Cited by 752Bone health and osteoporosis researchMenopause: Health Impacts and TreatmentsBone health and treatments

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs

Cummings, Steven R., Karpf, David B., Harris, Fran, Genant, Harry K., Ensrud, Kristine, LaCroix, Andrea Z., Black, Dennis M.·2002·The American Journal of Medicine

DOI 10.1016/s0002-9343(01)01124-x

Open this paper in CoChat — free account

Abstract

Purpose To estimate how much the improvement in bone mass accounts for the reduction in risk of vertebral fracture that has been observed in randomized trials of antiresorptive treatments for osteoporosis.Methods After a systematic search, we conducted a meta-analysis of 12 trials to describe the relation between improvement in spine bone mineral density and reduction in risk of vertebral fracture in postmenopausal women. We also used logistic models to estimate the proportion of the reduction in risk of vertebral fracture observed with alendronate in the Fracture Intervention Trial that was due to improvement in bone mineral density.Results Across the 12 trials, a 1% improvement in spine bone mineral density was associated with a 0.03 decrease (95% confidence interval [CI]: 0.02 to 0.05) in the relative risk (RR) of vertebral fracture. The reductions in risk were greater than predicted from improvement in bone mineral density; for example, the model estimated that treatments predicted to reduce fracture risk by 20% (RR = 0.80), based on improvement in bone mineral density, actually reduce the risk of fracture by about 45% (RR = 0.55). In the Fracture Intervention Trial, improvement in spine bone mineral density explained 16% (95% CI: 11% to 27%) of the reduction in the risk of vertebral fracture with alendronate.Conclusion Improvement in spine bone mineral density during treatment with antiresorptive drugs accounts for a predictable but small part of the observed reduction in the risk of vertebral fracture.

Integrity signals

Registry

Crossref · 10.1016/s0002-9343(01)01124-x

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures
Black, D. M., Cummings, S. R., Karpf, D. B., Cauley, J. A., Thompson, D. E., Nevitt, M. C., Bauer, D. C., Genant, H. K., Haskell, W. L., Marcus, R., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)07088-2 · Cited by 3,846
Self-citation
Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures
Marshall, D., Johnell, O., & Wedel, H. (1996) · BMJ · doi:10.1136/bmj.312.7041.1254 · Cited by 3,709
Reduction of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated With Raloxifene<SUBTITLE>Results From a 3-Year Randomized Clinical Trial</SUBTITLE>
Ettinger, B. (1999) · JAMA · doi:10.1001/jama.282.7.637 · Cited by 3,366
Effects of Risedronate Treatment on Vertebral and Nonvertebral Fractures in Women With Postmenopausal Osteoporosis<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
Harris, S. T. (1999) · JAMA · doi:10.1001/jama.282.14.1344 · Cited by 2,475
Effect of Alendronate on Risk of Fracture in Women With Low Bone Density but Without Vertebral Fractures<SUBTITLE>Results From the Fracture Intervention Trial</SUBTITLE>
Cummings, S. R. (1998) · JAMA · doi:10.1001/jama.280.24.2077 · Cited by 2,277
Self-citation
Effect of Oral Alendronate on Bone Mineral Density and the Incidence of Fractures in Postmenopausal Osteoporosis
Liberman, U. A., Weiss, S. R., Bröll, J., Minne, H. W., Quan, H., Bell, N. H., Rodriguez-Portales, J. A., Downs, R. W., Dequeker, J., Favus, M. J., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511303332201 · Cited by 2,276
Self-citation
Randomized Trial of the Effects of Risedronate on Vertebral Fractures in Women with Established Postmenopausal Osteoporosis
Reginster, J.-Y., Minne, H. W., Sorensen, O. H., Hooper, M., Roux, C., Brandi, M. L., Lund, B., Ethgen, D., Pack, S., Roumagnac, I., et al. (2000) · Osteoporosis International · doi:10.1007/s001980050010 · Cited by 1,580
A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study
Chesnut, C. H., Silverman, S., Andriano, K., Genant, H., Gimona, A., Harris, S., Kiel, D., LeBoff, M., Maricic, M., Miller, P., et al. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00490-3 · Cited by 1,122
Self-citation
Markers of bone resorption predict hip fracture in elderly women: The EPIDOS prospective study
Garnero, P., Hausherr, E., Chapuy, M. C., Marcelli, C., Grandjean, H., Müller, C., Cormier, C., Bréart, G., Meunier, P. J., & Delmas, P. D. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650111021 · Cited by 984
Intermittent Cyclical Etidronate Treatment of Postmenopausal Osteoporosis
Watts, N. B., Harris, S. T., Genant, H. K., Wasnich, R. D., Miller, P. D., Jackson, R. D., Licata, A. A., Ross, P. D., Woodson, G. C., Yanover, M., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007123230201 · Cited by 947
Self-citation

