Cited by 150SARS-CoV-2 and COVID-19 ResearchFood Allergy and Anaphylaxis ResearchDrug-Induced Adverse Reactions

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines

Open access

Moghimi, S. Moein·2021·Molecular Therapy

DOI 10.1016/j.ymthe.2021.01.030PMC PMC7862013

Open this paper in CoChat — free account

Abstract

Mortality from coronavirus disease 2019 (COVID-19) in populations at high risk, such as the elderly, certain ethnic groups (e.g., Black/African American, and Hispanic/Latino persons), obese individuals, and those with endothelial dysfunction is substantial. While treatment options are limited, vaccination against SARS-CoV-2, the virus that causes COVID-19, is the most important global strategy in controlling the pandemic. Thus, two lipid nanoparticle (LNP)-based mRNA vaccines (Pfizer-BioNTech and Moderna) against SARS-CoV-2 have already received emergency use authorization by the US Food and Drug Administration (FDA).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.ymthe.2021.01.030

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Retraction for Pushparaj et al., The cytokine interleukin-33 mediates anaphylactic shock
(2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210844109 · Cited by 4
Retracted
The pathophysiology of anaphylaxis
Reber, L. L., Hernandez, J. D., & Galli, S. J. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.06.003 · Cited by 534
Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine — United States, December 14–23, 2020
CDC COVID-19 Response Team, & Administration, F. A. D. (2021) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7002e1 · Cited by 481
Anaphylaxis: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data
Rüggeberg, J. U., Gold, M., Bayas, J. M., Blum, M. D., Bonhoeffer, J., Friedlander, S. F., Brito, G. D. S., Heininger, U., Imoukhuede, E. B., Khamesipour, A., et al. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.02.064 · Cited by 383
Risk of anaphylaxis after vaccination in children and adults.
McNeil, M. M., Weintraub, E. S., Duffy, J., Sukumaran, L., Jacobsen, S. J., Klein, N. P., Hambidge, S. J., Lee, G. M., Jackson, L. A., Irving, S. A., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.07.048 · Cited by 381
Pathways of anaphylaxis in the mouse.
Strait, R., Morris, S., Yang, M.-Y., Qu, X.-W., & Finkelman, F. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.123302 · Cited by 326
Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer
Ganson, N. J., Povsic, T. J., Sullenger, B. A., Alexander, J. H., Zelenkofske, S. L., Sailstad, J. M., Rusconi, C. P., & Hershfield, M. S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.034 · Cited by 275
Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Moderna COVID-19 Vaccine — United States, December 21, 2020–January 10, 2021
CDC COVID-19 Response Team, & Administration, F. A. D. (2021) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7004e1 · Cited by 270
An integrated assessment of morphology, size, and complement activation of the PEGylated liposomal doxorubicin products Doxil®, Caelyx®, DOXOrubicin, and SinaDoxosome
Wibroe, P. P., Ahmadvand, D., Oghabian, M. A., Yaghmur, A., & Moghimi, S. M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.11.021 · Cited by 203
Polyvinyl Pyrrolidone as a Plasma Expander
Ravin, H. A., Seligman, A. M., & Fine, J. (1952) · New England Journal of Medicine · doi:10.1056/nejm195212112472403 · Cited by 196

