Esophageal Resection for Cancer of the Esophagus: Long-Term Function and Quality of Life
Open accessAbstract
Background Information on function and quality of life of long-term survivors after esophageal resection for carcinoma is limited. Methods Between 1972 and 1990, 359 patients underwent esophagectomy for stage I or II esophageal carcinoma at Mayo Clinic. We evaluated long-term function and quality of life in 107 of these patients (81 men and 26 women) who survived 5 or more years. Median age at operation was 62 years (range, 30 to 81 years). The operation performed was an Ivor Lewis resection in 77 patients (72%), transhiatal esophagectomy in 14 (13%), extended esophagectomy in 4 (4%), thoracoabdominal esophagectomy in 4 (4%), and other in 8 (7%). Adenocarcinoma was present in 72 patients (67%), squamous cell carcinoma in 28 (26%), and other in 7 (7%). Thirty-four patients (32%) were in postsurgical stage I, 65 (61%) in stage IIA, and 8 (8%) in stage IIB. Median survival was 10.2 years (range, 5.0 to 23.2 years). Follow-up was complete for all patients. Results Gastroesophageal reflux was present in 64 patients (60%), symptoms of dumping in 53 (50%), and dysphagia to solid food in 27 (25%). Seventeen patients (16%) were asymptomatic. Factors affecting late functional outcome were analyzed. Patients who had a cervical anastomosis had significantly fewer reflux symptoms (p < 0.05). Dumping syndrome occurred more frequently in younger patients (p < 0.05) and women (p < 0.01). Quality of life was assessed separately by the Medical Outcomes Study 36-Item Short-Form Health Survey and compared with the national norm. Scores measuring physical functioning were decreased (p < 0.01). Scores measuring ability to work, social interaction, daily activities, emotional dysfunction, perception of health, and levels of energy were similar. Mental health scores were higher (p < 0.05). Conclusions We conclude that long-term functional outcome after esophagectomy for esophageal carcinoma is affected by age, sex, and type of reconstruction. Quality of life as judged by the patients is similar to the national norm.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dumping syndrome is a common complication of esophageal, gastric or bariatric surgery.
“Dumping syndrome, a common complication of esophageal, gastric or bariatric surgery, includes early and late dumping symptoms.”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [4]
The Functional Outcome passage (page not supplied) reports postprandial dumping symptoms in 53 of 107 long-term survivors after esophageal resection, supporting that dumping is common in this group. The cited passages do not establish how common it is after gastric or bariatric surgery. (LLM, conf=0.86)
Experimental — accuracy not yet measuredDumping syndrome has been reported to occur in approximately 20% of patients who undergo vagotomy with pyloroplasty, in up to 40% of patients after Roux-en-Y gastric bypass or sleeve gastrectomy, and in up to 50% of patients who undergo esophagectomy.
“Dumping syndrome has been reported to occur in approximately 20% of patients who undergo vagotomy with pyloroplasty, in up to 40% of patients after Roux-en-Y gastric bypass or sleeve gastrectomy, and in up to 50% of patients who undergo esophagectomy (3)(4)(5)(6)(7).”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
No references could be resolved yet.
Research works printed but not linked: 23
- O'Rourke I, Tait N, Bull C, Gebski V, Holland M, Johnson DC. Oesophageal cancer: outcome of modern surgical man- agement. Aust N Z J Surg 1995;65:11-6.
- King RM, Pairolero PC, Trastek VF, Payne WS, Bernatz PE. Ivor Lewis esophagogastrectomy for carcinoma of the esophagus: early and late functional results. Ann Thorac Surg 1987;44:119-22.
- Vigneswaran WT, Trastek VF, Pairolero PC, Deschamps C, Daly RC, Allen MS. Transhiatal esophagectomy for carci- noma of the esophagus. Ann Thorac Surg 1993;56:838-46.
- Vigneswaran WT, Trastek VF, Pairolero PC, Deschamps C, Daly RC, Allen MS. Extended esophagectomy in the man- agement of carcinoma of the upper thoracic esophagus. J Thorac Cardiovasc Surg 1994;107:901-7.
- Lizuka T, Isono K, Kakegawa T, Watanabe H. Parameters linked to ten-year survival in Japan of resected esophageal carcinoma. Chest 1989;96:1005-11.
- Pera M, Cameron AJ, Trastek VF, Carpenter HA, Zinsmeis- ter AR. Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction. Gastroenterology 1993;104:510-3.
- Pera M, Trastek VF, Carpenter HA, Allen MS, Deschamps C, Pairolero PC. Barrett's esophagus with high-grade dysplasia: an indication for esophagectomy? Ann Thorac Surg 1992;54: 199 -204.
- Edwards MJ, Gable DR, Lentsch AB, Richardson JD. The rationale for esophagectomy as the optimal therapy for Barrett's esophagus with high-grade dysplasia. Ann Surg 1996;223:585-91.
