Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism

[1] Production of single-stranded plasmid DNA

Vieira, J., & Messing, J. W. (1987) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(87)53044-0 · Cited by 2,558 · see citing works

Gene transfer into mouse lyoma cells by electroporation in high electric fields.

Neumann, E., Schaefer-Ridder, M., Wang, Y., & HOFSCHNEIDER, P. H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01257.x · Cited by 2,510 · see citing works

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

Mornet, É., Dupont, J., Vitek, A., & White, P. C. (1989) · PubMed · Cited by 440 · see citing works

Characterization of Two Genes Encoding Human Steroid 11β-Hydroxylase (P-45011β)

Mornet, E., Dupont, J., Vitek, A., & White, P. C. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)30030-4 · Cited by 405 · see citing works

The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.

Yanagibashi, K., Haniu, M., Shively, J. E., Shen, W. H., & Hall, P. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35682-x · Cited by 172 · see citing works

Isolation of Aldosterone Synthase Cytochrome P-450 from Zona Glomerulosa Mitochondria of Rat Adrenal Cortex

Ogishima, T., Mitani, F., & Ishimura, Y. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60408-9 · Cited by 141 · see citing works

A Heuristic Proposal for Understanding Steroidogenic Processes

Lieberman, S., Greenfield, N. J., & Wolfson, A. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-128 · Cited by 123 · see citing works

Cloning of cDNA and genomic DNA for human cytochrome P‐45011β

Kawamoto, T., Mitsuuchi, Y., Toda, K., Miyahara, K., Yokoyama, Y., Nakao, K., Hosoda, K., Yamamoto, Y., Imura, H., & Shizuta, Y. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81190-y · Cited by 96 · see citing works

Molecular cloning and expression of cDNAs encoding rat aldosterone synthase: Variants of cytochrome P-45011β

Matsukawa, N., 悠次, 野., Ying, Z., Higaki, J., Ogihara, T., & Okamoto, M. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91460-a · Cited by 95 · see citing works

Molecular cloning and expression of cDNAs encoding rat aldosterone synthase : variants of cytochrome P-450[11β]

松川, 直. (1992) · doi:10.11501/3060190 · Cited by 95 · see citing works

Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P‐450 in rat adrenal cortex

Imai, M., Shimada, H., Okada, Y., Matsushima‐Hibiya, Y., Ogishima, T., & Ishimura, Y. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81398-8 · Cited by 92 · see citing works

Stimulation of Aldosterone Biosynthesis in Adrenal Mitochondria by Sodium Depletion*

Marusic, E. T., & Mulrow, P. J. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105697 · Cited by 88 · see citing works

Molecular cloning and sequence analysis of cDNA encoding rat adrenal cytochrome P‐45011β

Nonaka, Y., Matsukawa, N., Morohashi, K., Omura, T., Ogihara, T., Teraoka, H., & Okamoto, M. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81053-1 · Cited by 84 · see citing works

Synthesis of Aldosterone by a Reconstituted System of Cytochrome P-45011β from Bovine Adrenocortical Mitochondria1

Wada, A., Ohnishi, T., Nonaka, Y., Okamoto, M., & Yamano, T. (1985) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a135264 · Cited by 82 · see citing works

Aldosterone biosynthesis by a reconstituted cytochrome P-45011β system

Wada, A., Okamoto, M., Nonaka, Y., & Toshio, Y. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91660-7 · Cited by 81 · see citing works

Molecular Cloning and Nucleotide Sequence of DNA of Mitochondrial Cytochrome P-450(11β) of Bovine Adrenal Cortex1

MOROHASHI, K.-I., YOSHIOKA, H., GOTOH, O., OKADA, Y., YAMAMOTO, K., MIYATA, T., SOGAWA, K., FUHI-KURIYAMA, Y., & OMURA, T. (1987) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a122089 · Cited by 69 · see citing works

Enzymatic Activities of P-450(llβ)s Expressed by Two cDNAs in COS-7 Cells1

Morohashi, K.-I., Nonaka, Y., Kirita, S., Hatano, O., Takakusu, A., Okamoto, M., & Omura, T. (1990) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a123099 · Cited by 62 · see citing works