Show all 19 references

Sorted by citations

Items 101–150 of 150

Intramuscular DNA vaccine provides protection in non-human primate and mouse models of SARS-CoV-2
Sood, S., Gary, E. N., Matar, M. M., Kim, J., Hojecki, C. E., Warner, B. M., Vendramelli, R., Truong, T., Smith, A., Rice, J. S., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1589584 · Cited by 3
In vivo immune engineering via mRNA therapeutics: reprogramming the post-infarction cardiac microenvironment
Liu, Y. H., Liu, R., Meng, C., Li, J., Yang, K., Zhang, F., Xia, X., Ye, G., & Yuan, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1873905 · Cited by 2
The discovery and development of mRNA vaccines for the prevention of SARS-CoV-2 infection
Xue, V. W., Wong, S. C. C., Li, B., & Cho, W. C. S. (2023) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2218083 · Cited by 2
Single cell phototransfection of mRNAs encoding SARS-CoV2 spike and nucleocapsid into human astrocytes results in RNA dependent translation interference
Kim, H., Brosseau, Q., Radzio, J., Wang, J., Muramatsu, H., Kuang, D., Grady, M. S., Chen, H. I., Wolf, J. A., Ulyanova, A. V., et al. (2024) · Frontiers in Drug Delivery · doi:10.3389/fddev.2024.1359700 · Cited by 2
Developing MiR‐133a Zipper Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
Yi, S. A., Pongkulapa, T., Nevins, S., Goldston, L. L., Chen, M., & Lee, K. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400654 · Cited by 3
The Development of Epitope-Based Recombinant Protein Vaccines against SARS-CoV-2
Khalid, K., Lim, H. X., Hwang, J. S., & Poh, C. L. (2024) · The AAPS Journal · doi:10.1208/s12248-024-00963-1 · Cited by 3
mRNA Vaccines: Immunology and Present and Future Potential
Khan, O. F., Couture‐Senécal, J., Lau, Y. M. A., Oproescu, A.-M., Pang, J., Tilstra, G., & Walz, B. A. (2024) · Springer eBooks · doi:10.1007/978-3-031-62772-9_5 · Cited by 2
Method for creating a recombinant strain of enterococcus L3-SARS based on biologically active strain Enterococcus faecium L3
Bormotova, E., Gupalova, T. V., & Suvorov, A. N. (2023) · Russian Journal for Personalized Medicine · doi:10.18705/2782-3806-2023-3-1-64-71 · Cited by 2
Transfusions of Blood Products Derived from Genetic Vaccine Recipients: Safety Concerns and Proposals for Specific MeasuresPreprint
Ueda, J., Motohashi, H., Hirai, Y., Yamamoto, K., Murakami, Y., Fukushima, M., & Fujisawa, A. (2024) · Preprints.org · doi:10.20944/preprints202403.0881.v2 · Cited by 1
“Nanoparticles as Vaccine Heroes: Unveiling Their Impact” – A Review
Zalavadiya, I., Vediya, P., Trivedi, U., & Asif, M. (2025) · E3S Web of Conferences · doi:10.1051/e3sconf/202561904001 · Cited by 1
Advancing beyond conventional vaccines: The potential of next-generation vaccines in combatting antibiotic-resistant bacteria
Heamchandsaravanan, A. R., Perumal, D., Nandha, R. V., & Dhandapani, P. (2025) · Indian Journal of Medical Microbiology · doi:10.1016/j.ijmmb.2025.100896 · Cited by 1
Multifunctional bio-nanostructure for cancer therapy: mini review
Ahuja, V., Chauhan, S., Singh, K. B., Dhillon, J. K., & Sharma, D. (2025) · Discover Applied Sciences · doi:10.1007/s42452-025-07592-z · Cited by 1
Exploring Potential Mechanisms for Epilepsy After mRNA COVID ‐19 Vaccination: An Extremely Rare Side‐Effect
Mutee, A. F., Shareef, A., Jyothi, S. R., Panigrahi, R., Abbot, V., Chauhan, A. S., Singh, S., Баходирович, А. Б., Sameer, H. N., Yaseen, A., et al. (2025) · Scandinavian Journal of Immunology · doi:10.1111/sji.70059 · Cited by 1
Advancing influenza virus treatment: in vitro and ex vivo studies of PI3K inhibitor-loaded lipid nanoparticles
Schroeder, J., Ismail, J., Holick, C. T., Jungwirth, J., Klement, L., Hoeppener, S., Kosan, C., Schmidtke, M., Löffler, B., Weber, C., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102587 · Cited by 1
The application development of nanoparticle-based drug delivery systems in combating drug resistance of lung cancer
Li, D., Wang, X., Zhao, J., Shi, M., Chen, B., & Su, G. (2025) · Alexandria Engineering Journal · doi:10.1016/j.aej.2025.12.002 · Cited by 1
Online public concern about allergic rhinitis and its association with COVID-19 and air quality in China: an informative epidemiological study using Baidu index
Yu, Y., Zhang, Q., Yao, X., Wu, J., He, J., He, Y., Jiang, H., Lu, D., & Ye, C. (2024) · BMC Public Health · doi:10.1186/s12889-024-17893-4 · Cited by 1
ALLERGIC REACTIONS WITH SKIN PRICK TEST AND INTRADERMAL TEST FROM THE ANTI COVID 19 VACCINES AT PATIENTS WITH HIGH RISK FOR HYPERSENSITIVITY OUR EXPERIENCE
