Effects of isosorbide dinitrate and nitroglycerin on central circulatory dynamics in coronary artery disease
Abstract
This study compares the effects and duration of the effects of 5 mg. of sublingual (SL) isosorbide dinitrate (ISD), 20 mg. of oral ISD, and 0.4 mg. of SL nitroglycerin (TNG) on central circulatory dynamics. Twenty-seven patients with coronary artery disease were evaluated with radioisotope techniques and determinations made of heart rate (HR), blood pressure (BP), cardiac index (CI), stroke volume index (SVI), left ventricular enddiastolic volume index (LVEDVI), and left ventricular ejection fraction (LVEF). There were significant and equivalent reductions in BP, SVI, LVEDVI, and CI 15 minutes after TNG, 1 hour after SL ISD, and 4 hours after oral ISD in addition to comparative increases in HR and EF by all drugs at these same time intervals. The effects of TNG were gone at 30 minutes while changes in LVEDVI, LVEF, and CI were present 4 hours after SL ISD and persistent changes in LVEDVI and SVI present 6 hours after oral ISD. We conclude that nitrates have significant effects on both preload and afterload and that the duration of effects of sublingual and oral ISD are truly long acting as compared to TNG.
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Acute nitrate-releasing agents decrease heart rate, systolic and diastolic blood pressures, and increase left ventricular ejection fraction.
“Acute exploitation of nitrate-releasing agents decreases heart rate, both systolic and diastolic blood pressures and, as a consequence, increases the left ventricular ejection fraction (Battock et al. 1976).”
From Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure (2016) · cites this paper as Battock et al. 1976
Cites
Use of Sublingual Nitroglycerin in Congestive Failure following Acute Myocardial Infarction
Gold, H. K., Leinbach, R. C., & Sanders, C. A. (1972) · Circulation · doi:10.1161/01.cir.46.5.839 · Cited by 236 · see citing works
A hemodynamic study of acute coronary insufficiency precipitated by exercise
Parker, J. O., Giorgi, S. D., & West, R. O. (1966) · The American Journal of Cardiology · doi:10.1016/0002-9149(66)90237-2 · Cited by 186 · see citing works
Clinical and Circulatory Effects of Isosorbide Dinitrate
Goldstein, R. E., Rosing, D. R., Redwood, D. R., BEISER, G. D., & Epstein, S. E. (1971) · Circulation · doi:10.1161/01.cir.43.5.629 · Cited by 172 · see citing works
Studies on Cardiac Dimensions in Intact Unanesthetized Man
Williams, J. F., Glick, G., & D, E. B. M. (1965) · Circulation · doi:10.1161/01.cir.32.5.767 · Cited by 168 · see citing works
Battock, D. J., ALVAREZ, H., & Chidsey, C. A. (1969) · Circulation · doi:10.1161/01.cir.39.2.157 · Cited by 139 · see citing works
Self-citationTherapy of Angina Pectoris with Propranolol and Long-Acting Nitrates
Goldbarg, A. N., Moran, J. F., Butterfield, T. K., NEMICKAS, R., & Bermudez, G. A. (1969) · Circulation · doi:10.1161/01.cir.40.6.847 · Cited by 83 · see citing works
The long-acting hemodynamic effects of isosorbide dinitrate
Sweatman, T. W., Strauss, G. S., Selzer, A., & Cohn, K. E. (1972) · The American Journal of Cardiology · doi:10.1016/0002-9149(72)90436-5 · Cited by 82 · see citing works
Frick, M. H., Balcon, R., Cross, D. F., & Sowton, E. (1968) · Circulation · doi:10.1161/01.cir.37.2.160 · Cited by 72 · see citing works
STEELE, P. P., DYKE, D. V., Trow, R. S., Anger, H. O., & Davies, H. (1974) · Heart · doi:10.1136/hrt.36.2.122 · Cited by 70 · see citing works
Self-citationNajmi, M., GRIGGS, D. M., Kasparian, H., & Novack, P. (1967) · Circulation · doi:10.1161/01.cir.35.1.46 · Cited by 65 · see citing works
Comparative Evaluation of Sublingual Long-Acting Nitrates
Klaus, A. P., Zaret, B. L., Pitt, B., & Ross, R. S. (1973) · Circulation · doi:10.1161/01.cir.48.3.519 · Cited by 48 · see citing works
Propranolol Combined with Isosorbide Dinitrate versus Placebo in Angina Pectoris
Aronow, W. S., & Kaplan, M. A. (1969) · New England Journal of Medicine · doi:10.1056/nejm196904172801601 · Cited by 45 · see citing works
Nitrates in the Prophylactic Treatment of Angina Pectoris
Goldstein, R. E., & Epstein, S. E. (1973) · Circulation · doi:10.1161/01.cir.48.5.917 · Cited by 41 · see citing works
Kasparian, H., Wiener, L., Duca, P. R., Gottlieb, R. S., & Brest, A. N. (1975) · American Heart Journal · doi:10.1016/0002-8703(75)90258-6 · Cited by 38 · see citing works
Isosorbide Dinitrate in Angina
