ATP-sensitive K+ channels may control glucose-induced electrical activity in pancreatic B-cells.
Abstract
Tolbutamide and diazoxide, which respectively decrease and increase the activity of ATP-sensitive K+ channels, were used to investigate whether these channels play a role in the control of glucose-induced electrical activity (slow waves with spikes) in pancreatic B-cells. Addition of tolbutamide to a medium containing 10 mM glucose largely mimicked the effects of a rise in glucose concentration from 10 to 15 mM on electrical activity, ionic fluxes and insulin release. Tolbutamide was still active in the presence of maximally effective concentrations of glucose (30-40 mM). Diazoxide restored slow waves of membrane potential in B-cells which were persistently depolarized by 30 mM glucose. It is concluded that ATP-sensitive K+ channels are still operative at high glucose concentrations. These channels could thus be one target on which physiological concentrations of glucose act to regulate electrical activity in B-cells and, hence, insulin release.
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Glucose and tolbutamide influence KATP-channel activity also at supra-threshold glucose concentrations.
“These data indicate, consistent with conclusions based on membrane potential measurements (261, 335), that glucose and tolbutamide influence KATP-channel activity also at supra-threshold glucose concentrations.”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [261]
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Intracellular ATP directly blocks K+ channels in pancreatic B-cells
Cook, D. L., & Hales, N. (1984) · Nature · doi:10.1038/311271a0 · Cited by 1,208 · see citing works
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Triggering and amplifying pathways of regulation of insulin secretion by glucose.
Henquin, J. C. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1751 · Cited by 1,201 · see citing works
Self-citationPancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
Gembal, M., Gilon, P., & Henquin, J. C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115714 · Cited by 494 · see citing works
Self-citationGöpel, S. O., Kanno, T., Barg, S., Eliasson, L., Galvanovskis, J., Renström, E., & Rorsman, P. (1999) · The Journal of General Physiology · doi:10.1085/jgp.114.6.759 · Cited by 137 · see citing works
Bertram, R., Satin, L. S., Pedersen, M. G., Luciani, D. S., & Sherman, A. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.097154 · Cited by 105 · see citing works
- Authors
- Henquin, J.-C.
- Affiliations
- Saarland University (DE)
- Corresponding author
- Henquin, Jean-Claude
- ORCID
- Henquin, Jean-Claude
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1988-10
- Volume
- 156
- Issue
- 2
- Pages
- 769-775
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2065997734
- Cited by
- 83
- References
- 1
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- ATP-sensitive potassium channels, pancreatic beta cells, slow waves, tolbutamide, diazoxide, insulin secretion, membrane potential, high glucose, ion flux
- MeSH terms
- Insulin Secretion, Adenosine Triphosphate, Animals, Calcium, Calcium Radioisotopes, Cell Membrane Permeability, Diazoxide, Electrophysiology, Female, Glucose, Insulin, Islets of Langerhans, Membrane Potentials, Rubidium Radioisotopes, Tolbutamide, Potassium Channels, Mice
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