- Gelfand GAJ, Finley RJ. Quality of life with carcinoma of the esophagus. World J Surg 1994;18:399 -405.
- Beahrs OH, Henson DE, Hutter RV, Kennedy BJ. American Joint Commission on Cancer: manual for staging of cancer. 4th ed. Philadelphia: Lippincott, 1992:59.
- Dixon WJ, Massey FJ Jr. Introduction to statistical analysis. 3rd ed. New York: McGraw-Hill, 1969:77-80, 116 -8, 156 -63, 344 -5, 509.
- Siegel S. Nonparametric statistics for the behavioral sci- ences. 1st ed. New York: McGraw-Hill, 1956:63-83, 104 -11, 161-72, 175-9, 184 -93.
- Kaplan EL, Meier P. Non-parametric estimation from incom- plete observation. J Am Stat Assoc 1958;53:457-81.
- Suzuki H, Shichisaburo A, Kitamura M, Hashimoto M, Izumi K, Sato H. An evaluation of symptoms and performance status in patients after esophagectomy for esophageal cancer from the viewpoint of the patient. Am Surg 1994;60:920-3.
- Nishihira T, Watanabe T, Ohmori N, et al. Long-term eval- uation of patients treated by radical operation for carcinoma of the thoracic esophagus. World J Surg 1984;8:778-85.
- Collard J-M, Otte J-B, Reynaert M, Kestens P-J. Quality of life three years or more after esophagectomy for cancer. J Thorac Cardiovasc Surg 1992;104:391-4.
- De Leyn P, Coosemans W, Lerut T. Early and late functional results in patients with intrathoracic gastric replacement after oesophagectomy for carcinoma. Eur J Cardio-thorac Surg 1992;6:79-85.
- Orringer MB, Marshall B, Stirling MC. Transhiatal esopha- gectomy for benign and malignant disease. J Thorac Cardio- vasc Surg 1993;105:265-77.
- Finley RJ, Lamy A, Clifton J, Evans KG, Fradet G, Nelems B. Gastrointestinal function following esophagectomy for ma- lignancy. Am J Surg 1995;169:471-5.
- Iannettoni MD, Whyte RI, Orringer MB. Catastrophic com- plications of the cervical esophagogastric anastomosis. J Thorac Cardiovasc Surg 1995;110:1493-501.
- Blazeby JM, Williams MH, Brookes ST, Alderson D, Farndon JR. Quality of life measurement in patients with oesophageal cancer. Gut 1995;37:505-8.
- Van Knippenberg FCE, Out JJ, Tilanus HW, Mud HJ, Hop WCJ, Verhage F. Quality of life in patients with resected oesophageal cancer. Soc Sci Med 1992;35:139-45.
- Kuwano H, Ikebe M, Baba K, et al. Operative procedures of reconstruction after resection of esophageal cancer and the postoperative quality of life. World J Surg 1993;17:773-6.
Cited by
Sorted by citations
American Gastroenterological Association Technical Review on the Management of Barrett's Esophagus
Spechler, S., Sharma, P., Souza, R., Inadomi, J., & Shaheen, N. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.031 · Cited by 981 · see citing works
Transthoracic versus transhiatal resection for carcinoma of the esophagus: a meta-analysis.
Hulscher, J., Tijssen, J. G., Obertop, H., & van Lanschot, J. V. (2001) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(00)02570-4 · Cited by 582 · see citing works
“A high incidence of vocal cord paralysis was mentioned after cervical anastomoses, after both transthoracic and transhiatal procedures, indicating that the recurrent nerve is mainly at risk during the cervical dissection and the construction of the anastomosis [8, 52, 63–65].”