Show all 35 references

Research works printed but not linked: 4

Cummings, 1996, Changes in BMD substantially underestimate the anti-fracture effects of alendronate and other antiresorptive drugs, J Bone Miner Res, 11, S102
Genant, 1998, Chronic intermittent cyclical administration of tiludronate in postmenopausal osteoporosis, Bone, 23, S175
Black, 1993, Prediction of new vertebral deformities, J Bone Miner Res, 8, S135
Cann, 1999, PTH effects in the femur, J Bone Miner Res, 14, S137

Sorted by citations

Items 501–600 of 751

Hepatocellular carcinoma and musculoskeletal system: A narrative literature review
Jadzic, J. S., & Djonić, D. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i15.2109 · Cited by 8
PREVALENCE OF OSTEOPOROSIS IN RELATION TO SERUM CALCIUM AND PHOSPHORUS IN AGING WOMEN
Shakoor, S., Ilyas, F., Abbas, N., Mirza, M. A., & Arif, S. (2014) · Journal of Global Innovations in Agricultural and Social Sciences · doi:10.17957/jgiass/2.2.511 · Cited by 8
Material properties and osteoporosis
Paschalis, E. P., Klaushofer, K., & Hartmann, M. A. (2019) · F1000Research · doi:10.12688/f1000research.18239.1 · Cited by 8
Recommendations on deprescribing of bisphosphonates in osteoporosis guidelines: a systematic review
Jepsen, D. B., Bergen, E. S., Pan, J., van Poelgeest, E. P., Osman, A., Burghle, A., Ryg, J., Thompson, W., & Lundby, C. (2023) · European Geriatric Medicine · doi:10.1007/s41999-023-00820-y · Cited by 9
Aktuelle Diagnostik und Therapie der Osteoporose auf der Basis der „European Guidance 2008“
Bartl, R., & Gradinger, R. (2009) · Der Orthopäde · doi:10.1007/s00132-008-1404-4 · Cited by 7
Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body
Eswaran, S. K., Bevill, G. R., Nagarathnam, P., Allen, M. R., Burr, D. B., & Keaveny, T. M. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2008.11.023 · Cited by 8
Biomechanical effects of simulated resorption cavities in cancellous bone across a wide range of bone volume fractions
Easley, S. K., Chang, M. T., Shindich, D., Hernandez, C. J., & Keaveny, T. M. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1657 · Cited by 8
Monitoring Anabolic Treatment
Bilezikian, J. P., & Rubin, M. R. (2006) · Elsevier eBooks · doi:10.1016/b9-78-012088-5/62650-039x · Cited by 8
Use of combination therapy in the treatment of primary osteoporosis: protocol for a network meta-analysis of randomised trials
Lou, S., Lv, H., Chen, Y., Zhang, L., & Tang, P. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-012802 · Cited by 8
Effects of Combination Therapy of Alendronate and Hormonal Therapy on Bone Mineral Density in Postmenopausal Korean Women: Multicenter, Randomized Controlled Clinical Trial
Yoon, B.-K., Lee, D., Park, M. C., Cho, S. H., Park, H. M., & Choi, Y. M. (2017) · Journal of Korean Medical Science · doi:10.3346/jkms.2017.32.6.992 · Cited by 8
Treatment of Postmenopausal Osteoporosis
Gupta, G., & Aronow, W. S. (2007) · Comprehensive Therapy · doi:10.1007/s12019-007-0017-x · Cited by 8
Similar Proportions of Women Lose Bone Mineral Density With Raloxifene or Alendronate Treatment
Adachi, J. D., Adami, S., Kulkarni, P. M., Wong, M., & Stock, J. L. (2005) · Journal of Clinical Densitometry · doi:10.1385/jcd:8:3:273 · Cited by 8
Comparison of Weekly Treatment of Postmenopausal Osteoporosis with Alendronate Versus Risedronate Over Two Years
Bonnick, S. L., Saag, K. G., Kiel, D. P., McClung, M. R., Hochberg, M. C., Burnett‐Bowie, S. M., Sebba, A. I., Kagan, R., Chen, E., Thompson, D. E., et al. (2006) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000251009.57462.83 · Cited by 8
Acoustic propagation in a random saturated medium: The monophasic case
