Impact of joint hypermobility syndrome on gastric accommodation and nutrient tolerance in functional dyspepsia
Abstract
Functional dyspepsia (FD) is defined as the presence of gastroduodenal symptoms in the absence of organic disease that is likely to explain the symptoms. Joint hypermobility (JH) refers to the increased passive or active movement of a joint beyond its normal range and is characteristically present in patients with joint hypermobility syndrome (JHS), which is a hypermobile subtype of Ehlers‐Danlos syndrome (EDS). Recent reports have highlighted the co‐existence of FD with Ehlers‐Danlos syndrome. Our aim was to study the prevalence of JHS in FD compared with healthy subjects and to study the impact of co‐existing JHS on gastric motility, nutrient tolerance, and dyspeptic symptoms in FD. Methods: FD patients filled out a dyspepsia symptom severity score. Intragastric pressure (IGP) was measured with high‐resolution manometry (HRM) during the intragastric infusion of nutrition drink (ND, 1.5 Kcal/ml, 60 ml/min) until maximal satiation in healthy subjects and FD. We compared IGP profiles and nutrient tolerance in HS and FD with or without JHS. Results: JHS was present in 54% of FD patients (n = 39, 41.2 ± 2.2 years old) and 7% of healthy subjects (n = 15, 27.3 ± 2.3 years old). IGP drop and nutrient tolerance were lower in non‐JHS‐FD compared with JHS‐FD and HS (AUC JHS‐FD: −17.9 ± 2.5 vs. non‐JHS‐FD: −13.0 ± 3.3 mmHg min,p = 0.2, HS:‐19.6 ± 2.9 mmHg min; ND tolerance non‐JHS‐FD: 671.0 ± 96.0 vs. JHS‐FD: 842.7 ± 105.7 Kcal,p = 0.25, HS: 980.0 ± 108.1 Kcal). Conclusion: JHS often co‐exists with FD. Non‐JHS‐FD was characterized by decreased accommodation and lower nutrient tolerance characterized compared with JHS‐FD. Clinicaltrials.gov, reference number NCT04279990.
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No changes in gastric accommodation have been observed in HSD/hEDS studies of functional dyspepsia using MRI or intragastric barostat measures, arguing against the hypothesis of altered compliance.
“although no changes in gastric accommodation have been observed in HSD/hEDS studies of functional dyspepsia using MRI or intragastric barostat measures, arguing against this hypothesis. 54 , 55”
From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [55]
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- Authors
- Carbone, F., Goelen, N., Fikree, A., Aziz, Q., & Tack, J.
- Affiliations
- KU Leuven (BE)
- Queen Mary University of London (GB)
- Corresponding author
- Tack, Jan
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2021-02-02
- Volume
- 33
- Issue
- 7
- Pages
- e14086-e14086
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W3128039875
- Cited by
- 5
- References
- 44
- Citations by year
- 2025: 2 · 2022: 3
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Keywords
- joint hypermobility syndrome, functional dyspepsia, gastric accommodation, nutrient tolerance, intragastric pressure, gastric motility, Ehlers-Danlos syndrome, high-resolution manometry
- MeSH terms
- Adult, Dyspepsia, Female, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Joint Instability, Male, Syndrome, Prevalence
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