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Cited by 111Acute Myocardial Infarction ResearchAntiplatelet Therapy and Cardiovascular DiseasesCardiac Ischemia and Reperfusion

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Timing of aspirin administration as a determinant of survival of patients with acute myocardial infarction treated with thrombolysis

Freimark, Dov, Matetzky, Shlomo, Leor, Jonathan, Boyko, Valentina, Barbash, Israel M, Behar, Solomon, Hod, Hanoch·2002·The American Journal of Cardiology
DOI 10.1016/s0002-9149(01)02256-1
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Abstract

Unlike thrombolytic agents, there are conflicting data regarding the time-dependent effect of aspirin treatment on outcome in acute myocardial infarction (AMI). We sought to evaluate the impact of timing of aspirin administration (before vs after thrombolysis) on mortality of patients with AMI. Our study included 1,200 patients with ST elevation AMI treated with thrombolysis. Early (n = 364) versus late (n = 836) users were defined as those receiving emergency aspirin before versus after initiation of thrombolysis, respectively. Time (median) from symptom onset to initiation of aspirin treatment was significantly shorter in early versus late users (1.6 vs 3.5 hours; p <0.001). There were no significant differences between the 2 groups with respect to baseline clinical characteristics. Early aspirin users were more likely to develop reischemia, to be treated with beta blockers, to be referred to coronary angiography, percutaneous transluminal coronary angioplasty, or coronary artery bypass graft surgery. Early users experienced lower mortality at 7 days (2.5% vs 6.0%, p = 0.01), 30 days (3.3% vs 7.3%, p = 0.008), and 1 year (5.0% vs 10.6%, p = 0.002) than late users. This survival benefit persisted for patients with and without previous aspirin therapy or revascularization and after adjustment for baseline characteristics and therapies at 7 days (odds ratio 0.36, 95% confidence interval 0.15 to 0.79), at 30 days (odds ratio 0.39, 95% confidence interval 0.17 to 0.82), and at 1 year (odds ratio 0.41, 95% confidence interval 0.21 to 0.74). Our study proposes a time-dependent benefit from aspirin in patients with AMI treated with thrombolysis.

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Crossref · 10.1016/s0002-9149(01)02256-1

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Research works printed but not linked: 1

  1. 1988, Randomised trial of intravenous streptokinase oral aspirin both, or neither among 17,187 cases of suspected acute myocardial infarction, Lancet, 2, 349

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Metadata

Authors
Freimark, D., Matetzky, S., Leor, J., Boyko, V., Barbash, I. M., Behar, S., & Hod, H.
Affiliations
Tel Aviv University (IL)
Corresponding author
Leor, Jonathan
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
2002-02
Volume
89
Issue
4
Pages
381-385
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/s0002-9149(01)02256-1
OpenAlex
W2004590941
Cited by
111
References
16
Citations by year
2026: 3 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 10 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 21 · 2014: 3 · 2013: 3 · 2012: 5
FWCI
2.62
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Keywords
aspirin, acute myocardial infarction, thrombolysis, ST-elevation myocardial infarction, timing of drug administration, mortality, beta-blockers, revascularization, coronary angioplasty, coronary artery bypass grafting
MeSH terms
Aged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Female, Humans, Male, Middle Aged, Myocardial Infarction, Thrombolytic Therapy, Survival Analysis, Randomized Controlled Trials as Topic

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