Svarça, L., Bojadzieva, S., Rashiti, P., & Rashiti-Bytyçi, A. (2024) · Journal of Morphological Sciences · doi:10.55302/jms2471067s · Cited by 1
Petechial Rash and Thrombocytopenia after the Booster Dose of Covid-19 Vaccine: A Case Report and Literature Review
Chowdhury, S., Samia, C., Chowdhury, N. S., Patousis, A., Gerothanasi, A., & Patousis, P. (2022) · International Journal of Immunology and Immunotherapy · doi:10.23937/2378-3672/1410063 · Cited by 1
Alergia a la vacuna Pfizer-BioNTech® demostrada mediante pruebas cutáneas
García, C. D. E., Macías-Robles, A. P., Grimaldo, R. M. C., Alonso, H. L. C., Alcalá, M. B., Nepomuceno, A. R., Amaya, D. E., Hernández, K. G. C., Díaz, B. B., & Campos-Téllez, H. H. (2023) · Revista Alergia México · doi:10.29262/ram.v69i2.1088 · Cited by 1
Immune Responses to Nanomaterials for Biomedical Applications
Bardi, G. (2021) · Nanomaterials · doi:10.3390/nano11051241 · Cited by 1
Are allergic diseases a risk factor for systemic side effects after COVID-19 vaccines?Preprint
Atayık, E., & Aytekin, G. (2022) · medRxiv · doi:10.1101/2022.01.23.22269704 · Cited by 1
Concerns regarding Transfusions of Blood Products Derived from Genetic Vaccine Recipients and Proposals for Specific MeasuresPreprint
Ueda, J., Motohashi, H., Hirai, Y., Yamamoto, K., Murakami, Y., Fukushima, M., & Fujisawa, A. (2024) · Preprints.org · doi:10.20944/preprints202403.0881.v1
Vaccination against COVID-19 Patients with Allergic Diseases. The Position of the Allergologist-Immunologist. Literature review
Markelova, E. V., Knysh, S. V., & Костинов, М. П. (2022) · Epidemiology and Vaccinal Prevention · doi:10.31631/2073-3046-2022-21-2-91-97
Elucidation of co-operative roles of non-specific interactions for poly(ethylene glycol) specific interactions and responses
Shiraishi, K. (2022) · Drug Delivery System · doi:10.2745/dds.37.122
Controversies Around COVID-19 Vaccines and Antidepressants: Scope and Perspective in Malaysia
Ng, C. G., Siew, W. H., Abousheishaa, A. A., Yin, L. S., Sulaiman, A. R. B., & Khin, K. C. (2022) · Current Drug Research Reviews · doi:10.2174/2589977515666221123093522
Pre-Existing Allergies Patients with Higher Viral Load and Longer Recovery Days Infected by SARS-CoV-2 Omicron BA.2 in Shanghai, China, 2022
Wen, R., Li, J., Wang, X., Xu, P., Li, G., Wang, J., Zeng, X., & Liu, C. (2023) · Journal of Asthma and Allergy · doi:10.2147/jaa.s402674
Human β-Defensin 23 as a Carrier for In Vitro and In Vivo Delivery of mRNA
Kim, K., Kim, J., Cho, S., & Ahn, D. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102477
ABDALA, a preventive vaccine against SARS-CoV-2, is safe in Chlorocebus aethiops sabaeus monkeys
Lizet, A., Iliana, S., Carlos, P. J., Mariby, G., Viviana, F., Avelina, L., Rebeca, C., Puente, P., Nancy, E., Valdés, R., et al. (2023) · Advances in Toxicology and Toxic Effects · doi:10.17352/atte.000014
A Comprehensive Review on Covid-19: Pathophysiology and Pharmacotherapy
Gohil Kashmira, J. (2023) · Neuroscience and Neurological Surgery · doi:10.31579/2578-8868/284
Sensibilización a polietilenglicol y polisorbato en pacientes alérgicos con reacciones adversas sistémicas posterior a la vacunación contra COVID-19
Gonzaga, E. F., López, C. C., López-García, A. I., Rivero‐Yeverino, D., López, J. J. R., Tapia, J. S. P., Sánchez, D. M. R., Rivera, A. A., Rodríguez, E. O. J., & Villada, E. V. (2025) · Revista Alergia México · doi:10.29262/ram.v72i4.1535
Additional file 1 of SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
Prieto‐Villalobos, J., Lucero, C. M. J., Rovegno, M., Gómez, G. I., Retamal, M. A., & Orellana, J. A. (2023) · Figshare · doi:10.6084/m9.figshare.24432057
Additional file 7 of Online public concern about allergic rhinitis and its association with COVID-19 and air quality in China: an informative epidemiological study using Baidu index
Yu, Y., Zhang, Q., Yao, X., Wu, J., He, J., He, Y., Jiang, H., Lu, D., & Ye, C. (2024) · Figshare · doi:10.6084/m9.figshare.26676236
Additional file 4 of Online public concern about allergic rhinitis and its association with COVID-19 and air quality in China: an informative epidemiological study using Baidu index
Yu, Y., Zhang, Q., Yao, X., Wu, J., He, J., He, Y., Jiang, H., Lu, D., & Ye, C. (2024) · Figshare · doi:10.6084/m9.figshare.26676227
Additional file 2 of SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
Prieto‐Villalobos, J., Lucero, C. M. J., Rovegno, M., Gómez, G. I., Retamal, M. A., & Orellana, J. A. (2024) · Figshare · doi:10.6084/m9.figshare.24432146
