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Usefulness of corticosteroid therapy in decreasing epinephrine requirements in critically ill infants with congenital heart disease
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“The use of glucocorticoids for catecholamine-resistant shock in the neonatal and pediatric population is another strategy that may be of benefit, including following cardiac surgery [19-21].”
From Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease (2016) · cites this paper as [20]
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No references could be resolved yet.
Research works printed but not linked: 7
- Hatherill, 1999, Adrenal insufficiency in septic shock, Arch Dis Child, 80, 51, 10.1136/adc.80.1.51 · DOI
- Duggan, 1998, Adrenal failure in the critically ill, Br J Anaesth, 81, 468, 10.1093/bja/81.3.468 · DOI
- Sasidharan, 1998, Role of corticosteroids in neonatal blood pressure homeostasis, Clin Perinatol, 25, 723, 10.1016/S0095-5108(18)30108-8 · DOI
- Anand, 1990, Hormonal-metabolic stress responses in neonates undergoing cardiac surgery, Anesthesiology, 73, 661, 10.1097/00000542-199010000-00012 · DOI
- Wernovsky, 1995, Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants, Circulation, 92, 2226, 10.1161/01.CIR.92.8.2226 · DOI · Paper page
- Weiskopf, 1985, Adrenal function following coronary bypass surgery, Am Heart J, 110, 71, 10.1016/0002-8703(85)90517-4 · DOI
- Wan, 1997, Inflammatory response to cardiopulmonary bypass, Chest, 112, 676, 10.1378/chest.112.3.676 · DOI
Cited by
Sorted by citations
Items 101–123 of 123
Steroid replacement therapy for severe heart failure after Norwood procedure
Inafuku, H., Takeuchi, M., Tachibana, K., & Imanaka, H. (2007) · Journal of Anesthesia · doi:10.1007/s00540-007-0552-8 · Cited by 2
“However, reports are limited regarding steroid replacement therapy in post-cardiac surgery neonates [5].”
BackgroundThe effects of thyroid hormones levels on prognosis after pediatric heart surgery
Gurcu, E., Yuksel, A., Velioglu, Y., & Signak, I. S. (2019) · Medical Science · doi:10.5455/medscience.2018.07.8969 · Cited by 2
“Many studies show that inotropic index is an important independent indicator in the mortality and the morbidity of children operated for congenital heart disease [5,6].”
BackgroundPediatric Anesthesia and Critical Care
Odegard, K. C., & Laussen, P. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5225-8.00111-2 · Cited by 2
Jones, S. (2025) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2025.4268 · Cited by 1
Shahzad, M., Alheraish, Y. A., Beheri, R., & Alarwan, K. (2023) · JOURNAL OF PEDIATRIC CRITICAL CARE · doi:10.4103/jpcc.jpcc_58_23 · Cited by 1
Chen, P.-J., Yeh, Y., Huang, C.-H., Wei, T., Lai, C., Yang, Y.-P., Chen, Y.-S., Wang, C.-H., & Lee, C.-T. (2023) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2023.03.069 · Cited by 1
Adenosine as cardioprotective in off-pump coronary artery bypass grafting
Aziz, M. M. A., Hamid, A., & Hamid, H. (2019) · Ain Shams Journal of Anesthesiology · doi:10.1186/s42077-019-0049-3 · Cited by 1
The Role of Prophylactic Postoperative Steroids in Pediatric Cardiac Operations
Graham, E. (2015) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000465 · Cited by 1
Epstein, D., & Markovitz, B. (2011) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3181fe290d · Cited by 1
Endocrine Function in Critical Heart Disease
Iliopoulos, I. D., Huff, C., & Graham, E. (2019) · Critical Heart Disease in Infants and Children · doi:10.1016/b978-1-4557-0760-7.00018-8 · Cited by 1
General Pre-Operative and Post-Operative Considerations in Pediatric Cardiac Patients
Dickerson, H. A., & Cabrera, A. G. (2013) · Springer eBooks · doi:10.1007/978-1-4471-4619-3_98 · Cited by 1
Ji, Q., Mei, Y., Wang, X.-S., Feng, J., Cai, J.-Z., Sun, Y.-F., & Dewei, W. (2010) · Perfusion · doi:10.1177/0267659110377818
Endocrine Effects of Arginine-Vasopressin After Pediatric Cardiac Surgery
Iliopoulos, I. D., Flores, S., Coghill, M., Koh, W., Alten, J. A., Cooper, D. S., Seo, J. D., & Loomba, R. S. (2025) · Pediatric Cardiology · doi:10.1007/s00246-025-04049-3
“This is in keeping with prior reports that have indicated that corticosteroids blunt systemic inflammatory response after cardiopulmonary bypass and aid postoperative recovery [20, 21].”