Gilbert, R. P., Panchenko, A., & Vasilic, A. (2010) · Mathematical Methods in the Applied Sciences · doi:10.1002/mma.1360 · Cited by 7
Multi-view information fusion using multi-view variational autoencoder to predict proximal femoral fracture load
Chen, Z., Keyak, J. H., Cao, X., Sha, Q., Wu, L., Luo, Z., Zhao, L., Tian, Q., Serou, M. J., Qiu, C., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1261088 · Cited by 7
Similar Relationship Between the Time Course of Bone Mineral Density Improvement and Vertebral Fracture Risk Reduction With Denosumab Treatment in Postmenopausal Osteoporosis and Prostate Cancer Patients on Androgen Deprivation Therapy
Ruixo, J. J. P., Zheng, J., & Mandema, J. W. (2013) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.228 · Cited by 7
Effects of Risedronate in Runx2 Overexpressing Mice, an Animal Model for Evaluation of Treatment Effects on Bone Quality and Fractures
Geoffroy, V., Paschalis, E. P., Libouban, H., Blouin, S., Ostertag, A., Chappard, D., Cros, M., Phipps, R. J., & de Vernejoul, M. C. (2011) · Calcified Tissue International · doi:10.1007/s00223-011-9480-6 · Cited by 7
Fourier Transform Infrared Imaging Analysis of Cancellous Bone in Alendronate- and Raloxifene-Treated Osteopenic Sheep
Calton, E. F., MacLeay, J. M., & Boskey, A. L. (2011) · Cells Tissues Organs · doi:10.1159/000324236 · Cited by 7
Brain and Human Body Modelling 2021
Makarov, S. N., Noetscher, G. M., & Nummenmaa, A. R. (2022) · Springer eBooks · doi:10.1007/978-3-031-15451-5 · Cited by 6
Fracture discrimination capability of ulnar flexural rigidity measured via Cortical Bone Mechanics Technology: study protocol for The STRONGER Study
Warden, S. J., Dick, A., Simon, J. E., Manini, T. M., Russ, D. W., Lyssikatos, C., Clark, L. A., & Clark, B. C. (2024) · JBMR Plus · doi:10.1093/jbmrpl/ziad002 · Cited by 6
Skeletal abnormalities in anorexia nervosa
Jacobson-Dickman, E. E., & Misra, M. (2010) · IBMS BoneKEy · doi:10.1138/20100429 · Cited by 7
The effects of discontinuing long term alendronate therapy in a clinical practice setting
da Silva, A. G., Vieira, J. G. H., Kunii, I. S., de Lana, J. M., & Lazaretti‐Castro, M. (2011) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302011000400006 · Cited by 7
Changes in spinal bone density, back muscle size, and visceral adipose tissue and their interaction following a multi-component exercise program in older men: secondary analysis of an 18-month randomized controlled trial
Turcotte, A., Kukuljan, S., Via, J. D., Gagnon, C., Abbott, G., & Daly, R. M. (2020) · Osteoporosis International · doi:10.1007/s00198-020-05484-z · Cited by 7
Pentosidine as a Biomarker for Poor Bone Quality and Elevated Fracture Risk
Pritchard, J. M., & Willett, T. L. (2017) · Biomarkers in disease · doi:10.1007/978-94-007-7693-7_32 · Cited by 8
Osteoporose – Was ist gesichert in der Therapie?
Jehle, P. M., & Pfeilschifter, J. (2009) · Der Internist · doi:10.1007/s00108-009-2460-5 · Cited by 7
Monitoring of Antiresorptive Therapy
Meier, C., NGUYEN, T., & Seibel, M. J. (2006) · Elsevier eBooks · doi:10.1016/b9-78-012088-5/62650-0406 · Cited by 7
Oral antiresorptive therapy
Pande, I., & Hosking, D. J. (2005) · Current Rheumatology Reports · doi:10.1007/s11926-005-0012-0 · Cited by 7
The relationship between osteoporotic fracture risk and a surrogate: Apparent discrepancies between analyses based on individual patient data and summary statistics
Barton, I. P. (2004) · Pharmaceutical Statistics · doi:10.1002/pst.123 · Cited by 7
Bone Turnover Markers
Garnero, P., & Delmas, P. D. (2004) · Elsevier eBooks · doi:10.1016/b0-12-475570-4/00218-3 · Cited by 7
Clinical Perspectives on Bone Quality in Osteoporosis
Licata, A. A. (2007) · Drugs & Aging · doi:10.2165/00002512-200724070-00001 · Cited by 7
