Therapy
- Hybridization Networks of mRNA and Branched RNA HybridsVassiliki Damakoudi, Tobias Feldner, Edina Dilji, Andrey Belkin, Clemens Richert · 2020 · ChemBioChem
- Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid as an Excipient in mRNA-Encapsulating Lipid NanoparticlesKumar Rajappan, Steven P. Tanis, Scott Roberts, Priya Prakash Karmali, Padmanabh Chivukula, Jin Zhuang, Mingxing Xin, Manman Zheng, Ian D. Edmonds · 2021 · Organic Process Research & Development
- Lipid Nanoparticle-Mediated Delivery of Therapeutic and Prophylactic mRNA: Immune Activation by Ionizable Cationic LipidsMelike Ongun, Abhijeet Girish Lokras, Camilla Foged, Aneesh Thakur · 2022 · RNA technologies
- An Overview of Gene Editing Modalities and Related Non-clinical Testing ConsiderationsSrishti Vats, Cristina Ballesteros, Selly Hung, Samantha Sparapani, Karen Wong, Julius Haruna, Christian Li, Simon Authier · 2023 · International Journal of Toxicology
- Increasing the siRNA knockdown efficiency of lipid nanoparticles by morphological transformation with the use of dihydrosphingomyelin as a helper lipidMasahiro Hashimoto, Sei Yonezawa, Furan Song, Chiori Nitta, Noriyuki Maeda, Koji Tomita, Ayano Yokouchi, Hiroyuki Koide, Tomohiro Asai · 2023 · Biomaterials Science
- Moderne Konzepte der Nanobiotechnologie für mRNA‐AbgabesystemeYue Wang, Chengzhong Yu · 2020 · Angewandte Chemie
- Development of a spermine lipid for transient antibody expressionShaowei Sui, Hao Wang, Jiajie Song, Wanyi Tai · 2022 · Bioorganic & Medicinal Chemistry
- Administration of lipid nanoparticle-encapsulated mRNA encoding CCR7, CXCL16 and GITRL effectively mobilizes antitumor T cell immunityJianyu Chen, Qingyan Cen, Rong Hu, Yingqi Qiu, Honghao Zhang, Hao Wang, Yuxing Hu, Xiaoling Xie, Yuhua Li · 2025 · International Journal of Biological Macromolecules
- Delivery strategies of messenger RNA therapeutics for brain disordersKounghwa Youn, Sunmin Oh, Hyo-wook Gil, Yongseok Choi, Gyochang Keum, Eun‐Kyoung Bang · 2025 · Bulletin of the Korean Chemical Society
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- A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced CardiotoxicityJimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou et al. · 2026 · Advanced Science
- Chemical engineering strategies to enhance mRNA–LNP stability for therapeutic applicationsZe Zhang, Yenhui Ong, Bowei Yang, Bangda Fan, Yi Yan Yang, Qianqian Ni · 2026 · Biomaterials Science
- DNA delivered by lipid nanoparticles induces CD8+ T cell–dependent antitumor responses and enhances anti–PD-L1 therapySeoyun Yum, Alba Rodríguez-García, Joan Castellsagué, Marta Giménez-Alejandre, Guillem Colell, Salut Colell, Teresa Lobo‐Jarne, Mark A LaRue, Michael A. Minnier, Mustafa N. Yazicioglu et al. · 2026 · JCI Insight
- A poorly reactogenic lipid nanoparticle-mRNA vaccine unveils an innate immune pathway for adverse reactionsTomohiro Takano, Keigo Kumagai, Hitoshi Iuchi, Kazutaka Terahara, Aya Mizuike, Eita Sasaki, Yu Adachi, Ryutaro Kotaki, Saya Moriyama, Shinichiro Ota et al. · 2026 · npj Vaccines
- Defining Composition–Cytokine Relationships Enables the Design of Lipid Nanoparticles with Programmed ImmunogenicityAdam Alexander Walters, Belal I. Hanafy, Chuan‐en Lu, Sara Marelli, Alaa Zam, Kai Liu, Rachel E. Foreman, Ramesh Soundararajan, Philippe Collin, Lennart Lindfors et al. · 2026 · Small
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