The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Circadian Variation in the Onset of Unstable Angina and Non-Q-Wave Acute Myocardial Infarction (The TIMI III Registry and TIMI IIIB)
Abstract
Circadian variation has been demonstrated in several types of acute cardiovascular disease, including acute myocardial infarction (AMI), sudden cardiac death, silent ambulatory ischemia, and thrombotic stroke. In contrast, no diurnal variation was observed in 1 study of non-Q-wave AMI, and limited data are available for unstable angina. To assess whether circadian variation is present in unstable angina and non-Q-wave AMI, we examined the time of onset of ischemic pain in 7,731 patients who were prospectively identified in the Thrombolysis in Myocardial Ischemia (TIMI) III Registry, 3,318 of whom were enrolled in the prospective study, and in 1,473 patients enrolled in the TIMI IIIB trial. A circadian variation in the onset of pain was observed, with an increase in the number of patients experiencing the onset of pain in the morning hours between 6 A.M. and 12 noon (p <0.001). This circadian variation was observed both in patients with unstable angina and in those with evolving non-Q-wave AMI. A similar circadian pattern was observed in all subgroups tested. These findings were confirmed in the TIMI IIIB trial and complement previous studies suggesting that circadian variation exists in the onset of the full spectrum of myocardial ischemic syndromes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Epidemiological studies show that adverse cardiovascular events peak in the morning (i.e., between 6 AM and noon)”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Cannon et al., 1997
Citations
Cites
Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction
Muller, J. E., Stone, P. H., Turi, Z. G., Rutherford, J. D., Czeisler, C. A., Parker, C., Poole, W. K., Passamani, E., Roberts, R., Robertson, T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132103 · Cited by 1,884
Mittleman, M. A., Maclure, M., Tofler, G. H., Sherwood, J. B., Goldberg, R. J., & Muller, J. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312023292301 · Cited by 1,431
Self-citationCircadian variation and triggers of onset of acute cardiovascular disease.
Muller, J. E., Tofler, G. H., & Stone, P. H. (1989) · Circulation · doi:10.1161/01.cir.79.4.733 · Cited by 1,426
Circadian variation in the frequency of sudden cardiac death.
Muller, J. E., Ludmer, P. L., Willich, S. N., Tofler, G. H., Aylmer, G., Klangos, I., & Stone, P. H. (1987) · Circulation · doi:10.1161/01.cir.75.1.131 · Cited by 1,083
Physical Exertion as a Trigger of Acute Myocardial Infarction
Willich, S. N., Lewis, M., Lowel, H., Arntz, H.-R., Schubert, F., & Schroder, R. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312023292302 · Cited by 682
Willich, S. N., Levy, D., Rocco, M. B., Tofler, G. H., Stone, P. H., & Muller, J. E. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)91027-7 · Cited by 653
Morning increase in onset of ischemic stroke.
Marler, J. R., Price, T. R., Clark, G., Muller, J. E., Robertson, T., Mohr, J. P., Hier, D. B., Wolf, P. A., Caplan, L. R., & Foulkes, M. A. (1989) · Stroke · doi:10.1161/01.str.20.4.473 · Cited by 515
Circadian variation of transient myocardial ischemia in patients with coronary artery disease.
Rocco, M. B., Barry, J., Campbell, S., Nabel, E. G., Cook, E. F., Goldman, L., & Selwyn, A. P. (1987) · Circulation · doi:10.1161/01.cir.75.2.395 · Cited by 510
McManus, J. L. (1994) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(94)70199-7 · Cited by 483
Willich, S. N., Linderer, T., Wegscheider, K., Leizorovicz, A., Alamercery, I., & Schröder, R. (1989) · Circulation · doi:10.1161/01.cir.80.4.853 · Cited by 374
Stone, P. H. (1996) · JAMA · doi:10.1001/jama.275.14.1104 · Cited by 365
CIRCADIAN VARIATION OF TOTAL ISCHAEMIC BURDEN AND ITS ALTERATION WITH ANTI-ANGINAL AGENTS
Mulcahy, D., Cunningham, D., Crean, P., Wright, C., Keegan, J., Quyyumi, A. A., Park, A., & Fox, K. M. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92414-2 · Cited by 315
Ridker, P. M., Manson, J. E., Buring, J. E., Muller, J. E., & Hennekens, C. H. (1990) · Circulation · doi:10.1161/01.cir.82.3.897 · Cited by 285
Self-citationStone, P. H. (1996) · JAMA · doi:10.1001/jama.1996.03530380046030 · Cited by 238
Diurnal Variation of and Activity during the Onset of Stroke
Tsementzis, S. A., Gill, J. S., Hitchcock, E. R., Gill, S. K., & Beevers, D. G. (1985) · Neurosurgery · doi:10.1227/00006123-198512000-00005 · Cited by 232
Tofler, G. H., Muller, J. E., Stone, P. H., Forman, S. A., Solomon, R. E., Knatterud, G. L., & Braunwald, E. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90356-r · Cited by 179