BackgroundAndo, N., Ozawa, S., Kitagawa, Y., Shinozawa, Y., & Kitajima, M. (2000) · Annals of Surgery · doi:10.1097/00000658-200008000-00013 · Cited by 565
Pathophysiology, diagnosis and management of postoperative dumping syndrome
Tack, J., Arts, J., Caenepeel, P., De Wulf, D., & Bisschops, R. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.148 · Cited by 387 · see citing works
Quality of Life in Long-Term Survivors of Adult-Onset Cancers
Gotay, C. C., & Muraoka, M. Y. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.9.656 · Cited by 317 · see citing works
van Beek, A. P., Emous, M., Laville, M., & Tack, J. (2017) · Obesity Reviews · doi:10.1111/obr.12467 · Cited by 288 · see citing works
Outcomes After Transhiatal and Transthoracic Esophagectomy for Cancer
Chang, A. C., Ji, H. L., Birkmeyer, N. J. O., Orringer, M. B., & Birkmeyer, J. D. (2008) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2007.10.007 · Cited by 275 · see citing works
Quality of life in “chronic” cancer survivors: a meta-analysis
Firkins, J. L., Hansen, L., Driessnack, M., & Dieckmann, N. F. (2020) · Journal of Cancer Survivorship · doi:10.1007/s11764-020-00869-9 · Cited by 298 · see citing works
International consensus on the diagnosis and management of dumping syndrome
Scarpellini, E., Arts, J., Karamanolis, G., Laurenius, A., Siquini, W., Suzuki, H., Ukleja, A., van Beek, A. V., Vanuytsel, T., Bor, S., et al. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0357-5 · Cited by 247 · see citing works
Derogar, M., Orsini, N., Sadr-Azodi, O., & Lagergren, P. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.40.3568 · Cited by 217 · see citing works
Health‐related quality of life among patients cured by surgery for esophageal cancer
Lagergren, P., Avery, K. N. L., Hughes, R., Barham, C., Alderson, D., Falk, S., & Blazeby, J. (2007) · Cancer · doi:10.1002/cncr.22833 · Cited by 205 · see citing works
“Neoadjuvant therapy, yes 29 (62) Type of surgery 2-Phase esophagectomy 42 (89) 3-Phase esophagectomy 2 (4) Transhiatal esophagectomy 3 (6) In-hospital complications 1 Complication 25 (53) Pulmonary problems 20 (43) Anastomotic leak, gastric necrosis 4 (8) Upper GI bleeding 2 (4) Cardiovascular problems 2 (4) Chylothor…”
Backgroundde Boer, A. D., van Lanschot, J. V., van Sandick, J. W., Hulscher, J., Stalmeier, P., de Haes, J. C., Tilanus, H., Obertop, H., & Sprangers, M. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.11.102 · Cited by 188 · see citing works
High-grade esophageal dysplasia: long-term survival and quality of life after esophagectomy.
Headrick, J. R., Nichols, F., Miller, D. L., Allen, M., Trastek, V., Deschamps, C., Schleck, C., Thompson, A., & Pairolero, P. (2002) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)03496-3 · Cited by 183
“The mean and standard deviation were then compared to age- and gender-matched national norms [12].”
BackgroundResultSelf-citationFast tracking after Ivor Lewis esophagogastrectomy.
Cerfolio, R., Bryant, A., Bass, C. S., Alexander, J., & Bartolucci, A. (2004) · Chest · doi:10.1378/chest.126.4.1187 · Cited by 171
Macefield, R. C., Jacobs, M., Korfage, I. J., Nicklin, J., Whistance, R. N., Brookes, S. T., Sprangers, M. A. G., & Blazeby, J. M. (2014) · Trials · doi:10.1186/1745-6215-15-49 · Cited by 178 · see citing works
“Some 55 relevant articles reporting 56 studies were identified (Table 1) [11-65].”
BackgroundSystematic review of health-related quality of life after esophagectomy for esophageal cancer.
Scarpa, M., Valente, S., Alfieri, R., Cagol, M., Diamantis, G., Ancona, E., & Castoro, C. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i42.4660 · Cited by 164 · see citing works
Vagal-Sparing Esophagectomy: A More Physiologic Alternative
Banki, F., Mason, R. J., DeMeester, S. R., Hagen, J. A., Balaji, N. S., Crookes, P. F., Bremner, C. G., Peters, J. H., & DeMeester, T. R. (2002) · Annals of Surgery · doi:10.1097/00000658-200209000-00009 · Cited by 157 · see citing works
The role of endoscopy in the evaluation and management of dysphagia.
Pasha, S., Acosta, R. D., Chandrasekhara, V., Chathadi, K. V., Decker, G., Early, D., Evans, J. A., Fanelli, R., Fisher, D. A., Foley, K. Q., et al. (2014) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2013.07.042 · Cited by 141 · see citing works
A comprehensive review of anastomotic technique in 432 esophagectomies.
Price, T. N., Nichols, F., Harmsen, W. S., Allen, M., Cassivi, S., Wigle, D., Shen, K., & Deschamps, C. (2013) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2012.11.045 · Cited by 140
“Either of these early or late complications prolongs recovery and has a negative impact on quality of life [1, 7–9].”
BackgroundSelf-citationArts, J., Caenepeel, P., Bisschops, R., Dewulf, D., Holvoet, L., Piessevaux, H., Bourgeois, S., Sifrim, D., Janssens, J., & Tack, J. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.11.025 · Cited by 142 · see citing works
Quality of life and persisting symptoms after oesophageal cancer surgery.