Editorial: Response to the American College of Physicians Osteoporosis Guideline, 2017 Update
Caplan, L., Hansen, K. E., & Saag, K. G. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40305 · Cited by 7
Pamidronate Down-regulates Tumor Necrosis Factor-alpha Induced Matrix Metalloproteinases Expression in Human Intervertebral Disc Cells
Kang, Y. M., Hong, S.-H., Yang, J., Oh, J.-C., Park, J., Lee, B. H., Lee, S., Kim, H., Lee, H., & Moon, S.-H. (2016) · Journal of Bone Metabolism · doi:10.11005/jbm.2016.23.3.165 · Cited by 6
Effects of D-003 (10 mg/day) on Bone Mineral Density of the Lumbar Spine and Femoral Neck in Postmenopausal Women: A Randomized, Double-Blinded Study
Ceballos, A., Castaño, G., Mendoza, S., González, J., Más, R., Fernández, L., Illnait, J., Mesa, M., Gámez, R., Fernández, J. C., et al. (2011) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2011.26.2.168 · Cited by 6
Factors Affecting Discontinuation of Alendronate Treatment in Postmenopausal Japanese Women With Osteoporosis
Iwamoto, J., Miyata, A., Satō, Y., Takeda, T., & Matsumoto, H. (2009) · Journal of the Chinese Medical Association · doi:10.1016/s1726-4901(09)70442-3 · Cited by 6
l-Carnitine, but not coenzyme Q10, enhances the anti-osteoporotic effect of atorvastatin in ovariectomized rats
Murad, H. A. S. (2016) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1500065 · Cited by 6
Effectiveness of bisphosphonates on bone mineral density in osteopenic postmenopausal women
Dong, S., Jiao, Y., & Yang, H.-L. (2021) · Medicine · doi:10.1097/md.0000000000026715 · Cited by 6
Efficacy and Safety of Generic Alendronate for Osteoporosis Treatment
Jarusriwanna, A., Malisorn, S., Tananoo, S., Areewong, K., Rasamimongkol, S., & Laoruengthana, A. (2024) · Orthopedic Research and Reviews · doi:10.2147/orr.s445202 · Cited by 7
Evidence of Sustained Vertebral and Nonvertebral Antifracture Efficacy with Ibandronate Therapy: A Systematic Review
Adami, S., Idolazzi, L., & Rossini, M. (2011) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x10395651 · Cited by 6
Is it the time to rethink clinical decision-making strategies? From a single clinical outcome evaluation to a Clinical Multi-criteria Decision Assessment (CMDA)
Migliore, A., Integlia, D., Bizzi, E., & Piaggio, T. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.06.024 · Cited by 6
Monitoring osteoporosis therapy: Can FRAX help assessing success or failure in achieving treatment goals?
Miedany, Y. M. E. (2014) · World Journal of Rheumatology · doi:10.5499/wjr.v4.i2.14 · Cited by 6
Prediction of cross section fracture path of cortical bone through nanoindentation array
Ma, Z., Qiang, Z., Zeng, K., Xiao, J., Zhou, L., Zu, L., Zhao, H., & Ren, L. (2021) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2020.104303 · Cited by 6
Skeletal fragility and bone quality.
Recker, R. R. (2007) · PubMed · Cited by 6
Principles of Bone Biomechanics
Turner, C. H., & Burr, D. B. (2006) · Elsevier eBooks · doi:10.1016/b978-0-323-03437-1.50013-0 · Cited by 6
Investigation of mineral and collagen organization in bone using Raman spectroscopy
Raghavan, M. (2011) · Deep Blue (University of Michigan) · Cited by 6
Remineralization of lytic spinal metastases after radiation therapy – A retrospective cohort study comparing conventional external beam radiation therapy with stereotactic ablative body radiation
den Brande, R. V., den Kieboom, M. V., Peeters, M., Billiet, C., & de Kelft, E. V. (2024) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2024.100805 · Cited by 5
Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis
Iwamoto, J. (2009) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s5982 · Cited by 5
Effets des traitements de l'ostéoporose sur la qualité osseuse
Benhamou, C.-L. (2006) · Revue du Rhumatisme · doi:10.1016/j.rhum.2006.06.008 · Cited by 7
Skeletal Health and Bone Strength: DXA and Beyond Growth for the Journal of Clinical Densitometry
Miller, P. D. (2008) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2008.01.002 · Cited by 5
Early changes in 25-hydroxyvitamin D levelsand bone markers after monthly risedronatewith cholecalciferol in Korean patients with osteoporosis
Chung, H., Koo, Kwon, H. N., Kang, S., Moon, Park, J. Y., Shin, Yoon, Y., Yoon, Y., Chang, M. C., et al. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s44395 · Cited by 5
Die Rolle des Labors in der Diagnostik und Verlaufskontrolle der Osteoporose
KRAENZLIN, M. E., Anliker, M., & Griesmacher, A. (2008) · Therapeutische Umschau · doi:10.1024/0040-5930.65.9.513 · Cited by 5
Relationship Between Bone Mineral Density and Risk of Vertebral Fractures with Denosumab Treatment in Japanese Postmenopausal Women and Men with Osteoporosis
Okubo, N., Matsui, S., Matsumoto, T., Sugimoto, T., Hosoi, T., Osakabe, T., Watanabe, K., Takami, H., Shiraki, M., & Nakamura, T. (2020) · Calcified Tissue International · doi:10.1007/s00223-020-00750-y · Cited by 5
Influence of dietary calcium intake on quantitative and qualitative parameters of bone tissue in Polish adults
Skowrońska‐Jóźwiak, E., Jaworski, M., Lorenc, R. S., & Lewiñski, A. (2016) · Annals of Agricultural and Environmental Medicine · doi:10.5604/12321966.1219194 · Cited by 5
Surface-specific Bone Formation Effects of Osteoporosis Pharmacological Treatments
Allen, M. R. (2008) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-008-9022-6 · Cited by 5
Bone remodeling markers: Assessment of fracture risk and fracture risk reduction
Blumsohn, A. (2003) · Current Osteoporosis Reports · doi:10.1007/bf02686912 · Cited by 5
Who will benefit from treatment with selective estrogen receptor modulators (SERMs)?
Sambrook, P. N. (2005) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2005.06.007 · Cited by 5
Pharmacologic treatment to prevent fractures: from markers to patients
Cummings, S. R. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0914-1 · Cited by 5
Self-citation
Ethical Issues in the Design of Osteoporosis Clinical Trials: The State of the Question
Heaney, R. P. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.6.1117 · Cited by 5
Utility of Type I Collagen-Derived Markers as Reflectors of Bone Turnover in Different Clinical Situations
Tähtelä, R. (2004) · Työväentutkimus Vuosikirja · Cited by 5
Novel techniques for assessment of bone tissue material properties
Rao, A. D. (2023) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000821 · Cited by 4
Spinal Metastases of the Vertebrae: Three Main Categories of Pain
den Brande, R. V., Billiet, C., Peeters, M., & de Kelft, E. V. (2024) · Life · doi:10.3390/life14080988 · Cited by 4
The Association of Bone Mineral Density with Distal Junctional Kyphosis and Distal Junctional Failure After Multilevel Spine Fusions: A Systematic Review and Meta-Analysis
Daher, Z., Jouppi, L. L., Anderson, B. G., Pierre, C. A., Davis, D. D., Patel, N. T., Gerstmeyer, J. R., Rao, G., Norvell, D. C., Cracchiolo, G., et al. (2025) · World Neurosurgery · doi:10.1016/j.wneu.2024.123598 · Cited by 5
Biochemical markers of bone turnover: clinical utility
Rosen, H. N. (2003) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200312000-00001 · Cited by 4
Pentosidine as a Biomarker for Poor Bone Quality and Elevated Fracture Risk
Pritchard, J. M., & Willett, T. L. (2016) · Biomarkers in disease · doi:10.1007/978-94-007-7745-3_32-1 · Cited by 4
Osteoporosis
Chapurlat, R. D., & Genant, H. K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00069-x · Cited by 4
Self-citation
Prolonged Treatments with Anti-Resorptive Agents and PTH Have Different Effects on Bone Strength and the Degree of Mineralization in Old Estrogen Deficient Osteoporotic Rats
Cheng, Z., Yao, W., Zimmermann, E. A., Busse, C., Ritchie, R. O., & Lane, N. E. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081005 · Cited by 4
Bone Mineral Density Response to Long-Term Bisphosphonate Treatment and Discontinuation in a Real-World Clinical Service
Powell, D., Evans, S. F., & Rakieh, C. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2023.04.011 · Cited by 4
Randomized head-to-head comparison of minodronic acid and raloxifene for fracture incidence in postmenopausal Japanese women: the Japanese Osteoporosis Intervention Trial (JOINT)-04
Uemura, Y., Sone, T., Tanaka, S., Miyazaki, T., Tsukiyama, M., Taguchi, A., Soen, S., Mori, S., Hagino, H., Sugimoto, T., et al. (2020) · Current Medical Research and Opinion · doi:10.1080/03007995.2020.1816537 · Cited by 4
Therapie der Osteoporose nach der „European Guidance 2008“
Bartl, R. (2008) · Der Internist · doi:10.1007/s00108-008-2192-y · Cited by 4
Prevalence of prevention and treatment modalities used in populations at risk of osteoporosis.
Rohr, C. I., Sarkar, A., Barber, K. R., & Clements, J. M. (2004) · PubMed · Cited by 4
Biochemical Markers of Bone Turnover – Clinical Aspects
Meier, C., Seibel, M. J., & KRAENZLIN, M. E. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-459-9_6 · Cited by 4
Anabolic Therapy of Osteoporosis in Women and in Men
Rubin, M. R., & Bilezikian, J. P. (2004) · Principles of Gender-Specific Medicine · doi:10.1016/b978-012440905-7/50366-2 · Cited by 4
Treating osteoporosis in post-menopausal women: a case approach.
Keller, M. I. (2004) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.71.10.829 · Cited by 4
Association between bone turnover markers and FRAX predicted fracture risk in Chinese adults: a cross-sectional study
Qu, X., Wang, Q., Luo, C., Li, Y., Tian, L., Xu, L., & Sheng, Z. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-08571-6 · Cited by 4
Impact of bone mineral density in reducing fracture risk in patients receiving alendronate plus alfacalcidol therapy
Itoi, E., Uemura, Y., Ohta, H., Nakamura, T., Fukunaga, M., Orimo, H., & Shiraki, M. (2020) · Journal of Orthopaedic Science · doi:10.1016/j.jos.2020.10.017 · Cited by 3
Treat-to-Target in Osteoporosis
Miedany, Y. M. E., & Bahlas, S. M. (2022) · Springer eBooks · doi:10.1007/978-3-030-87950-1_18 · Cited by 3
Ultrasound Scattering in Cortical Bone
Karbalaeisadegh, Y., & Muller, M. M. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-91979-5_9 · Cited by 3
Bone Density and Imaging of Osteoporosis
Chapurlat, R. D., Delmas, P. D., & Genant, H. K. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00068-x · Cited by 3
Self-citation
Diagnose und Verlaufskontrolle der Osteoporose
Meier, C., & KRAENZLIN, M. E. (2012) · Therapeutische Umschau · doi:10.1024/0040-5930/a000267 · Cited by 3
Marqueurs biochimiques du remodelage osseux
Cohen-Solal, M. E., & de Vernejoul, M. C. (2006) · Revue du Rhumatisme · doi:10.1016/j.rhum.2006.05.003 · Cited by 3
The Use of Teriparatide and PTH(1-84) for the Treatment of Osteoporosis
Wagman, R. B., & Miller, P. D. (2006) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1385/bmm:4:4:277 · Cited by 3
Fracture protection in osteoporosis with risedronate
Boonen, S., & Vanderschueren, D. (2004) · Hospital Medicine · doi:10.12968/hosp.2004.65.9.15983 · Cited by 3
Comparative Effectiveness of Pharmacologic Treatments to Prevent Fractures
Crandall, C. J., Newberry, S. J., Diamant, A. L., Lim, Y.-W., Gellad, W. F., Booth, M. J., Motala, A., & Shekelle, P. (2020) · Annals of Internal Medicine · Cited by 3
Dénosumab : traitement à vie de l’ostéoporose ?
Laroche, M. (2016) · La Presse Médicale · doi:10.1016/j.lpm.2015.12.010 · Cited by 3
Clinical Use of Parathyroid Hormone in Osteoporosis
Bilezikian, J. P. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-459-9_22 · Cited by 3
Strontium ranelate: new perspectives for the management of osteoporosis
Cortet, B. (2009) · Rheumatology · doi:10.1093/rheumatology/kep277 · Cited by 3
Diagnosing and Managing Post Menopausal Osteoporosis: Opportunities for Fracture Prevention
McGarry, K., Tammaro, D., & Cyr, M. G. (2003) · Comprehensive Therapy · doi:10.1007/s12019-003-0015-6 · Cited by 3
Reduced use of hormones and the drop in breast cancer
Roberts, H. (2009) · BMJ · doi:10.1136/bmj.b2116 · Cited by 3
MICROSTRUCTURAL STRESSES AND STRAINS ASSOCIATED WITH TRABECULAR BONE MICRODAMAGE
Nagaraja, S. (2006) · UPT. Syiah Kuala University Library (Syiah Kuala University) · Cited by 3
Book of Abstracts
(2005) · Climacteric · doi:10.1080/13697130512331390481 · Cited by 4
In vivo mechanical assessment of cortical bone rigidity enhances fracture discrimination beyond DXA in postmenopausal women
Clark, B. C., Manini, T. M., Simon, J. E., Clark, L. A., Lyssikatos, C., & Warden, S. J. (2026) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjag032 · Cited by 3
Biochemical bone markers and biological effects of osteoporosis therapy
Kovačev-Zavišić, B., Novaković-Paro, J., Djuric, N., Ičin, T., Todorovic-Djilas, L., & Kovacev, N. (2012) · Vojnosanitetski pregled · doi:10.2298/vsp1205432k · Cited by 2
Evaluation of bone density and hand grip strength in the course of drug treatment for osteoporosis
Schröder, G., Hoth, I., Flachsmeyer, D., Dutzke, M., Andresen, J. R., Andresen, R., & Schober, H. (2023) · Die Orthopädie · doi:10.1007/s00132-023-04367-5 · Cited by 2
Raman spectroscopy as a tool for monitoring osteoporosis therapy in postmenopausal osteoporosis
Beattie, J. R., & Towler, M. R. (2023) · Journal of Raman Spectroscopy · doi:10.1002/jrs.6602 · Cited by 2
Determination of the Combined Effects of Asian Herbal Medicine with Calcium and/or Vitamin D Supplements on Bone Mineral Density in Primary Osteoporosis: A Systematic Review and Meta-Analysis
Park, H.-J., Kim, M.-G., Yoo, Y.-S., Lee, B., Choi, Y., Son, C., & Lee, E. J. (2024) · Osteoporosis International · doi:10.1007/s00198-024-07061-0 · Cited by 2
Surrogate markers in assessment of bisphosphonate effectiveness in osteoporosis treatment (bone mineral density, bone turnover markers)
Belaya, Z. E., & Rozhinskaya, L. Y. (2024) · Osteoporosis and Bone Diseases · doi:10.14341/osteo13166 · Cited by 2
Application of a Neural Network Classifier to Radiofrequency-Based Osteopenia/Osteoporosis Screening
Adams, J., Zhang, Z., Noetscher, G. M., Nazarian, A., & Makarov, S. N. (2021) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc46164.2021.9630944 · Cited by 2
Drug therapy of osteoporosis
Resch, H., & Muschitz, C. (2008) · Springer eBooks · doi:10.1007/978-3-211-74221-1_2 · Cited by 2
Caso clínico a debate: vacaciones terapéuticas, ¿sí o no?
Nogués, X., Casado, E., Díaz Curiel, M., Gimeno, E. J., Eslava, A. T., Henríquez, M. S., Romero, J. G. D. T., & Malouf, J. (2014) · Revista de Osteoporosis y Metabolismo Mineral · doi:10.4321/s1889-836x2014000400009 · Cited by 2
Fisiología y fisiopatología ósea
Lafita, J. (2003) · Anales del Sistema Sanitario de Navarra · doi:10.4321/s1137-66272003000600002 · Cited by 2
Regional Variations in Trabecular Morphological Features of Femoral Head of Patients with Proximal Femoral Fractures
Lv, L., Meng, G., Gong, H., Zhu, D., Gao, J., & Zhao, M. (2015) · Journal of Bionic Engineering · doi:10.1016/s1672-6529(14)60122-0 · Cited by 2