Andrews, T. C., Fenton, T. R., Toyosaki, N., Glasser, S. P., Young, P. M., MacCallum, G., Gibson, R. S., Shook, T., & Stone, P. H. (1993) · Circulation · doi:10.1161/01.cir.88.1.92 · Cited by 161
Propranolol and the morning increase in the frequency of sudden cardiac death (BHAT study)
Peters, R. W., Muller, J. E., Goldstein, S., Byington, R. P., & Friedman, L. M. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90019-2 · Cited by 146
Triggering of Acute Myocardial Infarction by Heavy Physical Exertion
Mittleman, M. A., Maclure, M., Tofler, G. H., Sherwood, J. B., Goldberg, R. J., & Muller, J. E. (1994) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-199405010-00010 · Cited by 120
Time of onset of chest pain in acute myocardial infarction
Thompson, D. R., Blandford, R. L., Sutton, T. W., & Marchant, P. (1985) · International Journal of Cardiology · doi:10.1016/0167-5273(85)90354-7 · Cited by 91
Previous Aspirin Use May Attenuate the Severity of the Manifestation of Acute Ischemic Syndromes
David Garcia-dorado, A., Théroux, P., Tornos, P., Sambola, A., Oliveras, J., Santos, M., & Soler‐Soler, J. (1995) · Circulation · doi:10.1161/01.cir.92.7.1743 · Cited by 75
Parker, J. D., Testa, M. A., Jimenez, A. H., Tofler, G. H., Muller, J. E., Parker, J. O., & Stone, P. H. (1994) · Circulation · doi:10.1161/01.cir.89.2.604 · Cited by 70
Cannon, C. P., Thompson, B., McCabe, C. H., Mueller, H. S., Kirsnenbaum, J. M., Herson, S., Nasmith, J. B., CHAITMAN, B. R., D, E. B. M., & The TIMI III Investigators (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80707-3 · Cited by 52
Lack of diurnal variation in the onset of non-Q wave infarction.
Kleiman, N. S., Schechtman, K. B., Young, P. M., Goodman, D. A., Boden, W. E., Pratt, C. M., & Roberts, R. (1990) · Circulation · doi:10.1161/01.cir.81.2.548 · Cited by 50
Lambert, C. R., Coy, K. M., Imperi, G. A., & Pepine, C. J. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90827-8 · Cited by 39
Circadian variation in pain onset in unstable angina pectoris
Behar, S., Reicher-Reiss, H., Goldbourt, U., Kaplinsky, E., & Israel The Principal Investigators of SPRINT (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90107-v · Cited by 39
Cohen, M. C., Xiong, J., Parry, G., Adams, P. C., Chamberlain, D. A., Wieczorek, I., Fox, K. A. A., McBrede, R., Chesebro, J. H., & Fuster, V. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90540-h · Cited by 28
Optimizing the treatment of unstable angina
Cannon, C. P. (1995) · Journal of Thrombosis and Thrombolysis · doi:10.1007/bf01062711 · Cited by 21
Research works printed but not linked: 1
- Borzak, 1994, Prior aspirin use in unstable coronary disease: myth of aspirin resistance? (abstr), Circulation, 90, I, 232
Cited by
Sorted by citations
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,223
Impact of the human circadian system, exercise, and their interaction on cardiovascular function
Scheer, F. A. J. L., Hu, K., Evoniuk, H., Kelly, E. E., Malhotra, A., Hilton, M. F., & Shea, S. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006749107 · Cited by 332
Yeghiazarians, Y., Braunstein, J. B., Askari, A. T., & Stone, P. H. (2000) · New England Journal of Medicine · doi:10.1056/nejm200001133420207 · Cited by 255
The impact of the circadian timing system on cardiovascular and metabolic function
Morris, C. J., Yang, J. N., & Scheer, F. A. J. L. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00019-8 · Cited by 215
Circadian variation in cardiovascular events
Muller, J. E. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00278-7 · Cited by 210
Metadata
- Authors
- Cannon, C. P., McCabe, C. H., Stone, P. H., Schactman, M., Thompson, B., Theroux, P., Gibson, R. S., Feldman, T., Kleiman, N. S., Tofler, G. H., Muller, J. E., Chaitman, B. R., & Braunwald, E.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Cannon, Christopher P.
- ORCID
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 79
- Issue
- 3
- Pages
- 253-258
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W1979609806
- Cited by
- 122
- References
- 29
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 5
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl042311-03, 5r01hl042428-04, 1r01hl042419-01)
- National Heart, Lung, and Blood Institute (R01 HL 42419, R01-HL42311, R01-HL-42428)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Keywords
- circadian variation, unstable angina, diurnal variation, myocardial ischemia, thrombolysis
- MeSH terms
- Aged, Angina, Unstable, Circadian Rhythm, Electrocardiography, Female, Humans, Male, Middle Aged, Myocardial Infarction, Prospective Studies, Registries, Thrombolytic Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