Aldosterone biosynthesis and cytochrome P-45011β: evidence for two different forms of the enzyme in rats

Lauber, M., Sugano, S., Ohnishi, T., Okamoto, M., & Müller, J. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)91041-7 · Cited by 61 · see citing works

An Inherited Defect in Aldosterone Biosynthesis Caused by a Mutation in or near the Gene for Steroid 11-Hydroxylase

Globerman, H., Rösler, A., Theodor, R., New, M. I., & White, P. C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198811033191804 · Cited by 61 · see citing works

Expression of Two Kinds of Cytochrome P-450(11β) mRNA in Bovine Adrenal Cortex

Kirita, S., Morohashi, K.-I., Hashimoto, T., Yoshioka, H., Fujii‐Kuriyama, Y., & Omura, T. (1988) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a122533 · Cited by 58 · see citing works

Isolated Aldosterone Deficiency in Man: Acquired and Inborn Errors in the Biosynthesis or Action of Aldosterone*

Veldhuis, J. D., & Melby, J. C. (1981) · Endocrine Reviews · doi:10.1210/edrv-2-4-495 · Cited by 54 · see citing works

Aldosterone biosynthesis in mitochondria of isolated zones of adrenal cortex

Ohnishi, T., Akira, W., Lauber, M., Toshio, Y., & Okamoto, M. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90208-7 · Cited by 51 · see citing works

The role of cytochromes P-450 in adrenal steroidogenesis

Takemori, S., & Kominami, S. (1984) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(84)90223-8 · Cited by 51 · see citing works

19-Hydroxylation of 18-hydroxy-11-deoxycorticosterone catalyzed by cytochrome P-45011 beta of bovine adrenocortex.

Momoi, K., Okamoto, M., Fujii, S., Kim, C. Y., Miyake, Y., & Yamano, T. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32134-3 · Cited by 43 · see citing works

NAD+-dependent ADP-ribosyltransferase in renal brush-border membranes

Kempson, S. A., & Curthoys, N. P. (1983) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1983.245.5.c449 · Cited by 37 · see citing works

Optimum conditions for electric pulse-mediated gene transfer to mammalian cells in suspension.

Hama-Inaba, H., Takahashi, M., Kasai, M., Shiomi, T., Ito, A., Hanaoka, F., & Sato, K. (1987) · Cell Structure and Function · doi:10.1247/csf.12.173 · Cited by 32 · see citing works

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

Nelson, D. R., Kamataki, T., Waxman, D. J., Guengerich, F. P., Estabrook, R. W., Feyereisen, R., Gonzalez, F. J., Coon, M. J., GUNSALUS, I. C., Gotoh, O., et al. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.1 · Cited by 1,637 · see citing works

A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension

Lifton, R. P., Dluhy, R. G., Powers, M., Rich, G. M., Cook, S., Ulick, S., & Lalouel, J.-M. (1992) · Nature · doi:10.1038/355262a0 · Cited by 1,158 · see citing works

Human Cytochrome P450 Enzymes

Guengerich, F. P. (1995) · Springer eBooks · doi:10.1007/978-1-4757-2391-5_14 · Cited by 727 · see citing works

Molecular Genetics of Human Blood Pressure Variation

Lifton, R. P. (1996) · Science · doi:10.1126/science.272.5262.676 · Cited by 621 · see citing works

Steroidogenic enzymes: Structure, function, and role in regulation of steroid hormone biosynthesis

Hanukoglu, I. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90307-5 · Cited by 551 · see citing works

Primary Hyperaldosteronism in Essential Hypertensives: Prevalence, Biochemical Profile, and Molecular Biology¹

Fardella, C. E., Mosso, L., Gómez-Sánchez, C., Cortés, P., Soto, J., Gómez, L., Pinto, M., Huete, A., Oestreicher, E., Foradori, A., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.5.6596 · Cited by 14 · see citing works

Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review

Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works

The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex

Curnow, K. M., Tusie-Luna, M.-T., Pascoe, L., Natarajan, R., Gu, J.-L., Nadler, J. L., & White, P. C. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-10-1513 · Cited by 362 · see citing works

Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase

Lifton, R. P., Dluhy, R. G., Powers, M., Rich, G. M., Gutkin, M. C., Fallo, F., Gill, J. R., Feld, L. G., Ganguly, A., Laidlaw, J. C., et al. (1992) · Nature Genetics · doi:10.1038/ng0992-66 · Cited by 329 · see citing works

Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.