Viklund, P., Wengström, Y., Rouvelas, I., Lindblad, M., & Lagergren, J. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.02.005 · Cited by 130 · see citing works
Hordijk, M., van Hooft, J. V., Hansen, B., Fockens, P., & Kuipers, E. (2009) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2009.02.023 · Cited by 128 · see citing works
Reynolds, J., McLaughlin, R., Moore, J., Rowley, S., Ravi, N., & Byrne, P. J. (2006) · British Journal of Surgery · doi:10.1002/bjs.5373 · Cited by 128 · see citing works
Long‐term weight change after oesophageal cancer surgery
Martin, L., & Lagergren, P. (2009) · British Journal of Surgery · doi:10.1002/bjs.6723 · Cited by 122 · see citing works
Leaks, strictures, and necrosis: a review of anastomotic complications following esophagectomy.
Cassivi, S. (2004) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2004.03.011 · Cited by 119
A systematic review of the nutritional consequences of esophagectomy
Baker, M., Halliday, V., Williams, R. N., & Bowrey, D. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.08.010 · Cited by 114 · see citing works
“[30], who identified a cervical anastomosis to be associated with a lower risk of reflux symptoms compared to an intrathoracic (mediastinal) anastomosis.”
Nederlof, N., Tilanus, H. W., Tran, T. C. K., Hop, W., Wijnhoven, B., & de Jonge, J. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e31822676a9 · Cited by 112 · see citing works
Revisional surgery after esophagectomy: an analysis of 43 patients.
Kent, M., Luketich, J., Tsai, W., Churilla, P., Federle, M., Landreneau, R., Alvelo-Rivera, M., & Schuchert, M. (2008) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2008.04.098 · Cited by 111
Poghosyan, T., Gaujoux, S., Chirica, M., Munoz-Bongrand, N., Sarfati, E., & Cattan, P. (2011) · Journal of visceral surgery · doi:10.1016/j.jviscsurg.2011.09.001 · Cited by 109
de Boer, A. D., Genovesi, P. I. O., Sprangers, M., van Sandick, J. W., Obertop, H., & van Lanschot, J. V. (2000) · British Journal of Surgery · doi:10.1046/j.1365-2168.2000.01600.x · Cited by 104 · see citing works
Esophageal reconstruction for benign disease: early morbidity, mortality, and functional results.
Young, M. M., Deschamps, C., Trastek, V., Allen, M., Miller, D. L., Schleck, C., & Pairolero, P. (2000) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(00)01916-0 · Cited by 97
Self-citationTzovaras, G., Papamargaritis, D., Sioka, E., Zachari, E., Baloyiannis, I., Zacharoulis, D., & Koukoulis, G. (2012) · Obesity Surgery · doi:10.1007/s11695-011-0461-7 · Cited by 97 · see citing works
Sutcliffe, R. P., Forshaw, M., Tandon, R., Rohatgi, A., Strauss, D. C., Botha, A., & Mason, R. C. (2008) · Diseases of the esophagus · doi:10.1111/j.1442-2050.2008.00865.x · Cited by 93
Long-Term Health-Related Quality of Life for Disease-Free Esophageal Cancer Patients
Donohoe, C., McGillycuddy, E., & Reynolds, J. (2011) · World Journal of Surgery · doi:10.1007/s00268-011-1123-6 · Cited by 92 · see citing works
“Swallowing dysfunction is present in 25% to 59% of cases in reported series [6, 18, 21, 22].”
BackgroundParameswaran, R., McNair, A., Avery, K. N. L., Berrisford, R., Wajed, S., Sprangers, M., & Blazeby, J. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-0042-8 · Cited by 92
Mosconi, P., Apolone, G., Barni, S., Secondino, S., Sbanotto, A., & Filiberti, A. (2002) · Tumori Journal · doi:10.1177/030089160208800206 · Cited by 76 · see citing works
Brooks, J., Kesler, K., Johnson, C. S., Ciaccia, D., & Brown, J. W. (2002) · Journal of Surgical Oncology · doi:10.1002/jso.10175 · Cited by 91 · see citing works
Graham, A. J., Shrive, F. M., Ghali, W. A., Manns, B., Grondin, S. C., Finley, R. J., & Clifton, J. C. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.11.061 · Cited by 82 · see citing works
Shenfine, J., McNamee, P., Steen, N., Bond, J., & Griffin, S. (2005) · Health Technology Assessment · doi:10.3310/hta9050 · Cited by 87
Three-field lymph node dissection for esophageal cancer in elderly patients over 70 years of age.
Fang, W.-T., Igaki, H., Tachimori, Y., Sato, H., Daiko, H., & Kato, H. (2001) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(01)02896-x · Cited by 85 · see citing works
“Until now, esophagectomy, if applicable, offers the best palliation of dysphagia and chance for cure [1].”
BackgroundSurgery for esophageal cancer in elderly patients: The view from Nottingham
Alexiou, C., Beggs, D., Salama, F. D., Brackenbury, E. T., & Morgan, W. E. (1998) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(98)70159-x · Cited by 77 · see citing works
Long-term experiences after oesophagectomy/gastrectomy for cancer—A focus group study
Malmström, M., Ivarsson, B., Johansson, J., & Klefsgård, R. (2012) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2012.08.011 · Cited by 84 · see citing works
Intrathoracic gastric emptying of solid food after esophagectomy for esophageal cancer.
Lee, H.-S., Kim, M. S., Lee, J., Kim, S.-K., Kang, K., & Zo, J. (2005) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2005.02.049 · Cited by 78
An alternative postoperative pathway reduces length of hospitalisation following oesophagectomy
Tomaszek, S., Cassivi, S., Allen, M., Shen, K. R., Nichols, F., Deschamps, C., & Wigle, D. (2009) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2009.09.034 · Cited by 77
“Various studies to date have shown that overall quality of life seems not be impaired in long-term survivors following oesophagectomy [19—24].”
BackgroundSelf-citationVerschuur, E. M. L., Steyerberg, E. W., Tilanus, H. W., Polinder, S., Essink‐Bot, M., Tran, K., van der Gaast, A., Stassen, L. P. S., Kuipers, E. J., & Siersema, P. D. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604811 · Cited by 59 · see citing works
“Surgery for oesophageal cancer is often accompanied by significant morbidity (Zieren et al, 1996; Baba et al, 1997; McLarty et al, 1997; Blazeby et al, 2000; De Boer et al, 2000, 2004; Brooks et al, 2002; Fagevik Olsen et al, 2005; Viklund et al, 2006).”
BackgroundDas, A., Wells, C., Kim, H. J., Fleischer, D., Crowell, M., & Sharma, V. (2009) · Endoscopy · doi:10.1055/s-0029-1214612 · Cited by 75 · see citing works
Fuchs, H. F., Hölscher, A. H., Leers, J. M., Bludau, M., Brinkmann, S., Schröder, W., Alakus, H., Mönig, S., & Gutschow, C. A. (2015) · Gastric Cancer · doi:10.1007/s10120-015-0466-3 · Cited by 73 · see citing works
“From other research, we know that significant recuperation of HRQL takes place during the first 1–2 years [4, 14], and recovery to levels similar to that of a healthy reference population has been documented in a number of studies [21–25].”
BackgroundComplications of esophagectomy.
Raymond, D. (2012) · Surgical Clinics of North America · doi:10.1016/j.suc.2012.07.007 · Cited by 68
Delayed emptying of the gastric conduit after esophagectomy.
Konradsson, M., & Nilsson, M. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.11.80 · Cited by 65
“Delayed emptying of ingested food or fluid to the duodenum has been associated with short term adverse outcomes such as anastomotic leak, pneumonia, longer postoperative ICU and total hospital admission, and in the long term may cause a variety of symptoms, nutritional problems and have a marked effect on quality of l…”
BackgroundBowrey, D., Baker, M., Halliday, V., Thomas, A., Pulikottil-Jacob, R., Smith, K., Morris, T., & Ring, A. (2015) · Trials · doi:10.1186/s13063-015-1053-y · Cited by 65 · see citing works
“In the studies to report long-term outcome [3, 4], at five years or more after surgery, between 49 % and 95 % of patients had failed to regain lost weight postoperatively.”
BackgroundAdjusting to Life After Esophagectomy: The Experience of Survivors and Carers
Mccorry, N., Dempster, M., Clarke, C., & Doyle, R. (2009) · Qualitative Health Research · doi:10.1177/1049732309348366 · Cited by 65 · see citing works
“There have been several quantitative studies measuring quality of life following surgery (Lindars, 1994; McLarty et al., 1997), but with inconsistent results (perhaps because of problems of response shift, or variations in measurement instruments), and with limited utility for helping to appreciate…”
Patients' experiences of living with oesophageal cancer.
Andreassen, S., Randers, I., Näslund, E., Stockeld, D., & Mattiasson, A. (2006) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2006.01412.x · Cited by 64
“However, oesophagectomy did not appear to influence quality of life (McLarty et al. 1997).”
BackgroundFunctional conduit disorders after esophagectomy.
Donington, J. (2006) · Thoracic Surgery Clinics · doi:10.1016/j.thorsurg.2006.01.002 · Cited by 63
“In an analysis of long-term digestive function after esophagectomy from the Mayo Clinic, 33% to 46% of patients reported some level of dysphagia after esophagectomy, and in 3% to 4% of patients dysphagia was severe and occurred with liquids [8,9].”
BackgroundInfluentialBalloon dilatation of the pylorus for delayed gastric emptying after esophagectomy.
Kim, J.-H., Lee, H.-S., Kim, M. S., Lee, J., Kim, S.-K., & Zo, J. (2008) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2008.03.012 · Cited by 61
Vagotomy During Hiatal Hernia Repair: A Benign Esophageal Lengthening Procedure
Oelschlager, B., Yamamoto, K., Woltman, T. A., & Pellegrini, C. (2008) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-008-0520-0 · Cited by 61
Cost-effectiveness of photodynamic therapy for high-grade dysplasia in Barrett's esophagus.
Vij, R., Triadafilopoulos, G., Owens, D., Kunz, P., & Sanders, G. D. (2004) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(04)02167-4 · Cited by 60
Chronic opioid therapy in long-term cancer survivors
Carmona‐Bayonas, A., Jiménez‐Fonseca, P., Castañón, E., Vaswani, A. R., Sánchez-Bayona, R., Custodio, A. B., Calvo-Temprano, D., & Virizuela, J. A. (2016) · Clinical & Translational Oncology · doi:10.1007/s12094-016-1529-6 · Cited by 59 · see citing works
“However, pain rates tend to be higher than in the general population [11, 14].”
BackgroundComplications of esophageal resection and reconstruction.
Parekh, K., & Iannettoni, M. (2007) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2006.11.002 · Cited by 59
Fong, Z. V., Alvino, D. M. L., Castillo, C. F. F.-D., Nipp, R. D., Traeger, L. N., Ruddy, M., Lubitz, C. C., Johnson, C., Chang, D. C., Warshaw, A. L., et al. (2017) · Annals of Surgery · doi:10.1097/sla.0000000000002380 · Cited by 80 · see citing works
Gockel, I., Gönner, U., Domeyer, M., Lang, H., & Junginger, T. (2009) · Journal of Surgical Oncology · doi:10.1002/jso.21434 · Cited by 58 · see citing works
Anastomotic stricture complicating esophagectomy.
Rice, T. (2006) · Thoracic Surgery Clinics · doi:10.1016/j.thorsurg.2006.02.002 · Cited by 58
Teoh, A., Chiu, P., Ngo, D., Wong, S., Lau, J., & Ng, E. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181ce52fb · Cited by 57
Egberts, J., Schniewind, B., Bestmann, B., Schafmayer, C., Egberts, F., Faendrich, F., Kuechler, T., & Tepel, J. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-007-9615-1 · Cited by 57 · see citing works
Ben-David, K., Sarosi, G., Cendan, J., & Hochwald, S. (2010) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-010-1244-5 · Cited by 55
Ouattara, M., D'Journo, X., Loundou, A., Trousse, D., Dahan, L., Doddoli, C., Seitz, J., & Thomas, P. (2012) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezr182 · Cited by 54
“Feeding jejunostomy has been shown to be both effective and cost-efficient in the preoperative period and for long-term support in patients with cancer of the oesophagus [21–25].”
BackgroundEsophagogastrectomy: The influence of stapled versus hand-sewn anastomosis on outcome
Behzadi, A., Nichols, F., Cassivi, S., Deschamps, C., Allen, M., & Pairolero, P. (2005) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2005.06.025 · Cited by 54 · see citing works
“Regardless of the surgical approach, avoiding anastomotic complications is essential for minimizing early morbidity and maximizing long-term functional results and quality of life.(8,9) Short-term devastating complications include ischemia and leak, while long-term complications include stricture formation.”
BackgroundResultSelf-citationChronic symptoms after subtotal or partial oesophagectomy: diagnosis and treatment.
Lerut, T., & van Lanschot, J. V. (2004) · Best practice & research. Clinical gastroenterology · doi:10.1016/j.bpg.2004.06.029 · Cited by 54
Efficacy and safety of EMR to completely remove Barrett's esophagus: experience in 41 patients.
Gerke, H., Siddiqui, J., Nasr, I., Handel, D. M. V., & Jensen, C. S. (2011) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2011.06.009 · Cited by 53
Young, M. M., Deschamps, C., Allen, M., Miller, D. L., Trastek, V., Schleck, C. D., & Pairolero, P. (2000) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(00)01856-7 · Cited by 53
“1%) completed and returned a combined two-part questionnaire regarding esophageal function and quality of life after esophageal reconstruction [1].”
BackgroundSelf-citationQuality of life after oesophagectomy: the patients' perspective.
Kirby, J. (1999) · Diseases of the esophagus · doi:10.1046/j.1442-2050.1999.00040.x · Cited by 52
Experiences and expectations of patients after oesophageal cancer surgery: an explorative study.
Verschuur, E., Steyerberg, E., Kuipers, E., Essink-bot, M., Tran, K., van der Gaast, A., Tilanus, H., & Siersema, P. (2006) · European Journal of Cancer Care · doi:10.1111/j.1365-2354.2006.00659.x · Cited by 51
Acid and Duodenogastroesophageal Reflux after Esophagectomy with Gastric Tube Reconstruction
Yuasa, N., Sasaki, E., Ikeyama, T., Miyake, H., & Nimura, Y. (2005) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41109.x · Cited by 51
Surgical treatments for esophageal cancers
Allum, W., Bonavina, L., Cassivi, S., Cuesta, M. A., Dong, Z.-M., Felix, V., Figueredo, E. J., Gatenby, P. A. C., Haverkamp, L., Ibraev, M. A., et al. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12533 · Cited by 50
The Role of Identity in Adjustment among Survivors of Oesophageal Cancer
Clarke, C., McCorry, N., & Dempster, M. (2010) · Journal of Health Psychology · doi:10.1177/1359105310368448 · Cited by 41 · see citing works
“For oesophageal cancer survivors (following surgery) quality of life can be reduced (Lindars, 1994; McLarty et al., 1997) as a result of physical symptoms such as eating problems, reflux, cough, oesophageal pain, dry mouth, dysphagia and problems with taste (Viklund, Wengstrom, Rouvelas, Lindblad,…”
BackgroundZhang, C., Wu, Q.-C., Hou, P.-Y., Zhang, M., Li, Q., Jiang, Y.-J., & Chen, D. (2011) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2010.04.032 · Cited by 50
Quality of Life in Patients with Esophageal Cancer
Darling, G. E. (2013) · Thoracic surgery clinics/Thorac. surg. clin. · doi:10.1016/j.thorsurg.2013.07.011 · Cited by 54 · see citing works
“Conceptually it seems that this heterogeneity of the patient population would likely impact the HRQOL scores at least for physical and functional domains.(9,10) In a study of only patients with high-grade dysplasia, physical and emotional scores were similar or better than those for age-matched controls.”
Survival after oesophagectomy for cancer of the oesophagus
Stein, H. J., von Rahden, B. V., & Siewert, J. (2005) · Langenbeck's archives of surgery (Print) · doi:10.1007/s00423-004-0504-9 · Cited by 48
“[20] investigated long-term function after oesophagectomy, as well as quality-of life-parameters.”
BackgroundQuality of life after esophagectomy for cancer.
Sweed, M., Schiech, L., Barsevick, A., Babb, J., & Goldberg, M. (2002) · Oncology Nursing Forum · doi:10.1188/02.onf.1127-1131 · Cited by 48
“Despite improved rates of morbidity and mortality associated with curative surgical resection, some patients reportedly have experienced symptoms because of surgery (McLarty et al., 1997).”
BackgroundResultInfluentialInfluence of Surgery-related Factors on Quality of Life after Esophageal or Cardia Cancer Resection
Viklund, P., Lindblad, M., & Lagergren, J. (2005) · World Journal of Surgery · doi:10.1007/s00268-005-7887-9 · Cited by 47
Suboptimal intake of nutrients after esophagectomy with gastric tube reconstruction.
Haverkort, E., Binnekade, J., de Haan, R., Busch, O., Henegouwen, M. I. V. B., & Gouma, D. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.03.032 · Cited by 45
Quality of life after esophagectomy.
Fernández, F., & Meyers, B. (2004) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2004.03.008 · Cited by 44
Straatman, J., Joosten, P. J. M., Terwee, C. B., Cuesta, M. A., Jansma, E. P., & van der Peet, D. L. (2015) · Diseases of the Esophagus · doi:10.1111/dote.12405 · Cited by 52 · see citing works
Long-term function and quality of life after esophageal resection for cancer and Barrett's.
Deschamps, C., Nichols, F., Cassivi, S., Allen, M., & Pairolero, P. (2005) · Surgical Clinics of North America · doi:10.1016/j.suc.2005.01.018 · Cited by 41 · see citing works
Self-citationA prospective comparison of quality of life measures for patients with esophageal cancer
Blazeby, J., Kavadas, V., Vickery, C. W., Greenwood, R., Berrisford, R., & Alderson, D. (2005) · Quality of Life Research · doi:10.1007/s11136-004-0622-4 · Cited by 41
Schmidt, C., Bestmann, B., Küchler, T., Schmid, A., & Kremer, B. (2004) · World Journal of Surgery · doi:10.1007/s00268-003-7219-x · Cited by 39 · see citing works
“Postoperative hoarseness, daily quantity of food intake, reflux, and heartburn seem to be the most important factors for patients after esophageal resection [29].”
Blazeby, J. M. (2001) · Surgical Oncology · doi:10.1016/s0960-7404(01)00024-x · Cited by 34 · see citing works
Long-Term Quality of Life after Ivor Lewis Esophagectomy for Esophageal Cancer
Däster, S., Soysal, S., Stoll, L., Peterli, R., von Flüe, M., & Ackermann, C. (2014) · World Journal of Surgery · doi:10.1007/s00268-014-2576-1 · Cited by 38
“Studies have demonstrated that, in the long term, patients without tumor recurrence after esophagectomy achieved results comparable with preoperative values, or data from a healthy reference population [13–18].”
ResultAlterations in epidermal growth factor receptors 1 and 2 in esophageal squamous cell carcinomas
Gonzaga, I., Soares-Lima, S., de Santos, P. T. S., Blanco, T., de Reis, B. S. B., Quintella, D., de Oliveira, I. M., de Faria, P. D., Kruel, C. D., Andreollo, N., et al. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-569 · Cited by 37 · see citing works
“The poor prognosis of ESCC patients results from late stage diagnosis and the poor efficacy of treatment, with systemic chemotherapy having mainly a palliative role [3].”
BackgroundClinical analysis of reflux esophagitis following esophagectomy with gastric tube reconstruction
Yamamoto, S., Makuuchi, H., Shimada, H., Chino, O., Nishi, T., Kise, Y., Kenmochi, T., & Hara, T. (2007) · Journal of gastroenterology · doi:10.1007/s00535-007-2011-6 · Cited by 37
The esophageal remnant after gastric interposition.
D'Journo, X., Martin, J., Ferraro, P., & Duranceau, A. (2008) · Diseases of the esophagus · doi:10.1111/j.1442-2050.2008.00849.x · Cited by 36
Rahamim, J., Murphy, G., Awan, Y., & Junemann-Ramirez, M. (2003) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(03)00034-4 · Cited by 36
Haverkamp, L., van der Sluis, P. C., Verhage, R. J. J., Siersema, P., Ruurda, J., & van Hillegersberg, R. (2013) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-013-2159-8 · Cited by 35
Prognostic factors in patients with submucosal esophageal cancer
Natsugoe, S., Matsumoto, M., Okumura, H., Ikeda, M., Ishigami, S., Owaki, T., Takao, S., & Aikou, T. (2004) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2004.02.004 · Cited by 35
Koh, P. S., Turnbull, G., Attia, E., Lebrun, P., & Casson, A. (2004) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2003.12.034 · Cited by 35
“Altered swallowing after esophageal resection and reconstruction is reported frequently and may develop at any stage postoperatively, impacting significantly on quality of life [13].”
BackgroundDeloose, E., Bisschops, R., Holvoet, L., Arts, J., De Wulf, D., Caenepeel, P., Lannoo, M., Vanuytsel, T., Andrews, C., & Tack, J. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12333 · Cited by 35 · see citing works
Basis for molecular diagnostics and immunotherapy for esophageal cancer
Abdo, J., Agrawal, D., & Mittal, S. (2016) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2017.1260449 · Cited by 34
“lently among white males, and patients who present with EC are an average age of 67-years old [11,12].”
BackgroundQuality of life in patients with oesophageal cancer.
Blazeby, J., Alderson, D., & Farndon, J. (2000) · Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · doi:10.1007/978-3-642-59600-1_20 · Cited by 34
Functional outcome after Ivor Lewis esophagectomy for cancer
Deldycke, A., van Daele, E., Ceelen, W., van Nieuwenhove, Y., & Pattyn, P. (2016) · Journal of Surgical Oncology · doi:10.1002/jso.24084 · Cited by 33
“7% of the patients suffered from dysphagia, well within the range of 21–56% documented in the pertinent literature [3,8].”
BackgroundGastroparesis and Dumping Syndrome: Current Concepts and Management
Vavricka, S. R., & Greuter, T. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081127 · Cited by 37 · see citing works
Quality of life after esophagectomy for cancer
Djärv, T., & Lagergren, P. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.91 · Cited by 50 · see citing works
- Authors
- McLarty, A. J., Deschamps, C., Trastek, V. F., Allen, M. S., Pairolero, P. C., & Harmsen, W. S.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Deschamps, Claude
- Venue
- The Annals of Thoracic Surgery
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 63
- Issue
- 6
- Pages
- 1568-1571
- ISSN
- 0003-4975 (ISSN-L)
- OpenAlex
- W2094315259
- Cited by
- 272
- References
- 0
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 11 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 14 · 2014: 7 · 2013: 15 · 2012: 17
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Annals of Thoracic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Health Sciences › Medicine › Surgery › Esophageal and GI Pathology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
- Keywords
- esophageal cancer, esophagectomy, long-term functional outcome, quality of life, gastroesophageal reflux, dumping syndrome, dysphagia, cervical anastomosis, esophageal reconstruction, adenocarcinoma, squamous cell carcinoma, physical function, age and sex effects, late complications, long-term survivors, SF-36
- MeSH terms
- Actuarial Analysis, Adenocarcinoma, Adult, Age Factors, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Cause of Death, Deglutition, Deglutition Disorders, Esophageal Neoplasms, Female, Follow-Up Studies, Heartburn, Humans, Male, Middle Aged, Neoplasm Staging, Quality of Life, Sex Factors, Survival Rate, Confidence Intervals, Esophagectomy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