To Give or Not to Give? Corticosteroid Therapy in the Pediatric Cardiac ICU Is the Question
Wozniak, M. J., Mayer, S. L., & Zimmerman, J. J. (2025) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000003767
Wei, T., Wang, C.-H., Chan, W.-S., Yeh, Y.-C., Lai, C., Chao, A., Huang, C.-H., Wang, M.-J., Cheng, Y., Chen, Y.-S., et al. (2020) · doi:10.21203/rs.2.22931/v1
“The inotropic score was calculated as 100 × epinephrine dose (mcg/kg/min) + 100 × norepinephrine dose (mcg/kg/min) + dopamine dose (mcg/kg/min) + dobutamine dose (mcg/kg/min) [14].”
MethodLee, C.-T., Tu, Y.-K., Yeh, Y.-C., Chang, T., Shih, P., Chao, A., Huang, H.-H., Cheng, Y., & Yeh, Y. (2018) · Journal of critical care · doi:10.1016/j.jcrc.2017.04.046
“Inotropic score was calculated as 100 × epinephrine dose (mcg/kg/min)+100×norepinephrine dose (mcg/kg/min)+dopamine dose (mcg/kg/min) + dobutamine dose (mcg/kg/min) [15].”
MethodThe role of corticosteroid in septic shock patients.
Zhou, X.-S., Ye, Y., Li, J., & Tang, G.-H. (2018) · Journal of critical care · doi:10.1016/j.jcrc.2017.11.015
Fenoldopam use in a burn intensive care unit: a retrospective study
Simmons, J. W., Chung, K. K., Renz, E., White, C. E., Cotant, C. L., Tilley, M. A., Hardin, M. O., Jones, J. A., Blackbourne, L. H., & Wolf, S. E. (2010) · BMC Anesthesiology · doi:10.1186/1471-2253-10-9
“The dose of vasoactive agents is expressed as the modified inotropic score, a dimensionless variable calculated as (dobutamine dose × 1) + (norepinephrine dose × 100) + (vasopressin dose × 100), wherein dobutamine and norepinephrine doses are expressed as μg/kg/min and vasopressin dose is expressed as units/min [30-33…”
Recognition and Treatment of Low Cardiac Output States in Pediatric Cardiac Intensive Care
Byrnes, J. W., & Nelson, D. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802393-8.00043-0
Self-citationComparison of Transcutaneous and Intra-Arterial Blood Gas Monitoring in Pediatric Cardiac Surgery
Akyüz, M., Işık, O., Karakuş, E., Ayık, M., & Atay, Y. (2017) · doi:10.12956/tjpd.2017.323
“(5) tarafından tanımlanmış olup inotropik skor = dopamin mcg/kg/min × 1 + dobutamin mcg/kg/min × 1 + milrinon mcg/kg/min × 15 + epinefrin mcg/kg/min × 100 olarak hesaplanmıştır.”
Critical Care in Pediatric Cardiac Surgery
Kaulitz, R., Thompson, A. L., & Ziemer, G. (2017) · Springer eBooks · doi:10.1007/978-3-662-52672-9_10
Peri-operative Care of the Child with Congenital Heart Disease
Floh, A. A., Krawczeski, C. D., & Schwartz, S. M. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6359-6_25
Self-citationIntensivtherapie in der Kinderherzchirurgie
Kaulitz, R., & Ziemer, G. (2010) · Springer eBooks · doi:10.1007/978-3-540-79713-5_8
Metadata
- Authors
- Shore, S., Nelson, D. P., Pearl, J. M., Manning, P. B., Wong, H., Shanley, T. P., Keyser, T., & Schwartz, S. M.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Schwartz, Steven M
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 88
- Issue
- 5
- Pages
- 591-594
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2172221324
- Cited by
- 141
- References
- 0
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 11 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 5 · 2013: 8 · 2012: 6
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Cardiovascular Conditions and Treatments
- Keywords
- glucocorticoids, epinephrine requirement, congenital heart disease, critically ill infants, inotropic requirement, hemodynamic instability, neonatal cardiac surgery, adrenal insufficiency, stress response
- MeSH terms
- Adrenal Cortex Hormones, Dose-Response Relationship, Drug, Drug Interactions, Drug Therapy, Combination, Epinephrine, Female, Follow-Up Studies, Heart Defects, Congenital, Hemodynamics, Humans, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Male, Retrospective Studies, Severity of Illness Index, Critical Illness, Treatment Outcome
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