Battock, D. J., & Chidsey, C. A. (1971) · Circulation · doi:10.1161/01.cir.44.6.1147 · Cited by 4 · see citing works
Self-citationBeta Adrenergic Blockade and Combination Therapy in Coronary Artery Disease1
Battock, D. J., & Chidsey, C. A. (2015) · Advances in cardiology · doi:10.1159/000387644 · Cited by 2 · see citing works
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Nitrates and Nitrites in the Treatment of Ischemic Cardiac Disease
Nossaman, V. E., Nossaman, B. D., & Kadowitz, P. J. (2010) · Cardiology in Review · doi:10.1097/crd.0b013e3181c8e14a · Cited by 116 · see citing works
Lee, G. A., Mason, D. T., & DeMaria, A. N. (1978) · The American Journal of Cardiology · doi:10.1016/0002-9149(78)90136-4 · Cited by 96 · see citing works
Berger, H. J., Matthay, R. A., Pytlik, L., GOTTSCHALK, A. R., & Zaret, B. L. (1979) · Seminars in Nuclear Medicine · doi:10.1016/s0001-2998(79)80014-8 · Cited by 83 · see citing works
Nossaman, B. D., Pankey, E. A., & Kadowitz, P. J. (2012) · Critical Care Research and Practice · doi:10.1155/2012/290805 · Cited by 70 · see citing works
Gherbesi, E., Gianstefani, S., Angeli, F., Ryabenko, K., Bergamaschi, L., Armillotta, M., Guerra, E., Tuttolomondo, D., Gaibazzi, N., Squeri, A., et al. (2024) · Echocardiography · doi:10.1111/echo.15753 · Cited by 66 · see citing works
Ammirati, F., Colivicchi, F., Biffi, A., Magris, B., Pandozi, C., & Santini, M. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70284-4 · Cited by 54 · see citing works
Nitrates: Why and how should they be used today?
Silber, S. (1990) · European Journal of Clinical Pharmacology · doi:10.1007/bf01417564 · Cited by 50 · see citing works
Chander, A., Brenner, M., Läutamaki, R., Voicu, C., Merrill, J., & Bengel, F. M. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.053819 · Cited by 48 · see citing works
Alsop, P., & Hauton, D. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3418-7 · Cited by 37 · see citing works
Nitrate’s Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction Trial
Zakeri, R., Levine, J. A., Koepp, G. A., Borlaug, B. A., Chirinos, J. A., LeWinter, M. M., VanBuren, P., Dávila‐Román, V. G., Fuentes, L. D. L., Khazanie, P., et al. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001598 · Cited by 37 · see citing works
Nitroglycerin and nitrate esters
Warren, S. E., & Francis, G. S. (1978) · The American Journal of Medicine · doi:10.1016/0002-9343(78)90692-7 · Cited by 27 · see citing works
Zhao, N., Xu, J., Singh, B., Yu, X., Wu, T., & Huang, Y. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010726.pub2 · Cited by 25 · see citing works
Nitrate Therapy for Angina Pectoris
Corwin, S. (1985) · Archives of Internal Medicine · doi:10.1001/archinte.1985.00360030186032 · Cited by 24 · see citing works
STEELE, P. P., Rainwater, J. O., Jensen, D. P., Vogel, R. A., & Battock, D. J. (1978) · CHEST Journal · doi:10.1378/chest.74.5.526 · Cited by 19 · see citing works
Self-citationSTEELE, P. P., Maddoux, G. L., Kirch, D. L., & Vogel, R. A. (1978) · CHEST Journal · doi:10.1378/chest.73.1.19 · Cited by 18 · see citing works
Self-citationAbshagen, U. (1985) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-69524-7_10 · Cited by 14 · see citing works
Osuna, P. P., Moreno, L. M. G., Jiménez, A., Sánchez-Castillo, A. S., Luengo, C. M., Hernández, J., Bazo, L. C., Bueno, M. C., Domínguez, M. D., & Ledesma, C. (1985) · The American Journal of Cardiology · doi:10.1016/0002-9149(85)90370-4 · Cited by 12 · see citing works
Fiedler, V. B., & Nitz, R. (1981) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00506260 · Cited by 11 · see citing works
Hemodynamic effects of high-dose sustained-action oral isosorbide dinitrate in stable angina
Udhoji, V. N., & Heng, M. K. (1984) · The American Journal of Medicine · doi:10.1016/0002-9343(84)90778-2 · Cited by 10 · see citing works
Effect of nitrate on determinants of myocardial oxygen consumption during exercise
Crawford, M. H., & Amon, K. W. (1982) · International Journal of Cardiology · doi:10.1016/0167-5273(82)90093-6 · Cited by 9 · see citing works
Nitroglycerin Ointment: a Review
Francis, G. S., & Hagan, A. D. (1977) · Angiology · doi:10.1177/000331977702801208 · Cited by 7 · see citing works
Simonetti, I., Michelassi, C., Caterina, R. D., Marzilli, M., & L’Abbate, A. (1989) · American Heart Journal · doi:10.1016/0002-8703(89)90775-8 · Cited by 6 · see citing works
Stimulators of soluble guanylyl cyclase: future clinical indications.