Additional file 2 of Online public concern about allergic rhinitis and its association with COVID-19 and air quality in China: an informative epidemiological study using Baidu index
Yu, Y., Zhang, Q., Yao, X., Wu, J., He, J., He, Y., Jiang, H., Lu, D., & Ye, C. (2024) · Figshare · doi:10.6084/m9.figshare.25138062
Additional file 5 of Online public concern about allergic rhinitis and its association with COVID-19 and air quality in China: an informative epidemiological study using Baidu index
Yu, Y., Zhang, Q., Yao, X., Wu, J., He, J., He, Y., Jiang, H., Lu, D., & Ye, C. (2024) · Figshare · doi:10.6084/m9.figshare.26676230
Additional file 3 of Online public concern about allergic rhinitis and its association with COVID-19 and air quality in China: an informative epidemiological study using Baidu index
Yu, Y., Zhang, Q., Yao, X., Wu, J., He, J., He, Y., Jiang, H., Lu, D., & Ye, C. (2024) · Figshare · doi:10.6084/m9.figshare.26676224
Additional file 8 of Online public concern about allergic rhinitis and its association with COVID-19 and air quality in China: an informative epidemiological study using Baidu index
Yu, Y., Zhang, Q., Yao, X., Wu, J., He, J., He, Y., Jiang, H., Lu, D., & Ye, C. (2024) · Figshare · doi:10.6084/m9.figshare.26676239
Additional file 1 of Online public concern about allergic rhinitis and its association with COVID-19 and air quality in China: an informative epidemiological study using Baidu index
Yu, Y., Zhang, Q., Yao, X., Wu, J., He, J., He, Y., Jiang, H., Lu, D., & Ye, C. (2024) · Figshare · doi:10.6084/m9.figshare.25138009
Additional file 6 of Online public concern about allergic rhinitis and its association with COVID-19 and air quality in China: an informative epidemiological study using Baidu index
Yu, Y., Zhang, Q., Yao, X., Wu, J., He, J., He, Y., Jiang, H., Lu, D., & Ye, C. (2024) · Figshare · doi:10.6084/m9.figshare.26676233
mRNA vaccines against viral pathogens: molecular design, delivery systems, and clinical applications
Xu, W., Wang, J., Liu, X., Lü, M., Zhang, Z. K., & Li, L. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1821852
Levan Inspired Hybrid Composites Materials: Bridging Natural Polysaccharides with Biomedical Technology
Ahuja, V., Solanki, P., Pahal, S., Yang, Y., Bhatia, S. K., & Raina, T. K. (2026) · Macromolecular Bioscience · doi:10.1002/mabi.70208
Safety of Pharmaceutical Nanosuspensions in Drug Delivery: Evidence, Knowledge Gaps, and Safety-By-Design Strategies
Ma, Y., Wang, L., & Wang, Y. (2026) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6c00558
Histamine-Mediated Hypersensitivity Following COVID-19 Vaccination
Borah, A., Tamhane, A., Kulkarni, S., & Pradhan, M. (2026) · Galore International Journal of Health Sciences and Research · doi:10.52403/gijhsr.20260321
RNA therapeutics: current status and future directions
Yang, B., Sedano, M. J., Perez, K. L., Vijayaraghavan, M., Reid, V. A., Yallapu, M. M., Chauhan, S. C., Dhandayuthapani, S., Ramos, E., & Gadad, S. S. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-03032-5 · Cited by 1
mRNA lipid nanoparticle vaccines: current status, challenges and future prospects
吴志能, Lou, J., Cheng, Y., Li, M., Wang, Z., Liu, N., Gao, X., Zheng, A., & Zhang, H. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00600-7
A Modular Glycoengineered Exosome Platform for Targeted Delivery via Chemoenzymatic Engineering of Surface Sialic Acids
Wu, Z., Xu, R., Chen, L., Zhang, L., Wang, S., Fan, X., Wang, Z., Zhang, X., Zhou, Z., Hong, H., et al. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6c01221
Dual-State Tumor-Activated RNA Delivery for Tumor-Selective and Precision Therapy
Song, Y., Jiang, T., Shen, X., Chintrakulchai, W., Yanagida, K., 飯田恵介, Kobayashi, M., Muguruma, K., Honda, Y., Guo, H., et al. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6c16995
Comparative Analysis of Poly(Ethylene Glycol) (PEG) and Poly(2‐Ethyl‐2‐Oxazoline) (PEtOx) for Organic Solvent‐Free Lipid Nanoparticle Formulations
Streiber, M., Holick, C. T., Gath, L., Tsarenko, E., Bachmann, V., Litsiou, S., Harder, L., Rosenberger, L. J., Rusevski, A., Kimmig, J., et al. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.5724119
Vergleich von Polyethylenglykol (PEG) und Poly(2‐ethyl‐2‐oxazolin) (PEtOx) für die lösungsmittelfreie Formulierung von Lipidnanopartikeln
Streiber, M., Holick, C. T., Gath, L., Tsarenko, E., Bachmann, V., Litsiou, S., Harder, L., Rosenberger, L. J., Rusevski, A., Kimmig, J., et al. (2026) · Angewandte Chemie · doi:10.1002/ange.5724119

