The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.
Chemokines IL-8, GROα, MCP-1, IP-10, and Mig Are Sequentially and Differentially Expressed During Phase-Specific Infiltration of Leukocyte Subsets in Human Wound Healing
Open accessAbstract
Healing of cutaneous wounds requires a complex integrated network of repair mechanisms, including the action of newly recruited leukocytes. Using a skin repair model in adult humans, we investigated the role chemokines play in sequential infiltration of leukocyte subsets during wound healing. At day 1 after injury, the C-X-C chemokines IL-8 and growth-related oncogene alpha are maximally expressed in the superficial wound bed and are spatially and temporally associated with neutrophil infiltration. IL-8 and growth-related oncogene alpha profiles also correlate with keratinocyte migration and subsequently subside after wound closure at day 4. Macrophage infiltration reaches the highest levels at day 2 and is paralleled by monocyte chemoattractant protein-1 mRNA expression in both the basal layer of the proliferative epidermis at the wound margins and mononuclear cells in the wound area. Other monocyte-attracting chemokines such as monocyte chemoattractant protein-3, macrophage inflammatory protein-1alpha and -1beta, RANTES, and 1309 are undetectable. At day 4, perivascular focal lymphocyte accumulation correlates with strong focal expression of the C-X-C chemokines Mig and IP-10. Our results suggest that a dynamic set of chemokines contributes to the spatially and temporally different infiltration of leukocyte subsets and thus integrates the inflammatory and reparative processes during wound repair.
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“In the THS-exposed mouse wounds [65] the levels of this chemokine are lower after 5 days post-wounding suggesting poor remodelling of the wound tissue.”
From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [65]
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“In the THS-exposed mouse wounds [65] the levels of this chemokine are lower after 5 days post-wounding suggesting poor remodelling of the wound tissue.”
From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [65]
Experimental — accuracy not yet measuredIn the citing paper
“Neutrophils represent the most abundant inflammatory cells to infiltrate a new wound and function mainly to remove debris and prevent infection [22, 23].”
From Immunology of Wound Healing (2018) · cites this paper as [22]
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Metadata
- Authors
- Engelhardt, E., Toksoy, A., Goebeler, M., Debus, S., Bröcker, E.-B., & Gillitzer, R.
- Affiliations
- University of Würzburg (DE)
- Corresponding author
- Gillitzer, Reinhard
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 153
- Issue
- 6
- Pages
- 1849-1860
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC1866330
- OpenAlex
- W2010087085
- Cited by
- 435
- References
- 64
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 12 · 2023: 15 · 2022: 9 · 2021: 17 · 2020: 15 · 2019: 12 · 2018: 18 · 2017: 25 · 2016: 10 · 2015: 15 · 2014: 20 · 2013: 13 · 2012: 23
- FWCI
- 17.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- chemokines, wound healing, skin wound healing, leukocyte infiltration, neutrophil infiltration, macrophage infiltration, keratinocyte migration, interleukin-8, CXCL1, MCP-1, CXCL10, CXC chemokines, skin inflammation, lymphocyte accumulation, spatiotemporal gene expression
- MeSH terms
- Adult, Cell Division, Chemotactic Factors, Female, Growth Substances, Humans, Immunohistochemistry, Leukocytes, Male, Middle Aged, RNA, Messenger, Time Factors, Wound Healing, Keratinocytes, Interleukin-8, In Situ Hybridization, Neovascularization, Physiologic, Chemokines, Chemokine CCL2, Chemokines, CXC, Intercellular Signaling Peptides and Proteins, Chemokine CXCL10, Chemokine CXCL1, Chemokine CXCL9
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