Nossaman, B. D., & Kadowitz, P. J. (2013) · Europe PMC (PubMed Central) · Cited by 5 · see citing works
Usefulness of vasodilator therapy in acute and chronic valvular regurgitation
Greenberg, B., & Rahimtoola, S. H. (1984) · Current Problems in Cardiology · doi:10.1016/0146-2806(84)90014-8 · Cited by 5 · see citing works
Current Management of Heart Failure with Preserved Ejection Fraction
Patel, A. H., Natarajan, B., & Pai, R. G. (2022) · International Journal of Angiology · doi:10.1055/s-0042-1756173 · Cited by 3 · see citing works
Zhao, N., Xu, J., Singh, B., Wu, T., & Yu, X. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010726 · Cited by 1 · see citing works
Razzolini, R., Chioin, R., Corbara, F., Calvanese, A., Miraglia, G., Egloff, C., Maiolino, P., Mario, C. D., & Volta, S. D. (1987) · International Böhringer Mannheim symposia · doi:10.1007/978-3-642-72689-7_30 · Cited by 1 · see citing works
DeMaria, A. N., Lee, G. A., & Mason, D. T. (1983)
Nitrate: Warum und wie sie heute eingesetzt werden sollten
Silber, S. (1991) · European Journal of Clinical Pharmacology · doi:10.1007/bf01418411
臨床 急性心筋梗塞症における血行動態とニトログリセリン静注法による vasodilator 療法(第1報)
道昭, 廣., 守衛, 関., 川守田, 英., 正彦, 青., 長村, 好., 岳, マ., 廣沢弘七郎, 真弘, 遠., & 昌道, 中. (1979) · 心臓 · doi:10.11281/shinzo1969.11.5_494
DeMaria, A. N., Lee, G. A., Low, R. I., & Mason, D. T. (1983) · Steinkopff eBooks · doi:10.1007/978-3-642-85323-4_14
Schneider, W., & Kaltenbach, M. (1984) · Springer eBooks · doi:10.1007/978-3-642-69451-6_34
DeMaria, A. N., Lee, G. A., Low, R. I., & Mason, D. T. (1983) · Steinkopff eBooks · doi:10.1007/978-3-662-12598-4_14
- Authors
- Battock, D. J., Levitt, P. W., & Steele, P. P.
- Corresponding author
- Battock, Dennis J.
- Venue
- American Heart Journal
- Publisher
- Elsevier BV
- Published
- 1976-10
- Volume
- 92
- Issue
- 4
- Pages
- 455-458
- ISSN
- 0002-8703 (ISSN-L)
- OpenAlex
- W2048632716
- Cited by
- 33
- References
- 17
- Citations by year
- 2024: 1 · 2022: 1 · 2016: 2 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- isosorbide dinitrate, nitroglycerin, coronary artery disease, nitrate, sublingual administration, oral administration, preload, afterload, left ventricular ejection fraction, stroke volume, left ventricular end-diastolic volume, cardiac index, blood pressure, heart rate, duration of drug action
- MeSH terms
- Administration, Oral, Blood Pressure, Cardiac Output, Cardiac Volume, Coronary Disease, Nitroglycerin, Heart Rate, Hemodynamics, Humans, Isosorbide Dinitrate, Male
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