Authors: Moghimi, S. M.
Affiliations: Newcastle University (GB)
Corresponding author: Moghimi, S. Moein
ORCID: Moghimi, S. Moein
Venue: Molecular Therapy
Publisher: Elsevier BV
Published: 2021-03
Volume: 29
Issue: 3
Pages: 898-900
ISSN: 1525-0016 (ISSN-L)
DOI: 10.1016/j.ymthe.2021.01.030
PMC: PMC7862013
OpenAlex: W3126797562
Cited by: 150
References: 19
Citations by year: 2026: 12 · 2025: 20 · 2024: 33 · 2023: 33 · 2022: 32 · 2021: 20
FWCI: 9.34
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 367 d)
Locations: Molecular Therapy (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
Keywords: allergic reactions, anaphylaxis, COVID-19 vaccines, SARS-CoV-2, BNT162b2, Moderna vaccine, vaccine safety, emergency use authorization
MeSH terms: COVID-19, SARS-CoV-2, COVID-19 Vaccines, mRNA Vaccines, BNT162 Vaccine, 2019-nCoV Vaccine mRNA-1273, Amino Alcohols, Anaphylaxis, Decanoates, Excipients, Humans, Liposomes, Polyethylene Glycols, Vaccines, Synthetic, Mass Vaccination, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks