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Cited by 391Cardiovascular Syncope and Autonomic DisordersConnective tissue disorders researchHeart Rate Variability and Autonomic Control

The DOI matches its Crossref record; 50 of the 53 references it cites were found in a registry or an index.

Dysautonomia in the joint hypermobility syndrome

Gazit, Yael, Nahir, A.Menahem, Grahame, Rodney, Jacob, Giris·2003·The American Journal of Medicine
DOI 10.1016/s0002-9343(03)00235-3
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Abstract

Purpose Extraarticular manifestations of the joint hypermobility syndrome may include the peripheral nervous system. The purpose of this study was to investigate autonomic function in patients with this syndrome.Methods Forty-eight patients with the joint hypermobility syndrome who fulfilled the 1998 Brighton criteria and 30 healthy control subjects answered a clinical questionnaire designed to evaluate the frequency of complaints related to the autonomic nervous system. Next, 27 patients and 21 controls underwent autonomic evaluation: orthostatic testing, cardiovascular vagal and sympathetic functions, catecholamine levels, and adrenoreceptor responsiveness.Results Symptoms related to the autonomic nervous system, such as syncope and presyncope, palpitations, chest discomfort, fatigue, and heat intolerance, were significantly more common among patients. Orthostatic hypotension, postural orthostatic tachycardia syndrome, and uncategorized orthostatic intolerance were found in 78% (21/27) of patients compared with in 10% (2/21) of controls. Patients with the syndrome had a greater mean (+/- SD) drop in systolic blood pressure during hyperventilation than did controls (-11 +/- 7 mm Hg vs. -5 +/- 5 mm Hg, P = 0.02) and a greater increase in systolic blood pressure after a cold pressor test (19 +/- 10 mm Hg vs. 11 +/- 13 mm Hg, P = 0.06). Patients with the syndrome also had evidence of alpha-adrenergic (as assessed by administration of phenylephrine) and beta-adrenergic hyperresponsiveness (as assessed by administration of isoproterenol).Conclusion The autonomic nervous system-related symptoms of the patients have a pathophysiological basis, which suggests that dysautonomia is an extraarticular manifestation in the joint hypermobility syndrome.

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Research works printed but not linked: 2

  1. Streeten, 1988, Abnormal orthostatic changes in blood pressure and heart rate in subjects with intact sympathetic nervous function, J Lab Clin Med, 111, 326
  2. Grahame, 1992, Joint hypermobility; proposed new criteria for joint hypermobility, Br J Rheumatol, 31, 205

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Metadata

Authors
Gazit, Y., Nahir, A. M., Grahame, R., & Jacob, G.
Affiliations
  • Technion – Israel Institute of Technology (IL)
  • University College London (GB)
Corresponding author
Jacob, Giris
ORCID
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2003-07
Volume
115
Issue
1
Pages
33-40
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/s0002-9343(03)00235-3
OpenAlex
W2022790525
Cited by
390
References
53
Citations by year
2026: 9 · 2025: 18 · 2024: 17 · 2023: 15 · 2022: 14 · 2021: 20 · 2020: 21 · 2019: 21 · 2018: 24 · 2017: 29 · 2016: 21 · 2015: 25 · 2014: 25 · 2013: 22 · 2012: 12
FWCI
9.91
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
joint hypermobility syndrome, autonomic dysfunction, autonomic nervous system, orthostatic intolerance, postural orthostatic tachycardia syndrome, orthostatic hypotension, catecholamine levels, beta-adrenergic responsiveness, extra-articular manifestations, syncope, hyperventilation
MeSH terms
Adolescent, Adult, Aged, Arrhythmias, Cardiac, Autonomic Nervous System Diseases, Blood Pressure, Catecholamines, Female, Humans, Joint Instability, Male, Middle Aged, Surveys and Questionnaires, Severity of Illness Index, Body Mass Index

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