The DOI matches its Crossref record; 284 of the 284 references it cites were found in a registry or an index.
CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?
Open accessAbstract
Chimeric antigen receptor (CAR) T cell therapy has garnered significant excitement due to its success for hematological malignancies in clinical studies leading to the US Food and Drug Administration (FDA) approval of three CD19-targeted CAR T cell products. In contrast, the clinical experience with CAR T cell therapy for solid tumors and brain tumors has been less encouraging, with only a few patients achieving complete responses. Clinical and preclinical studies have identified multiple "roadblocks," including (1) a limited array of targetable antigens and heterogeneous antigen expression, (2) limited T cell fitness and survival before reaching tumor sites, (3) an inability of T cells to efficiently traffic to tumor sites and penetrate physical barriers, and (4) an immunosuppressive tumor microenvironment. Herein, we review these challenges and discuss strategies that investigators have taken to improve the effector function of CAR T cells for the adoptive immunotherapy of solid tumors.
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Cited by
Chimeric antigen receptor-modified macrophages ameliorate liver fibrosis in preclinical models
Dai, H., Zhu, C., Huai, Q., Xu, W., Zhu, J., Zhang, X., Zhang, X., Sun, B., Xu, H., Zheng, M., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.01.034 · Cited by 114
Strategies to enhance CAR-T persistence
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Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer
Jin, Y., Lorvik, K. B., Jin, Y., Beck, C., Sike, A., Persiconi, I., Kvaløy, E., Saatcioglu, F., Dunn, C., & Kyte, J. A. (2022) · Molecular Therapy - Oncolytics · doi:10.1016/j.omto.2022.06.007 · Cited by 26
Chimeric Antigen Receptor T-Cell Therapy: What We Expect Soon
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TNC‑targeted CAR‑macrophage therapy alleviates liver fibrosis in mice
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Metadata
- Authors
- Wagner, J., Wickman, E., DeRenzo, C., & Gottschalk, S.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 28
- Issue
- 11
- Pages
- 2320-2339
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W3085241535
- Cited by
- 380
- References
- 284
- FWCI
- 17.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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