The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Nocturnal recovery of gastric acid secretion with twice-daily dosing of proton pump inhibitors
Abstract
OBJECTIVES: It is our experience that many patients treated with proton pump inhibitors (PPI) b.i.d. recover acid secretion during the night. Our aim was to assess the efficacy of omeprazole and lansoprazole b.i.d. on nocturnal gastric acidity. METHODS: Three groups were studied with intragastric pH monitoring. Group 1 consisted of 17 patients with gastroesophageal reflux disease (GERD) taking omeprazole 20 mg b.i.d. Group 2 was 16 male volunteers taking omeprazole 20 mg b.i.d. and Group 3 comprised 12 volunteers taking lansoprazole 30 mg b.i.d. RESULTS: The percentages of time that subjects had pH < 4 were lower during supine than upright periods in Groups 1 and 3 (P < 0.01). Recovery of nocturnal acid secretion lasting > 1 h, termed acid breakthrough, occurred in three-fourths of all individuals within 12 h from intake of the evening dose of PPI. Median time to acid breakthrough for the whole group was 7.5 h. CONCLUSION: Nocturnal acid breakthrough occurs in a majority of patients and normal volunteers taking PPI b.i.d.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Healing and relapse of severe peptic esophagitis after treatment with omeprazole
Hetzel, D. J., Dent, J., Reed, W. D., Narielvala, F. M., Mackinnon, M., McCarthy, J. H., Mitchell, B., Beveridge, B. R., Laurence, B. H., Gibson, G. G., et al. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90162-x · Cited by 777
Lind, T., Cederberg, C., Ekenved, G., Haglund, U., & Olbe, L. (1983) · Gut · doi:10.1136/gut.24.4.270 · Cited by 501
Circadian Rhythm of Gastric Acid Secretion in Man
MOORE, J. G., & ENGLERT, E. (1970) · Nature · doi:10.1038/2261261a0 · Cited by 239
The Physiology of Gastric Acid Secretion
Epstein, F. H., Wolfe, M. M., & Soll, A. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812293192605 · Cited by 238
Feldman, M., & Richardson, C. T. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90943-1 · Cited by 230
Katzka, D. A., & Do, C. (1994) · PubMed · Cited by 221
Mulder, C. J. J., Fockens, P., Meijer, J. W. R., van der Heide, H., Wiltink, H. H., & Tytgat, G. N. J. (1996) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199606000-00010 · Cited by 192
Prichard, P. J., Yeomans, N. D., Mihaly, G. W., Jones, D. B., Buckle, P. J., Smallwood, R. A., & Louis, W. J. (1985) · Gastroenterology · doi:10.1016/s0016-5085(85)80133-5 · Cited by 180
Role of gastric acid suppression in the treatment of gastro-oesophageal reflux disease.
Bell, N. J., & Hunt, R. H. (1992) · Gut · doi:10.1136/gut.33.1.118 · Cited by 180
Leite, L. P., Johnston, B. T., Just, R., et al. (1996) · PubMed · Cited by 131
Cited by
Koufman, J. A., Aviv, J. E., Casiano, R. R., & Shaw, G. Y. (2002) · Otolaryngology–Head and Neck Surgery · doi:10.1067/mhn.2002.125760 · Cited by 666
Control of Gastric Acid Secretion in Health and Disease
Schubert, M. L., & Peura, D. A. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.05.021 · Cited by 481
Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors
Sifrim, D., & Zerbib, F. (2012) · Gut · doi:10.1136/gutjnl-2011-301897 · Cited by 346
Huang, J.-Q., & Hunt, R. H. (2001) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2001.0184 · Cited by 127
Acid Suppression Therapy: Where Do We Go from Here?
Scarpignato, C., Pelosini, I., & Di Mario, F. (2006) · Digestive Diseases · doi:10.1159/000091298 · Cited by 119
Metadata
- Authors
- Peghini, P.
- Venue
- The American Journal of Gastroenterology
- Published
- 1998-05
- Volume
- 93
- Issue
- 5
- Pages
- 763-767
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2024697584
- Cited by
- 317
- References
- 17
- FWCI
- 19.27
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nocturnal recovery of gastric acid secretion with twice-daily dosing of proton pump inhibitors. https://app.cochat.ai/papers/10.1016/s0002-9270(98)00101-4
- The paper
- Peghini, P. (1998). Nocturnal recovery of gastric acid secretion with twice-daily dosing of proton pump inhibitors. The American Journal of Gastroenterology. https://doi.org/10.1016/s0002-9270(98)00101-4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