Pascoe, L., Curnow, K. M., Slutsker, L., Connell, J. M., Speiser, P. W., New, M. I., & White, P. C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8327 · Cited by 271 · see citing works

Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.

Kawamoto, T., Mitsuuchi, Y., Toda, K., Yokoyama, Y., Miyahara, K., Miura, S., Ohnishi, T., Ichikawa, Y., Nakao, K., & Imura, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1458 · Cited by 245 · see citing works

Human Cytochrome P450 Enzymes

Guengerich, F. P. (2007) · Springer eBooks · doi:10.1007/0-387-27447-2_10 · Cited by 220 · see citing works

Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal

Staels, B., Hum, D., & Miller, W. L. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.3.8387159 · Cited by 206 · see citing works

Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8.

Curnow, K. M., Slutsker, L., Vítek, J., Cole, T. J., Speiser, P., New, M. I., White, P. C., & Pascoe, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4552 · Cited by 205 · see citing works

Cytochrome P450: Structure, function, and generation of reactive oxygen species

Bernhardt, R. (1995) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0048267 · Cited by 196 · see citing works

Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency.

Pascoe, L., Curnow, K. M., Slutsker, L., Rösler, A., & White, P. C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.4996 · Cited by 188 · see citing works

Human NCI-H295 adrenocortical carcinoma cells: a model for angiotensin- II-responsive aldosterone secretion

Bird, I. M., Hanley, N. A., Word, R. A., Mathis, J. M., McCarthy, J. L., Mason, J. I., & Rainey, W. E. (1993) · Endocrinology · doi:10.1210/endo.133.4.8404594 · Cited by 186 · see citing works

Genetic determinants of human hypertension.

Lifton, R. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8545 · Cited by 177 · see citing works

Different Isozymes of Mouse 11/ß-Hydroxylase Produce Mineralocorticoids and Glucocorticoids

Domalik, L. J., Chaplin, D., Kirkman, M. S., Wu, R. C., Liu, W., Howard, T. A., Seldin, M. F., & Parker, K. L. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-12-1853 · Cited by 171 · see citing works

Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin

Takeda, Y., Miyamori, I., Yoneda, T., Hatakeyama, H., Inaba, S., Furukawa, K., Mabuchi, H., & Takeda, R. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768832 · Cited by 168 · see citing works

FAMILIAL HYPERALDOSTERONISM TYPE II: FIVE FAMILIES WITH A NEW VARIETY OF PRIMARY ALDOSTERONISM

Stowasser, M., Gordon, R. D., Tunny, T. J., Klemm, S. A., Finn, W. L., & Krek, A. L. (1992) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1992.tb00462.x · Cited by 154 · see citing works

Human Cytochrome P450 Enzymes

Guengerich, F. P. (2015) · Springer eBooks · doi:10.1007/978-3-319-12108-6_9 · Cited by 150 · see citing works

STEROID 11β-HYDROXYLASE DEFICIENCY AND RELATED DISORDERS

White, P. C. (2001) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(08)70019-7 · Cited by 144 · see citing works

High frequency of congenital adrenal hyperplasia (classic 11β‐hydroxylase deficiency) among Jews from Morocco

Rösler, A., Leiberman, E., & Cohen, T. (1992) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320420617 · Cited by 144 · see citing works

Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism

Ogishima, T., Shibata, H., Shimada, H., Mitani, F., Suzuki, H., Saruta, T., & Ishimura, Y. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99077-0 · Cited by 141 · see citing works

Structural Insights into Aldosterone Synthase Substrate Specificity and Targeted Inhibition

Strushkevich, N. V., Gilep, A. A., Shen, L., Arrowsmith, C. H., Edwards, A. M., Usanov, S. A., & Park, H. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1287 · Cited by 136 · see citing works

Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree.

Pascoe, L., Jeunemaı̂tre, X., Lebrethon, M. C., Curnow, K. M., Gómez-Sánchez, C. E., Gasc, J., Saez, J. M., & Corvol, P. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118279 · Cited by 134 · see citing works

Aldosterone synthase deficiency and related disorders

White, P. C. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.10.013 · Cited by 131 · see citing works

The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme

Curnow, K. M., Mulatero, P., Emeric-Blanchouin, N., Aupetit-Faisant, B., Corvol, P., & Pascoe, L. (1997) · Nature Structural & Molecular Biology · doi:10.1038/nsb0197-32 · Cited by 102 · see citing works

Modulation of aldosterone and cortisol synthesis on the molecular level

Lisurek, M., & Bernhardt, R. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.11.008 · Cited by 98 · see citing works

Familial hyperaldosteronism

Stowasser, M., & Gordon, R. D. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00097-8 · Cited by 93 · see citing works

CYP17- and CYP11B-dependent steroid hydroxylases as drug development targets

Hakki, T., & Bernhardt, R. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.07.006 · Cited by 91 · see citing works

Recombinant<i>CYP11B</i>Genes Encode Enzymes that Can Catalyze Conversion of 11-Deoxycortisol to Cortisol, 18-Hydroxycortisol, and 18-Oxocortisol¹

Mulatero, P., Curnow, K. M., Aupetit-Faisant, B., Foekling, M., Gomez-Sanchez, C., Veglio, F., Jeunemaitre, X., Corvol, P., & Pascoe, L. (1998) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.83.11.5237 · Cited by 88 · see citing works

The Human Steroid Hydroxylases CYP11B1 and CYP11B2

Bureik, M., Lisurek, M., & Bernhardt, R. (2002) · Biological Chemistry · doi:10.1515/bc.2002.174 · Cited by 88 · see citing works

The biosynthesis of steroids and triterpenoids

Brown, G. D. (1998) · Natural Product Reports · doi:10.1039/a815653y · Cited by 88 · see citing works

FSH in therapy: physiological basis, new preparations and clinical use

Simoni, M., & Nieschlag, E. (1995) · Reproductive Medicine Review · doi:10.1017/s0962279900000557 · Cited by 84 · see citing works

Aldosterone synthase (CYP11B2) expression and myocardial fibrosis in the failing human heart

Satoh, M., Nakamura, M., Saitoh, H., Satoh, H., Akatsu, T., Iwasaka, J., Masuda, T., & Hiramori, K. (2002) · Clinical Science · doi:10.1042/cs1020381 · Cited by 83 · see citing works

Aldosterone biosynthesis and action in vascular cells

Takeda, R., Hatakeyama, H., Takeda, Y., Iki, K., Miyamori, I., Sheng, W. P., Yamamoto, H., & Blair, I. A. (1995) · Steroids · doi:10.1016/0039-128x(94)00026-9 · Cited by 79 · see citing works

The biochemical phenotypes of two inborn errors in the biosynthesis of aldosterone

Ulick, S., Wang, J. Z., & Morton, D. H. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.6.1592889 · Cited by 79 · see citing works

Genetic variation in P450c11AS in Chilean patients with low renin hypertension

Fardella, C. E., Rodriguez, H., Montero, J., Zhang, G., Vignolo, P., Rojas, A., Villarroel, L., & Miller, W. L. (1996) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.81.12.8954040 · Cited by 77 · see citing works

Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their functional expression in COS-7 and V79 chinese hamster cells

Denner, K., Doehmer, J., & Bernhardt, R. (1995) · Endocrine Research · doi:10.3109/07435809509030460 · Cited by 77 · see citing works

Glucocorticoid-remediable aldosteronism

Dluhy, R. G., & Lifton, R. P. (1999) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.84.12.6256 · Cited by 74 · see citing works

The CYP11B subfamily

Schiffer, L., Brixius‐Anderko, S., Hannemann, F., Eiden-Plach, A., & Bernhardt, R. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.10.011 · Cited by 73 · see citing works

Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure−Activity and Structure−Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives

Lucas, S., Negri, M., Heim, R., Zimmer, C., & Hartmann, R. W. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101470k · Cited by 71 · see citing works

Primary aldosteronism

Stowasser, M., & Gordon, R. D. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018090-00002 · Cited by 71 · see citing works

Frame shift by insertion of 2 basepairs in codon 394 of CYP11B1 causes congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency

Helmberg, A., Ausserer, B., & Kofler, R. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.5.1430088 · Cited by 71 · see citing works

Molecular cloning and expression during spermatogenesis of a cDNA encoding testicular 11β‐hydroxylase (P450 11β ) in rainbow trout (Oncorhynchus mykiss)

Kusakabe, M., Kobayashi, T., Todo, T., Lokman, P. M., Nagahama, Y., & Young, G. (2002) · Molecular Reproduction and Development · doi:10.1002/mrd.10145 · Cited by 70 · see citing works

Mutation T318M in the CYP11B2 gene encoding P450c11AS (aldosterone synthase) causes corticosterone methyl oxidase II deficiency.

(1995) · PubMed Central · Cited by 68 · see citing works

Isolation and characterization of rat CYP11B genes involved in late steps of mineralo- and glucocorticoid syntheses.

Mukai, K., Imai, M., Shimada, H., & Ishimura, Y. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52987-2 · Cited by 66 · see citing works

Disorders of the Aldosterone Synthase and Steroid 11β-Hydroxylase Deficiencies

Peter, M., Dubuis, J.-M., & Sippell, W. G. (1999) · Hormone Research in Paediatrics · doi:10.1159/000023374 · Cited by 63 · see citing works

Evidence for compromised aldosterone synthase enzyme activity in preeclampsia

Shojaati, K., Causevic, M., Kadereit, B., Dick, B., Imobersteg, J., Schneider, H., Beinder, E., Kashiwagi, M., Frey, B. M., Frey, F. J., et al. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.66031.x · Cited by 59 · see citing works

Modelling of three-dimensional structures of cytochromes P450 11B1 and 11B2

Belkina, N. V., Lisurek, M., Ivanov, A. S., & Bernhardt, R. (2001) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(01)00331-2 · Cited by 59 · see citing works

Genetic Analysis of Aldosterone Synthase in Patients with Idiopathic Hyperaldosteronism

Takeda, Y., Furukawa, K., Inaba, S., Miyamori, I., & Mabuchi, H. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.5.5671 · Cited by 59 · see citing works

Aldosterone: The minority hormone of the adrenal cortex

Müller, J. (1995) · Steroids · doi:10.1016/0039-128x(94)00021-4 · Cited by 58 · see citing works

Congenitally defective aldosterone biosynthesis in humans: The involvement of point mutations of the P-450C18 gene (CYP11B2) in CMO II deficient patients

Mitsuuchi, Y., Kawamoto, T., Rösler, A., Naiki, Y., Miyahara, K., Toda, K., Kuribayashi, I., Orii, T., Yasuda, K., Miura, K., et al. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91827-d · Cited by 55 · see citing works

Steroid Hydroxylation: Microbial Steroid Biotransformations Using Cytochrome P450 Enzymes

Bureik, M., & Bernhardt, R. (2007) · Wiley eBooks · doi:10.1002/9783527611522.ch6 · Cited by 54 · see citing works

Deletion Hybrid Genes, due to Unequal Crossing Over between<i>CYP11B1</i>(11β-Hydroxylase) and<i>CYP11B2</i>(Aldosterone Synthase) Cause Steroid 11β-Hydroxylase Deficiency and Congenital Adrenal Hyperplasia¹

Portrat, S., Mulatero, P., Curnow, K. M., Chaussain, J.-L., Morel, Y., & Pascoe, L. (2001) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.86.7.7671 · Cited by 46 · see citing works

Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination – Insights from metandienone metabolism

Parr, M. K., Zöllner, A., Fußhöller, G., Opfermann, G., Schlörer, N. E., Zorio, M., Bureik, M., & Schänzer, W. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.07.020 · Cited by 45 · see citing works

Functional expression of the cDNAs encoding rat 11β‐hydroxylase [cytochrome P450(11β)] and aldosterone synthase [cytochrome P450(11β, aldo)]

Nonaka, Y., & Okamoto, M. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16449.x · Cited by 43 · see citing works

Genetic Diseases of Steroid Metabolism

White, P. C. (1994) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61147-4 · Cited by 42 · see citing works

Hereditary Defect in Biosynthesis of Aldosterone: Aldosterone Synthase Deficiency 1964–19971

Peter, M., Fawaz, L., Drop, S. L. S., Visser, H. K. A., & Sippell, W. G. (1997) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.82.11.4399 · Cited by 40 · see citing works

Human aldosterone synthase: Recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level

Hobler, A., Kagawa, N., Hutter, M. C., Hartmann, M. F., Wudy, S. A., Hannemann, F., & Bernhardt, R. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.03.002 · Cited by 39 · see citing works

The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein prssessing aldosterone synthase activity

Miyahara, K., Kawamoto, T., Mitsuuchi, Y., Toda, K., Imura, H., Gordon, R. D., & Shizuta, Y. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)92286-7 · Cited by 39 · see citing works

Steroid 11β-Hydroxylase Deficiency and Related Disorders

White, P. C., & Speiser, P. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30100-2 · Cited by 38 · see citing works

The potential of targeting CYP11B

Bernhardt, R. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1151873 · Cited by 35 · see citing works

Congenital Hyperreninemic Hypoaldosteronism Unlinked to the Aldosterone Synthase (CYP11B2) Gene

Kayes, K. M., Tannin, G. M., Shulman, D. I., Peled, D., Jones, K. L., Karaviti, L. P., & White, P. C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.8005 · Cited by 32 · see citing works

Molecular genetic study in two patients with congenital hypoaldosteronism (types I and II) in relation to previously published hormonal studies

Peter, M., Bünger, K., Drop, S., & Sippell, W. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1390096 · Cited by 31 · see citing works

Structure/function relationship of CYP11B1 associated with Dahl's salt‐resistant rats

Nonaka, Y., Fujii, T., Kagawa, N., Waterman, M. R., Takemori, H., & Okamoto, M. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2580869.x · Cited by 31 · see citing works

Homozygous Deletion of Arginine-173 in the CYP11B2 Gene in a Girl with Congenital Hypoaldosteronism

Peter, M., Nikischin, W., Heinz‐Erian, P., Fussenegger, W., Kapelari, K., & Sippell, W. G. (1998) · Hormone Research in Paediatrics · doi:10.1159/000023278 · Cited by 31 · see citing works

Genetic recombination as a cause of inherited disorders of aldosterone and cortisol biosynthesis and a contributor to genetic variation in blood pressure

Pascoe, L., & Curnow, K. M. (1995) · Steroids · doi:10.1016/0039-128x(94)00003-u · Cited by 30 · see citing works

Metabolism of Oral Turinabol by Human Steroid Hormone–Synthesizing Cytochrome P450 Enzymes

Schiffer, L., Brixius‐Anderko, S., Hannemann, F., Zapp, J., Neunzig, J., Thevis, M., & Bernhardt, R. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.066829 · Cited by 29 · see citing works

In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17

Enberg, U., Farnebo, L., Wedeil, A., Grondai, S., Thorén, M. C., Grimelius, L., Kjellman, M., Bäckdahl, M., & Hamberger, B. (2001) · World Journal of Surgery · doi:10.1007/s00268-001-0035-2 · Cited by 29 · see citing works

Mutations in CYP11B1 Gene Converting 11 -Hydroxylase into an Aldosterone-Producing Enzyme Are Not Present in Aldosterone-Producing Adenomas

Pilon, C., Mulatero, P., Barzon, L., Veglio, F., Garrone, C., Boscaro, M., Sonino, N., & Fallo, F. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.11.6125 · Cited by 28 · see citing works

Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes

Erdmann, B., Gerst, H., B�low, H., Lenz, D., B�hr, V., & Bernhardt, R. (1995) · Histochemistry and Cell Biology · doi:10.1007/bf01464326 · Cited by 28 · see citing works

Molecular biology of 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase enzymes

White, P. C., Pascoe, L., Curnow, K. M., Tannin, G. M., & Rösler, A. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90309-7 · Cited by 28 · see citing works

Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma

Wu, K., Chen, Y., Chu, S., Hung, K., Hsieh, T. S., & Hsieh, B. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.3.7883831 · Cited by 27 · see citing works

Molecular biology of rat steroid 11ß-hydroxylase [P450(11ß)] and aldosterone synthase [P450(11ß, Aldo)]

Okamoto, M., & Nonaka, Y. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90367-r · Cited by 27 · see citing works

Multisteroid analysis in children with terminal aldosterone biosynthesis defects

Peter, M., Partsch, C., & Sippell, W. G. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.5.7745009 · Cited by 27 · see citing works

Modulation of aldosterone biosynthesis by adrenodoxin mutants with different electron transport efficiencies

Cao, P., & Bernhardt, R. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00704.x · Cited by 26 · see citing works

Mutation THR-185 ILE is associated with corticosterone methyl oxidase deficiency type II

Peter, M., Bünger, K., Sólyom, J., & Sippell, W. G. (1998) · European Journal of Pediatrics · doi:10.1007/s004310050833 · Cited by 26 · see citing works

Analysis of Unilateral Adrenal Hyperplasia with Primary Aldosteronism from the Aspect of Messenger Ribonucleic Acid Expression for Steroidogenic Enzymes: A Comparative Study with Adrenal Cortices Adhering to Aldosterone-Producing Adenoma

Shigematsu, K., Kawai, K., Irie, J., Sakai, H., Nakashima, O., Iguchi, A., Shimamatsu, J., Shimamatsu, K., Kusaba, Y., & Takahara, O. (2005) · Endocrinology · doi:10.1210/en.2005-0765 · Cited by 26 · see citing works

Fetal and Neonatal Adrenocortical Physiology

Winter, J. S. D. (2004) · Elsevier eBooks · doi:10.1016/b978-0-7216-9654-6.50190-9 · Cited by 26 · see citing works

The effect of amino‐acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme

Bechtel, S., Belkina, N., & Bernhardt, R. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02729.x · Cited by 26 · see citing works

Structural differences in 5′-flanking regions of rat cytochrome P-450aldo and P-45011β genes

Mukai, K., Imai, M., Shimada, H., Okada, Y., Ogishima, T., & Ishimura, Y. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81321-x · Cited by 26 · see citing works

Five novel mutations in CYP11B2 gene detected in patients with aldosterone synthase deficiency type I: Functional characterization and structural analyses

Nguyen, H.-H., Hannemann, F., Hartmann, M. F., Małunowicz, E., Wudy, S. A., & Bernhardt, R. (2010) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2010.04.016 · Cited by 25 · see citing works

The human genome contains only two CYP11B (P450c11) genes

Zhang, G., & Miller, W. L. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784078 · Cited by 25 · see citing works

Human adrenal CYP11B1: Localization by in situ-hybridization and functional expression in cell cultures

Erdmann, B., Denner, K., Gerst, H., Lenz, D., & Bernhardt, R. (1995) · Endocrine Research · doi:10.3109/07435809509030458 · Cited by 25 · see citing works

Cellular origin of aldosteronomas

Ganguly, A. (1992) · Journal of Molecular Medicine · doi:10.1007/bf00235519 · Cited by 24 · see citing works

The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: Old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension

Hakki, T., Hübel, K., Waldmann, H., & Bernhardt, R. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.12.011 · Cited by 23 · see citing works

REGULATION OF ALDOSTERONE BIOSYNTHESIS: THE END OF THE ROAD?

Müller, J. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02306.x · Cited by 23 · see citing works

Cloning and expression of cytochrome P450(11β) of porcine adrenal cortex

Sun, T., Zhao, Y., Nonaka, Y., & Okamoto, M. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)00167-k · Cited by 23 · see citing works

The hamster adrenal cytochrome P450C11 has equipotent 11β-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity

Véronneau, S., Bernard, H., Cloutier, M., Courtemanche, J., Ducharme, L., Lefèbvre, A., Mason, J. I., & Lehoux, J. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00249-9 · Cited by 23 · see citing works

Aldosterone synthase deficiency caused by a homozygous L451F mutation in the CYP11B2 gene

Nguyen, H.-H., Hannemann, F., Hartmann, M. F., Wudy, S. A., & Bernhardt, R. (2008) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.11.009 · Cited by 22 · see citing works

Separate induction of the two isozymes of cytochrome P-45011 in rat adrenal zona glomerulosa cells

Müller, J., & Oertle, M. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90077-a · Cited by 22 · see citing works

Molecular genetic studies in a case series of isolated hypoaldosteronism due to biosynthesis defects or aldosterone resistance

Turan, İ., Kotan, L. D., Taştan, M., Gürbüz, F., Topaloglu, A. K., & Yüksel, B. (2018) · Clinical Endocrinology · doi:10.1111/cen.13603 · Cited by 21 · see citing works

The presence of two cytochrome P450 aldosterone synthase mRNAs in the hamster adrenal

Lehoux, J., Mason, J. I., Bernard, H., Ducharme, L., Lehoux, J., Véronneau, S., & Lefèbvre, A. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90003-5 · Cited by 21 · see citing works

CORTICOSTEROIDS IN ESSENTIAL HYPERTENSION: MULTIPLE CANDIDATE LOCI AND PHENOTYPIC VARIATION

Connell, J., Kenyon, C. J., Ingram, M. C., Holloway, C., Jamieson, A., Panarelli, M., Inglis, G., & Fräser, R. (1996) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1996.tb02743.x · Cited by 20 · see citing works

Steroid 11-Beta-Hydroxylase Deficiency Caused by Compound Heterozygosity for a Novel Mutation, p.G314R, in One CYP11B1 Allele, and a Chimeric CYP11B2/CYP11B1 in the Other Allele

Kuribayashi, I., Nomoto, S., Massa, G., Oostdijk, W., Wit, J. M., Wolffenbuttel, B. H. R., Shizuta, Y., & Honke, K. (2005) · Hormone Research in Paediatrics · doi:10.1159/000087074 · Cited by 18 · see citing works

Defects of Adrenal Steroidogenesis

Yau, M., Khattab, A., Pina, C., Yuen, T., Meyer‐Bahlburg, H. F. L., & New, M. I. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00104-9 · Cited by 18 · see citing works

Molecular identity and gene expression of aldosterone synthase cytochrome P450

Okamoto, M., Nonaka, Y., Takemori, H., & Doi, J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.187 · Cited by 17 · see citing works

Molecular cloning and expression of cDNAs encoding rat aldosterone synthase: Variants of cytochrome P-45011β

Matsukawa, N., 悠次, 野., Ying, Z., Higaki, J., Ogihara, T., & Okamoto, M. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91460-a · Cited by 95 · see citing works

Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism

Ogishima, T., Shibata, H., Shimada, H., Mitani, F., Suzuki, H., Saruta, T., & Ishimura, Y. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99077-0 · Cited by 141 · see citing works

Cloning and Expression of a Rat Cytochrome P-450 11β-Hydroxylase/Aldosterone Synthase (CYP11B2) cDNA Variant

Zhou, M. Y., & Gómez-Sánchez, C. E. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1792 · Cited by 9 · see citing works

Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P‐450 in rat adrenal cortex

Imai, M., Shimada, H., Okada, Y., Matsushima‐Hibiya, Y., Ogishima, T., & Ishimura, Y. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81398-8 · Cited by 92 · see citing works

Functional expression of the cDNAs encoding rat 11β‐hydroxylase [cytochrome P450(11β)] and aldosterone synthase [cytochrome P450(11β, aldo)]

Nonaka, Y., & Okamoto, M. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16449.x · Cited by 43 · see citing works