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Cited by 99Cardiac pacing and defibrillation studiesCardiovascular and exercise physiologyCardiac Health and Mental Health

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Exercise performance following cardiac resynchronization therapy in patients with heart failure and ventricular conduction delay

Auricchio, Angelo, Kloss, Michael, Trautmann, Silke Isabelle, Rodner, Susanne, Klein, Helmut·2002·The American Journal of Cardiology
DOI 10.1016/s0002-9149(01)02200-7
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Abstract

Patients with heart failure (HF) frequently have an impaired heart rate response to exercise and reduced oxygen consumption (VO(2)). Cardiac resynchronization therapy (CRT) has been shown to increase functional capacity in patients with HF and conduction delay. However, detailed analysis of improvement in functional capacity after CRT is still lacking. This study aimed to provide a detailed analysis of the changes in metabolic, ventilation parameters, and heart rate profiles in patients with HF and ventricular conduction delay following implantation with resynchronization devices. We provided a retrospective review on 50 patients in New York Heart Association functional class >II, with left ventricular ejection fraction <35%, on optimal medical therapy, and whose functional capacity was evaluated by cardiopulmonary exercise testing before and after CRT. Detailed analysis of VO(2), carbon dioxide production (VCO(2)), heart rate, minute ventilation (V(E) [liters per minute]), tidal volume (V(T)), respiratory rate, and heart rate profile during exercise were performed. Following CRT, peak VO(2) increased significantly from 14 +/- 4 to 17 +/- 4 (p <0.0001), and VO(2) at anaerobic threshold increased from 9 +/- 2 to 12 +/- 3 (p <0.001). All ventilation and metabolic parameters significantly increased following CRT. Similarly, heart rate at rest significantly decreased after CRT (76 +/- 12 vs 72 +/- 12 beats/min, p <0.05), whereas the maximum achieved heart rate increased significantly from 119 +/- 20 to 125 +/- 24 beats/min (p <0.05). The proportion of patients with chronotropic incompetence was significantly reduced after CRT (50% before CRT vs 34.7 after CRT; p <0.05). Patients with the baseline peak VO(2) <14 ml/kg/min benefited most from the implantation of a CRT device. In conclusion, CRT significantly improves all ventilation and metabolic parameters of patients with HF and conduction delay. Patients with more depressed metabolic and ventilation parameters and higher heart rate at baseline seem to benefit most from this therapeutic approach.

Overview

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Crossref · 10.1016/s0002-9149(01)02200-7

Cites

26 of 26 references verified0 citation errors · 0 not checkable

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  • A number of treatments ranging from pharmacological such as intravenous iron, device therapies such as cardiac resynchronization therapy, and non-pharmacological options such as aerobic exercise are associated with improved exercise capacity.

    “A number of treatments ranging from pharmacological such as intravenous iron, device therapies such as cardiac resynchronization therapy, and non‐pharmacological options such aerobic exercise are associated with improved exercise capacity. 41 , 42 , 43”

    From Prioritizing symptom management in the treatment of chronic heart failure (2020) · cites this paper as [43]

Citations

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Research works printed but not linked: 4

  1. Martin, 1999, The metabolic-chronotropic relation in patients with heart failure, Rev Port Cardiol, 18, 887
  2. Auricchio, 2000, Long-term benefit as a result of pacing resynchronization in congestive heart failure, Circulation, 102, II-693
  3. Saxon, 1998, The magnitude of sympathoneural activation in advanced heart failure is altered with chronic biventricular pacing, PACE, 21, 914
  4. Breithard, 2000, Non-invasive determination of optimal pacing site by doppler echocardiography in comparison to invasive hemodynamic testing, J Am Coll Cardiol, 35, 117A

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Metadata

Authors
Auricchio, A., Kloss, M., Trautmann, S. I., Rodner, S., & Klein, H.
Affiliations
University Hospital Magdeburg (DE)
Corresponding author
Auricchio, Angelo
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
2002-01
Volume
89
Issue
2
Pages
198-203
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/s0002-9149(01)02200-7
OpenAlex
W2049511322
Cited by
99
References
26
Citations by year
2026: 1 · 2025: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 5
FWCI
5.47
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
cardiac resynchronization therapy, heart failure, ventricular conduction delay, exercise capacity, peak oxygen uptake, chronotropic incompetence, heart rate response to exercise, ventilatory parameters, CO2 emissions, anaerobic threshold, functional capacity
MeSH terms
Adaptation, Physiological, Analysis of Variance, Cardiac Pacing, Artificial, Exercise Test, Female, Heart Conduction System, Heart Failure, Heart Rate, Humans, Male, Middle Aged, Oxygen Consumption, Pulmonary Ventilation, Retrospective Studies, Exercise, Treatment Outcome, Exercise Tolerance, Ventricular Dysfunction, Left

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