Authors: Cummings, S. R., Karpf, D. B., Harris, F., Genant, H. K., Ensrud, K., LaCroix, A. Z., & Black, D. M.
Affiliations: University of California, San Francisco (US)
Geron (United States) (US)
University of Minnesota (US)
University of Washington (US)
Corresponding author: Cummings, Steven R.
ORCID: Cummings, Steven R.
Genant, Harry K.
Ensrud, Kristine
LaCroix, Andrea Z.
Black, Dennis M.
Venue: The American Journal of Medicine
Publisher: Elsevier BV
Published: 2002-03
Volume: 112
Issue: 4
Pages: 281-289
ISSN: 0002-9343 (ISSN-L)
DOI: 10.1016/s0002-9343(01)01124-x
OpenAlex: W2110828193
Cited by: 752
References: 35
Citations by year: 2026: 7 · 2025: 10 · 2024: 17 · 2023: 12 · 2022: 12 · 2021: 16 · 2020: 25 · 2019: 10 · 2018: 11 · 2017: 18 · 2016: 25 · 2015: 19 · 2014: 24 · 2013: 29 · 2012: 43
FWCI: 8.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The American Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords: osteoporosis, vertebral fractures, bone mineral density, antiresorptive agents, alendronate, postmenopausal women, Fracture Intervention Trial, fracture risk reduction, bone mass
MeSH terms: Bone Resorption, Female, Fractures, Spontaneous, Humans, Regression Analysis, Risk Factors, Spine, Bone Density, Osteoporosis, Postmenopausal, Logistic Models, Spinal Fractures, Alendronate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks