The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Prognostic value of heart rate variability in chronic congestive heart failure (Veterans Affairs’ Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure)
Abstract
Although the value of heart rate variability (HRV) for risk stratification after acute myocardial infarction has been demonstrated, the value of low HRV as a predictor of sudden cardiac death in patients with ischemic cardiomyopathy has not been shown convincingly to date. We retrospectively analyzed electrocardiographic data from 179 patients in the Veterans Affairs' Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure to determine if HRV (expressed as the SD of the normal-to-normal RR intervals [SDNN]) would be useful as a predictor of overall mortality and sudden death. Because our goal was to identify high-risk patients, we compared patients in the lowest quartile of HRV with the remaining patients. Among the 127 patients meeting inclusion criteria, SDNN <65.3 ms (the lowest quartile) was the sole independent factor predictive of survival in a multivariate model (p = 0.0001). A Cox proportional-hazards model revealed that each increase of 10 ms in SDNN conferred a 20% decrease in risk of mortality (p = 0.0001). Furthermore, patients with SDNN <65.3 ms had a significantly increased risk of sudden death (p = 0.016). Thus, HRV was the sole independent predictor of overall mortality and was significantly associated with sudden death in this population.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Sudden death, increased morbidity and mortality following cardiac surgery in hostile or depressed patients, and increased death rates in patients with sepsis or organ failure are linked clinically to decreased vagus nerve activity (50)(51)(52)(53)(54).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [52]
Citations
Cites
Kleiger, R. E., Miller, J. P., Bigger, J. T., & Moss, A. J. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)90795-8 · Cited by 3,995
Rovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120
Frequency domain measures of heart period variability and mortality after myocardial infarction
Bigger, J. T., Fleiss, J. L., Steinman, R. C., Rolnitzky, L. M., Kleiger, R. E., & Rottman, J. N. (1992) · Circulation · doi:10.1161/01.cir.85.1.164 · Cited by 1,712
Risk Stratification and Survival after Myocardial Infarction
The Multicenter Postinfarction Research Group (1983) · New England Journal of Medicine · doi:10.1056/nejm198308113090602 · Cited by 1,599
Amiodarone in Patients with Congestive Heart Failure and Asymptomatic Ventricular Arrhythmia
Singh, S. N., Fletcher, R. D., Fisher, S. G., Singh, B. N., Lewis, H. D., DEEDWANIA, P. C., Massie, B. M., Colling, C. L., & Lazzeri, D. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507133330201 · Cited by 1,217
Self-citationNolan, J., Batin, P. D., Andrews, R., Lindsay, S. J., Brooksby, P., Mullen, M., Baig, W., Flapan, A. D., Cowley, A., Prescott, R. J., et al. (1998) · Circulation · doi:10.1161/01.cir.98.15.1510 · Cited by 1,179
Farrell, T. G., Bashir, Y., Cripps, T., Malík, M., Poloniecki, J. D., Bennett, E., Ward, D. E., & Camm, A. J. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90791-7 · Cited by 730
ODEMUYIWA, O., Malík, M., Farrell, T., Bashir, Y., Poloniecki, J. D., & Camm, J. A. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90774-f · Cited by 370
Bigger, J. T., Fleiss, J. L., Rolnitzky, L. M., & Steinman, R. C. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90106-b · Cited by 334
Cripps, T., Malík, M., Farrell, T., & Camm, A. J. (1991) · Heart · doi:10.1136/hrt.65.1.14 · Cited by 299
Cited by
Sorted by citations
Physiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563
Sztajzel, J. M. (2004) · Swiss Medical Weekly · doi:10.4414/smw.2004.10321 · Cited by 782
Improvements in heart rate variability with exercise therapy
Routledge, F. S., Campbell, T. S., McFetridge-Durdle, J. A., & Bacon, S. L. (2010) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(10)70395-0 · Cited by 381
Posttraumatic Stress Disorder, Cardiovascular, and Metabolic Disease: A Review of the Evidence
Dedert, E. A., Calhoun, P. S., Watkins, L. L., Sherwood, A., & Beckham, J. C. (2010) · Annals of Behavioral Medicine · doi:10.1007/s12160-010-9165-9 · Cited by 263
Vulnerable Atherosclerotic Plaque
Casscells, W., Naghavi, M., & Willerson, J. T. (2003) · Circulation · doi:10.1161/01.cir.0000069329.70061.68 · Cited by 237
Metadata
- Authors
- Bilchick, K. C., Fetics, B., Djoukeng, R., Gross Fisher, S., Fletcher, R. D., Singh, S. N., Nevo, E., & Berger, R. D.
- Affiliations
- Johns Hopkins University (US)
- United States Department of Veterans Affairs (US)
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 90
- Issue
- 1
- Pages
- 24-28
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2122859962
- Cited by
- 288
- References
- 20
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 3 · 2021: 17 · 2020: 13 · 2019: 12 · 2018: 12 · 2017: 14 · 2016: 10 · 2015: 9 · 2014: 16 · 2013: 15 · 2012: 10
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r44hl061903-03)
- National Heart, Lung, and Blood Institute (P50-HL52307, P50HL052307, R44 HL61903)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- heart rate variability, chronic congestive heart failure, SDNN, all-cause mortality, sudden cardiac death, risk stratification, antiarrhythmic therapy, veterans
- MeSH terms
- Aged, Amiodarone, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Chronic Disease, Female, Heart Failure, Heart Rate, Humans, Male, Predictive Value of Tests, Prognosis, Retrospective Studies, Risk Factors, Stroke Volume, United States, United States Department of Veterans Affairs, Electrocardiography, Ambulatory, Comorbidity, Multivariate Analysis, Proportional Hazards Models, Survival Analysis, Death, Sudden, Cardiac, Myocardial Ischemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
